New drug combo tested for tough cancers

NCT ID NCT05514444

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 30 times

Summary

This early-phase study tested a new drug called MK-4464, given alone or with another drug (pembrolizumab), in 64 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check safety and how the drug moves through the body. This is not a cure; it is a first step to see if the drug is safe enough for further testing.

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Contacts and locations

Locations

  • Amsterdam UMC, locatie VUmc ( Site 0400)

    Amsterdam, North Holland, 1081HV, Netherlands

  • Hadassah Medical Center-Oncology ( Site 0302)

    Jerusalem, 9112001, Israel

  • Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 0401)

    Amsterdam, North Holland, 1066CX, Netherlands

  • Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0201)

    Toronto, Ontario, M5G 2M9, Canada

  • Rambam Health Care Campus-Oncology Division ( Site 0300)

    Haifa, 3109601, Israel

  • The University of Louisville, James Graham Brown Cancer Center ( Site 0100)

    Louisville, Kentucky, 40245, United States

Conditions

Explore the condition pages connected to this study.