Persistent fetal circulation syndrome
MONDO:0022430A cardiopulmonary disorder characterized by systemic arterial hypoxemia secondary to pulmonary hypertension and extrapulmonary right to left shunting across the foramen ovale and ductus arteriosus.
Also known as: PPHN, persistent fetal circulation, persistent foetal circulation, persistent pulmonary hypertension of the newborn
11 clinical trials for this condition and its sub-types, 11 tagged with Persistent fetal circulation syndrome itself.
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Which drug works best for sick newborns? small trial aims to find out
Disease control Recruiting nowThis pilot study tests two medicines, dopamine and norepinephrine, in 30 full-term or near-term newborns with low blood pressure and lung problems caused by pulmonary hypertension. The goal is to see which drug better improves blood flow and oxygen levels. Results could help doct…
Phase 4 • Sponsor: University of California, Davis • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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Smart machine takes over weaning of lung medicine for sick newborns
Disease control Recruiting nowThis study tests a new smart device that automatically lowers the dose of inhaled nitric oxide in newborns with persistent pulmonary hypertension. The device aims to make the weaning process safer and more consistent by using a gradual, real-time reduction instead of manual step …
Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Could your genes raise Baby's risk from common painkillers?
Knowledge-focused Recruiting nowThis study is investigating whether natural differences in the PTGS1 gene make some newborns more likely to develop a serious lung condition called persistent pulmonary hypertension (PPHN) after their mothers took over-the-counter pain relievers (NSAIDs) during pregnancy. Researc…
Sponsor: Medical College of Wisconsin • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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New study tracks treprostinil use in newborns with lung condition
Knowledge-focused Recruiting nowThis observational study will follow 60 newborns with persistent pulmonary hypertension (PPHN) who receive treprostinil as part of their routine care. Researchers will collect data on how the drug is used, its safety, and its effectiveness in real-world hospital settings. The goa…
Sponsor: Ferrer Internacional S.A. • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:05 UTC