New implant could keep dialysis lifelines open longer

NCT ID NCT02513303

Completed Disease control Sponsor: Vascular Therapies, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a special collagen implant coated with sirolimus (rapamycin) placed around a new dialysis fistula during surgery. The goal was to see if it helps the fistula become usable for dialysis sooner and stay working longer. About 269 people with advanced kidney disease who needed or were about to start dialysis took part. The implant is designed to reduce scarring and improve blood flow.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sirolimus (also known as Rapamycin) delivered via a collagen implant placed around the fistula during surgery
What this could lead to: If successful, this implant could help dialysis fistulas work better and last longer, reducing the need for repeat surgeries.
What could go wrong: This is a completed phase 3 trial, but results are not yet widely available. The implant may not improve fistula function enough to change standard care, and there could be risks like infection or scarring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome congenital arteriovenous fistula dialysis disequilibrium syndrome end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTERIOVENOUS FISTULA CHRONIC KIDNEY FAILURE COMPLICATION OF HEMODIALYSIS COMPLICATION OF RENAL DIALYSIS END STAGE KIDNEY DISEASE END-STAGE RENAL DISEASE ESRD VASCULAR ACCESS COMPLICATION

Contacts and locations

Locations

AKDHC Medical Research Service

Phoenix, Arizona, 85012, United States
Nephrology Consultants, LLC

Huntsville, Alabama, 35805, United States
Northeast Clinical Research Center

Bethlehem, Pennsylvania, 18017, United States
San Diego Institute of Medical Research

Escondido, California, 92025, United States

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