New implant could speed up dialysis fistula maturation
NCT ID NCT05425056
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times
Summary
This phase 3 trial tests a sirolimus-releasing collagen implant placed around a new dialysis fistula during surgery. The goal is to help the fistula mature faster so it can be used for dialysis. The study involves 136 people aged 65+ with kidney failure who are new to hemodialysis. Results will compare fistula maturation and long-term usability between those who get the implant and those who don't.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sirolimus-eluting collagen implant (Sirogen)
- What this could lead to
- If it works, this implant could help dialysis patients get a working fistula sooner and reduce complications.
- What could go wrong
- This is a small, early-phase 3 trial with only 136 participants. The implant may not improve fistula outcomes and carries risks like infection or allergic reaction.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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American Access Care of Miami
Miami, Florida, 33156, United States
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Arteries & Veins
El Paso, Texas, 79912, United States
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Atrium Health
Charlotte, North Carolina, 28204, United States
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Augusta University
Augusta, Georgia, 30912, United States
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Barts Health NHS Trust of Royal London Hospital
London, United Kingdom
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Houston Methodist
Houston, Texas, 77030, United States
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Houston Methodist
Sugar Land, Texas, 77479, United States
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James Eric Gardner, MD PC
Memphis, Tennessee, 38115, United States
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Lundquist Institute for Biomedical Innovation
Torrance, California, 90502, United States
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MedStar Cardiovascular Research Network at MedStar Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
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Sentara Norfolk General Hospital/Sentara Health Research Center
Norfolk, Virginia, 23507, United States
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St George's University Hospitals NHS Foundation Trust
London, United Kingdom
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St Helier Hospital
Carshalton, SM5 1AA, United Kingdom
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Surgical Specialists of Charlotte
Charlotte, North Carolina, 28207, United States
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The Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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The Regional Medical Center/Dialysis Access Institute
Orangeburg, South Carolina, 29118, United States
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University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom
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University of Louisville
Louisville, Kentucky, 40202, United States
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Veterans Affairs San Diego Health Center
San Diego, California, 92161, United States
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