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Why some get fitter faster: exercise study probes muscle clues

NCT ID NCT06141512

Knowledge-focused Sponsor: University of Stirling Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at why some people improve their aerobic fitness more than others with exercise. Researchers had 21 healthy men do short, intense cycling workouts and measured changes in fitness and certain muscle signals called myokines. The goal was to see if low responders have weaker myokine responses, which could help design better exercise plans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Reduced-exertion high-intensity interval training (REHIT)
What this could lead to
If successful, this could help explain why some people improve their fitness more than others with exercise, potentially leading to personalized training programs.
What could go wrong
This is a small, early-stage study with only 21 healthy men, so results may not apply to women or people with health conditions. It is observational and does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Oct 2023

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male * Age ≥ 18 y or \<40 y * BMI \< 35 kg/m2 * otherwise healthy, untrained individuals Exclusion Criteria: * Age \<18 y or \>40 y * BMI \> 35 kg/m2 * classification of 'highly physically active' according to the International Physical Activity Questionnaire (IPAQ) * answering 'yes' to one or more questions on a standard Physical Activity Readiness Questionnaire (PAR-Q) * resting heart rate ≥100bpm, clinically significant hypertension (140/90 mmHg) * a personal history of metabolic or cardiovascular disease * Female participants because of unknown effects of the menstrual cycle on the levels of the measured myokines.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

General health

Contacts and locations

Locations

  • University of Stirling

    Stirling, FK9 4LA, United Kingdom

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