New drug combo shows promise for Tough-to-Treat bile duct cancer
NCT ID NCT03044587
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 36 times
Summary
This phase 2 trial tested a new chemotherapy combination (Nal-IRI with 5-FU and leucovorin) against a standard treatment (gemcitabine plus cisplatin) in 93 people with advanced biliary tract cancer that could not be removed by surgery. The study aimed to see which approach better controls tumor growth and improves survival. Results will help determine if this new combo deserves further study.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Universitätsklinikum Ulm
Ulm, 89081, Germany
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nal-IRI (a chemotherapy drug) combined with 5-fluorouracil and leucovorin
What this could lead to
If successful, this could provide a new chemotherapy option for people with advanced biliary tract cancer who cannot have surgery.
What could go wrong
This is an early phase 2 trial with a small number of participants, so results may not confirm effectiveness. Chemotherapy can cause significant side effects.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.