Which drug is better for low BP in C-Sections? new study has answers
NCT ID NCT07153601
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compared two medications, norepinephrine and phenylephrine, for treating low blood pressure during spinal anesthesia in C-sections. 46 women were randomly given one of the two drugs when their blood pressure dropped. Both drugs worked well, but norepinephrine kept the heart rate more stable, while phenylephrine caused a slower heart rate. The results suggest norepinephrine may be a better choice for managing this common complication.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- norepinephrine and phenylephrine
- What this could lead to
- If confirmed, norepinephrine could become the preferred drug for managing low blood pressure during C-sections, offering better heart rate stability.
- What could go wrong
- This was a small, single-center study with only 46 participants. Larger trials are needed to confirm the results and ensure safety across diverse populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
46 people
The number who actually took part.
- Started
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Feb 2025
- Finished
-
May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female patients aged 18-40 years * Undergoing elective cesarean section * Receiving spinal anesthesia * Classified as ASA Physical Status II * Stable baseline hemodynamics prior to anesthesia * Not using inotropic, chronotropic, or vasoactive drugs before surgery Exclusion Criteria: * Emergency cesarean section * Fetal distress * Preeclampsia or eclampsia * Contraindications to spinal anesthesia (e.g., coagulopathy, infection at injection site) * Known allergy to norepinephrine or phenylephrine * Hemodynamic instability prior to vasopressor administration * Withdrawal from study or refusal to participate * Failure to develop post-spinal hypotension
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Adam Malik Hospital
Medan, North Sumatra, Indonesia
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Other studies related to the condition(s) this trial covers.
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