New radiation dosing strategy aims to tame large brain metastases
NCT ID NCT01705548
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase I trial tested a special type of radiation called hypofractionated radiosurgery for people with large brain metastases (tumors that spread from other cancers). The goal was to find the safest and most effective dose while limiting damage to healthy brain tissue. Twenty-four adults with solid tumors and one large brain metastasis (at least 3 cm) received radiation in 5 sessions over 1-2 weeks. Researchers monitored side effects and tumor control to determine the best dose for future studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hypofractionated Radiosurgery (radiation therapy)
- What this could lead to
- If successful, this could establish a safer, more effective radiation dose for treating large brain metastases, potentially improving local tumor control while reducing side effects.
- What could go wrong
- This is a small, early-phase trial focused on safety and dosing, not efficacy. The approach may still cause brain tissue damage (radiation necrosis) or fail to control the tumor long-term.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342, United States
-
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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