New drug aims to tame parathyroid glands in dialysis patients

NCT ID NCT05832931

Completed Disease control Sponsor: Pathalys Pharma Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a drug called PLS240 in 362 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). Participants received either PLS240 or a placebo during dialysis three times a week for 27 weeks, followed by an open-label phase where everyone could get PLS240. The goal was to see if PLS240 could safely lower parathyroid hormone levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PLS240 (a drug given intravenously during dialysis)
What this could lead to: If successful, PLS240 could become a new treatment to better manage secondary hyperparathyroidism in people on dialysis, potentially reducing complications.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The drug may not prove more effective than placebo, and side effects like low calcium levels are possible.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure secondary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END-STAGE KIDNEY DISEASE (ESKD) SECONDARY HYPERPARATHYROIDISM

Contacts and locations

Locations

Site Number: BGR001-1

Plovdiv, 4002, Bulgaria
Site Number: BGR002-1

Blagoevgrad, 2700, Bulgaria
Site Number: BGR003-1

Sofia, Sofia-Grad, 1309, Bulgaria
Site Number: BGR004-1

Sofia, Sofia-Grad, 1431, Bulgaria
Site Number: ESP001-1

Lleida, 25198, Spain
Site Number: ESP002-1

Valencia, 46014, Spain
Site Number: ESP003-1

Pamplona, 31008, Spain
Site Number: ESP004-1

Madrid, 28034, Spain
Site Number: ESP005-1

Madrid, 28046, Spain
Site Number: ESP006-1

Seville, 41009, Spain
Site Number: POL002-1

Żyrardów, Masovian Voivodeship, 96-300, Poland
Site Number: POL005-1

Oleśnica, Lower Silesian Voivodeship, 56-400, Poland
Site Number: PRT001-1

Carregado, Lisbon District, 2580-588, Portugal
Site Number: PRT002-1

Forte Da Casa, Lisbon District, 2625-384, Portugal
Site Number: PRT003-1

Portimão, Faro District, 8500-311, Portugal
Site Number: SRB001-1

Belgrade, 11000, Serbia
Site Number: SRB002-1

Zaječar, 19000, Serbia
Site Number: SRB003-1

Kragujevac, 34000, Serbia
Site Number: SRB005-1

Novi Sad, 21000, Serbia
Site Number: USA001-1

San Diego, California, 92111-3636, United States
Site Number: USA002-1

The Woodlands, Texas, 77384-8042, United States
Site Number: USA003-1

Lone Tree, Colorado, 80124-3191, United States
Site Number: USA004-1

San Antonio, Texas, 78251-4498, United States
Site Number: USA005-1

San Antonio, Texas, 78229-4605, United States
Site Number: USA006-1

Norfolk, Virginia, 23504-2303, United States
Site Number: USA007-1

Shelbyville, Indiana, 46176-8591, United States
Site Number: USA008-1

Gallup, New Mexico, 87301-5611, United States
Site Number: USA009-1

Hartford, Connecticut, 06112-1272, United States
Site Number: USA010-1

Jersey City, New Jersey, 07305, United States
Site Number: USA011-1

The Bronx, New York, 10461-2755, United States
Site Number: USA012-1

Houston, Texas, 77074-1802, United States
Site Number: USA013-1

Dalton, Georgia, 30720, United States
Site Number: USA014-1

Houston, Texas, 77054-3835, United States
Site Number: USA015-1

Columbus, Mississippi, 39705-2024, United States
Site Number: USA016-1

Pine Bluff, Arkansas, 71603-4921, United States
Site Number: USA017-1

Las Vegas, Nevada, 89107-6100, United States
Site Number: USA018-1

Denver, Colorado, 80210-5073, United States
Site Number: USA019-1

San Dimas, California, 91773-3537, United States
Site Number: USA020-1

Fairfield, California, 94534, United States
Site Number: USA021-1

San Diego, California, 92111-3636, United States
Site Number: USA022-1

Kansas City, Missouri, 64111-2925, United States
Site Number: USA023-1

Fullerton, California, 92835-3639, United States
Site Number: USA024-1

Austin, Texas, 78751-3014, United States
Site Number: USA025-1

McAllen, Texas, 78503-1251, United States
Site Number: USA026-1

Baton Rouge, Louisiana, 70808-4791, United States
Site Number: USA027-1

Boise, Idaho, 83706-1248, United States
Site Number: USA028-1

Oxford, Mississippi, 38655, United States
Site Number: USA029-1

San Antonio, Texas, 78202-2916, United States
Site Number: USA030-1

Glendale, California, 91206-4015, United States
Site Number: USA031-1

Beverly Hills, California, 90211-2921, United States
Site Number: USA032-1

Anaheim, California, 92801-2817, United States
Site Number: USA033-1

Winston-Salem, North Carolina, 27103-7154, United States
Site Number: USA034-1

Hollywood, Florida, 33024-2776, United States
Site Number: USA035-1

Salinas, California, 93901-4446, United States
Site Number: USA036-1

Whittier, California, 90606-3007, United States
Site Number: USA037-1

Arlington, Texas, 76015-2363, United States
Site Number: USA039-1

Manhasset, New York, 11030-3802, United States
Site Number: USA040-1

Spartanburg, South Carolina, 29301-5085, United States
Site Number: USA042-1

Coral Gables, Florida, 33134-2049, United States
Site Number: USA043-1

Greenville, North Carolina, 27834-4300, United States
Site Number: USA045-1

Oxnard, California, 93036-3075, United States
Site Number: USA046-1

Riverside, California, 92505-3081, United States
Site Number: USA049-1

Knoxville, Tennessee, 37924-3606, United States
Site Number: USA050-1

Wauwatosa, Wisconsin, 53226-4339, United States
Site Number: USA052-1

Charlotte, North Carolina, 28277-9720, United States
Site Number: USA053-1

Atlanta, Georgia, 30342-1626, United States
Site Number: USA055-1

Coral Gables, Florida, 33134-2060, United States
Site Number: USA056-1

Fort Worth, Texas, 76110-1865, United States

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