End stage renal failure

This early-stage trial tests a vaccine called OSU-2131, designed to help the immune system fight Epstein-Barr virus (EBV). EBV can cause cancers in people who have weakened immune systems, such as those awaiting organ transplants. The study includes healthy volunteers and transpl…

This study tests if a new drug called siplizumab can safely prevent kidney transplant rejection better than the current standard treatment. About 120 adults receiving a kidney transplant will be split into three groups: two groups get different doses of siplizumab, and one gets t…

This study tests whether a carefully controlled low protein diet (about 0.6 grams of protein per kilogram of body weight each day) can help people with advanced chronic kidney disease delay the need for dialysis or a kidney transplant. The study enrolls adults with stage 4-5 or f…

This study compares two methods for creating an arteriovenous fistula (AVF) in people with end-stage kidney disease who need dialysis. The newer endovascular method uses a needle through the skin, while the traditional surgical method requires an incision. Researchers will enroll…

This phase 1 trial tests whether giving a bone marrow infusion along with a deceased donor kidney transplant can help the body accept the new kidney without needing lifelong anti-rejection drugs. The study enrolls adults with end-stage kidney disease who are already listed for a …

This study tests whether a special treatment before a kidney transplant can help the body accept the new organ without needing lifelong anti-rejection drugs. Participants receive radiation and immune-suppressing drugs, followed by an infusion of donor stem cells and the patient's…

This trial investigates whether using icodextrin, a special dialysis solution, can help people on peritoneal dialysis (a type of home dialysis for kidney failure) stay on a lower-dose regimen for longer. Participants are randomly assigned to receive either icodextrin or a standar…

This study tests a new drug called AP306 in 168 adults on maintenance hemodialysis who have high phosphate levels (hyperphosphatemia). Participants take one of several fixed doses of AP306 or a placebo daily for 8 weeks. The main goal is to see if AP306 safely lowers blood phosph…

This study tests whether semaglutide, a diabetes drug, is safe and tolerable for people with type 2 diabetes who are on dialysis. About 100 participants will either receive weekly semaglutide injections or standard care for 26 weeks. The goal is to see if patients can stick with …

This study tests whether taking creatine supplements and doing light exercise during dialysis sessions can help people with advanced kidney disease maintain muscle strength and body health. About 48 adults on dialysis will take either creatine or a placebo daily for 8 weeks, whil…

This study tests a device called the Amplifi Vein Dilation System, which is a temporary blood pump used before creating a dialysis access point (fistula) in the arm. The goal is to see if it helps widen small veins so the fistula works better for dialysis. About 160 adults with e…

This study tests a special cartridge (pHA130) added to regular dialysis to remove toxins that standard dialysis misses. One hundred adults with kidney failure on maintenance dialysis will be split into two groups: one gets the new cartridge once a week plus standard dialysis twic…

This phase 3 trial tests whether ravulizumab, given intravenously, can reduce the severity of delayed graft function (DGF) in adults at high risk after kidney transplant. DGF is when the new kidney is slow to start working, often requiring dialysis. The study will compare ravuliz…

This phase 3 trial compares two induction therapies—rabbit anti-thymocyte globulin (rATG) and basiliximab—in 244 sensitized kidney transplant recipients who do not have pre-existing donor-specific antibodies. The goal is to see which drug better prevents biopsy-proven acute rejec…

This study tests whether adding terlipressin to standard care helps maintain stable blood pressure during kidney transplant surgery. Researchers will compare two groups of 150 adults: one receiving terlipressin plus dobutamine, the other dobutamine alone. The main goal is to see …

This trial tests whether a drug called coated aldehyde oxystarch (Xiqing) can reduce protein-bound uremic toxins in adults with end-stage renal disease who are on dialysis. Participants take the drug three times daily for three months. Researchers measure toxin levels in the bloo…

This study tests a new device that creates a connection between an artery and a vein using a small needle puncture instead of open surgery. The goal is to provide a reliable access point for dialysis in people with kidney failure. About 126 adults will be enrolled and followed fo…

This study tests a new drug called AZD7760 in healthy volunteers and people with end-stage kidney disease who are on dialysis. The goal is to see if the drug is safe and how the body processes it. If it works, it could help prevent serious staph infections that often occur in dia…

This early-phase trial tests a combined kidney and bone marrow transplant from the same donor to help the body accept the new kidney without needing lifelong anti-rejection drugs. Up to 12 adults with kidney failure will receive the treatment. The goal is to see if this approach …

This study tests a drug called CSL300 in people with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if it can reduce the risk of heart attacks or heart-related death. About 3110 adults will take part, and half will get the drug whi…

This study tests a program that helps people with obesity who are waiting for a kidney transplant lose weight. Participants will receive education, a calorie tracking app, a continuous glucose monitor, a weight scale, and a food scale. The goal is to see if this program is practi…

This study looks at kidney transplant patients who take immunosuppressants to prevent organ rejection. It compares the effects of belatacept, a newer drug, against standard anticalcineurins on blood vessel function. The goal is to see if belatacept improves vascular health and re…

This early-phase trial tests whether a powerful immune reset using a patient's own stem cells can clear the antibodies that block them from receiving a kidney transplant. Ten highly sensitized adults with end-stage kidney disease will undergo intense conditioning to wipe out thei…

This study is testing whether a kidney from a genetically modified pig can safely work in people with end-stage renal disease who cannot get a human kidney. Up to 50 participants will receive the pig kidney and be followed for at least 24 weeks to check survival, kidney function,…

This study tests whether a new type of immunotherapy called CAR T cells can safely lower the immune system's reactivity in people waiting for a kidney transplant. Participants have a very high chance of rejecting most donor kidneys (cPRA of 99.5% or higher). The treatment involve…

This study tests whether giving two common drugs, tranexamic acid and desmopressin, before surgery can reduce bleeding in patients with chronic kidney disease or acute kidney injury. About 100 adults having noncardiac surgery will be randomly assigned to receive one or both drugs…

This study tests whether a personalized, gradual start to dialysis is safer and improves quality of life compared to the standard fixed schedule. It involves 350 adults with end-stage kidney disease who recently started dialysis. Researchers will track hospital visits, overall he…

This study tests if empagliflozin, a diabetes drug, can reduce sugar absorption during peritoneal dialysis in 30 adults with end-stage kidney disease. Participants will receive either the drug or a placebo in a crossover design, followed by an 8-week open-label phase where everyo…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study tests whether a combination of belatacept and sirolimus works better than the standard drugs tacrolimus and MMF in children aged 13-20 who receive a kidney transplant. The goal is to reduce the risk of organ rejection and protect kidney function. Participants are rando…

This study compares starting dialysis twice a week versus the standard three times a week in elderly patients (60+) with end-stage kidney disease who still produce some urine. The goal is to see if fewer sessions reduce hospitalizations, falls, and other complications while maint…

This study tests a special monitor that predicts low blood pressure during dialysis in ICU patients. The goal is to prevent dangerous drops by alerting doctors early. About 46 adults with kidney injury or failure will take part. If successful, this approach could make dialysis sa…

This study tests whether giving a kidney transplant recipient blood stem cells from their sibling donor can train the body to accept the new kidney without lifelong anti-rejection drugs. Fifteen adults receiving a kidney from an identical sibling will get a conditioning regimen o…

This study tests whether a short course of the blood thinner apixaban can help new dialysis access points (arteriovenous fistulas) mature properly in people with end-stage kidney disease. About 190 adults will receive either apixaban or a placebo around the time of fistula creati…

This study looks at different ways to give iron to people with kidney failure who are on peritoneal dialysis. Participants will get either high-dose or low-dose intravenous iron, or oral iron tablets. The main goal is to see if a larger trial is possible by checking how many peop…

This study tests whether a daily 25 mg dose of empagliflozin (a diabetes drug) is safe and helps preserve remaining kidney function in 20 adults on peritoneal dialysis. Participants must still produce at least 250 mL of urine daily. The trial measures changes in kidney filtration…

This early-stage trial tests a new cell therapy called Eight Treg in 9 people receiving a kidney from a living donor. The therapy uses the patient's own immune cells, grown in a lab, to help the body accept the new kidney without strong anti-rejection drugs. The main goal is to c…

This phase 2 trial tests whether a single infusion of a patient's own regulatory T cells (TRK-001) can prevent the immune system from attacking a new kidney. 34 living-donor kidney transplant recipients will either receive standard anti-rejection drugs alone or those drugs plus t…

This study tests a new type of artificial blood vessel (STARgraft) for people with end-stage kidney disease who need dialysis. The graft is placed in the arm to help connect the patient to the dialysis machine. The goal is to see if it works better than standard grafts at keeping…

This trial tests a drug called imlifidase in highly sensitized children aged 1-17 who need a kidney transplant. The drug aims to quickly clear antibodies that would normally cause rejection, turning a positive crossmatch negative and allowing the transplant to happen. Researchers…

This study tests whether a drug called treprostinil can help prevent injury to a new kidney during transplant surgery. About 20 adults receiving a deceased donor kidney will get the drug through an IV for two days, starting just before surgery. The goal is to see if it improves b…

This study tests whether an experimental drug called AV-001 can protect the brain from injury caused by hemodialysis. The drug is designed to strengthen blood vessels in the brain and reduce inflammation. Researchers will enroll 60 adults who have been on dialysis for at least th…

This early-phase trial tests a single dose of AZD0120, a CAR-T cell therapy that targets two immune proteins (CD19 and BCMA), in 12 highly sensitized adults with end-stage kidney disease awaiting a transplant. The goal is to safely reduce the antibodies that make finding a compat…

This study tests whether adding sodium thiosulfate (STS) to the fluid that keeps donated kidneys cold during transport can help them work sooner after transplant. About 120 adults with kidney failure who receive a kidney from a deceased donor will take part. Half of the kidneys w…

This study tests a device called EchoMark/EchoSure that is implanted during fistula surgery for dialysis patients. The device uses automated ultrasound to monitor healing every two weeks. The goal is to see if it helps the fistula mature faster and reduces the need for additional…

This study tests whether storing donated kidneys at 10°C (instead of the usual 4°C on ice) helps them work better after transplant. About 30 adults waiting for a kidney transplant will take part. Researchers will measure kidney function and check for early injury using urine test…

This study tests whether a daily ergothioneine supplement can replenish low levels of this nutrient in people with kidney failure who are on dialysis. Dialysis removes waste but also strips away beneficial chemicals like ergothioneine. Researchers will give 28 participants either…

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease. The device is designed to remove waste and extra fluid from the blood during in-center dialysis sessions. Researchers will check how safe it is and how well it works in 46…

This Phase 3 trial tests an oral drug called AND017 for anemia in people on dialysis due to end-stage kidney disease. About 300 participants will receive either AND017 capsules or a standard injected ESA. The goal is to see if AND017 can maintain healthy hemoglobin levels as well…

This study tests a genetically modified pig kidney (called the 10 GE Xenokidney) in 50 adults with end-stage kidney disease who cannot get a human kidney transplant or face a long wait. The goal is to see if the pig kidney works safely and well, improving survival and quality of …

This study is testing a device called the WavelinQ EndoAVF System that creates a connection between an artery and a vein (AV fistula) in people who need dialysis. The goal is to make it easier to start and continue dialysis with fewer complications. About 280 adults with end-stag…

This phase 3 trial tests XyloCore, a dialysis solution with less glucose and added xylitol and L-carnitine, in 170 adults with end-stage kidney disease on continuous ambulatory peritoneal dialysis. The goal is to see if it can maintain dialysis effectiveness while improving metab…

This study tests whether dapagliflozin, a drug usually used for diabetes, can help people with end-stage kidney disease who are on peritoneal dialysis. Over six months, 38 participants will take the drug daily to see if it improves fluid removal, dialysis adequacy, and urine outp…

This study tests a special silicone jacket that wraps around a donor kidney during transplant surgery to keep it warm. The goal is to see if the jacket is safe to use in different types of kidney transplants. Twenty adult recipients will be enrolled, and the study will track any …

This study compares a once-daily anti-rejection drug (Envarsus XR) to the standard twice-daily drug in 78 adults receiving a kidney transplant. The goal is to see if the once-daily option reduces hidden rejection and improves immune system markers. Participants will be followed f…

This study tests a special scale that measures heart signals and fluid levels in people on peritoneal dialysis for kidney failure. The goal is to see if the scale can warn patients and doctors early when fluid overload is about to happen, so they can take action before an emergen…

This study looks at whether a plant-focused diet can help malnourished adults on peritoneal dialysis (a type of kidney treatment) improve their nutrition and overall health. About 100 participants will be randomly assigned to either a plant-focused diet or a standard kidney diet …

This study tests whether canagliflozin, a diabetes drug, can improve fluid removal and reduce scarring in people on peritoneal dialysis for kidney failure. Thirty adults will receive either the drug or a placebo for 26 weeks, then switch. The goal is to see if the drug helps the …

This study tests a home monitoring system called VIEWER for people with advanced chronic kidney disease (stage 5) or end-stage renal disease. The system includes a tablet, blood pressure cuff, scale, oxygen monitor, and motion tracker. Researchers want to see if using this platfo…

This study tests whether a single injection of Berinert, a protein that reduces inflammation, into a donor kidney just before transplant can improve kidney function in the first year. Researchers will compare this to a placebo in 180 high-risk patients receiving deceased-donor ki…

This study tests a special wrap called SelfWrap that is placed around blood vessels during surgery to create a connection for dialysis. The wrap helps the vessels grow strong and work well without extra procedures. About 600 adults with advanced kidney disease who need a new dial…

This study looks at whether a type of dialysis done more often but with a slower flow can help kidney patients who have been in the hospital regain muscle strength and function. About 50 adults with end-stage kidney disease will take part. They will do a rehab program with exerci…

This study tests whether adding urea to the dialysis fluid can prevent dialysis disequilibrium syndrome — a set of neurological symptoms like headache, confusion, and seizures — in people with kidney failure who need urgent dialysis for severe electrolyte problems. Researchers wi…

This study tests a blood filtering procedure called rheopheresis to treat calciphylaxis, a rare condition causing painful skin wounds in people on dialysis. About 138 participants will receive either rheopheresis or a sham procedure to see if it helps wounds heal completely withi…

This phase 3 trial tests whether AP301, a drug taken with meals, can safely lower high blood phosphate in people on kidney dialysis. About 264 participants will receive either AP301 or a low-dose version for 8 weeks, then all get AP301 for 24 weeks. The goal is to see if AP301 he…

This study tests whether a ketoanalogue supplement (Ketosteril) can prevent muscle loss in 100 adults with stage 4 or 5 chronic kidney disease who are on a moderately low-protein diet. Participants take the supplement daily for a period, and researchers measure changes in muscle …

This study tracks 150 adults with end-stage kidney disease who use the EndoForce System to connect a dialysis graft to a vein. The device is already FDA-approved, so this is not an experiment—it's a check on long-term safety and how well it works over time. Researchers will monit…

This study tests three different approaches given during donor anesthesia to help the new kidney work better right after transplant. The goal is to see which method—mannitol, dopamine, or extra fluids—best improves kidney function. The study involves 60 adults with end-stage kidn…

This study looks at whether an automated insulin delivery system (the Medtronic 780G) can help adults with diabetes and advanced kidney disease manage their blood sugar better than their usual insulin injections. Participants will use the system for 8 weeks and then switch to the…

This phase 3 trial compares two common beta blockers—metoprolol and carvedilol—in about 2,540 hemodialysis patients. The goal is to see if metoprolol, which is removed by dialysis, leads to fewer major heart events like heart attacks, strokes, or heart failure hospitalizations. P…

This study looks at whether lowering high parathyroid hormone levels can help protect bone density in people with advanced chronic kidney disease. About 70 adults aged 50 and older with kidney failure not on dialysis will be assigned to different treatment targets for their hormo…

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns, instead of standard care. The goal is to lower the risk of dangerously low blood pressure during treatment and improve overall blood pressure control. About 6…

This study looks at whether adding CoQ10 (a supplement that supports cell energy) to high-intensity interval training can help people with end-stage kidney disease build muscle and improve physical function. 156 adults on dialysis will be assigned to exercise alone or exercise pl…

This study tests whether a manuka honey mouthwash can improve gum health in people with kidney failure who are on dialysis and also have gum disease. About 150 adults will rinse with a diluted honey solution three times daily. Researchers will measure gum attachment, bleeding, pl…

This phase 2 study tests a drug called nedosiran (DCR-PHXC) in 28 people with primary hyperoxaluria type 1 (PH1) who have severe kidney impairment, with or without dialysis. The goal is to see if the drug safely lowers plasma oxalate levels, which can cause kidney stones and dama…

This study tests whether a personalized sodium (salt) management feature on dialysis machines can help people with end-stage kidney disease. It compares the new approach to standard dialysis in 130 adults. The goal is to see if it reduces weight gain between sessions, improves fl…

This study tests a new device called the InnAVasc graft, which is surgically placed in the arm to provide a reliable access point for hemodialysis in people with end-stage kidney disease. About 133 participants will receive the graft and be followed for two years to see how well …

This early-phase trial tests whether a stomach acid drug called vonoprazan fumarate can reduce delayed graft function, a common complication where a new kidney doesn't work right away. About 47 first-time kidney transplant recipients will take the drug for seven days after surger…

This study tests whether giving a donor kidney a 4-6 hour warm bath on a machine (normothermic machine perfusion) right before transplant helps it work better a year later. The trial includes 240 adults receiving a kidney from a donor aged 50 or older. Half get the standard cold …

This trial tests whether a smartphone app (Yueya mini-program and WeChat) can help people with end-stage renal disease who are on maintenance hemodialysis. The app provides personalized guidance on diet, exercise, medications, and health monitoring. Researchers will compare outco…

This study looks at how long kidney transplant patients should take a common antibiotic (TMP-SMX) to prevent a serious lung infection called PJP. About 450 participants will be randomly assigned to different treatment durations. The goal is to find the safest and most effective l…

This study tests whether special filters (sorption technologies) can lower inflammation in people on long-term hemodialysis for kidney failure. About 60 adults with high inflammation levels will receive the filter during their regular dialysis sessions. The main goal is to see if…

This study tests whether thiazide diuretics (water pills) can lower blood pressure in people on peritoneal dialysis who have high blood pressure. About 40 adults with end-stage kidney disease will take the drug and have their blood pressure, weight, and body fluid levels measured…

This study tests whether exercising during dialysis, with or without a blood flow restriction cuff, can reduce heart strain and improve heart function in kidney patients. About 108 adults on dialysis will be randomly assigned to standard care, exercise alone, or exercise with blo…

This study tests whether canagliflozin, a drug used for diabetes, can improve heart structure in people with advanced kidney disease (stage 4 or 5) or on dialysis. About 92 participants will receive either the drug or a placebo for 12 months, with heart changes measured by MRI. T…

This study tests whether empagliflozin, a diabetes medicine, is safe and helps control body fluid levels in 60 adults who are starting hemodialysis for end-stage kidney disease. Participants will take either empagliflozin or a placebo for 12 weeks. The goal is to see if the drug …

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, or the antidepressant plus teletherap…

This early-stage study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop taking lifelong anti-rejection medications. Ten adults with a well-functioning kidney from a matched living donor will receive a conditioning treatm…

This study is testing whether taking aspirin can safely lower the risk of major heart problems, like heart attacks and strokes, in people with kidney failure who are on dialysis. About 9,000 adult dialysis patients will be randomly assigned to take aspirin or not, and researchers…

This study is testing a new dialysis machine called Moda-flx for people with end-stage kidney disease who are already on stable dialysis. The goal is to see if the machine is safe and works well both in a clinic and at home when used by trained patients or care partners. About 50…

This study tests a device called VasQ that is placed around a blood vessel connection (fistula) used for dialysis in people with kidney failure. The goal is to see if VasQ helps the fistula work well enough for dialysis sooner and for longer compared to standard fistula creation.…

This study tests a device that helps people on dialysis get needles into their fistula more easily. It is for patients whose fistula is too deep for standard needle sticks. The study will check if the device works well and is safe over 6 to 12 months. About 100 adults will take p…

This study tests a treatment called physiologic insulin resensitization (PIR) in 120 adults with advanced chronic kidney disease and type 2 diabetes. The goal is to see if PIR can improve kidney function better than standard care. Participants will be randomly assigned to receive…

This study looks at whether kidney transplants from HIV-positive donors are safe and effective for HIV-positive recipients. Researchers will follow 30 adults with HIV and end-stage kidney disease who receive a kidney from an HIV-positive donor. The goal is to learn more about pat…

This early-stage trial tests a drug called KN060 in 12 adults with end-stage kidney disease who are on regular hemodialysis. The goal is to see if KN060 is safe and can prevent blood clots from forming in the dialysis machine or the patient's blood vessels. Participants will rece…

This study tests whether giving the antiviral drug remdesivir for 10 days can prevent severe COVID-19 in kidney transplant recipients who have mild or no symptoms. About 15 adults will receive the drug starting just before their transplant. The goal is to see if this approach all…

This study tests a procedure called renal denervation, which uses ultrasound to calm overactive kidney nerves, in 12 dialysis patients with hard-to-treat high blood pressure. The goal is to see if it safely lowers blood pressure over 3 to 6 months. It is a small, early-stage tria…

This study tests a liquid medication called ACE Reno, taken under the tongue four times daily for 12 weeks, in 300 adults with chronic kidney disease from diabetes, high blood pressure, autoimmune disorders, or other causes. The goal is to see if it safely reduces protein in the …

This study compares two ways to create an arteriovenous fistula (AVF) for dialysis in people with advanced kidney disease. The standard end-to-side method is being tested against a newer piggyback technique that may reduce blockages and failures. About 130 adults who need dialysi…

This study tests a mobile app that helps people with kidney problems adjust their water pill (diuretic) doses day by day to control swelling. Thirty participants will use the app for 90 days, entering daily weight and blood pressure readings. The goal is to see if the app helps t…

This study tests a new feature on a dialysis machine that tries to predict and prevent sudden drops in blood pressure during treatment. About 56 adults on long-term dialysis who often have low blood pressure will be randomly assigned to use the feature or not, then switch. The go…

This study tests a new drug called pegmolesatide, alone or combined with roxadustat, to treat anemia in 240 adults on dialysis for chronic kidney disease. Participants currently on another anemia drug (rHuEPO) will switch to one of three treatment plans for 24 weeks. The goal is …

This study tests whether giving a thyroid hormone supplement (levothyroxine) to dialysis patients with mild hypothyroidism can improve their quality of life and heart health. About 336 adults on hemodialysis will receive either the hormone or a placebo for up to two years. The go…

This study tests whether the drug patiromer can safely allow people on chronic dialysis to relax their strict low-potassium diet. About 40 participants will receive either patiromer or a placebo daily. The goal is to see if patiromer keeps potassium levels stable while patients e…

This study tests whether a device that measures brain waves (called BIS) can detect dialysis disequilibrium syndrome, a complication that can occur during first-time dialysis. Twenty new dialysis patients will be monitored during their first three sessions. The goal is to see if …

This study looks at whether a special ultrasound inside the vein (IVUS) can find blockages better than the usual X-ray method in people on dialysis. About 50 adults with kidney failure who have trouble with their dialysis access will take part. The goal is to see if IVUS gives cl…

This study is testing a new smart sensor that listens to chest sounds to help doctors screen for pneumonia in people who have had a stroke or are on dialysis for kidney failure. About 50 adults will take part, and the sensor's findings will be checked against chest X-rays. The go…

This study tests a program called CAPABLE Transplant, where an occupational therapist, nurse, and handy worker visit people at home over 4 months. The goal is to help kidney transplant candidates who are currently inactive on the waitlist become active again, and to improve their…

This study compares two types of ultrasound-guided nerve blocks for pain control after open kidney removal surgery. Ninety adults will receive either a rhomboid intercostal sub-serratus plane block or an external oblique intercostal block. Researchers will measure how long it tak…

This pilot study tests a 13-week Dialectical Behavioural Therapy (DBT) skills training program for Canadians who have recently started or will soon start facility-based hemodialysis. The goal is to see if the program is feasible and helpful for improving mental health and reducin…

This study tests whether a 4-week mindfulness meditation program can improve sleep quality, reduce stress, and ease symptoms in people receiving hemodialysis. Fifty adults on dialysis will either get meditation plus usual care or usual care alone. Researchers will measure changes…

This study tests whether an artificial intelligence (AI) program can help people on dialysis feel less anxious and cope better with stress. About 60 adults will use personalized relaxation techniques guided by AI during their dialysis sessions. Researchers will measure changes in…

This study is testing whether a new type of dialyzer, called Theranova, can help reduce common symptoms like pain, fatigue, and poor sleep in people with end-stage renal disease who are on dialysis. About 100 participants will use their usual dialyzer for the first 4 weeks and th…

This study tests whether a 12-week home-based exercise program is safe and practical for adults aged 60 and older who are waiting for a kidney transplant. Participants will either receive usual care plus a physical activity tracker, or usual care plus the tracker and online exerc…

This study tests whether a 15-20 minute session in a specially designed sensory modulation room before kidney transplant surgery can reduce pain, anxiety, and sleep problems afterward. The room has dim lights, nature videos, calming music, and tactile objects like stress balls. R…

This study tests whether a nerve block called transversalis fascia plane block can reduce pain after kidney transplant surgery. Fifty adults will receive either the nerve block plus standard painkillers or standard painkillers alone. The goal is to see if the block lowers pain sc…

This study looks at whether adding a blood-filtering step called hemoadsorption to regular dialysis can help people with kidney failure who still have bothersome symptoms like itching, tiredness, and trouble sleeping. Researchers will follow 120 adults for 6 months, tracking how …

This study tests whether a drug called icatibant can prevent sudden drops in blood pressure during dialysis, a common and serious problem. About 26 adults with kidney failure who often experience these drops will receive either the drug or a placebo in random order. The goal is t…

This study tests whether progressive muscle relaxation exercises can reduce depression and fatigue in people receiving hemodialysis. Sixty patients will practice these relaxation techniques, and researchers will measure changes in their mood and energy levels. The goal is to see …

This study tests whether using social virtual reality (VR) during dialysis sessions can reduce loneliness and other symptoms in people with end-stage kidney disease. Sixty participants will use VR glasses for 30-45 minutes, three times a week, for four weeks. Researchers will com…

This study tests whether letting a bladder catheter fall out on its own (passive removal) is better than having a nurse pull it out (active removal) after urological surgery. 160 men will be randomly assigned to one method. Researchers will measure satisfaction, pain, and anxiety…

This study tests whether having dialysis patients report their symptoms every month – and automatically alerting their care team when symptoms are severe – can improve their quality of life. About 2,293 adults with end-stage kidney disease on dialysis will take part across French…

This study is testing a program called TĀCcare 2.0, which combines medication and talk therapy to help people on hemodialysis manage pain, fatigue, and depression. About 424 adults who have been on dialysis for at least 3 months will take part. The goal is to see if this team-bas…

This study looks at a new way to do dialysis using just one needle in the arm instead of two, which may cause less damage to the blood vessel used for treatment. About 100 adults on long-term dialysis will try this method, and researchers will check if it keeps dialysis working w…

This study tests whether doing physical therapy during dialysis or just before it works better for people with end-stage kidney disease. 72 adults on hemodialysis will be split into two groups and exercise twice a week for 12 weeks. Researchers will measure walking ability, stren…

This early-phase study tests whether taking amino acid supplements during dialysis can reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. Researchers will compare a single amino acid (valine) with a mix of essential amino acids in 28 adults on …

This study tests whether personalized support from an exercise teacher and a nurse can help people on hemodialysis become more physically active at home. The study will include 70 adults who have been on dialysis for less than a year. The goal is to see if this support leads to l…

This study tests whether a symptom-monitoring system called SMaRRT-HD helps dialysis patients feel better. About 2,400 adults on hemodialysis at up to 36 U.S. clinics will either use the system or receive usual care. The system lets patients report symptoms on a tablet and alerts…

This study tests whether a 6-week aerobic exercise program (done on non-dialysis days) can lower serum uric acid levels, improve walking ability, and boost quality of life in 32 adults aged 40-60 who are on hemodialysis. Half will exercise 3 times a week; the other half will rece…

This study tests whether a program that combines gentle walking with progressive muscle relaxation can help reduce the extreme tiredness (fatigue) that many people with end-stage kidney disease feel while on dialysis. Researchers will enroll 40 adults who are on hemodialysis and …

This study tests whether a set of breathing exercises, called breath booster training, can strengthen respiratory muscles and improve quality of life in people on hemodialysis. Fifty patients aged 50 to 60 will do the exercises three times a week during their dialysis sessions. R…

This study tests whether applying magnetic stimulation can help relieve low back pain and maintain muscle mass in people with end-stage kidney disease who are on dialysis. Researchers will measure pain levels, physical function, and quality of life in 18 adult participants. The g…

This study tests whether a 12-week aerobic exercise program (cycling) during hemodialysis sessions can improve sleep quality, depression, and anxiety in kidney patients. 100 adults on maintenance dialysis will be split into an exercise group and a control group. The goal is to se…

This study compares two anesthesia methods—general anesthesia with sevoflurane and combined spinal-epidural anesthesia—in adults receiving a kidney transplant. Researchers will measure blood markers related to cell damage and protection to see if one method better shields the new…

This study looks at how well the immune system works in people with end-stage kidney disease. Researchers will take blood samples from 100 patients and healthy donors to study T-cells, a key part of the immune system. They also plan to test a lab technique to restore T-cell funct…

This study looks at a type of immune cell called memory B cells in people waiting for a kidney transplant who have certain antibodies. Researchers want to understand why some of these cells cause rejection while others don't. They will analyze blood samples from 51 patients to fi…

This study is testing three different low doses of the blood thinner rivaroxaban in 10 adults on chronic hemodialysis. The goal is to see how the drug behaves in the body and how much it thins the blood, to find a dose that might lower bleeding risks. Participants will take each …

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This early-stage study looks at how safe a new drug called INCB123667 is for people with severe kidney disease or kidney failure. Researchers will measure how the drug moves through the body and check for side effects. The study involves 16 adults aged 18 to 85.

This pilot study looks at whether giving dialysis on the same day as surgery is better than not giving it for people with end-stage kidney disease. About 30 participants will be randomly assigned to one of two schedules. Researchers will track safety issues like electrolyte probl…

This study uses special MRI scans to look at how well a donated kidney works in the recipient and how the donor's remaining kidney adapts over one year. It includes 80 adults (donors and recipients) and aims to help doctors choose the best kidneys for transplant. The goal is to b…

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

This study follows 100 adults with end-stage kidney disease who need long-term dialysis but have no working access sites left. Researchers are watching how well the HeRO and Super HeRO grafts perform over two years, checking for infections, blockages, and overall safety. The goal…

This study watches what happens to the lungs when doctors use a balloon to clear a clot in a dialysis patient's arm graft. Using a special belt that takes pictures of lung activity, researchers will check if tiny clot pieces briefly affect how air and blood flow in the lungs. Twe…

This study looks at whether making changes at hospitals and dialysis centers can help more people with kidney failure start the process to get a transplant. About 14,000 patients at five large transplant centers will be included. The goal is to see if these changes lead to more p…

This study at Yale University is testing whether the body can store sodium without holding onto extra water, a concept called 'water-free sodium storage.' Ten adults on peritoneal dialysis with heart failure will receive either a special dextrose solution or standard dialysis flu…

This study looks at how quickly people on dialysis gain weight from drinking fluids between sessions. It aims to understand if thirst right after dialysis leads to more fluid intake. The results could help improve care for kidney patients.

This study looks at how long a person has been on dialysis and how much urine they still make affects bladder size and flexibility. Researchers will measure bladder function in 87 adults with kidney failure who are waiting for a transplant. The goal is to find bladder problems ea…

This study tests whether community health workers and special training for doctors can help more kidney patients get on the transplant waitlist. Five patients will be assigned to either usual care or extra support from a community health worker who addresses social needs like hou…

This study looks at whether a new type of dialysis filter (medium cut-off dialyzer) helps kidney patients live longer and have fewer complications compared to standard filters. Researchers will review medical records from 1,000 adults on maintenance dialysis. The study is observa…

This study collects small tissue samples from the abdomen of children and adults undergoing peritoneal dialysis (a type of kidney treatment). The goal is to learn how the lining of the belly changes over time with dialysis. Researchers will also take samples from healthy people h…

This study looks at how genes influence the risk of kidney disease. Anyone 18 or older living in the US can join, even without kidney disease. Participation is online: you fill out health surveys and mail in a saliva sample. You may get free genetic ancestry information in return…

This study asks 500 adults with advanced kidney disease to complete a questionnaire that presents different dialysis options. Patients choose between home dialysis (with a financial allowance) and in-center dialysis (without the allowance) 13 times, each with varying features lik…

This study looks at a rare but serious condition called calciphylaxis, where small blood vessels in the skin harden, often leading to death. Researchers will compare 860 adults with chronic kidney disease—some who have calciphylaxis and some who don't—to find clues about what cau…

This study looks at whether kidney failure changes how well the flu vaccine works in people on dialysis. Researchers will compare the immune response of 146 dialysis patients and healthy volunteers after they get the flu shot. Participants will give blood samples over several mon…

This study is for older adults, including those in the hospital or with low priority care needs. Researchers want to see if newer methods, like body scans and blood tests, can better detect malnutrition and kidney problems than current standard tests. The goal is to make diagnosi…

This study looks at how the drug eloralintide enters the bloodstream and leaves the body in people with severe kidney disease or kidney failure, compared to healthy volunteers. About 28 participants will receive a single shot under the skin. The study lasts about 14 weeks and doe…

This study tests whether a nurse-led foot care education program, based on the Health Belief Model, can improve foot care knowledge and behavior in diabetic patients undergoing hemodialysis. Fifty participants will be randomly assigned to receive the training or standard care. Th…

This study compares three ways to check for fluid overload (too much fluid in the body) in people doing dialysis at home. Researchers will ask about symptoms, do a physical exam, and use a safe ultrasound of the lungs. The goal is to find which method works best to help prevent h…

This study tests whether a simple neck ultrasound can accurately measure fluid status in people receiving chronic haemodialysis. Researchers will compare ultrasound results with standard methods in 100 participants. The goal is to find a safer, non-invasive way to guide fluid rem…

This study surveys 100 adults on chronic dialysis to understand how the treatment impacts their sexual quality of life. Participants fill out a questionnaire during a dialysis session, covering sexual function and body image. The goal is to gather up-to-date information to help h…

This study tests a new method to help patients understand complex spine or prostate surgeries before they agree to them. Instead of just reading a form, patients watch multimedia content and answer questions to check their understanding. The goal is to see if this approach makes …

This study looks at how well three AI models—ChatGPT, Gemini, and Deepseek—can diagnose and suggest treatments for urology diseases. Researchers will use 800 past patient records from four hospitals to check the AI's accuracy and usefulness. The goal is to understand if AI can he…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome affects the way the body processes drugs. Researchers will collect blood samples from 150 adults and children to measure inflammation markers and estimate how they mig…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to better understand how these conditions interact and to find ways to predict and improve patient outcomes. No new treatments or procedure…

This study aims to understand the link between calcium and phosphorus from food and the stage of kidney disease in patients with advanced chronic kidney disease (stage 4-5). Researchers will compare two methods of tracking diet: taking photos of meals and weighing food. The goal …

This study is testing a new food questionnaire called EvalSel to see how well it measures salt intake in hospitalized patients with high blood pressure or kidney problems. Researchers will compare the questionnaire results with a 24-hour urine test, which is the gold standard for…

This study reviews medical records of 10 adult transplant patients who have a hard-to-treat CMV infection along with severe kidney disease or kidney failure. Researchers want to see how safe the drug maribavir is for these patients. No new treatments or procedures are given; the …

This study tests whether a 12-week virtual exercise and education program is practical for people with end-stage kidney disease who are waiting for a transplant. About 30 participants will either do the program or receive usual care. The main goal is to see if enough people join,…

This study looks at whether using a lower amount of bicarbonate in the dialysis fluid is better for the heart than the usual higher amount. About 141 hospitalized adults on long-term dialysis will be randomly assigned to receive either lower or higher bicarbonate during their dia…

This study follows 544 adults with advanced kidney disease who need an arteriovenous fistula for dialysis. Researchers want to find out why some people develop hand ischemia (reduced blood flow) after surgery. They will track symptoms like cold hands, pain, or sores to identify r…

This study looks at why some kidney transplant patients, especially those with a kidney disease called FSGS, develop protein in their urine again after surgery. Researchers will examine blood and kidney tissue samples taken before and after the transplant to find the cause. The g…

This pilot study tests whether adjusting magnesium levels in dialysis fluid can reduce harmful blood cell activation during treatment. Fifteen adults with kidney failure will try three different dialysis fluid recipes over six weeks. Researchers will measure blood cell counts and…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study looks at how the body handles a new drug called S-892216 in people with mild, moderate, or severe kidney problems, including those on dialysis, compared to people with healthy kidneys. About 40 adults will take a single dose of the drug, and researchers will measure it…

This study is testing a new blood test that looks for kidney-specific DNA to detect injury or rejection after a kidney transplant. Researchers will measure these DNA markers before and after surgery in 30 patients with end-stage kidney disease. The goal is to see if the test can …

This study is testing a new device called PatenSee that can check the health of dialysis access points without touching the patient. About 90 adults with kidney failure who need regular dialysis will take part. The device uses light and sound to see and hear the access point, and…

This study looks at how the body controls sodium levels in people with end-stage kidney disease who are on dialysis. Researchers will give participants either water or a concentrated salt solution to see how their sodium levels change. The goal is to better understand hyponatremi…

This study tests whether a digital website called Careverse can help caregivers of people with serious illnesses engage more in advance care planning. About 200 caregivers will be randomly assigned to use the website or receive usual care. Researchers will measure how involved ca…

This study looks at whether the sounds made by blood flowing through an arteriovenous fistula (AVF) can tell doctors how healthy the fistula is. Researchers will use MRI and ultrasound to measure blood flow and compare it to the sounds recorded. If a clear link is found, it could…