New chemo cocktail targets liver tumors in pancreatic cancer
NCT ID NCT06538623
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tested a combination of chemotherapy drugs given directly into the liver artery for people with pancreatic cancer that had spread only to the liver and stopped responding to standard treatment. The 40 participants received a mix of oxaliplatin, irinotecan liposomes, fluorouracil, and leucovorin via hepatic artery infusion, followed by either more infusion or an oral chemo pill. The goal was to see if this approach could improve survival and tumor shrinkage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Liposomal irinotecan, oxaliplatin, fluorouracil, leucovorin, and tegafur/gimeracil/oteracil (S-1)
- What this could lead to
- If it works, this could offer a new second-line treatment option for people with pancreatic cancer that has spread only to the liver.
- What could go wrong
- This is a small, early-phase trial with only 40 people and no comparison group, so results may not be definitive. The chemotherapy combination also carries typical chemo side effects like nausea, fatigue, and low blood counts.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, 2000010, China
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