New drug combo tested for Hard-to-Treat cancers

NCT ID NCT05514444

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-stage study tested a new drug called MK-4464, given alone or with another drug (pembrolizumab), in 64 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check the safety of the drug and how the body processes it. This is a first step to see if the drug is safe enough for further testing.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary โ€” we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Amsterdam UMC, locatie VUmc ( Site 0400)

    Amsterdam, North Holland, 1081HV, Netherlands

  • Hadassah Medical Center-Oncology ( Site 0302)

    Jerusalem, 9112001, Israel

  • Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 0401)

    Amsterdam, North Holland, 1066CX, Netherlands

  • Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0201)

    Toronto, Ontario, M5G 2M9, Canada

  • Rambam Health Care Campus-Oncology Division ( Site 0300)

    Haifa, 3109601, Israel

  • The University of Louisville, James Graham Brown Cancer Center ( Site 0100)

    Louisville, Kentucky, 40245, United States