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Could a simple annual blood test shield cancer survivors from heart attacks and strokes?

NCT ID NCT07738250

Knowledge-focused Sponsor: Samsung Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study looks at whether getting a yearly LDL cholesterol test could help cancer survivors avoid serious heart problems like heart attacks and strokes. Researchers will analyze health records from over a million cancer survivors in Korea, comparing those who had the test with those who didn't. The goal is to see if routine testing leads to better heart care and fewer cardiovascular events, which could inform long-term survivorship care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If annual LDL testing proves beneficial, it could support routine heart-disease prevention as part of long-term cancer survivorship care.
What could go wrong
This is an observational study, so it can only show associations, not cause and effect. The results may be influenced by other health factors and may not apply to all cancer survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,294,726 people

The number who actually took part.

Started

Jan 2016

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of cancer survivors identified from a nationwide Korean cancer registry linked to national health insurance claims. Eligibility is reassessed at a series of annual emulated trial baselines beginning 1 year after cancer diagnosis. Individuals may contribute to more than one annual trial if they continue to meet all eligibility criteria. At each baseline, participants must be alive, statin-naive, and free of prior cardiovascular disease, myocardial infarction, stroke, familial hypercholesterolemia, percutaneous coronary intervention, and coronary artery bypass grafting. Participants are classified according to whether annual LDL-C testing occurred, and are followed for statin initiation and cardiovascular outcomes.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals with a diagnosis of cancer recorded in the nationwide cancer registry and health insurance database * Alive and under observation at least 1 year after the initial cancer diagnosis * Eligible for entry at an annual emulated trial baseline * Not receiving statin therapy at the corresponding trial baseline * Available information on age, sex, cancer type, year of cancer diagnosis, cancer stage, diabetes mellitus, hypertension, and dyslipidemia * Continuous eligibility for outcome ascertainment in the national health insurance database Exclusion Criteria: * History of cardiovascular disease before the corresponding trial baseline * History of myocardial infarction or stroke before the corresponding trial baseline * History of familial hypercholesterolemia * History of percutaneous coronary intervention or coronary artery bypass grafting * Use of statin therapy before or at the corresponding trial baseline * Missing information required to determine eligibility, exposure status, or prespecified baseline covariates

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Conditions

The condition(s) this trial relates to.

cancer cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer survivorship Cardiovascular disease

More trials for these conditions

Other studies related to the condition(s) this trial covers.