Secondary neoplasm

This trial investigates whether adding everolimus (RAD001) to trastuzumab (Herceptin) can help people with a specific type of advanced breast cancer that has stopped responding to trastuzumab alone. The study includes people with HER2-positive, PTEN-deficient metastatic breast ca…

This study tests whether combining two targeted drugs, avutometinib and adagrasib, can shrink tumors in people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants must have already tried a KRAS G12C inhibitor and seen their c…

This phase 2 study tested two drugs—durvalumab and cetuximab—together in 35 people with head and neck cancer that had come back or spread and was no longer responding to standard treatments. The goal was to see if the combination could shrink tumors. The study is complete, and re…

This phase 2 trial tested the immunotherapy drug pembrolizumab (Keytruda) alone or combined with idelalisib or ibrutinib in 65 patients with chronic lymphocytic leukemia (CLL) or low-grade B-cell non-Hodgkin lymphoma (NHL) that had returned or stopped responding to treatment. The…

This phase 2 trial investigates whether a single, low dose of radiation to the small intestine can help the immune system recognize and attack tumors again in people with advanced solid cancers that have stopped responding to immunotherapy. Participants receive 1Gy of radiation t…

This phase 2 trial tested the chemotherapy drug carboplatin in 16 men with metastatic castration-resistant prostate cancer that has specific gene changes in the homologous recombination pathway. The goal was to see if carboplatin could shrink tumors or lower PSA levels. The study…

This study tested a new oral drug called BGB-43395 in 33 Chinese patients with advanced or metastatic HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. The goal was to find a safe dose and see if it can shrink tumors wh…

This study tested a new under-the-skin shot version of the cancer drug pembrolizumab (Keytruda) in 142 people with advanced solid tumors. The goal was to see how well the body absorbs the drug compared to the standard IV infusion. Researchers also checked for side effects and how…

This early-phase trial tested whether a new type of immune cell therapy (CD22 CAR T cells) could be safely made and given to 10 children and young adults whose B-cell leukemia or lymphoma had come back or stopped responding to treatment. The therapy uses the patient's own immune …

This early-stage trial tested an experimental drug called LVGN6051, which activates immune cells by targeting CD137, both alone and combined with the approved immunotherapy Keytruda. The study involved 105 adults with advanced or metastatic cancers that had spread. The main goal …

This study looked at whether adding focused radiation (SBRT) or surgery to standard treatments like chemo or hormone therapy helps people with breast cancer that has spread to just one or two places. 129 participants were randomly assigned to get standard care alone or standard c…

This study tested a combination of whole-brain radiation and a chemotherapy drug (thiotepa) injected into the spinal fluid for people with solid tumors that spread to the lining of the brain and spinal cord. 58 participants received this treatment along with their regular cancer …

This registry followed 152 patients with colorectal cancer that had spread mainly to the liver. Doctors used tiny beads called LifePearl Microspheres loaded with the chemotherapy drug irinotecan, delivered directly to the liver's blood supply. The goal was to see how and when thi…

This early-phase study tested a new radioactive drug called 177Lu-CTR-FAPI in 12 people with advanced solid tumors (breast cancer, sarcoma, or thyroid cancer) that had spread and no longer responded to standard treatments. The main goals were to see if the drug is safe and how it…

This study tested a new drug called MRG004A in 39 adults with advanced or metastatic solid tumors that have a specific marker called tissue factor. The goal was to find the safest dose and see if the drug can shrink tumors. Researchers monitored side effects and how well the drug…

This study tested giving focused radiation before surgery to people with cancer that spread to the brain. The goal was to see if this approach is safe and might lower the chance of the tumor coming back. 26 adults with brain metastases took part. The treatment aims to control the…

This registry followed 500 adults with colorectal cancer that spread to the liver. All were treated with a microwave ablation device that uses heat to destroy tumors. The goal was to see how well the device controls tumors locally over 12 months and to track any side effects. The…

This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone dr…

This study tested a combination of two drugs, acalabrutinib and pembrolizumab, in 161 people with various blood cancers such as lymphoma, leukemia, and multiple myeloma. The main goal was to check safety and side effects, while also seeing if the tumors shrank. The approach aims …

This study tested an experimental drug called CBX-12 in 69 adults with advanced solid tumors (like ovarian, lung, breast, or colon cancer) that had stopped responding to standard therapies. The main goals were to check the drug's safety, find the best dose, and see if it could sh…

This phase I trial tested a special type of radiation called hypofractionated radiosurgery for people with large brain metastases (tumors that spread from other cancers). The goal was to find the safest and most effective dose while limiting damage to healthy brain tissue. Twenty…

This early-phase trial tested a new drug called M6223, which blocks a protein called TIGIT that can turn off immune cells. M6223 was given alone or together with another drug, bintrafusp alfa, to 58 people with advanced solid tumors that had stopped responding to standard treatme…

This phase 2 trial tested a drug called patritumab deruxtecan (HER3-DXd) in 63 patients with breast cancer, lung cancer, or other solid tumors that had spread to the brain or the lining of the brain and spinal cord. The drug is designed to seek out and destroy cancer cells carryi…

This study tested whether a single, high dose of targeted radiation can control cancer that has spread to just a few spots (1-5 tumors). 150 adults with limited metastatic cancer received this treatment to see if it could delay further spread and improve survival. The goal is to …

This early-phase trial tested a new drug called AZD8186 combined with the chemotherapy docetaxel in 23 patients with advanced solid tumors that have PTEN or PIK3CB gene mutations. The main goal was to find the safest dose and understand side effects. The study is complete, but re…

This early-phase study tested a combination of two drugs, cabozantinib and TAS-102, in 15 people with advanced colorectal cancer that had spread and stopped responding to standard treatments. The main goal was to find the safest dose and identify side effects. The study is comple…

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This early-stage trial tested a modified vaccinia virus (VV-GMCSF-Lact) injected directly into tumors of 34 women with recurrent or metastatic breast cancer that no longer responded to standard treatments. The main goal was to check safety and find the highest safe dose. Research…

This early-stage trial tested an experimental drug called CTX-471, given alone or with the approved drug Keytruda, in 100 adults with advanced cancers like lung cancer, melanoma, and head and neck cancer. The goal was to see if the combination is safe and tolerable for patients w…

This study tested a chemotherapy cocktail called FOLFIRINOX in 72 patients aged 70 or older with metastatic pancreatic cancer. The doses were adjusted based on each person's genetics to reduce side effects while still fighting the tumor. The goal was to see if this approach could…

This phase 2 trial tested the drug sunitinib in 21 patients with kidney cancer that had spread to the brain. The goal was to see if the drug could shrink brain tumors by blocking blood flow and cell growth. Researchers measured how many patients had a response after two treatment…

This phase 2 trial tested whether adding the drug veliparib to standard chemotherapy (cisplatin) helps people with metastatic triple-negative or BRCA-related breast cancer, including those with brain metastases. The study enrolled 344 participants to see if the combination slows …

This study tested a new drug called TAK-676, alone and with pembrolizumab, in 248 adults with advanced solid tumors that had no standard treatment options. The main goal was to check safety and find the highest dose that causes few side effects. The study also looked at how well …

This early study tested whether giving a single dose of nivolumab with either ipilimumab or relatlimab before surgery is safe and possible for people with melanoma that has spread to the brain. Only one person took part, so results are very limited. The goal was to see how the dr…

This phase 3 trial tested whether a surgical procedure called laparotomy plus heated chemotherapy (HIPEC) could improve outcomes for colorectal cancer patients at high risk of cancer spreading in the abdomen. 150 patients who had already undergone surgery and chemotherapy were ra…

This early-phase trial tested the safety of combining pioglitazone (a diabetes drug) with carboplatin (a chemotherapy) in 14 people with advanced solid tumors that could not be cured with standard treatments. The goal was to find the best dose and see if the combination is safe. …

This early-phase study tested a new immune cell therapy called PD-L1 t-haNK in 16 adults with advanced solid cancers that had spread or could not be removed by surgery. The main goals were to check safety, find the best dose, and see if the treatment could shrink tumors. The ther…

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested whether a new type of immune cell therapy, called CD22 CAR T cells, could be made from patients' own blood cells and safely given to adults with hard-to-treat B-cell leukemia or lymphoma. The main goals were to see if the cells could be produced successfully and…

This phase 2 trial tested a combination of chemotherapy drugs given directly into the liver artery for people with pancreatic cancer that had spread only to the liver and stopped responding to standard treatment. The 40 participants received a mix of oxaliplatin, irinotecan lipos…

This pilot study tested whether giving gamma knife radiation before surgery for brain metastases is safe and feasible. Eleven adults with 1 to 4 brain tumors took part. The goal was to see how many patients could have surgery after radiation and how many had no visible tumor left…

This early-phase study tested a combination of two drugs, temsirolimus and cetuximab, in 45 adults with advanced or metastatic solid tumors that had not responded to standard treatments. The goal was to check safety and see if blocking two cancer pathways at once could slow tumor…

This study tested whether a device that uses focused ultrasound can safely and temporarily open the blood-brain barrier in people with HER2-positive breast cancer that has spread to the brain. Eight participants received the procedure, and researchers checked for side effects and…

This early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…

This early-phase trial tested a new drug called ALRN-6924 combined with the chemotherapy paclitaxel in 28 adults with advanced solid tumors that had spread or couldn't be removed by surgery, including a type of breast cancer. The main goal was to find the safest dose and check fo…

This phase II trial tested whether adding sorafenib to cetuximab works better than cetuximab alone for patients with advanced head and neck cancer that has come back or spread. Fifty-five adults with various types of head and neck cancer took part. The study measured how long pat…

This early study tested combining the immunotherapy drug pembrolizumab with precise radiation (stereotactic radiosurgery) in 25 people with melanoma or lung cancer that had spread to the brain. The main goal was to check for serious side effects. Researchers also tracked how long…

This study tests whether adding a third drug, ipilimumab, to the standard two-drug combination (atezolizumab and bevacizumab) improves survival and tumor shrinkage in people with advanced liver cancer. About 229 patients will receive either the standard two drugs or all three. Th…

This study tested a new approach for people with large brain metastases (tumors that spread from other cancers). Instead of the usual surgery followed by radiation, patients received focused radiation first, then surgery. The goal was to see if this order reduces side effects and…

This study tested a 5-day course of high-dose radiation therapy (SBRT) for people with solid tumors that have spread to up to 5 spots in the body. The goal was to see if giving a stronger dose to the tumor while protecting normal tissue could control the disease and limit side ef…

This phase 2 trial tested a three-part treatment for people with colorectal cancer that spread to the liver and stopped responding to standard treatments. The approach combines two minimally invasive procedures (TACE and HAIC) with the targeted drug regorafenib. The goal was to s…

This early-phase trial tested the drug avelumab (Bavencio) combined with whole-brain radiotherapy in 16 patients with leptomeningeal disease, a condition where cancer spreads to the lining of the brain and spinal cord. The main goal was to find a safe dose and check for side effe…

This study compares two radiation approaches for leptomeningeal metastases, a condition where cancer spreads to the fluid and lining around the brain and spinal cord. One group receives proton craniospinal irradiation, which targets the entire brain and spine, while the other get…

This phase II trial tested the drug infigratinib in 17 adults with advanced or metastatic solid tumors that have specific FGFR gene mutations. The drug works by blocking overactive FGFR proteins that help cancer grow. The study measured how many patients' tumors shrank or stabili…

This study tested a radioactive drug called radium-223 in 921 men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if it helps them live longer and controls the cancer. Participants received either the drug …

This early-phase trial tested a new treatment called BZ019, made from a patient's own immune cells modified to attack cancer. It involved 12 adults with aggressive B-cell lymphomas that had not responded to standard therapy. The main goals were to check safety and see if the trea…

This completed phase II study tested a combination of two drugs—tadalafil (Cialis) and pembrolizumab (Keytruda)—in 7 adults with advanced head and neck cancer that had spread or come back. The goal was to see if the combination was safe and could help control the disease. Because…

This study tested a precise type of radiation called fractionated stereotactic radiotherapy (FSRT) in 33 adults with 1 to 4 small brain metastases (each 2 cm or smaller). The goal was to see if this approach could control the tumors while avoiding serious side effects like radiat…

This study tested whether letting cancer patients choose their own smoking cessation treatment helps them quit. 126 patients with tobacco-related cancers received either varenicline, bupropion, or nicotine patches based on their preference, plus counseling. The goal was to see if…

This early study tested a new cell therapy called QH104 in just 3 patients whose solid tumors had spread to the lining of the brain (meningeal metastases) and had a specific marker called B7H3. The treatment uses specially engineered immune cells (CAR-γδ T cells) injected directl…

This study tested a new immunotherapy drug, ezabenlimab, combined with other cancer medicines in 211 adults with advanced solid tumors that had spread. The goal was to see if the tumors shrank or disappeared. Participants received different drug combinations, and doctors monitore…

This early-phase trial tested a new oral drug called ART4215 in 93 people with advanced or metastatic solid tumors, including breast cancer. The main goals were to find a safe dose and check for side effects when given alone or with other cancer drugs (talazoparib or niraparib). …

This early-stage study tested a new drug called PRT2527, alone or with other cancer drugs (zanubrutinib or venetoclax), in 86 people with various blood cancers that had returned or stopped responding to standard treatments. The main goals were to check safety, find the best dose,…

This early-phase trial tested whether adding two chemotherapy drugs (6-mercaptopurine and 6-thioguanine) to an immunotherapy drug (Atezolizumab) could help treat advanced solid tumors that have stopped responding to standard treatments. The study enrolled 18 adults with metastati…

This study tested a new bone graft material, ZetaMet, in 10 women with breast cancer that spread to their spine, causing bone defects. The graft was implanted into the damaged vertebra to see if it could safely stabilize the spine and reduce pain. The main goals were to track com…

This phase II trial tested whether combining the immunotherapy drug pembrolizumab (Keytruda) with targeted radiation therapy could help patients whose non-Hodgkin lymphoma had returned or stopped responding to treatment. Seventeen adults with aggressive lymphoma types received bo…

This study tested whether analyzing the genes of a person's salivary gland tumor could help doctors pick a more effective drug. 114 people with advanced or returning cancer joined. First, their tumor was genetically profiled. Then, if a targetable gene change was found, they got …

This early-stage trial tested a new drug called MRX-2843 in 42 adults with advanced solid tumors that had spread or come back after other treatments. The main goal was to check safety and find the right dose. Researchers monitored side effects and how the drug moved through the b…

This study tested a combination of two immunotherapy drugs, low-dose ipilimumab and pembrolizumab, in 24 people with advanced melanoma that had spread to the brain. The goal was to see if the treatment could shrink or control brain tumors and improve survival. Participants receiv…

This study tested the drug osimertinib (Tagrisso) in 73 patients with a specific type of lung cancer that had spread to the lining of the brain and spinal cord (leptomeningeal metastases). Patients took one 80 mg tablet daily. The goal was to see if the drug could improve overall…

This early-phase trial tested an experimental drug called ADG116, which helps the immune system attack cancer cells. The study included 72 adults with advanced solid tumors that had stopped responding to standard treatments. Some participants received ADG116 alone, while others g…

This early-phase study tested a new drug called WTX-330 in 25 adults with advanced solid tumors or lymphoma that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the drug could shrink tumors. The study is now comp…

This early-phase trial tested a new drug called FL115 in 18 adults with advanced solid tumors that had stopped responding to standard treatments. FL115 is designed to strengthen the body's immune cells to fight cancer. The main goal was to check safety and find the right dose, wh…

This early-phase study tested an experimental oral drug called Q702 in 51 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find a safe dose and check for side effects, while also looking at whether the drug could shrink …

This phase 1 study tested an experimental drug called LY3039478 in 247 people with advanced or metastatic cancer, including lymphoma. The main goal was to find a safe dose and see how the drug affects the body. Researchers also looked for signs that the drug might shrink tumors.

This early-phase study tested a new radioactive drug called [177Lu]Lu-TEFAPI-06 in 5 people with advanced solid tumors that had spread and were no longer responding to standard treatments. The main goal was to check safety and see how the drug moves through the body. Researchers …

This early-phase study tested a new mix of three drugs—IL-15, nivolumab, and ipilimumab—in 31 adults with cancers that no longer respond to standard treatments. The goal was to find the safest dose and see if the combination could help the immune system attack tumors. Participant…

This phase 2 trial tested the drug furmonertinib in 24 people with advanced non-small cell lung cancer (NSCLC) that has EGFR mutations and spread to the brain. The goal was to see how long the drug could keep brain tumors from growing. Participants took a daily pill, and research…

This phase II trial tested a combination of two drugs—MOR00208 (an antibody that targets cancer cells) and lenalidomide (which boosts the immune system)—in 41 people with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or prolymphocytic leukemia (PLL). Some …

This early-phase study tested a new treatment called NG-350A, a virus designed to target tumors and boost immune activity, combined with the immunotherapy drug pembrolizumab. Fourteen people with advanced epithelial cancers that had stopped responding to standard treatments recei…

This study tested a new drug, TAK-981, combined with the immunotherapy pembrolizumab in 161 adults with advanced or metastatic solid tumors that could not be cured. The main goals were to check safety and see if the combination could shrink tumors. Participants received treatment…

This early-phase trial tested a combination of two drugs — IRX-2 and durvalumab — in 19 people with advanced head and neck cancer that could not be cured by standard treatments. The goal was to see if the combination was safe and could boost the immune response inside tumors. The…

This early-phase study tested adding the drug pirfenidone to standard chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe dose and see if the combination could shrink tumors. 48 participants were enrolled, and the study is now comp…

This study tested a combination of three immunotherapy drugs (ipilimumab, nivolumab, and BMS-986156) with or without precise radiation therapy in 51 people with advanced solid cancers that had spread to the liver or lungs. The goal was to find the safest dose of BMS-986156 and se…

This early-phase study tested a combination of two experimental drugs (AK127 and AK104) in 67 people with advanced or metastatic solid tumours that had stopped responding to standard treatments. The main goals were to check safety and find the right dose, while also looking for s…

This early-phase study tested whether combining stereotactic radiosurgery (precise radiation) with the immunotherapy drug nivolumab (Opdivo) is safe and can shrink tumors in people with breast cancer that has spread to the brain. Fourteen participants received the combination. Th…

This study tested giving a precise, high-dose radiation treatment (stereotactic radiosurgery) to brain metastases before surgical removal. The goal was to see if this approach improves local control at 6 months. The trial enrolled 70 adults with up to 4 brain metastases from cert…

This early-phase trial tested a new way to treat advanced cancers that have spread. It combined a special type of radiation with two immunotherapy drugs (MEDI4736 and tremelimumab) to see if the combination is safe and tolerable. The study included 53 adults with advanced melanom…

This early-phase trial tested several combinations of cancer drugs, including niraparib, TSR-042, bevacizumab, and various chemotherapies, in 60 patients with advanced or metastatic cancer. The main goal was to find safe doses for future studies. The trial has been completed, but…

This study tested a new way to give the drug trastuzumab (Herceptin) to women with HER2-positive breast cancer that had spread to the lining of the brain. Instead of through a vein, the drug was injected directly into the spinal fluid via a lumbar puncture or a special reservoir.…

This phase 2 trial tested a combination of a short, intense course of radiation (quad-shot) and the immunotherapy drug pembrolizumab in 21 people with advanced, recurrent, or metastatic head and neck cancer. The goal was to see if the combination could shrink tumors and be safe. …

This phase 2 trial tested a combination of two immunotherapy drugs, ipilimumab and nivolumab, in 18 adults with leptomeningeal metastases—cancer that has spread to the lining of the brain and spinal cord. The study aimed to see if this drug combo could improve survival. Results s…

This study tested whether giving higher doses of radiation over five sessions is safe for people with brain metastases that are 2 to 6 cm in size. These larger tumors are often too risky for a single high-dose treatment. The trial enrolled 13 adults and aimed to find the highest …

This study tested whether a portable device that creates low-intensity electric fields (called Tumor Treating Fields, or TTFields) can help control brain tumors that have spread from non-small cell lung cancer. 298 adults with 1 to 10 brain metastases received standard radiosurge…

This study tested a combination of an oral bacterial product (VE800) and the immunotherapy drug nivolumab in 56 people with advanced or metastatic cancers like melanoma, stomach, and colorectal cancer. The goal was to see if the bacteria could help the immune system fight tumors …

This early-phase study tested an experimental drug (MK-1454) injected directly into tumors, either alone or with pembrolizumab (Keytruda), in 156 people with advanced solid tumors or lymphomas. The main goals were to find the safest dose and check for side effects. The study also…

This early-phase trial tested a combination of two drugs, vandetanib and everolimus, in 151 people with advanced or metastatic cancer that had stopped responding to standard treatments. The goal was to find the safest dose and see if the combination could slow or stop cancer grow…

This early-phase trial tested two drugs—sapanisertib and ziv-aflibercept—in 83 people with advanced solid tumors that had spread or could not be removed. The goal was to find the safest dose and check for side effects. Sapanisertib blocks enzymes that help cancer cells grow, whil…

This early-stage study tested a new drug called PRT3789, alone or with chemotherapy (docetaxel), in people with advanced solid tumors that have a specific change in the SMARCA4 gene. The main goals were to check safety, find the best dose, and see if the drug shrinks tumors. 135 …

This early-phase study tested a new antibody called HMBD-002, given alone or with pembrolizumab, in 48 adults with advanced solid tumors (like lung or breast cancer) that had stopped responding to standard treatments. The main goals were to check safety, find the best dose, and s…

This early-stage trial tested a new drug called vibostolimab, either alone or combined with other cancer drugs, in 474 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the dr…

This study looked at the safety and effectiveness of continuing sitravatinib, a targeted cancer drug, either alone or combined with other therapies like nivolumab or pembrolizumab, in people with advanced or metastatic solid tumors. It enrolled 52 patients who were already benefi…

This early-stage study tested a new drug called MK-4464, given alone or with another drug (pembrolizumab), in 64 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check the safety of the drug and how the body processes it. Thi…

This early-phase trial tested a four-drug combination (entinostat, atezolizumab, carboplatin, and etoposide) in 3 people with extensive-stage small cell lung cancer that had not been treated before. The goal was to find a safe dose and see if the combination could be given for at…

This study tested different combinations of immunotherapy drugs in 59 adults with advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if these combinations are safe and can help shrink tumors or lower PSA levels. Participants received up to fo…

This phase 2 trial tested whether adding stereotactic body radiation therapy (SBRT) to standard checkpoint immunotherapy improves tumor response in 106 people with advanced metastatic cancer. Participants received either immunotherapy alone or immunotherapy plus SBRT to one tumor…

This study looked at the long-term safety of the drug sacituzumab govitecan (Trodelvy) in 25 people with metastatic solid tumors who were already benefiting from the treatment. Participants continued to receive the drug intravenously, and researchers tracked any side effects or l…

This phase 2 trial tested a new chemotherapy combination (Nal-IRI with 5-FU and leucovorin) against a standard treatment (gemcitabine plus cisplatin) in 93 people with advanced biliary tract cancer that could not be removed by surgery. The study aimed to see which approach better…

This early-stage trial tested a combination of immune cells in 9 people with stage IV solid tumors that had stopped responding to standard treatments. The main goal was to see if the therapy is safe and to check for any signs that it might control the disease. The study is now co…

This study tested an experimental drug called ozuriftamab vedotin in 42 people with head and neck cancer that returned or spread. The goal was to see if the drug could shrink tumors and to check for side effects. Participants received the drug alone or with other treatments, and …

This study tested a new two-drug combination (bemcentinib plus pembrolizumab) in 99 adults with advanced lung cancer that had already been treated. The goal was to see if the combination could shrink tumors or stop them from growing. Participants received both drugs by mouth or I…

This early-phase study tested a combination of three drugs—selinexor, nivolumab, and ipilimumab—in 11 adults with advanced or metastatic solid tumors that had stopped responding to standard treatments. The main goal was to check the safety and tolerability of the combination, whi…

This study tested a robotic system called EPIONE that helps doctors guide needles into bones during CT scans. The robot is used for procedures like biopsies, tumor treatments, and bone repairs. Researchers wanted to see if the robot could make these procedures safer and more accu…

This early-stage trial tested a new therapy called SUPLEXA in 46 adults with advanced solid tumors or blood cancers that had spread. SUPLEXA is made from a patient's own immune cells, which are processed in a lab to become more active against cancer. The main goal was to check sa…

This study tested a new drug called AZD3759 against standard targeted therapies (erlotinib or gefitinib) in 492 people with advanced EGFR-mutant lung cancer that had spread to the brain. The goal was to see if AZD3759, which is designed to better reach the brain, could keep the c…

This study tested a new radiation technique called SABR in 13 adults with cancer that had spread to more than 10 spots in the body. The goal was to see if giving high-dose, precise radiation to all cancer sites is safe. Researchers looked for side effects and quality of life chan…

This early-stage trial tested an experimental drug called EVT801 in 32 adults with advanced solid tumours that had stopped responding to standard treatments. The main goal was to check the drug's safety and find the best dose to use in future studies. Participants took EVT801 cap…

This study tested a new 3D bone scan camera (VERITON-CT) that takes only 25 minutes and uses less radiation than standard scans. Researchers compared it to conventional 2D scans in 146 people with suspected or known bone metastases. The goal was to see if the new method could acc…

This completed study tested whether a special type of MRI called dynamic susceptibility contrast (DSC) perfusion MRI can accurately tell the difference between radiation-induced brain damage and tumor regrowth in people whose cancer has spread to the brain. Eight patients who had…

This study looked at 30 adults with lung cancer that had spread to the brain. Researchers compared two standard MRI sequences (T1 and T2*) to see which one better detects and tracks brain metastases after chemotherapy or targeted therapy. The goal is to improve diagnosis and moni…

This study tested a special PET scan tracer called FLT in 50 adults with brain tumors (gliomas or metastases). The goal was to see if FLT-PET can measure how fast tumor cells are growing, which could help doctors diagnose and predict tumor behavior better than current scans like …

This study tested whether a special PET scan (called 18F-DOPA PET-CT) can find brain metastases as well as or better than standard MRI in people with lung cancer, breast cancer, or melanoma. 32 adults with untreated brain metastases took part. The goal was to see if this PET meth…

This study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…

This study looked at whether using a liquid biopsy (a blood test that detects cancer DNA) early in the diagnostic process could help doctors diagnose and recommend treatment faster for people with advanced lung or gastrointestinal cancer. 463 participants were enrolled across mul…

This study tested whether an early, quick PET scan using F-DOPA can help doctors tell the difference between a brain tumor coming back and damage from radiation therapy. Eight patients who already needed a PET scan for their brain metastases took part. The goal was to see if meas…

This pilot study tested whether a special PET/CT scan using a radioactive tracer called Ga-68 PSMA-11 can detect treatment response in patients with metastatic adenoid cystic carcinoma, a rare salivary gland cancer. Six adults with this cancer underwent the scan at two time point…

This study tests whether the drug SENS-401 can prevent hearing loss caused by cisplatin, a common chemotherapy. Adults with cancer who are scheduled to receive cisplatin take SENS-401 before, during, and after treatment. Hearing is measured with a standard test to see if the drug…

This study tested a new approach that combines a minimally invasive spine-stabilizing procedure (kyphoplasty) with a single dose of targeted radiation given during surgery. The goal was to see if this combination could better control pain from cancer that has spread to the spine.…

This study tested whether a personalized exercise program helps people with early-stage lung cancer or cancer that spread to the lungs recover better after surgery. 182 participants were randomly assigned to either the exercise program or usual care. The main goal was to see if t…

This study tested a program called PRISM, which teaches skills like stress management and goal setting, to see if it helps racial minority patients with serious illnesses feel more resilient and communicate better with their healthcare providers. The study enrolled 28 seriously i…

This study tested whether an online exercise and education program could help cancer patients and survivors feel better during the COVID-19 pandemic. Thirty adults with metastatic breast or gynecological cancer, or breast cancer survivors, took part. The program aimed to reduce f…

This study looked at 53 patients with cancer that spread to the upper arm bone, causing pain and limited movement. Researchers compared older and younger patients who had shoulder replacement surgery to see if age affected recovery. The goal was to find out if this surgery is saf…

This study looked at whether cancer patients already taking strong opioids like morphine can stop taking paracetamol without their pain getting worse. 204 adults with metastatic cancer and stable pain on both medications were randomly assigned to continue paracetamol or switch to…

This study tested whether a web-based tool called eSNAP, combined with a caregiver navigator, could help family caregivers of brain cancer patients feel less anxious and burdened. The tool helps caregivers map out their support network, while the navigator provides guidance. Rese…

This study tested a program called LiveWell, which teaches practical skills to help people with metastatic lung cancer manage stress, anxiety, and sadness. One participant completed the 8-session video-based training. The goal was to see if the program is usable and helpful for i…

This study tested whether a more intense, precisely targeted type of radiation (SBRT) works better than standard radiation for reducing pain from cancer that has spread to the spine. About 219 adults with painful spinal metastases took part. The main goal was to see if SBRT leads…

This study tested a short talking therapy called CALM for advanced cancer patients with depression. It involved 90 people in Korea and aimed to see if the therapy was practical and helpful. The therapy focuses on managing symptoms, relationships, and finding meaning.

This completed Phase 3 trial tested whether a fentanyl spray (Pecfent) could prevent pain when moving patients with bone metastases during radiotherapy. 39 adults with cancer that spread to bone and who had pain during positioning for radiation took part. The study compared fenta…

This study tested whether one dose of radiation works as well as two doses for reducing pain from cancer that has spread to the bones. 102 adults with painful bone metastases took part. The goal was to see if a single treatment could provide similar pain relief and reduce the nee…

This study tested a new device called Spinery® that uses radio-frequency energy to treat painful tumors that have spread to the spine or nearby bones. 52 adults who could not have or did not benefit from standard treatments received the procedure. The goal was to see if the devic…

This study tested a 6-week online pain management program for breast cancer survivors who still have bothersome pain after treatment. The program included education, exercises, and psychological strategies to cope with pain. Researchers wanted to see if it helps reduce pain's imp…

This early-phase study tested an investigational drug called SHR-2017 in 25 adults with solid tumors that spread to the bone. The goal was to see how the drug moves through the body, whether it reduces pain and bone complications, and how safe it is. Participants had at least one…

This study tested whether a team of nutrition experts working remotely with doctors could improve the health and well-being of 158 people with stage IV cancer undergoing chemotherapy. The goal was to prevent weight loss, muscle loss, and poor nutrition, which are common but often…

This study tested whether psilocybin, a substance from certain mushrooms, given with therapy could safely reduce anxiety and depression in 55 people with metastatic cancer. Participants received counseling and a pharmaceutical-grade psilocybin dose. The trial focused on safety an…

This phase 1 trial tested whether a second psilocybin-assisted group therapy retreat is safe and helpful for anxiety in 15 patients with metastatic cancer who had only a partial response to their first retreat. Psilocybin, the active ingredient in magic mushrooms, is given in a g…

This study tested a therapy called Managing Cancer and Living Meaningfully (CALM) to see if it helps people with brain cancer feel less distressed. 60 adults with brain tumors or brain metastases who had high depression or death anxiety took part. The study measured how many peop…

This study tested whether a gel called PuraBond, applied to the surgical wound during mouth or throat surgery, can reduce pain and bleeding afterward. 73 patients were randomly assigned to receive the gel or not. Researchers measured pain levels over 30 days and tracked complicat…

This study tested whether supervised breathing exercises could reduce pain, shortness of breath, and improve daily function in 58 terminal-stage cancer patients receiving palliative care. One group did diaphragmatic and pursed-lip breathing with a physiotherapist, while the other…

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…

This completed study looked at 130 hospitalized cancer patients to see if hand grip strength could predict short-term outcomes like death within 30 days, ICU admission, or hospital readmission. Researchers measured grip strength within 24 hours of admission using a simple, non-in…

This completed study looked at 40,000 people with metastatic cancer who received the drug nivolumab. Researchers compared the old way of dosing (based on body weight) with a newer, simpler fixed dose. They used national health data to see if the fixed dose was just as good and mo…

This study looked at 170 patients with aggressive B-cell lymphoma who received CAR-T cell therapy. Researchers used surveys to track how patients felt about their fatigue, symptoms, and daily functioning over time. The goal was to understand the real-world impact of the treatment…

This study compared two types of radiation for people with 11 to 20 brain tumors that spread from other cancers. One group got Gamma Knife radiosurgery, which targets each tumor precisely. The other got whole brain radiation, which treats the entire brain. The goal was to see whi…

This study analyzed health records from over 229,000 people with newly diagnosed lung cancer in Korea to see if getting a brain MRI every year helps find cancer that has spread to the brain. The goal was to learn whether these scans catch brain metastases earlier, when they might…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This study looked at medical records of 938 adults with solid tumors who received immunotherapy. Researchers compared how well the treatment worked when cancer had spread to different organs like the liver, brain, lung, or bone. The goal is to understand why some metastatic sites…

This study tested a special communication program for doctors and parents of children with advanced cancer. The goal was to help families and doctors agree on treatment goals, especially for children nearing end of life. Researchers measured whether this improved the child's qual…

This study looked at whether combining detailed MRI scans with whole genome sequencing can help doctors choose the best treatment for people with liver cancer. Researchers studied 200 adults who were scheduled for liver surgery. The goal was to see if these advanced tests provide…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study looked at 30 colorectal cancer patients to see if tumor deposits (small clusters of cancer cells found near the main tumor) can help predict survival and whether the cancer spreads to other organs. Researchers tracked overall survival and the appearance of new metastas…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study looked at whether analyzing the DNA of a patient's tumor can help doctors pick a targeted therapy for advanced or metastatic cancer. Researchers enrolled 550 adults with various solid tumors that had spread. They took biopsy or blood samples to search for genetic chang…

This study looked at how common iron deficiency is in cancer patients starting chemotherapy. Researchers checked iron levels in 480 adults with solid tumors or lymphoma. The goal was to find out how many patients might benefit from iron injections, without using other drugs like …

This study aims to develop and validate a scoring system to identify which patients with metastatic breast cancer are likely to live longer with third-line chemotherapy. Researchers will collect clinical, histological, and biological data from 267 women starting a third line of t…

This study tested whether a planned meeting between a hospitalized cancer patient, their family doctor, and a specialist could reduce unplanned hospital visits. 667 adults with metastatic solid tumors were randomly assigned to either the standard discharge process or this organiz…

This completed study from Mayo Clinic interviewed 33 adults with brain or central nervous system (CNS) tumors, along with their caregivers, to learn about their biggest challenges and needs. The goal was to identify areas where doctors and healthcare teams can offer better suppor…

This study looked at spinal fluid from 7 women with breast cancer that may have spread to the lining of the brain. Researchers analyzed proteins in the fluid to see if they can find a pattern that helps diagnose this condition. The goal was to learn more, not to test a treatment.

This study looked at 28 women with breast cancer that spread to their bones. Researchers compared two types of scans—PET-CT and whole-body MRI—to see if they agree on whether the bone tumors are stable, improving, or getting worse. The goal is to find a reliable way to monitor tr…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This study compared anxiety, depression, and quality of life between 125 cancer patients who joined clinical trials and those who received standard treatment. Researchers used questionnaires to measure stress and emotional well-being. The goal was to understand how trial particip…

This study looked at spinal fluid from 51 breast cancer patients whose cancer may have spread to the lining of the brain and spinal cord (leptomeningeal metastases). Researchers compared a new blood test technique (CellSearch) with standard spinal fluid analysis to see which bett…

This study looked at how patients with advanced cancer respond to being offered a conversation about their future care preferences. Researchers invited 71 patients to discuss their wishes and tracked who took part. The goal was to learn more about what helps patients feel ready t…

This study followed 60 adults with diffuse large B-cell lymphoma or transformed lymphoma who received commercial axi-cel therapy. Researchers measured changes in memory, attention, executive function, hand strength, and quality of life using surveys and cognitive tests. The goal …

This study tested a website designed to help people with advanced cancer plan for end-of-life care, including medical wishes, legal documents, and financial tasks. About 100 patients took part to see if the tool reduced distress and improved planning. The goal was to learn whethe…

This study tested whether a blood test can find tumor cells or substances released by intestinal polyps. Researchers compared blood samples from 120 people with and without polyps during a colonoscopy. The goal is to see if these markers could help predict or monitor cancer sprea…

This study looked at 403 breast cancer patients whose cancer had spread to the lining of the brain and spinal cord. Researchers collected detailed medical information to understand what factors affect survival. They used this data to create a new scoring system that could help do…

This completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…

This study looked at whether using a CPAP machine (commonly used for sleep apnea) during radiation therapy can reduce the amount of radiation reaching the lungs. Eight people with left-sided breast cancer or lung cancer took part. Researchers compared lung radiation doses with an…

This study looked at whether liver cancer spreads differently in men and women. Researchers analyzed data from over 19,000 patients and used computer models to create separate prediction tools for each gender. The goal was to better understand risk factors for cancer spread at th…

This completed study used artificial intelligence to examine CT scans from 274 liver cancer patients who had already received radiation therapy. The goal was to find the radiation dose that causes a visible liver reaction, which could help doctors avoid liver injury in future tre…

This study followed 196 people with advanced lung or stomach cancer who had not yet received treatment. Researchers wanted to see if emotional distress before starting immunotherapy, along with certain blood markers of inflammation and metabolism, could predict how long patients …

This study analyzed data from over 93,000 people diagnosed with a gastrointestinal carcinoid tumor between 2000 and 2022. Researchers wanted to find out if these patients are more likely to develop a second, different gastrointestinal cancer. They used a large cancer database to …

This study looked back at the medical records of 545 patients with bone tumors that had spread (metastatic). The goal was to see how these patients were treated in real life and what their outcomes were. The study focused on three types of bone tumors: osteosarcoma, Ewing sarcoma…

This completed study followed 183 cancer patients starting checkpoint inhibitor therapy to see how often they develop autoantibodies—proteins that can mistakenly attack the body's own tissues. Researchers collected blood samples to track changes in several types of autoantibodies…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study tested whether choosing cancer drugs based on the genetic makeup of a patient's tumor works better than standard treatment. It included 742 adults with advanced solid tumors that had stopped responding to usual therapies. Patients were randomly assigned to receive eith…

This study examined genetic and epigenetic changes in brain metastases from solid cancers. Researchers collected tumor tissue, blood, and spinal fluid from 21 patients during surgery to compare molecular profiles. The goal was to see if liquid biopsies could reliably reflect the …

This study looked back at medical records of 300 people with EGFR-positive non-small cell lung cancer that had spread to the brain or spinal cord. All patients were treated with the drug firmonertinib. Researchers analyzed how long the drug controlled brain tumors and explored wh…

This study tested whether an automated system can grow cancer cells from patient samples (blood, fluid, or tumor tissue) inside chicken eggs. Researchers aimed to see if at least half of the samples would successfully grow. The goal is to create a better, cheaper way to study can…

This completed study aimed to create a biobank of 'organoids'—tiny, 3D mini-tumors grown from liver cancer tissue. Researchers collected samples from 48 patients with colorectal cancer that spread to the liver or with primary liver cancer. The goal was to see if they could reliab…

This study tested whether giving cancer patients and their families a booklet of questions before a palliative care consultation helps them ask more questions or express more concerns. 121 adults with metastatic cancer and limited life expectancy took part. The booklet covered ei…

This completed study examined tumor samples from 3820 people with advanced solid tumors to find how many have NTRK gene fusions. Researchers used genetic testing to identify these rare changes. The study did not test any treatment, but aims to guide future targeted therapy decisi…

This study tested whether small devices called Calypso beacons, placed near lung tumors, can help doctors track the tumor's position during radiation while the patient holds their breath. 48 adults with lung cancer took part. The goal was to see if this approach is feasible and t…

This completed study gathered information from nearly 1,000 patients who received or were scheduled to receive HyperArc stereotactic radiosurgery, a precise radiation treatment for brain tumors. The goal was to collect data on survival and tumor control to compare HyperArc with o…

This study tested the EchoTip AcuCore, a needle used during endoscopic ultrasound to collect tissue samples from the pancreas, liver, and other organs. 183 adults with conditions like cancer or chronic pancreatitis took part. The main goal was to see if the needle could get a goo…

This completed study looked at 312 patients with advanced breast cancer who received either trastuzumab deruxtecan or sacituzumab govitecan. Researchers collected real-world information on side effects and how long the cancer was kept under control. The goal was to see how these …

This completed study reviewed medical records of 1,250 advanced cancer patients who visited the emergency department. Researchers looked at factors like age, tumor type, and blood test results to see which patients were at higher risk of dying within 90 days. The goal is to help …

This study tested a program called PLAN to help Latino cancer patients plan for their future medical care. Twenty-seven patients with advanced cancer took part. The program aimed to improve their understanding and communication about advance care planning with doctors and family.…

This study looked back at medical records of over 2,100 patients with metastatic soft tissue sarcoma treated in France between 1990 and 2013. Researchers analyzed which treatments patients received, including chemotherapy and local therapies, and how long they lived. The goal is …