Can a fentanyl spray stop pain during cancer radiation?
NCT ID NCT02426697
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 3 trial tested whether a fentanyl spray (Pecfent) could prevent pain when moving patients with bone metastases during radiotherapy. 39 adults with cancer that spread to bone and who had pain during positioning for radiation took part. The study compared fentanyl to a placebo to see if it reduced pain scores.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fentanyl transmucosal (Pecfent)
What this could lead to
If effective, this could offer a way to prevent pain during radiotherapy sessions for people with bone metastases, making treatment more comfortable.
What could go wrong
This is a small, completed Phase 3 trial with only 39 participants, so results may not apply to everyone. Fentanyl is a strong opioid with risks like addiction and side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Centre Henri Becquerel
Rouen, 76038, France