CARDIOVASCULAR

This study aims to improve the heart health of home health aides, a group that often neglects their own health while caring for others. Forty home health aides will take part in a 10-week program called Life's Essential 8, guided by trained peer coaches. The program focuses on he…

This study is testing a new treatment called CTX310, which uses CRISPR gene editing to turn off a gene linked to high cholesterol and fats. It is for adults aged 18 to 75 whose lipid levels remain high despite standard treatments. The goal is to see if the therapy is safe and can…

This study looks at whether a set of health interventions can help women going through menopause reduce inflammation, improve heart health, slow biological aging, and ease symptoms like hot flashes. Researchers will enroll 200 women aged 45-55 who are in late menopause transition…

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney disease to help develop better diagnostic tests. Researchers will compare new test methods with standard ones to see if they are accurate and reliable. The goal is to creat…

This study tests a tool called 'Breathlessness diagnostics in a Box' (BiaB) to see if it helps doctors in the Netherlands, Spain, and Portugal find the cause of breathlessness faster than usual care. About 900 adults with unexplained or worsening breathlessness will take part. Th…

This study aims to understand why some cancer patients develop heart problems after receiving immune checkpoint inhibitors (a type of immunotherapy). Researchers will analyze blood samples and genetic factors from 1,200 adults starting this treatment. The goal is to find ways to …

This study looks at whether giving critically ill patients red blood cells from a donor of the same sex (sex-matched) versus the opposite sex (sex-mismatched) affects their chances of survival. Over 11,000 adults in intensive care who need a transfusion will be randomly assigned …

This study follows 5 people with recent spinal cord injuries for one year to see how their heart and blood pressure change. Researchers will test if a gentle electrical stimulation on the back can help stabilize blood pressure. The goal is to understand the body's response over t…

This study tests a small, wearable sensor that measures lactate levels through the skin in people recovering from heart surgery. Researchers want to see if the sensor is as accurate as standard blood tests. If it works, it could mean fewer needle sticks and faster monitoring for …

This study looks at how a 2-hour bout of sitting affects blood pressure over the next 24 hours in healthy adults aged 18-65. Researchers will measure artery function and blood pressure before, during, and after sitting, and test whether blocking certain artery-relaxing chemicals …

This study is testing whether a new web-based AI platform called Okaya can accurately detect fatigue and depression in people with heart conditions. Researchers will compare the platform's results to standard questionnaires (PHQ-9 and FAS). About 100 adults who speak English and …

This study looks at how drinking enough water—either plain or as non-sugary drinks—affects hydration, blood sugar control, and heart health. Researchers will track 144 adults with normal weight or obesity over 8 weeks. The goal is to see if better hydration can lower risks for di…