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Fruits and veggies may rival medication for kidney health

NCT ID NCT06545461

Disease control Sponsor: Donald Wesson Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with stage 3 kidney disease were followed for up to 10 years. The goal was to see if these simple, low-cost approaches could preserve kidney function better than usual care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fruits and vegetables (dietary intervention) and sodium bicarbonate tablets
What this could lead to
If successful, this could show that a simple dietary change (eating more fruits and vegetables) is as effective as medication for slowing kidney disease and lowering heart risks.
What could go wrong
This is a small, completed trial with 108 participants, so results may not apply to everyone. Dietary changes can be hard to maintain long-term, and sodium bicarbonate may cause stomach upset or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

108 people

The number who actually took part.

Started

Jun 1998

Finished

Oct 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Non-malignant high blood pressure or hypertension 2. 18-70 yrs old 3. urine albumin-to-creatine ratio \> 200 mg/g creatinine 4. estimated glomerular filtration rate (eGFR) 30 to 59 ml/min/1.73 m2 5. Plasma total CO2 (PTCO2) \> 22 but \< 24 mmol/l 6. able to tolerate angiotensin converting enzyme \[ACE\] inhibition drug therapy because guidelines recommend it for patients with albuminuric CKD 7. non-smoking 8. greater than or equal to 2 primary care visits in the preceding year, indicating compliance 9. Able to provide informed consent. Exclusion Criteria: 1. Malignant hypertension or history thereof 2. primary kidney disease or findings consistent thereof such as \> 3 red blood cells per high powered field of urine or urine cellular casts 3. history of diabetes or fasting glucose greater than or equal to 110/mg/dl 4. history of hematologic disorders, malignancies, chronic infections, current pregnancy, history or clinical evidence of CVD 5. peripheral edema or diagnosis associated with edema such as heart/liver failure or nephrotic syndrome because of the sodium load that accompanies NaHCO3 therapy 6. baseline plasma potassium concentration \> 4.6 mmol/l to reduce the risk for hyperkalemia in those participants randomized to F+Vs which increases dietary potassium intake 7. taking, or unable to stop taking, drugs other than ACE inhibitors that limit urine potassium excretion 8. Unable to provide informed consent.

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Conditions

The condition(s) this trial relates to.

Acidosis Albuminuria cardiovascular disorder chronic kidney disease chronic renal failure syndrome hypertensive disorder metabolic acidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Chronic kidney diseases Hypertension

More trials for these conditions

Other studies related to the condition(s) this trial covers.