End stage renal failure

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This trial tests a new cell therapy called TX200-TR101 in people who receive a kidney from a living donor. The therapy is made from the patient's own immune cells, which are genetically modified to help the body accept the donated kidney instead of rejecting it. The study focuses…

This study tests whether a 3-month nurse-led program can reduce frailty and improve self-management in people undergoing peritoneal dialysis. The program includes personalized assessments, education, exercise training, and social support. Researchers compare this program to stand…

This study looks at whether a new method of measuring parathyroid hormone (PTH) can help doctors better manage calcium and phosphate levels in people on hemodialysis. About 80 patients with end-stage kidney disease will be randomly assigned to have their PTH measured either with …

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study compares two dialysis filters, SOLACEA-H and HYDROLINK-NVU, to see if SOLACEA-H can allow dialysis sessions with less or no blood thinner (heparin). The trial involves 20 adults who have been on dialysis for at least 3 months and are medically stable. Each participant …

This completed study tested whether adding AC-134, a dietary supplement, to a low-protein diet helps protect kidney function in people with chronic kidney disease. Researchers measured kidney function, protein in urine, and waste products in the blood of 100 adults aged 20-90 wit…

This study tested two different combinations of immunosuppressant drugs in 88 adults who received a new kidney. The goal was to see which plan better protects kidney function over the short term. All participants took lifelong anti-rejection medication, so this is about managing …

This study tested whether face-to-face nutrition education about potassium could help people on maintenance hemodialysis control their potassium levels. Fifty adult patients with high potassium took part. The goal was to reduce complications and improve quality of life.

This study tested a drug called sacubitril/valsartan (a heart failure medication) in 45 adults who had just started hemodialysis. The goal was to see if it could improve heart function and help preserve any remaining kidney function compared to a placebo. Participants took the dr…

This study looked at how well the Ellipsys Vascular Access System works for creating arteriovenous (AV) fistulas in people with end-stage kidney disease who need dialysis. A total of 142 patients were followed for 12 months to see how long the access stayed open and how safe the …

This study looked at whether a high-protein drink with added curcumin (a compound from turmeric) could lower inflammation and oxidative stress in adults on hemodialysis for advanced kidney disease. 39 participants were randomly assigned to receive either the curcumin drink or a p…

This study tested whether a smart app called Weiyin Health could improve follow-up care for 223 adults on peritoneal dialysis for kidney failure. One group used the app for reminders, AI questions, and risk alerts, while the other got standard care via WeChat and phone calls. The…

This completed study tested an oral supplement made from generally recognized as safe (GRAS) ingredients in 8 people with end-stage kidney disease. Two participants had not produced urine for 16 and 22 years. The goal was to see if the supplement could restore even a small amount…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This study tested whether the drug sacubitril/valsartan can improve heart function in people with heart failure who are on chronic hemodialysis. 52 patients were split into two groups: one received the drug, the other standard care. Researchers measured changes in heart ultrasoun…

This study tested whether using sevoflurane gas for anesthesia during kidney transplant surgery helps the new kidney recover faster than standard propofol anesthesia. 120 adults receiving a kidney transplant were randomly assigned to one of the two anesthetics. Researchers tracke…

This study looked at whether adding citrate to the fluid used during dialysis can slow the buildup of calcium in blood vessels. 54 adults on hemodialysis who already had some vessel hardening took part. Each person used a standard fluid for 12 months and a citrate fluid for anoth…

This study tested a drug called imlifidase in 113 highly sensitized kidney patients who had a positive crossmatch against a deceased donor. The drug was given before transplant to reduce the risk of rejection. The main goal was to see how many patients still had a working kidney …

This phase 2 trial tested a new combination of drugs—siplizumab, belatacept, and mycophenolic acid—in 76 people who just received a kidney transplant. The goal was to see if this combo is safer and works better than the usual immunosuppression therapy. Researchers measured side e…

This phase 3 trial tested a drug called imlifidase in 64 highly sensitized kidney transplant patients who had almost no chance of finding a compatible donor. The drug breaks down harmful antibodies, allowing a transplant from a donor that would normally be rejected. The study mea…

This study compared two types of home dialysis for people with end-stage kidney disease: nighttime automated dialysis (APD) and daytime manual dialysis (CAPD). 137 non-diabetic adults tried each method for 12 weeks. The goal was to see if nighttime dialysis was as good as daytime…

This study compared two types of IV fluids given to kidney transplant patients during their first week after surgery. The goal was to see which fluid better prevents electrolyte imbalances and helps the new kidney work well. About 159 adult patients who received a kidney from a l…

This study tested whether taking probiotics or synbiotics (probiotics plus fiber) for 6 months could improve health in 60 adults with kidney failure on dialysis. Researchers measured changes in blood toxins, heart health, quality of life, and thinking ability. The goal was to see…

This study looked at how a tacrolimus tablet (TacroBell) works in people who received a kidney transplant. The goal was to measure drug levels in the blood and see how well patients tolerated it. 128 adults who were getting a kidney from a deceased or living donor took part. The …

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This study tested two different drug combinations (Simulect or ATG, plus standard medications) in 60 kidney transplant patients at high risk of rejection. The goal was to see which approach better prevents treatment failure, including rejection, graft loss, or death, within 6 mon…

This study tested a new drug called MT-6548 against a standard treatment (darbepoetin alfa) for anemia in people on dialysis for chronic kidney disease. About 323 participants in Japan received either the new drug or the standard one to see if it worked as well at keeping hemoglo…

This study tested a new dialysis filter (Clearum HS) in 20 adults with end-stage kidney disease who were already on dialysis. The goal was to see if the new filter safely removes waste products like urea as well as or better than standard filters. Participants used their usual fi…

This study tested whether a new training package called TEACH-PD could lower infection rates in patients starting peritoneal dialysis (PD). Over 1,400 adults from multiple countries were randomly assigned to receive either the TEACH-PD training or standard PD training. The resear…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease improve their blood pressure. 320 adults with moderate to severe kidney disease and uncontrolled high blood pressure took part. The goal was to see if the coachin…

This study tested a personalized way to dose the blood thinner enoxaparin in 50 children after kidney transplant. The goal was to prevent dangerous blood clots in the new kidney while avoiding excessive bleeding. Doctors used a computer model (Bayesian approach) to adjust doses b…

This study tested whether a low dose of the blood thinner rivaroxaban (Xarelto) could reduce major heart problems like heart attacks and strokes in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receiv…

This study looked at 45 adults on hemodialysis who had a blocked superior vena cava (SVC), a large vein in the chest. Doctors used surgery or a tube-like device to reopen the vein and relieve symptoms. The goal was to improve blood flow and quality of life for these patients.

This study tested a new dialysis needle called the Argyle Safety Fistula Cannula with an anti-reflux valve. It was used in 40 adults with end-stage kidney failure who get dialysis three times a week for 12 weeks. The goal was to see if the needle is safe and works well for hemodi…

This pilot study tested whether using central blood pressure (measured near the heart) instead of the usual arm cuff leads to better outcomes in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central BP target or a standard arm BP…

This study tested whether kidneys from deceased donors with hepatitis C can be safely transplanted into people without hepatitis C. All 201 participants received antiviral medication after transplant to clear any infection. The goal was to see if this approach could safely increa…

This study looked at whether garlic supplements can improve blood vessel function and reduce inflammation in adults with kidney failure who are on hemodialysis. Fifty-eight patients took garlic extract or a placebo for a period of time. Researchers measured markers of inflammatio…

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. Participants used the new filter three times a week for 12 weeks. The goal was to see if it safely maintained albumin levels while improving removal of certain waste products. The trial is …

This study looked at 1,819 elderly patients (aged 60+) with end-stage kidney disease to see if getting a living donor kidney transplant that is not a perfect match (ABO- or HLA-incompatible) helps them live longer compared to waiting for a compatible deceased donor. The approach …

This study tests whether giving donor stem cells and a drug called Campath-1H can help kidney transplant recipients stop taking anti-rejection medications permanently. Eighty-eight patients receiving a kidney from an identical sibling will get the stem cell infusions and temporar…

This early-stage study tested a new approach to help kidney transplant recipients stop taking anti-rejection drugs. Eight adults received donor stem cells along with a special mix of medications to see if their bodies would accept the new kidney without needing lifelong drugs. Th…

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft, which would requir…

This study tested whether using a special scale (bioimpedance) to measure body fluid levels each month could help doctors set the right dry weight for hemodialysis patients. The goal was to reduce serious complications like heart attacks, strokes, and low blood pressure during di…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study examined whether adding a monthly blood-cleaning procedure (hemoperfusion) to regular dialysis can reduce the risk of death, especially from heart or brain problems. Researchers reviewed records of 879 adult dialysis patients over 10 years, comparing those who received…

This study tested a new drug called FR104 in 10 people who received a kidney transplant. The goal was to see if the drug is safe and helps prevent the body from rejecting the new kidney. Researchers monitored side effects and kidney function over time.

This study tested a drug called MCI-196 in 245 adults on dialysis who have high phosphate levels, a common problem in advanced kidney disease. After a 4-week washout and 12-week dose adjustment, patients were randomly assigned to continue MCI-196 or switch to a placebo for 4 week…

This study tested a drug called MCI-196 in 336 adults on dialysis with chronic kidney disease and high phosphorus levels. After a washout period, some patients received MCI-196 and others a placebo to see if the drug could safely lower phosphorus. The goal was to manage a common …

This study tested the long-term safety of a drug called MCI-196 (Colestilan) in 116 adults with stage 5 chronic kidney disease who are on dialysis and have high phosphorus levels. Participants took flexible doses of the drug for 52 weeks. The main goal was to see how many side ef…

This Phase 3 trial tested MCI-196, a drug that binds phosphorus and lowers cholesterol, in 642 adults on dialysis with chronic kidney disease. Participants received either MCI-196 or a placebo for 12 weeks. The goal was to see if the drug could safely reduce both serum phosphorus…

This study tested the long-term safety of a drug called MCI-196 in 632 adults with chronic kidney disease on dialysis who have high phosphorus levels. Participants took the drug for up to 52 weeks to see how it affected their phosphorus and cholesterol. The goal was to help contr…

This study tested a new drug called MCI-196 to lower bad cholesterol in people with advanced chronic kidney disease who are on dialysis. About 260 adults took part, comparing MCI-196 to a standard statin (simvastatin) and a placebo. The goal was to see if MCI-196 works better tha…

This study tested a special device called the Amplifi Vein Dilation System in 19 adults with end-stage kidney disease who needed a vein connection (fistula) for dialysis. The goal was to see if the device could safely widen the vein and help the fistula mature faster. The study m…

This study looked at whether taking L-carnitine or Coenzyme Q10 supplements could lower oxidative stress (a type of cell damage) in adults with end-stage kidney disease who are on regular hemodialysis. Fifty-two participants took one of the supplements or a placebo for 12 weeks, …

This study tested a device called Carry Life UF in 28 adults with end-stage kidney disease who use continuous ambulatory peritoneal dialysis (CAPD) at home. The device adds glucose to the dialysis fluid already in the belly to help remove more fluid over a 5-hour session. Researc…

This study looked at 78 people with advanced kidney failure who needed a surgery to create an arteriovenous fistula (a connection between an artery and vein) for dialysis. The goal was to see if using a nerve block (axillary block) instead of local anesthesia could reduce early p…

This study tested whether taking oral L-carnitine (a natural supplement) three times a week for three months could reduce inflammation and improve nutrition in 50 adults with advanced kidney failure on chronic hemodialysis. Participants were randomly assigned to receive either L-…

This study looked at whether taking vitamin C by mouth can safely lower the amount of erythropoietin (a drug for anemia) needed by people with end-stage kidney disease on regular dialysis. Sixty adults on stable dialysis with low iron levels and moderate anemia took part. Researc…

This pilot study tested a combination of two drugs—belatacept and a proteasome inhibitor—to lower strong immune antibodies in 5 highly sensitized kidney transplant candidates. The goal was to increase their chances of finding a compatible donor. The study has completed, but resul…

This study tested whether using a smart grip device with a game-like app could improve blood vessel function and hand strength in 52 kidney patients who had just had a first arteriovenous fistula surgery. Participants used the device daily for eight weeks, and researchers tracked…

This study tested whether a nurse-led nutritional education program could help hemodialysis patients in Morocco lower dangerously high potassium levels. Thirty adults with end-stage kidney disease received 12 weeks of dietary guidance on potassium, fluids, and salt. After the pro…

This study tested whether a daily probiotic drink could slow the buildup of calcium in blood vessels (vascular calcification) in 84 adults with advanced chronic kidney disease. Participants took either the probiotic or a placebo for 6 months, and researchers tracked changes in ki…

This study tested a new device called FLEX-1 that creates a special blood vessel connection (called an arteriovenous fistula) for people with advanced kidney disease who need dialysis. Sixteen adults with stage 4 or 5 chronic kidney disease took part. The goal was to see if the d…

This study tested a new device called FLEX-1 to create a special blood vessel connection (arteriovenous fistula) for dialysis in 17 adults with advanced chronic kidney disease. The goal was to see if the device is safe and works well for hemodialysis. The study focused on complic…

This study tested a new medicine called ASKP1240 in 149 people who received a new kidney. The goal was to see if it could prevent the body from rejecting the kidney as well as or better than current standard treatments. Participants received different combinations of drugs, and r…

This phase 3 trial tested a lab-grown blood vessel (Human Acellular Vessel, or HAV) against the standard surgically created fistula in 242 people with end-stage kidney disease on hemodialysis. The goal was to see which option works better for providing reliable access to filter b…

This study tested a single dose of a new drug called ASKP1240 in 50 people who just received a kidney transplant. The goal was to see how the drug moves through the body, how safe it is, and how well it works. Participants were randomly assigned to get the drug or a placebo, and …

This Phase 3 trial tested a new drug called AP301 in 474 Chinese adults on dialysis who had high phosphorus levels. Participants took AP301, a low dose of AP301, or the standard drug sevelamer carbonate with meals. The main goal was to see how well AP301 lowers phosphorus compare…

This study tested a special collagen implant coated with sirolimus (rapamycin) placed around a new dialysis fistula during surgery. The goal was to see if it helps the fistula become usable for dialysis sooner and stay working longer. About 269 people with advanced kidney disease…

This study tested whether a routine biopsy three months after kidney transplantation can help doctors adjust immunosuppressive drugs to prevent graft loss and reduce side effects. 346 patients were split into two groups: those with mild inflammation received extra steroids, while…

This phase 3 trial tests a sirolimus-releasing collagen implant placed around a new dialysis fistula during surgery. The goal is to help the fistula mature faster so it can be used for dialysis. The study involves 136 people aged 65+ with kidney failure who are new to hemodialysi…

This study tested whether adjusting the first dose of the immunosuppressant drug tacrolimus based on a patient's CYP3A5 gene helps reach the right blood levels faster after kidney transplant. 280 kidney transplant recipients were randomly assigned to receive either a standard dos…

This study tested whether personalized diet education could help hemodialysis patients lower high blood phosphate levels, a common and risky condition. Two hundred adults on dialysis were split into two groups: one received standard care, the other added targeted counseling on lo…

This early study tested a single shot of an experimental drug called MK-2060 in 14 people with stage 4 chronic kidney disease. The main goal was to see if it was safe and how the body handles it. Only the first part of the study was completed; the later parts were not started for…

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). Participants received either PLS240 or a placebo intravenously three times a week for 27 weeks, followed by …

This study allowed 25 people with end-stage kidney disease to keep using the HemoCare hemodialysis system at home while the device was being reviewed for market approval. The main goal was to track safety events like side effects or device problems. Participants needed a trained …

This study tested a drug called PLS240 in 362 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). Participants received either PLS240 or a placebo during dialysis three times a week for 27 weeks, followed b…

This study tested whether advanced ultrasound techniques can predict if an arteriovenous fistula (AVF) will work for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and blood flow in 76 patients before and after AVF surgery. The goal was to…

This study tested whether an electronic stethoscope can help doctors detect narrowing (stenosis) of the arteriovenous fistula in hemodialysis patients. Researchers collected sound recordings from 30 adults on long-term dialysis over 3 months. The goal was to see if the device cou…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This Phase 2 trial tested whether thymalfasin, a synthetic version of a natural immune-boosting protein, could prevent COVID-19 infection in 189 kidney dialysis patients. These patients are at high risk due to weakened immune systems and frequent clinic visits. The study measured…

This study tested whether listening to music and applying acupressure before needle insertion can reduce pain in dialysis patients. 72 participants were split into four groups: music plus acupressure, acupressure alone, music alone, or standard care. Pain was measured during thre…

This study tests whether a non-invasive device that sends mild electrical pulses to nerves in the neck can reduce restless legs syndrome in people undergoing dialysis. Thirty-six adults aged 40-50 will receive either real or sham stimulation three times a week for four weeks. Res…

This study tested whether a structured education program could help people on dialysis manage chronic itch and improve their quality of life. 104 adults with kidney failure and itch took part, receiving either two educational sessions or standard care. The program focused on unde…

This study tested whether a combined aerobic and resistance exercise program could improve physical function and muscle health in people receiving peritoneal dialysis. Thirty-six adults on dialysis for at least six months were split into an exercise group and a usual-care group. …

This pilot study tested an optimized dialysis technique using a special membrane and biofeedback software to see if it helps kidney failure patients recover faster after treatment. 18 patients on standard dialysis who took at least 4 hours to recover were observed. The study meas…

This study tested whether wearing virtual reality goggles during the needle stick for dialysis can lower pain and anxiety. Fifty adults on hemodialysis were randomly assigned to either watch VR content during the procedure or receive usual care. The results will show if a simple,…

This study tested a device that uses ultrasound to help guide needles into the blood vessels of people with end-stage kidney disease who need dialysis. Ten adults with an arteriovenous fistula or graft took part. The main goal was to see if the device could help place needles suc…

This study looked at whether online laughter therapy could help people on hemodialysis feel less depressed, anxious, and stressed, and improve their quality of life. Sixty-nine adults who were on dialysis took part. They did laughter therapy sessions online. The results showed th…

This study tested if hand reflexology massage could reduce fatigue and anxiety in adults with end-stage kidney disease who are on maintenance hemodialysis. 70 patients were split into two groups: one received eight 21-minute hand massage sessions during dialysis over four weeks, …

This study tested whether massage and progressive muscle relaxation exercises can reduce the frequency and severity of muscle cramps in people undergoing hemodialysis. 79 patients participated, and the goal was to see if these non-drug approaches offer relief. The findings could …

This study tested a drug called nemolizumab to see if it can reduce severe itching in adults with chronic kidney disease who are on dialysis. 258 participants received either nemolizumab or a placebo as injections every 4 weeks for 12 weeks. The main goal was to see how many peop…

This study tested whether doing handgrip exercises before and after surgery can improve the size and function of dialysis fistulas in people with advanced kidney disease. 40 patients participated, and the main goal was to see if the fistula diameter increased. The approach is sim…

This study tested whether light exercise or a technique called remote ischaemic preconditioning (rIPC) — using a blood pressure cuff to briefly restrict blood flow to the arm — could protect the heart during dialysis. 33 adults on hemodialysis took part in three sessions: one wit…

This study tested whether a 10-minute vibration massage or static stretching exercise could reduce the severity and duration of muscle cramps that often occur during hemodialysis. Thirty adults with chronic kidney disease on dialysis were randomly assigned to receive vibration ma…

This study tested a program led by nurses that combined personalized nutrition advice and supervised exercise for people on hemodialysis. The goal was to see if it could improve their overall quality of life. 120 adults on long-term dialysis took part, with half receiving the pro…

This study tested whether lowering the temperature of the dialysis fluid from 36.5°C to 36°C could reduce the tiredness patients often feel after dialysis. Fifty-seven adults on maintenance hemodialysis received three sessions of 'cold dialysis' over one week. Researchers measure…

This study tested two non-drug methods—reflexology (foot massage) and sleep hygiene education—to improve sleep and comfort in 60 adults on hemodialysis. Both approaches helped, but reflexology was more effective. The results suggest a simple, drug-free option for better rest in d…

This study tested whether guided breathing exercises (4-7-8 breathing and diaphragmatic breathing) can help reduce pain, anxiety, and improve comfort during the needle insertion for dialysis. 90 adults on hemodialysis were split into three groups: two doing different breathing ex…

This study tested whether a six-month aerobic exercise program done during dialysis sessions could improve heart function in people with end-stage kidney disease. Eighteen adults on hemodialysis pedaled a stationary bike for 30 minutes, three times a week, while receiving treatme…

This study tested whether giving oral care education and reminder cards to adults on hemodialysis could improve their oral health and help them adjust to their chronic disease. 82 patients received one-on-one training, a reminder card, and a checklist to track daily oral care. Re…

This study looked at whether adding exercise during dialysis sessions can help older adults (over 60) with chronic kidney disease improve their muscle strength and daily function. Ninety participants were split into three groups: one did cycling plus breathing exercises, another …

This study looked at whether a 26-week exercise program, including home-based resistance training and cycling during dialysis, could reduce symptom burden and improve quality of life in 133 adults with end-stage kidney disease on chronic hemodialysis. Participants were assessed a…

This study tested whether a 12-week nurse-led program could help people on hemodialysis feel better and function better. 220 patients were split into two groups: one got the extra program during dialysis sessions, and the other got standard care. The program included light exerci…

This study looked at whether doing specific exercises during dialysis sessions can improve how well people with chronic kidney disease function in daily life. Fifty-six adults on maintenance hemodialysis were split into groups doing lumbar stabilization exercises, breathing muscl…

This study tested whether watching calming VR videos (nature, forest, seaside) during needle insertion could reduce pain, distress, and improve comfort in 52 hemodialysis patients. Patients used VR headsets starting three minutes before the procedure. The goal was to see if this …

This study tested whether abdominal massage can relieve constipation in people receiving hemodialysis. 49 adults took part. Researchers measured changes in constipation severity, quality of life, and stool consistency. The goal was to see if this simple, noninvasive technique cou…

This study tested whether doing art therapy during hemodialysis sessions can reduce common symptoms like fatigue and discomfort, and improve patients' sense of spiritual well-being. Sixty adults on dialysis took part; half received at least 30 minutes of art therapy per session w…

This study looked at whether doing resistance or flexibility exercises while receiving hemodialysis can improve health and quality of life. 49 adults on regular dialysis were split into three groups: resistance exercise, flexibility exercise, or usual care. Researchers measured c…

This study tested a traditional Chinese medicine patch made from herbs like ginger and Artemisia on 21 dialysis patients who had pain from their fistula. The patch was placed on specific acupoints during dialysis sessions for 4 weeks. Researchers measured pain, depression, and qu…

This study tested whether a guided mindfulness meditation program, practiced during dialysis sessions, could reduce anxiety and improve spiritual well-being in people with chronic kidney disease. Fifty-eight adults on hemodialysis were randomly assigned to either the meditation g…

This study tested a nerve block called a supraclavicular brachial plexus block in 50 children aged 6 to 18 who were having surgery to create an arteriovenous fistula for dialysis. The goal was to see if the block could reduce the amount of opioid pain medicine needed during and a…

This study looked at whether a 12-week home exercise program could help people aged 45 and older with advanced chronic kidney disease (stages 4-5) who are not on dialysis. The program included strength and aerobic exercises done 3-4 times a week. Researchers measured changes in m…

This study tested whether a nerve block called an erector spinae plane (ESP) block can reduce pain and the need for strong painkillers after a kidney transplant. Forty adults having a kidney transplant were randomly assigned to receive either the ESP block or no block. All patien…

This study tested whether virtual museum visits using VR glasses during hemodialysis can reduce symptoms and anxiety. Sixty patients were randomly assigned to either a virtual museum tour or standard care. The goal was to see if this simple, non-drug approach improves well-being …

This study compared two types of nerve blocks — erector spinae plane block and transmuscular quadratus lumborum block — for pain after kidney transplant. Forty adults received one of the two blocks with bupivacaine. Researchers measured pain scores and painkiller use over 24 hour…

This study tested whether inhaling lavender oil can reduce headache severity and anxiety in people undergoing hemodialysis. 62 patients were split into two groups: one inhaled lavender oil during dialysis sessions for 4 weeks, while the other received standard care. Researchers m…

This study tested whether press needle acupuncture can reduce severe itching in people with chronic kidney disease who are on dialysis. 38 patients received either a real press needle or a sham (fake) needle on specific acupoints for 4 weeks. The goal was to see if the real needl…

This study looked at whether smelling geranium essential oil can help reduce tiredness and improve sleep in people receiving dialysis for kidney failure. 90 adults on dialysis took part in a crossover trial where they received both the aromatherapy and a placebo at different time…

This study looked at whether a simple home-based exercise program could help reduce anxiety and depression in people receiving hemodialysis. 54 adults on dialysis were split into two groups: one did home exercises for 6 months, the other did not. Researchers measured changes in d…

This study tested whether sleep hygiene education plus motivational interviewing can improve sleep and quality of life in people on hemodialysis. Forty patients were split into two groups: one received face-to-face sleep training plus four online motivational sessions over six we…

This study tested whether nurse-led stretching exercises during dialysis sessions can reduce the burden of muscle cramps. Sixty adults on maintenance hemodialysis who had leg cramps were split into two groups: one did supervised lower-leg stretches during dialysis twice a week fo…

This study tested whether lidocaine or benzocaine sprays could reduce pain and improve satisfaction during needle insertion for hemodialysis. 60 patients were randomly assigned to receive one of the two numbing sprays or a placebo. The goal was to see if these sprays make the pro…

This study tested if doing hand grip exercises for six weeks helps the arm blood vessel connection (fistula) used for dialysis grow stronger and work better. 34 adults with kidney failure on dialysis were randomly assigned to either do the exercises or receive standard care. The …

This study tested whether a home-based exercise program can reduce low back pain and improve quality of life in 30 adults receiving peritoneal dialysis for end-stage kidney disease. Participants followed a structured exercise routine while continuing their usual dialysis care. Re…

This study looked at 41 people on hemodialysis to see if doing resistance exercises at the beginning or end of a session affects blood pressure and well-being. Participants did lower-body exercises with sandbags three times a week for eight weeks. Researchers measured blood press…

This study tested whether interpersonal psychotherapy-based counseling could help people on hemodialysis adjust to their illness and reduce depression. 48 adults who had been on dialysis for at least 6 months were split into two groups: one received the counseling for 8 weeks, th…

This study tested whether a home-based digital brain training program could help with depression, thinking skills, and quality of life in 36 people with cancer or end-stage kidney disease. Participants used a computer program called Rejuvenate for 30 minutes, four times a week, f…

This study tested whether a story-based digital game played during hemodialysis sessions can help patients feel less anxious and learn more about their diet and treatment. 40 adults on regular dialysis played the game once a week for 4 weeks, each session lasting 10-15 minutes. R…

This study tests a program designed to increase living donor kidney transplants among Hispanic patients with end-stage renal disease. The program provides Spanish-language education and outreach by bicultural health workers. Researchers will compare transplant rates between Hispa…

This study tests whether advanced ultrasound techniques (2D and 3D speckle-tracking echocardiography) can detect early signs of heart muscle dysfunction in children aged 4 to 18 with end-stage kidney disease who have been on dialysis for at least a year. Researchers aim to see if…

This study looked at how dialysis patients personally feel about their treatment. Researchers asked 26 adults with kidney failure to rank 24 statements about their experience. The goal was to better understand their perspectives, not to test a new drug or device.

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study follows people over 75 with advanced chronic kidney disease to better understand their health and treatment paths. Researchers want to create a tool that predicts which patients are at high risk of dying soon after starting dialysis. The goal is to help patients, famil…

This study aims to create and test a new mathematical formula that estimates how much sodium (salt) people on peritoneal dialysis consume. The researchers will enroll 30 adults who have been on peritoneal dialysis for at least three months and have no remaining kidney function. I…

This study follows 211 people with IgA nephropathy who previously took a 6-9 month course of the steroid methylprednisolone in the TESTING trial. Researchers want to see if the steroid helped prevent end-stage kidney disease (needing dialysis or a transplant) over the long term. …

This study looked at 49 kidney transplant patients to see how two different induction therapies—thymoglobulin and basiliximab—affect B cells, a type of immune cell. Researchers compared the B cell profiles between the two groups and with data from patients who had chronic antibod…

This study looked at how the drug LY3502970 behaves in people with healthy kidneys compared to those with kidney problems. Researchers measured how much drug gets into the blood and how fast the body clears it. The goal is to understand if kidney impairment changes drug levels, w…

This study looked at how well a new dialysis solution works compared to the usual one in people with kidney failure who are on peritoneal dialysis. Seven stable patients each tried both solutions during a single 4-hour session. The goal was to measure fluid removal and changes in…

This study looked at 166 older adults (65+) on hemodialysis to compare three types of vascular access: fistulas, grafts, and catheters. The goal was to see which option leads to fewer complications and better quality of life. Researchers tracked how many procedures were needed to…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study tested a home education program called Explore Transplant@Home for nearly 1,000 patients with chronic kidney disease. The program mailed videos, postcards, and texts to teach about kidney transplant options, especially from living donors. The goal was to see if this ap…

This study tested a new device called EchoMark LP, which is implanted near a surgically created blood vessel connection (fistula) used for dialysis. The device works with a special ultrasound system (EchoSure) to measure blood flow, depth, and diameter of the fistula. The trial i…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study looked at 58 adults on hemodialysis to understand how the mix of bacteria in their gut relates to waste products in their blood. Researchers measured different types of gut bacteria and chemicals they produce, like short-chain fatty acids and uremic toxins. The goal wa…

This study looked at whether a 12-week cycling program during hemodialysis can reduce heart muscle stress (called stunning) in adults with end-stage kidney disease. 111 participants either cycled or rested during their dialysis sessions. Researchers measured heart function with u…

This study tested whether a program of videos and text messages (called KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor. 422 adults who were already being evaluated for a kidney transplant took part. The study compared those who …

This study tested a program called SPIRIT that helps kidney dialysis patients and their families plan for end-of-life care. The program involved two face-to-face sessions to improve communication and decision-making. Researchers enrolled 852 patients and their surrogates from dia…

This study looked at whether starting dialysis at a specific time, based on a new mathematical formula, could help people with end-stage kidney disease live longer. 388 patients were randomly assigned to start dialysis either at an 'optimal' or 'late' time. Researchers tracked de…

This completed study from Aarhus University looked at how the urea cycle works in 10 people with end-stage kidney disease on dialysis. Participants received a 3-hour alanine infusion, and researchers measured urea production before and after dialysis. The goal was to understand u…

This study looked at whether adjusting the amount of magnesium in the dialysis fluid could help keep blood magnesium levels in a healthy range for people with kidney failure on hemodialysis. Fifty-four adults took part in this pilot crossover trial. The goal was to gather informa…

This study looked at whether people on hemodialysis know how to safely disconnect themselves from the dialysis machine during an emergency, like a fire or power outage. Researchers tested 620 patients from multiple countries using a checklist. The goal was to see if patients coul…

This study tested a communication tool called 'Best Case/Worst Case' for older adults with advanced kidney disease. Doctors were trained to discuss best, worst, and most likely outcomes for treatment options. The goal was to see if this approach helps patients receive more pallia…

This study looked at 2,500 kidney transplant patients to find out why some develop cancer. The main focus was on the immunosuppressive drugs that prevent organ rejection, which can also raise cancer risk. Researchers tracked patients from four regions in France over 10 years to i…

This study looked at how the drug LY3537031 moves through the body in people with different levels of kidney function. It included 31 adults with normal kidneys, kidney impairment, or end-stage kidney disease. The goal was to measure drug levels in the blood and how long it takes…

This study looked at 395 adults on long-term dialysis to find out how often their blood pressure drops dangerously during treatment and what makes it more likely. Researchers collected information on patients' health history, medications, and dialysis settings. The goal is to hel…

This pilot study tested a shared decision-making tool called the Donor Offer Plan (DOP) for people on the kidney transplant waiting list. 100 participants reviewed an online education module and discussed their donor preferences with a transplant nurse. The goal was to see if thi…

This study looked at whether the ratio of two types of blood cells (platelets and lymphocytes) can predict heart complications in people on long-term dialysis. Researchers followed 80 dialysis patients to see if this simple blood test ratio was linked to problems like hardening o…

This study looked at specific molecules in the blood of 180 people with chronic kidney disease (CKD) and 60 healthy volunteers. The goal was to see if these molecules could help diagnose CKD early or predict when a common treatment for anemia stops working. The researchers measur…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This completed study looked at how the drug Advagraf (a form of tacrolimus) works in 45 adults who received a kidney transplant. The goal was to find better ways to dose the drug by measuring its levels in the blood right after transplant and three months later. Researchers compa…

This study looks at how a single 5 mg dose of the blood thinner apixaban is processed in people with end-stage kidney disease who are on peritoneal dialysis, compared to people with normal kidney function. Researchers measured drug levels in the blood over time. The goal is to un…

This completed Phase 1 study looked at how the drug avacopan is processed in 13 people with normal kidney function and those with end-stage renal disease requiring hemodialysis. Researchers measured drug levels in the blood and dialysis fluid after a single dose. The goal was to …

This study tested a program called DIAL-SDM that trains kidney doctors and coaches older patients (65+) with advanced kidney disease to have better conversations about dialysis. The goal was to see if the program was practical and acceptable. 102 patients, their caregivers, and 2…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients did standard 4-hour sessions three times a week, while others did shorter 2-hour sessions six times a week. The goal was to find out whic…

This completed study at Huashan Hospital looked at data from 778 adults on long-term hemodialysis. Researchers used artificial intelligence to build models that could give early warnings about inadequate dialysis and help diagnose complications like heart disease. The goal is to …

This study tested whether having dialysis patients regularly fill out questionnaires about their symptoms and well-being helps them communicate better with their doctors and nurses. Over 3,900 adults on dialysis in Alberta and Ontario took part. The goal was to see if sharing the…

This study tested a program called ED GOAL that helps older adults with serious illnesses like heart failure or cancer discuss their end-of-life wishes with doctors and family, starting in the emergency department. Researchers enrolled 141 patients and measured whether the progra…

This completed study analyzed data from 256 adults on maintenance hemodialysis to identify how symptoms group together. Researchers used statistical methods to find patterns in symptom co-occurrence and examined links with other health conditions and sex. The goal is to help doct…

This study looked at whether eating at different times during hemodialysis affects blood pressure stability and how well the treatment removes waste from the body. Researchers divided 40 adults with chronic kidney disease into groups that ate at set times or followed their usual …

This study aimed to find out how often people in Reunion Island start dialysis as an emergency and what social or medical factors lead to that. Researchers followed 233 adult patients beginning dialysis at local centers. The goal was to gather information to improve care and redu…

This study looked at 50 adults on maintenance hemodialysis to find the link between how fast fluid is removed (ultrafiltration rate) and sudden drops in blood pressure during treatment. The goal was to identify a safer threshold to prevent intradialytic hypotension. Researchers a…

This study tested whether a fast, concise presentation style called Pecha Kucha (20 slides, 20 seconds each) can improve how well hemodialysis patients follow their diet and fluid restrictions. Sixty patients took part, and researchers measured their attitudes toward diet therapy…

This study looked at whether it is safe to stop regularly checking blood flow in the arm veins used for dialysis. Instead, doctors would only treat problems when they cause symptoms during dialysis. The goal was to see if this approach reduces the number of procedures and medical…

This completed study looked at why people on chronic hemodialysis often have high blood pressure between sessions. Researchers measured weight gain, heart function, and blood chemicals in 32 stable dialysis patients. The goal was to understand the relative roles of fluid gain, ho…

This study tested a prediction tool that uses routine lab results to estimate a patient's risk of kidney injury after heart surgery. Researchers looked at data from 2,500 adults who had heart surgery to see how well the tool worked. The goal is to help doctors catch kidney proble…

This study looked at how kidney doctors (nephrologists) think about choosing the right dialysis treatment for patients with kidney failure. Researchers interviewed 25 doctors across Belgium to understand their beliefs and attitudes. The goal is to find out if doctors' own views a…

This study looked at whether using a lower dialysate flow rate (300 ml/min instead of the usual 500 ml/min) affects how well dialysis cleans the blood, how quickly patients recover after treatment, and their overall quality of life. Eighty adults with end-stage kidney disease on …

This study looked at whether training community health workers to focus on kidney disease care, and teaching doctors about trauma-informed care, could improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. The study involved 153 patients fro…

This study tested whether teaching dialysis staff and providing support to patients could reduce episodes of dangerously low blood pressure during treatment. Over 1,400 patients across multiple clinics took part. The goal was to make dialysis sessions safer and more stable.

This study looked at how common prediabetes is in people with end-stage kidney disease who are on dialysis. Researchers screened 262 adult dialysis patients who had never been diagnosed with diabetes or prediabetes. The goal was to find out how many had prediabetes, which can inc…

This early-stage study tested a single dose of the experimental drug KBP-5074 in 11 people with severe chronic kidney disease, including some on dialysis. The main goal was to check safety and how the drug moves through the body. No treatment benefits were measured; the study onl…

This study tested a program called the Live Donor Champion Program, which trains a friend or family member to help a kidney patient find a live donor. The program was offered to 111 patients on the kidney transplant waitlist. Researchers wanted to see if the program could be succ…

This study looked at whether analyzing the fluid used to preserve kidneys on a LifePort® machine could help predict how well the kidney will work after transplant. Researchers measured chemicals in the fluid and compared them to early kidney function in 40 recipients. The goal is…

This study used a special MRI technique to measure phosphate and ATP (energy) levels inside muscle cells of 11 kidney dialysis patients during a 4-hour session. The goal was to find out whether phosphate removed during dialysis comes from inside cells. If it does, it might explai…

This study tested a patient-friendly website and printouts to help kidney transplant candidates compare transplant centers. Researchers wanted to see if the new format helped people understand which centers accept patients like them. A total of 268 adults waiting for a kidney tra…

This completed pilot study tested whether the HemoCept device can accurately measure fluid removal during dialysis in 26 adults with end-stage kidney disease. Researchers compared device readings before and after dialysis to changes in dry weight. The goal is to see if this non-i…

This study looked at whether a special planning tool, called a POST form, helps older adults (65+) get the medical care they prefer at the end of life. Researchers worked with 389 people, including those with dementia, to see if their treatment matched their wishes. The goal was …

This study looked at small pieces of donor kidney tissue to see if certain substances could predict how well the organ would work after transplant. Researchers tested blood, urine, and biopsy samples from 24 kidney transplant recipients. The goal was to find early signs of organ …

This completed Phase 1 study looked at how different levels of kidney function affect the way the body processes a single dose of the drug AZD6234. Researchers compared 24 adults with various degrees of kidney impairment to healthy volunteers. The goal was to understand how the d…

This completed Phase 1 study looked at how the drug MK-5684 behaves in the body of men with severe kidney disease or end-stage renal disease compared to healthy men. Twenty-four participants received a single dose, and researchers measured drug levels in the blood over time. The …

This pilot study tested a device called HemoCept in 12 adults with end-stage kidney disease on dialysis. The goal was to see if the device could accurately track changes in hydration during fluid removal. Researchers compared device readings to changes in dry weight before, durin…

This study looked at how the drug BMS-986278 behaves in people with normal kidneys, severe kidney disease, or kidney failure on dialysis. 27 adults took a single dose to measure drug levels and check for side effects. The goal was to gather safety information, not to treat the di…

This study looked at how certain heart-related proteins change in the blood of 26 adults with end-stage kidney disease during two types of dialysis. The goal was to understand the patterns of these proteins, which may help doctors better monitor heart health in dialysis patients.…

This study looked at whether vitamin D levels in the blood are related to early signs of artery hardening (atherosclerosis) in people on dialysis. Researchers measured vitamin D and used ultrasound to check artery thickness in 90 adults with kidney failure. The goal was to see if…

This pilot study looked at how hemodialysis changes the electrical properties of skin and muscle in 18 adults on chronic dialysis. Researchers measured these changes to better understand fluid shifts during treatment. The goal was to gather knowledge, not to test a new treatment.

This study tested whether trained transplant navigators could help kidney failure patients complete the steps needed to get a kidney transplant. About 167 adults on dialysis were assigned to either a navigator or usual care. The navigator provided tailored help and information to…

This completed study looked at fat tissue in 23 men with advanced chronic kidney disease (stage V) who were not on dialysis. Researchers compared their fat cells to those of healthy men to understand why kidney disease causes problems like weight loss and insulin resistance. Fat …