End stage renal failure

This trial compares removing a urinary catheter on day 3 versus day 6 after a living donor kidney transplant. The goal is to see if earlier removal reduces urinary tract infections within 30 days without causing more complications like urine leaks. The study involves 172 adult ki…

This Phase 3 trial tests a lab-grown blood vessel (ATEV) against the standard surgically created fistula in 121 women with end-stage kidney disease who need dialysis. The goal is to see if the ATEV allows more days without a catheter and reduces infections over 12 months. If succ…

This study follows 150 people who received imlifidase before a kidney transplant to see how long their new kidney works. Researchers will check for graft failure (return to dialysis, re-transplant, or kidney removal) over 5 years. A separate group of similar patients not receivin…

This study compares two types of dialysis in 64 adults with end-stage kidney disease. One group gets standard hemodialysis, the other gets hemodiafiltration, which uses both diffusion and convection to remove waste. The main goal is to see if hemodiafiltration leads to less weigh…

This study tests a drug called pegcetacoplan in 320 adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). The goal is to see if the drug helps the kidney work sooner and r…

This study tests whether a special form of calcium and magnesium (effervescent calcium-magnesium citrate) can slow down harmful calcium buildup in the heart and blood vessels of people with end-stage kidney disease on dialysis. About 269 adults will take either this supplement or…

This study compares two types of surgery to create dialysis access in older adults (60+) with end-stage kidney disease. One method connects a vein directly to an artery (fistula), the other uses a synthetic tube (graft). The goal is to see which leads to fewer infections and more…

This phase 2 trial tests whether giving the HPV vaccine (Gardasil 9) to adults before a kidney transplant helps their immune system fight HPV after transplant, when they must take drugs that weaken immunity. About 51 participants will receive the vaccine before surgery, and resea…

This Phase 3 trial tests whether dapagliflozin (Forxiga), a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalization in 1750 people with severe chronic kidney disease. Unlike earlier studies, this trial includes patients on dia…

This early-phase study tests whether a single infusion of special immune cells (regulatory dendritic cells) from the kidney donor can help the recipient's body accept the new kidney with fewer side effects. 14 first-time kidney transplant recipients will receive the cells one wee…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This pilot study tests whether adding a special type of dialysis (peritoneal dialysis) between regular hemodialysis sessions can remove extra sodium and fluid from the body. Ten adults on hemodialysis will receive this extra treatment twice a week for three weeks. Researchers wil…

This study tests a new device called STARgraft-3, a tube used for dialysis in people with end-stage kidney disease. The goal is to see if it stays open longer and resists infection better than standard grafts. About 21 adults will be followed for up to a year to check how well th…

This study tests a special dialysis fluid containing amino acids (protein building blocks) to see if it can improve the nutritional status of adults with end-stage kidney disease who are on peritoneal dialysis. About 50 participants will replace one daily dialysis bag with this s…

This study tests whether motivational interviewing, a counseling style that encourages patients to find their own reasons for change, can help African American adults on hemodialysis attend all their sessions. 176 participants will either receive the coaching or standard care, an…

This study looks at whether adding more magnesium to the fluid used during dialysis can help people with kidney failure live longer and have fewer heart-related hospital stays. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial …

This study tests whether giving estrogen through a vein during kidney transplant surgery can reduce damage to the new kidney. It includes 30 women who need dialysis and are getting a kidney from a deceased donor. The goal is to see if estrogen helps the kidney work better right a…

Some people waiting for a kidney transplant have immune systems that reject most donors, leading to years of waiting. This study tests whether two drugs—carfilzomib (used for multiple myeloma) and belatacept (an immune-suppressing drug)—can reduce that sensitivity. About 21 parti…

This study tests whether adding a special filter (hemoperfusion) to regular dialysis can better remove waste products like beta-2 microglobulin, parathyroid hormone, and C-reactive protein from the blood. About 410 adults with end-stage kidney disease on maintenance dialysis will…

This study looks at whether people with ANCA vasculitis who have reached end-stage kidney disease can safely stop taking immunosuppressive medications. The goal is to see if stopping these drugs lowers the risk of serious infections and other side effects without causing dangerou…

This study tests a drug called ARGX-117 in people who get a kidney from a deceased donor and are at risk for delayed graft function (when the kidney takes time to start working). About 103 participants will receive either the drug or a placebo by IV. The goal is to see if the dru…

This study looks at whether canagliflozin, a drug used for diabetes, can safely reduce protein in the urine (a sign of kidney damage) in people with advanced chronic kidney disease (CKD), including those on dialysis. About 35 adults with CKD stage 4 or 5 will take the drug for up…

This study compares two methods for placing peritoneal dialysis catheters in adults with advanced chronic kidney disease. The Moncrief-Popovich technique buries the catheter under the skin before use, while the conventional method places it directly. Researchers will track how lo…

This study tests an oral drug called vadadustat (Vafseo) for treating anemia in people with end-stage kidney disease who are on hemodialysis. About 2,200 adults will be randomly assigned to take vadadustat three times a week or continue standard injectable treatments. The goal is…

This study tests whether a 6-month exercise and personalized diet plan can help patients with obesity (BMI 40-44) lose weight so they can become active on the kidney transplant waiting list. Ten adults who are currently listed as 'inactive' due to their weight will follow a fitne…

This study tests whether a daily dose of alpha lipoic acid, an antioxidant supplement, can lower the risk of heart problems in 50 children who are on regular hemodialysis. Participants will either take the supplement or a placebo pill for a period, and researchers will monitor fo…

This study tests a new pill, vadadustat, taken three times a week, against the usual injected medicine for anemia in people with kidney failure who are on dialysis. About 350 adults will take part to see if the pill can safely keep their red blood cell levels in a healthy range. …

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This phase 2 study tests whether a drug called TCD601 (siplizumab), combined with donor bone marrow cells and mild chemotherapy, can train the immune system to accept a new kidney without needing lifelong anti-rejection drugs. The trial involves 18 adults receiving a kidney from …

This study tests a 1-month course of three medicines (isoniazid, rifapentine, and vitamin B6) to treat latent tuberculosis in 25 adults with end-stage kidney disease who are candidates for a kidney transplant. The goal is to see if this shorter treatment is safe and easy to compl…

This study tests whether two drugs, daratumumab and belatacept, can lower the immune system's sensitivity in kidney transplant candidates who are very hard to match. About 19 highly sensitized patients will receive the treatment to see if it reduces their antibody levels or allow…

This study tests whether semaglutide, a once-weekly injection, can improve blood sugar control in people with type 2 diabetes who are on chronic dialysis. About 43 participants will receive either semaglutide or a placebo for over a year, and their blood sugar levels will be trac…

This early-stage trial tests whether a patient's own fat-derived stem cells, applied during surgery, can prevent dialysis fistulas from failing. About 74 adults with advanced kidney disease will receive either stem cells or a placebo. The goal is to see if the treatment improves …

This pilot study tests a new diet for people on hemodialysis who have high potassium levels. Instead of cutting out all high-potassium foods like fruits and vegetables, the diet focuses on avoiding foods with potassium that is easily absorbed, such as additives, processed meats, …

This study tests whether delivering specially designed meals can improve nutrition in elderly, low-income patients with end-stage kidney disease who are on dialysis. Twenty-five participants will first eat their usual diet for 4 weeks, then receive personalized meals for another …

This study looks at whether giving testosterone to men with low testosterone and kidney failure can help them recover better after a kidney transplant. About 50 men will receive testosterone before and after their transplant, and their safety and recovery will be compared to a si…

This study compares robot-assisted kidney transplant to the standard open surgery in 106 adults with end-stage kidney disease. The goal is to see if the robotic approach reduces serious complications like bleeding or blood clots within 30 days after surgery. Participants are rand…

This early-stage study tests a conditioning regimen to make the recipient's immune system accept a donor kidney without needing lifelong anti-rejection medication. About 20 adults with kidney failure receiving their first transplant from a living donor will participate. The main …

This study tests a new surgical method called RADAR for creating blood vessel connections needed for dialysis in 200 people with end-stage kidney disease. The goal is to see if this technique leads to fewer blockages and better long-term function compared to the standard approach…

This study follows 11 kidney transplant patients who received an experimental cell therapy called TX200-TR101 in an earlier trial. Researchers will monitor them for up to 15 years to check for long-term side effects and how well their transplanted kidney is doing. The goal is to …

This early study tests whether the drug belumosudil, given with donor stem cells, can help the body accept a new kidney without needing strong anti-rejection drugs for life. Sixteen adults with end-stage kidney disease will receive a living donor kidney and stem cell transplant, …

This study looks at how well a new robotic surgery system (Medtronic Hugo) works for urologic procedures like removing prostate, bladder, or kidney tumors. About 144 adults will have surgery with the robot, and doctors will check if the surgery is completed without switching to a…

This study follows 64 highly sensitized kidney transplant patients who previously received either imlifidase or standard care in an earlier trial. Researchers will track how many patients are alive and free of dialysis at 3 and 5 years, as well as graft survival. The goal is to s…

This phase 2 trial tests whether adding belumosudil (Rezurock) to standard care can prevent scarring in new kidney transplants. About 40 adults receiving their first or second kidney will be randomly assigned to get the drug or a placebo for a year. The study tracks serious side …

This study tests whether kidneys from donors with hepatitis C can be safely transplanted into people without the virus. Recipients will take the antiviral drug Epclusa for 12 weeks to prevent or treat infection. The goal is to see if this approach is safe and effective, potential…

This study tests whether measuring blood pressure at home, rather than only at the dialysis center, helps prevent dangerous blood pressure drops during dialysis. 200 adults with end-stage kidney disease on dialysis will be assigned to either home or clinic blood pressure targets.…

This study tests whether dapagliflozin, a drug used in adults for diabetes and kidney protection, can reduce protein leakage in the urine of children with chronic kidney disease. Ten children aged 4 to 18 with persistent proteinuria despite standard therapy will take the drug, an…

This study tests whether the drug nicorandil can lower the risk of serious heart problems like heart attacks and strokes in people with coronary artery disease who are on kidney dialysis. Researchers are giving 15 mg of nicorandil daily to 268 participants and tracking heart-rela…

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

This study looks at 75 kidney transplant patients to compare two different drug combinations given right after transplant. One group gets a single dose of RATG plus basiliximab, while the other gets seven doses of RATG plus basiliximab. The goal is to see which approach causes fe…

This study is testing a new type of graft (called aXess) for people with end-stage kidney disease who need hemodialysis but can't have a standard fistula. The graft is made of a biodegradable material that may help reduce complications. About 140 adults will be enrolled to see if…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was designed as a randomized trial but was withdrawn before enrolling any participants. No results are available.

This study tests whether wearing bright light glasses during dialysis can reduce severe fatigue in people with end-stage kidney disease. Sixty adults on hemodialysis will use the glasses for one hour, three times a week, for four weeks. The goal is to see if this simple, non-drug…

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study tests whether adding mindfulness (guided meditation) to a group exercise program during dialysis can improve safety, adherence, and quality of life for people with chronic kidney disease. Thirty participants will be split into two groups: one doing exercise plus mindfu…

This study tests whether a live, online exercise program can improve physical function in adults waiting for a kidney transplant. Eighty participants will either join twice-weekly virtual exercise sessions or a health education class. The main goal is to see if they can stand up …

This study tests whether a 5-week virtual reality program that teaches positive thinking skills can help reduce depression and improve quality of life in people on hemodialysis. Sixty-one adults with end-stage kidney disease and mild-to-moderate depressive symptoms will either re…

This study tests whether adding a structured exercise program during dialysis sessions can improve strength, walking ability, and quality of life for people with end-stage kidney disease. About 800 patients will be randomly assigned to either dialysis plus exercise or dialysis al…

This study tests two simple activities—pedaling a stationary bike and using a breathing device—during dialysis sessions to see if they reduce fatigue and improve sleep. 102 adults on hemodialysis will be split into three groups: one does leg exercises, one does breathing exercise…

This study tests if anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, severe joint pain. Standard treatments can be risky for these patients. The study measures pain …

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce the need for strong painkillers after a kidney transplant from a living donor. Sixty adult participants will receive a carbohydrate drink, Tylenol, gabapentin, a local numbing injection, and ea…

This study tests a virtual reality platform designed for people on hemodialysis. The platform includes games to encourage exercise, plus nutritional advice and psychological support. Researchers hope it will improve patients' walking ability, quality of life, and overall well-bei…

This study compares continuous spinal anesthesia to general anesthesia for people receiving a kidney transplant. The goal is to see if the spinal method keeps blood pressure more stable and reduces pain. Sixty adults with end-stage kidney disease are taking part.

This study explores whether doing origami (paper folding) can help people on hemodialysis feel more comfortable and improve their quality of life. Researchers will enroll 60 adults who have been on dialysis for at least six months. Participants will do origami activities, and the…

This study tests two numbing medicines, ropivacaine and lidocaine, in 40 adults with end-stage kidney disease who need surgery to create a blood vessel connection (fistula) for dialysis. Patients are randomly assigned to receive one of the two drugs during surgery, and neither th…

This study tests whether a 12-week exercise program done during dialysis can improve muscle oxygen levels and dialysis quality in kidney patients who also have muscle loss (sarcopenia). About 40 patients will either exercise on a bike and do resistance moves during their first tw…

This study investigates why people with advanced chronic kidney disease (not yet on dialysis) often feel deep fatigue. Researchers will measure muscle strength and fatigue using simple tests like hand grip and walking speed. The goal is to understand how kidney disease affects ne…

This study was designed to see how a low dose of bevacizumab (Avastin) behaves in the body and whether it safely lowers a certain protein (VEGF-A) in people with kidney failure on dialysis. The goal was to gather information for a future trial on preventing dialysis access failur…

This study was designed to see if different types of anesthesia could help a surgically created blood vessel connection (called a fistula) work better for dialysis patients. The plan was to compare three methods: a nerve block in the armpit, a nerve block in the neck, and local a…

This study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…

This early study is testing whether the diabetes and heart failure drug empagliflozin (Jardiance) is safe for people on dialysis for kidney failure. The drug is already approved for other uses but has not been studied in dialysis patients. Researchers will give 24 participants ei…

This study gives a single dose of bepirovirsen to 32 adults with hepatitis B, some with kidney disease and some healthy. Researchers measure how much drug gets into the blood and how long it stays. The goal is to see if kidney problems change drug levels, which could affect futur…

This study looks at whether people who received a kidney transplant later regret their choice. Researchers will survey 250 patients one year after their transplant to measure feelings of regret and quality of life. The goal is to understand how common regret is and help doctors s…

This study follows 96 people with end-stage kidney disease who need a brachiocephalic fistula for dialysis. Researchers collect data from exams, blood tests, and imaging to track changes in the vein over time. The goal is to learn what causes cephalic arch stenosis, a common narr…

This study looks at whether advanced monitoring devices can accurately measure blood thickness (hematocrit) and oxygen levels during continuous dialysis in critically ill patients with acute kidney injury or end-stage kidney failure. About 30 adults in the intensive care unit wil…

This observational study follows 25 people with end-stage kidney disease who are receiving a living donor kidney transplant. Researchers want to see how protein in the urine (proteinuria) relates to blood flow in the native kidneys before and after transplant. They also check for…

This study uses a continuous glucose monitor (a small sensor) to track blood sugar levels in 40 adults with diabetes and end-stage kidney disease who are on dialysis. The goal is to see how glucose changes during and between dialysis sessions over two weeks, and whether those pat…

This study looks at whether high-intensity cycling during hemodialysis can protect the heart from damage that dialysis sometimes causes. Fifteen adults on dialysis will exercise at different intensities during their sessions. Researchers will use echocardiograms to measure heart …

This study looks at 1000 people who had a first arteriovenous fistula (AVF) created for dialysis. Researchers want to know how many are actually being used for dialysis two years later, and why some are not. The goal is to understand what prevents these fistulas from being used.

This study looks at data from 3,500 kidney transplant patients to understand if a technique called normothermic machine perfusion (NMP) improves outcomes. NMP keeps donated kidneys warm and oxygenated before transplant, but there is no registry field to track it. Researchers will…

This study uses health records from 17,000 Canadian adults to understand why some people switch from peritoneal dialysis (done at home) to hemodialysis (done in a clinic). Researchers will look at how often this happens, what predicts it, and what happens to patients after the sw…

This study tests whether a video decision aid helps older adults with advanced kidney disease plan their future medical care. About 456 patients aged 65 and older will watch a video explaining dialysis, non-dialysis management, and CPR, then record their preferences. The goal is …

This study looks at how to improve dialysis for children with kidney failure. Researchers will measure how well different dialysis settings remove waste from the blood while also tracking how much water is used. The goal is to find the best balance between cleaning the blood and …

This study is investigating whether a substance called copeptin, which is a stable marker of the hormone vasopressin, is linked to blood pressure changes that happen during hemodialysis. Researchers will measure copeptin levels in routine blood samples from 71 adults on chronic d…

This study examines how end-stage renal disease (ESRD) impacts recovery after pancreatic surgery. Researchers will review medical records of 100 patients to compare complication rates, hospital stays, and costs based on kidney function and dialysis use. The goal is to provide cle…

This study tests whether a tele-health navigator program can help more kidney transplant candidates find living donors. About 347 adults with end-stage kidney disease will either get the navigator support or standard care. The goal is to see if remote guidance increases donor scr…

This study looked at 122 adults who received a kidney from a living donor. Researchers wanted to see if the amount of fluids given in the first 4 hours after surgery affected how well the new kidney worked. They measured kidney function and complications in the first week and fir…

This study tests whether an educational video can help adults with serious cancer understand and use palliative care. 172 participants will either receive standard care plus brochures, or standard care plus a tailored video and extra materials. Researchers will track knowledge, a…

This study tests a program that gives kidney failure patients personalized support to help them find a living donor for a kidney transplant. The goal is to increase the number of living donor transplants in Alberta, Canada. About 66 patients will take part, and researchers will t…

This study compares a new, less invasive needle-based method (endo-AVF) with traditional surgery for creating arteriovenous fistulas (AVFs) needed for dialysis. About 21 adults will be randomly assigned to one of the two techniques to see if a larger trial is feasible. The goal i…

This pilot study tests a support program called MuST AKT for people with kidney failure who need a transplant. The program helps patients talk to family and friends about living kidney donation. Researchers want to see if this support leads to more potential donors starting the e…

This study tests a special education program for veterans with advanced chronic kidney disease. The goal is to help them understand their condition and choose the best type of dialysis, especially home dialysis. About 656 veterans will take part to see if this program improves th…

This study was designed to observe people with chronic kidney disease (CKD) and end-stage kidney disease (ESKD) to understand how the disease naturally progresses and how well current treatments work. It planned to enroll adults diagnosed with CKD or ESKD and follow their health …

This study is testing whether a simple urine test can detect signs of kidney transplant rejection in children. Researchers are looking for specific molecules in urine that signal the body is attacking the new kidney. If the test works, it could help doctors spot problems early wi…

This study tests whether an educational program and a mobile health app can help adults with kidney failure find a living donor for a transplant. About 775 participants who haven't yet identified a donor will take part. The goal is to see if these tools increase the number of liv…

This study compares two types of dialysis filters in 30 kidney patients to see which one causes less damage to white blood cells and reduces inflammation. One filter is made of a special material called PMMA that may remove more harmful substances. The goal is to understand how d…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…