Dermatitis

This study tests whether a newer antifungal cream (luliconazole) works better than the standard treatment (ketoconazole) for pityriasis versicolor, a common fungal skin infection that causes light or dark patches. About 86 adults with the infection will use one of the two creams …

This study tests whether a cream containing ruxolitinib (Opzelura) combined with corticosteroid injections or pills can improve facial vitiligo. It includes people aged 12 and older with active, non-segmental vitiligo affecting the face. Participants use the cream twice daily and…

This study tests whether upadacitinib, a drug already approved for eczema, can help people who have both atopic dermatitis (a type of eczema) with moderate to severe itching and a hard-to-treat autoimmune liver disease called cholangitis. The drug works by blocking a pathway invo…

This study compares the standard antifungal drug itraconazole alone versus itraconazole combined with isotretinoin (an acne medication) in adults with tinea corporis or cruris (ringworm of the body or groin). The goal is to see if the combination shortens treatment time and impro…

This study tests whether Maraviroc, a drug currently used for HIV, can reduce muscle inflammation and improve function in adults with myositis that hasn't responded to standard treatments. Ten participants will take a daily 300mg tablet for 12 weeks and undergo muscle biopsies an…

This study compares two topical medications—clascoterone cream and adapalene gel—for treating mild acne vulgaris. Researchers will enroll 60 people aged 12 to 35 with mild acne and randomly assign them to use one of the treatments for 12 weeks. The goal is to see which treatment …

This study tests two surgical techniques to treat stable white patches on the skin that are not caused by vitiligo. Both methods involve transplanting the patient's own skin cells, followed by laser therapy to boost color return. Twenty-two adults will each receive both treatment…

This study explores whether giving people with mild-to-moderate eczema a straightforward treatment plan using only Opzelura cream helps them stick to their medication routine. Participants apply the cream twice daily until their skin clears, then as needed. Some participants also…

This study compares two standard steroid treatments for hypertrophic lichen planus, a chronic skin condition that causes thick, intensely itchy plaques. Fifty adults will be randomly assigned to apply a strong steroid cream twice daily for 12 weeks or receive steroid injections i…

This early-stage trial tests a new topical film called ZYG24004 for athlete's foot (tinea pedis). About 64 adults with the infection will apply the film to their feet once or twice. The main goals are to check safety, how the body processes the drug, and whether it can clear the …

This phase 2a trial tests whether a daily pill called ACT-777991 can help return color to the face of adults with non-segmental vitiligo. About 30 participants will take either the drug or a placebo for 24 weeks. Researchers will measure changes in skin color using a standard sco…

This study tests a drug called nemolizumab in toddlers aged 6 to 23 months with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams or ointments. The goal is to see how the drug moves through the body, if it is safe, and if it helps control the conditio…

This study looks at how safe and effective Takhzyro is for teenagers and adults with hereditary angioedema (HAE) in everyday medical care in South Korea. HAE is a rare condition that causes sudden swelling under the skin or inside the body. The study will track side effects and h…

This small study will test a drug called emapalumab in 5 adults with a rare, rapidly worsening lung disease linked to dermatomyositis. The drug is already used for a similar immune overreaction condition. Researchers will check if it improves oxygen needs, lung function, and CT s…

This trial tests whether the drug sebetralstat can prevent swelling attacks in people with hereditary angioedema (HAE) when taken before a medical procedure. Participants aged 12 and older with HAE type I or II will take sebetralstat just before their scheduled procedure. The mai…

This study tests a new medicine called GR2301, given as shots under the skin, together with light therapy for people with vitiligo (a condition that causes white patches on the skin). The trial has two parts: first, finding the right dose, then testing how well it works. About 11…

This study follows 470 adults with chronic spontaneous urticaria (hives) who are starting remibrutinib, a new drug. Researchers will track how well it controls symptoms and any side effects over two years in real-world clinics. The goal is to see if remibrutinib works as well out…

This study tests whether a low daily dose of the acne drug isotretinoin can clear moderate to severe acne as effectively as the standard dose, but with fewer side effects. About 164 people aged 18-45 will be randomly assigned to one of two dose groups. Researchers will track acne…

This study tests an experimental pill called ENV-294 for adults with moderate-to-severe atopic dermatitis (eczema). About 200 participants will take either one of three doses of ENV-294 or a placebo daily for 12 weeks. Researchers will measure changes in eczema severity, symptoms…

This study looks at 120 adults with moderate-to-severe psoriasis who take secukinumab, a biologic drug. It compares two maintenance schedules: the standard every-4-week injection versus a non-standard schedule (longer intervals or lower dose). The goal is to see which schedule ke…

This study will test whether a newer cream called tapinarof works better than the standard betamethasone cream for mild-to-moderate plaque psoriasis. About 120 adults will use one of the two creams daily for up to 12 weeks. The main goal is to see how many people get at least a 7…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests an experimental drug called D-2570 in 160 adults with non-segmental vitiligo, a condition that causes white patches on the skin. Participants take either D-2570 or a placebo pill once daily for 24 weeks, with an optional 24-week extension. The goal is to see if t…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard narrowband UVB light treatment can help restore skin color in people with vitiligo. Five adults with non-segmental vitiligo will receive UVB twice a week for 24 …

This early-phase trial tests an injection called KSVCBD, a type of CAR-T cell therapy, in 60 adults with severe autoimmune diseases like lupus and scleroderma. The goal is to see if it's safe and to get a first look at whether it might help control the disease. Participants recei…

This study tests a new cream called VC005 for people aged 12 and older with mild to moderate atopic dermatitis (eczema). The goal is to see if the cream can clear or nearly clear the skin rash better than a cream without medicine. About 360 participants will use either the study …

This study tests a cream called ruxolitinib on children aged 2 to 11 with a common type of vitiligo (white patches on skin). The goal is to see if the cream can safely bring back skin color over 24 weeks. About 20 children will apply the cream daily and visit the clinic for check…

This early study will test whether a daily omega-3 cream and serum can change the balance of bacteria on eczema-affected skin. Ten adults with eczema will apply the treatment for 14 days, and researchers will measure four types of bacteria before and after. The study is explorato…

This Phase 3 study tests whether lebrikizumab, an injectable drug, can safely and effectively treat nummular eczema in adults who haven't gotten enough relief from topical steroids or can't use them. About 270 participants will receive either lebrikizumab or a placebo injection. …

This Phase 2 trial tests whether adding benralizumab (a drug already used for asthma) to standard corticosteroid treatment can help people with DRESS syndrome recover faster and spend fewer days in the hospital. DRESS is a rare, severe allergic reaction to certain medications tha…

This study compares two oral medications, methotrexate and tofacitinib, for treating chronic plaque psoriasis. About 88 adults with moderate to severe psoriasis who haven't improved with topical treatments will be randomly assigned to one of the drugs and followed for six months.…

This early-phase study tests whether the drug efgartigimod (VYVGART) can lower harmful collagen VII antibodies and improve wound healing in people with two rare blistering skin conditions: recessive dystrophic epidermolysis bullosa (RDEB) and epidermolysis bullosa acquisita (EBA)…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests an experimental pill called LW402 in 180 adults with non-segmental vitiligo, a condition that causes white patches on the skin. The pill works by blocking certain immune signals. Participants will take one of three doses or a placebo for up to 52 weeks to see if …

This study compares two treatments for stable vitiligo: microneedling with a topical solution (minoxidil) alone versus microneedling with the same solution plus narrow-band UV light therapy. Thirty adults with stable non-segmental vitiligo will be enrolled. The goal is to see if …

This study tests whether wearing compression stockings alone can prevent repeat episodes of erysipelas (a bacterial skin infection) as well as the usual approach of antibiotics plus stockings. About 200 adults who have had at least two infections in the same leg will be randomly …

This study looks at whether switching to a pill called ivarmacitinib can help people with moderate-to-severe eczema (atopic dermatitis) who did not get enough relief from standard injectable drugs. About 300 adults will take the pill for 16 weeks. The goal is to see if their skin…

This study tests two oral medications—roflumilast and methotrexate—for psoriasis in skin folds and genital areas, which are often hard to treat with creams alone. Fifty-six adults with topical-resistant psoriasis will take one of the two pills for 16 weeks. Researchers will measu…

This phase 3 trial tests whether RSS0393 ointment can improve plaque psoriasis compared to a placebo. About 600 adults with mild-to-moderate psoriasis will apply the ointment daily for 8 weeks. The main goal is to see if more people achieve clear or almost-clear skin with RSS0393…

This study tests a new drug called MG-K10 in 180 teens aged 12-17 with moderate-to-severe eczema that hasn't responded well to creams. The drug is given as a shot every two weeks for a year. Researchers will check if it clears skin and reduces itching better than a placebo.

This study tests the drug adalimumab in 30 Chinese children aged 4 to 17 with severe plaque psoriasis that hasn't improved with creams or light therapy. The goal is to see if adalimumab can safely reduce skin symptoms like redness and scaling. The main measure is how many childre…

This early-stage study tests a new drug called cizutamig in about 20 adults with IgE-mediated allergies, including food allergies. The main goal is to see if the drug can safely lower IgE levels, which are antibodies that trigger allergic reactions. Researchers will also monitor …

This Phase 3 trial tests whether combining two drugs, tofacitinib and imatinib, can safely clear the painful pustules of palmoplantar pustulosis (PPP), a rare chronic skin disease on the palms and soles. About 135 adults with moderate-to-severe PPP will receive either the combo o…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study is testing a gel called CABTREO, which combines three acne-fighting ingredients (clindamycin, adapalene, and benzoyl peroxide), in children aged 9 to 11 with moderate to severe acne. The goal is to see if it is safe and works well over 12 weeks. About 100 kids will app…

This study tests whether exosomes from umbilical cord stem cells can safely help restore skin color in adults with vitiligo. 96 participants with active or stable vitiligo will receive either exosome infusions or injections alongside standard light therapy and ointment. The goal …

This study compares two prescription creams, tacrolimus and crisaborole, for treating mild to moderate eczema in children and teens aged 2 to 20. Both creams are steroid-free and aim to control inflammation without the side effects of long-term steroid use. Over 8 weeks, 72 parti…

This study tests whether adding a special cell secretion (called secretome) to standard light therapy helps restore skin color better in people with vitiligo. About 150 adults with stable vitiligo will receive either light therapy alone, or light therapy plus secretome applied th…

This Phase 2 study tests a new biologic drug called AK139 in 168 adults with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams. Participants will receive either AK139 or a placebo by injection. The study aims to see if AK139 can safely clear skin and …

This study tests three different gels for mild-to-moderate acne: a standard clindamycin-retinoid combo, a clindamycin-retinoid-dexamethasone combo, and a gel made from stem-cell secretions (secretome). About 189 people will use one of the three gels for 8 weeks. Researchers will …

This early-stage trial will test whether injecting adalimumab (Humira) into the eye during Boston KPro surgery is safe for 8 patients with severe corneal damage. The study focuses on side effects and tolerability, not yet on how well it works. It is for people who have run out of…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This study tests whether adding metformin (a diabetes drug) to the standard psoriasis treatment secukinumab works better than secukinumab alone for overweight or obese Chinese patients with moderate-to-severe plaque psoriasis. About 186 participants will be randomly assigned to r…

This phase 3 trial tests whether injecting a patient's own blood (autologous whole blood therapy) can help control chronic hives that don't respond to high-dose antihistamines. 40 adults with chronic idiopathic urticaria will receive either the blood injections plus antihistamine…

This phase 3 study tests an injectable drug called MG-K10 for people aged 12 and older with moderate-to-severe atopic dermatitis (eczema) that hasn't improved with creams. About 498 participants will receive either MG-K10 or a placebo to see if it safely reduces skin redness, itc…

This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …

This study tests whether adding low-dose steroid pills to a standard vitiligo skin-cell transplant surgery helps prevent a pale ring around the treated area and improves overall skin color restoration. About 60 people with stable vitiligo will be randomly assigned to get surgery …

This Phase 2 trial tests an experimental drug called CMS-D001 in 160 adults with moderate to severe atopic dermatitis (eczema) that hasn't responded well to creams. Participants will take one of three doses of the drug or a placebo daily for several weeks. The main goal is to see…

This study tests whether clearing Staphylococcus aureus bacteria from the skin can reduce eczema severity in people with atopic dermatitis. Researchers will enroll 100 participants aged 6 and older with moderate-to-severe disease. The goal is to see if decolonization improves ski…

This study tests a cream called clascoterone (1%) against a placebo in 692 people aged 12 and older with moderate to severe acne. Participants apply the cream to their face twice daily for 12 weeks. The goal is to see if the cream clears acne better than a placebo, with fewer sid…

This early-stage trial tests a new drug called HB0043, a bispecific antibody that targets two inflammatory proteins (IL-17A and IL-36R) linked to acne. About 21 adults with moderate to severe facial acne will receive either the drug or a placebo. The main goal is to check safety …

This study tests a new cream made with tiny nanoparticles of the drug apremilast for people with mild to moderate plaque psoriasis. Thirty-six adults will apply the cream twice daily for 12 weeks, and researchers will compare it to a standard steroid cream and a combination of bo…

This study compares two steroid-free ointments—crisaborole and tacrolimus—for treating mild-to-moderate eczema in 148 Pakistani patients aged 2 and older. Researchers will measure skin improvement and side effects over 8 weeks to see which works better and is safer. The goal is t…

This study tests an experimental tablet called CMS-D001 for adults with moderate to severe plaque psoriasis. About 540 participants will receive either the drug or a placebo to see if it improves skin symptoms like redness, scaling, and thickness. The goal is to measure how many …

This phase 3 trial tests an injection called ADSTEM for adults with moderate-to-severe atopic dermatitis (eczema) that hasn't responded well to standard treatments. About 286 people aged 19 to 70 will receive either the study drug or a placebo. The main goal is to see if the inje…

This study tests an injection called JYB1904 in 180 adults with chronic spontaneous urticaria (hives and itching lasting over 6 weeks) that isn't well controlled by standard antihistamines. Participants receive either the drug or a placebo every 12 weeks for 48 weeks. The main go…

This study tests two prescription gels—metronidazole and clindamycin—to see which works better for moderate acne. Sixty adults aged 18 to 35 will apply the gel twice daily for 12 weeks. Doctors will check acne severity at the start and at weeks 4, 8, and 12 to measure improvement…

This early-phase trial will test different ways of using permethrin cream to treat scabies in 68 infants and children aged 1 month to 4 years. The goal is to see which strategy works best to kill the mites and relieve itching. Researchers will check skin scrapings under a microsc…

This phase 3 trial compares a new injectable drug, GS101, to the established treatment Dupixent for adults with moderate-to-severe atopic dermatitis (eczema). About 572 participants will receive either GS101 or Dupixent every other week for a year. The main goal is to see if GS10…

This Phase 2 trial tests a new gel (AP4500) containing the antifungal drug terbinafine for mild to moderate toenail fungus. About 200 adults will apply the gel once or twice daily for 48 weeks. Researchers will compare it to a placebo and an existing treatment (Jublia) to see if …

This study compares two treatments for generalized vitiligo: PUVA therapy (a light-based treatment) and the pill Tofacitinib. Researchers will enroll 64 adults with stable vitiligo covering more than 10% of their body. The goal is to see which treatment works better and is safer …

This phase 4 trial tests whether adding recaticimab to vunakizumab works better than vunakizumab alone for adults with moderate-to-severe plaque psoriasis and high cholesterol. Forty participants will be randomly assigned to receive either the drug combo or vunakizumab plus a pla…

This study tests whether surgically removing the central mole (halo nevus) in people with vitiligo leads to better skin color restoration than using medication alone. Sixty participants aged 6 to 45 will be randomly assigned to either have the mole removed plus standard treatment…

This study compares two treatments for pityriasis versicolor, a fungal skin infection that causes discolored patches. One group will apply a clotrimazole cream twice daily for two weeks, while the other takes itraconazole pills daily for five days. The trial aims to see which app…

This study will test the drug ivarmacitinib in 1,000 people aged 12 to 75 with moderate-to-severe atopic dermatitis (eczema). Participants take a daily pill for up to 52 weeks, with the option to adjust the dose. Researchers will measure how well the drug clears skin rashes and r…

This study compares three treatments for vulvar lichen sclerosus, a chronic skin condition causing itching and pain. 45 women aged 30-80 will receive either a steroid cream, an immune-modulating cream, or platelet-rich plasma (PRP) injections. The goal is to see which approach be…

This study tests whether narrow-band ultraviolet B (NB-UVB) light therapy can help people with ringworm infections that don't get better with standard antifungal drugs. The trial will enroll 36 adults who have had at least two relapses in the past six months. Half will receive UV…

This study tests an injection called stapokibart for people with moderate to severe bullous pemphigoid, a painful blistering skin condition. The goal is to see if it can help patients stop taking steroids and keep the disease under control for 36 weeks. About 200 adults aged 18 t…

This study compares two ways of delivering methotrexate to treat vitiligo patches: using a low-intensity electric current (iontophoresis) versus a standard gel. Thirty adults with stable vitiligo will be randomly assigned to one of the two treatments for 8 weeks. Researchers will…

This study tests whether aripiprazole (Abilify) can reduce urges and behaviors in adults with trichotillomania (hair-pulling) or skin-picking disorder. One hundred participants will receive either the drug or a placebo for 6 weeks. Researchers will track symptom changes using sta…

This study tests a cream called terbinafine hydrochloride for treating fungal ear infections (otomycosis). About 50 adults with symptoms like itching, pain, and discharge will have the cream applied in the ear every two days for two weeks. The goal is to see if the cream clears b…

This phase 4 trial will test the drug apremilast in 425 adults with moderate-to-severe psoriasis. Over 32 weeks, researchers will measure how well the drug clears skin patches and monitor for side effects. The goal is to confirm apremilast's effectiveness and safety in a real-wor…

This Phase 3 trial tests a medicated foam called OPA-15406 (difamilast) for atopic dermatitis (eczema) in children aged 2 and older, and infants under 2. About 198 participants will apply the foam twice daily for 8 weeks. The main goal is to see if the foam clears or nearly clear…

This study tests a new injectable drug called SIM0278 for adults with moderate to severe atopic dermatitis (eczema) that needs systemic treatment. About 184 participants will receive either a low, medium, or high dose of SIM0278 or a placebo. The main goal is to see how much ecze…

This Phase 3 trial tests a medicated foam called OPA-15406 (difamilast) for adults with atopic dermatitis, a common skin condition causing red, itchy rashes. About 156 participants will apply the foam or a placebo twice daily for 4 weeks. The goal is to see if the foam clears or …

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

This study tests whether crisaborole 2% ointment works better than tacrolimus 0.1% ointment for children aged 2-18 with mild to moderate eczema. 66 children will apply one of the creams twice daily for 28 days. The main goal is to see how many achieve clear or almost clear skin b…

This phase 2 trial tests an oral tablet called HSK47388 in 220 adults with moderate-to-severe plaque psoriasis. Participants take the drug or a placebo once daily for 16 weeks. The main goal is to see if the drug can reduce psoriasis severity by at least 75% compared to placebo.

This phase 2 trial tests an oral drug called HSK44459 for adults with moderate to severe plaque psoriasis. About 150 participants will receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug can reduce psoriasis skin symptoms by at least 75%.

This study tests whether AI-powered decision trees can help general practitioners better diagnose and manage allergies. About 600 patients with suspected allergies will be enrolled, and doctors will use an app that suggests next steps based on symptoms. The goal is to see if this…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study will test whether artificial intelligence can help diagnose oral lesions that might turn into cancer. Researchers will use photos of the lesions and cell samples from the mouth, along with a special blue stain, to train an AI model. The goal is to see if the AI can mat…

This study will test a special ultrasound technique called shear-wave elastography to see if it can better detect tendon inflammation (enthesitis) in people with psoriatic arthritis. Researchers will compare this method with standard ultrasound and also look at how it relates to …

This study tests whether leaving the white, creamy coating (vernix caseosa) on a newborn's skin for at least 24 hours after birth can prevent eczema (atopic dermatitis) during the first year of life. Over 1,300 mother-infant pairs in Chile will be randomly assigned to either keep…

This study tested whether taking a cistanche supplement for 8 weeks, along with a supervised training program, improves anaerobic exercise performance and recovery in young men. 56 men aged 18-25, either elite or amateur athletes, were randomly assigned to receive cistanche extra…

This early-phase trial tests a new drug called TLL-018 in 36 adults with moderate-to-severe chronic spontaneous urticaria (hives) that standard antihistamines can't control. The goal is to see how quickly TLL-018 reduces itching and hives after the first dose. Participants will r…

This study tests a new barrier cream (Dermategrity "Anti-fecal" Barrier Cream) that contains zinc oxide and a natural plant extract to protect and heal skin damaged by incontinence. Sixty adults with incontinence-associated dermatitis will receive either the new cream or a standa…

This virtual clinical trial will test whether GenLabs' Social Skin products—a cleanser, serum, and cream—can improve acne symptoms and help skin heal better than a placebo. About 150 healthy adults aged 18 to 65 with acne will use the products for 30 days. The main goal is to see…

Cellulitis is a painful bacterial skin infection. This study tests whether adding naproxen (an anti-inflammatory drug) to standard antibiotics helps reduce redness and pain faster than antibiotics alone. About 884 adults with cellulitis will take either naproxen or a placebo for …

This study tests whether an artificial intelligence-powered digital education program can reduce the severity of radiodermatitis (skin irritation from radiation) and improve quality of life in women with breast cancer. 38 patients will be randomly assigned to either receive the A…

This phase 2 trial tests a medicated foam called roflumilast on skin rashes caused by checkpoint inhibitor cancer drugs. Twenty adults with mild to severe rash will apply the foam daily for 16 weeks. The goal is to see if it safely reduces rash severity and improves quality of li…

This study looks at whether lowering salt in your diet can make eczema less severe. Forty adults with eczema will eat a low-salt diet for 24 weeks. For 5 weeks they'll take salt pills, and for another 5 weeks they'll take placebo pills, to see the real effect of sodium. Researche…

This study tests whether adding a pill called pentoxifylline to standard skin creams can improve mild-to-moderate psoriasis. About 140 adults will take either the study drug or a placebo twice daily for 12 weeks. Researchers will measure changes in skin severity, itch, and qualit…

This study tests whether isotretinoin or doxycycline works better for treating an acne-like rash that can appear in people taking certain cancer drugs. About 50 participants who already have a moderate to severe rash will receive one of the two medications. The goal is to see whi…

This Phase 2 study tests lebrikizumab (Ebglyss) in 15 adults with moderate-to-severe prurigo nodularis, a skin condition causing intense itching and hard bumps. Participants receive injections every two weeks for 24 weeks. The main goals are to measure how much itching decreases …

This Phase 1 trial will test the safety and tolerability of multiple doses of PG-033 tablets in 30 healthy adults. Participants will be randomly assigned to receive either PG-033 or a placebo. The study aims to find out how the drug moves through the body and whether it causes an…

This Phase 2 trial tests whether the experimental drug HRS-3095 can reduce itching and wheals in adults with chronic spontaneous urticaria (hives) that isn't well controlled by antihistamines. About 190 participants will receive either the drug or a placebo daily for 4 weeks. The…

This study tests whether adding oral iron supplements to standard eczema treatment can reduce skin symptoms and improve quality of life in adolescents aged 12 to 16 with mild to moderate atopic dermatitis. Researchers will also check if iron levels in the blood affect how well th…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests a gel called VC005 on adults with mild to moderate atopic dermatitis (eczema). About 120 participants will use either the gel or a placebo to see if it safely reduces skin redness, itching, and rash. The goal is to ease symptoms, not cure the condition.

This study will test whether methotrexate or apremilast works better at reducing itching and improving daily life in 80 adults with psoriasis. Participants will take one of the two oral medications for 8 weeks. The main goal is to see which drug provides more relief from the itch…

This early-phase trial tests a probiotic capsule containing five bacterial strains to treat moderate to severe acne in 34 adults aged 18 to 45. The idea is that improving gut health and reducing inflammation may calm acne breakouts. Researchers will also track blood sugar spikes …

This study tests a gel made from hyaluronan (HA35) to see if it can quickly relieve moderate-to-severe itching from conditions like eczema, insect bites, and hives. About 30 adults will apply the gel once, and researchers will check itch levels at several time points up to 24 hou…

This study tests whether adding ear acupressure (using tiny seed patches on specific ear points) to a standard antihistamine (Loratadine) can better reduce hives symptoms and improve quality of life compared to a sham ear treatment. Sixty-six adults with Wind-Heat type urticaria …

This study looks at whether adding a bacterial lysate (OM-85) to standard antihistamines can better control chronic spontaneous urticaria (CSU), also known as chronic hives. Researchers will observe 132 adults who have not responded well to antihistamines alone. The main goal is …

This small pilot study will test a new type of light therapy for moderate-to-severe acne. A special gel is applied to the face, then activated with red light to kill bacteria and reduce inflammation. Ten people aged 16 and older will receive treatments twice a week. The goal is t…

This study tests whether Xdemvy eye drops can reduce eyelash mite irritation and improve comfort for people who wear special scleral lenses. Five adult lens users with moderate to severe Demodex blepharitis will use the drops and report changes in symptoms like dryness, itching, …

This study tests a cream called roflumilast 0.15% for itching in people with mild to moderate atopic dermatitis (eczema). About 40 participants aged 12 and older will apply the cream once daily for 4 weeks. Researchers will track how patients describe their itch and other skin se…

This study tests whether daily soaks with normal saline (salt water) can reduce severe skin reactions caused by radiation therapy. About 150 adults with head and neck cancer or sarcoma will either get standard care or standard care plus a 5-10 minute saline soak each day. Researc…

This early-stage study tests a new drug called HXN5003 in 28 healthy adults to see if it is safe and how the body processes it. The drug is being developed for atopic dermatitis (eczema). Participants receive either the drug or a placebo, and researchers monitor for side effects …

This early-stage trial is testing an experimental drug called IBI3033 in 16 adults with moderate-to-severe atopic dermatitis (eczema). The main goal is to check if the drug is safe and how the body processes it. Participants will receive either IBI3033 or a placebo injection over…

This study tests a new medicine called MG-K10 for people with chronic hives (itchy welts) that don't get better with standard allergy pills. About 226 teens and adults will receive either the drug or a placebo injection every few weeks. The goal is to see if MG-K10 reduces itchin…

This study tests two medical creams containing urea (20% and 40%) on people with mild plaque psoriasis or non-pustular palmoplantar psoriasis. Each participant applies the cream to one affected area and leaves a similar area untreated for comparison. The goal is to see if the cre…

This study tests a cream called PROXERA PSOMED 30, which contains 30% urea, for treating nail psoriasis. 21 adults with nail psoriasis will apply the cream to one nail and Vaseline to another nail twice daily for 24 weeks. Researchers will compare how much each nail improves usin…

This study tests whether taking oral probiotics for 12 weeks can reduce acne lesions and lower inflammation in people with moderate acne. Researchers will compare probiotics to a placebo in 64 Pakistani participants aged 15-35. The goal is to find a safe, antibiotic-free way to m…

This study tests if adding sodium hyaluronate (a common moisturizer in artificial tears) to autologous serum eye drops provides better relief for moderate-to-severe dry eye disease. About 20 adults with dry eye from conditions like Sjögren's syndrome will use the new mix in one e…

This study tests whether a cream made from metformin, a common diabetes drug, can safely improve mild psoriasis. About 55 adults will apply either the metformin cream or a placebo twice daily for two months. Researchers will check skin biopsies and symptom scores to see if the tr…

This study tests whether a probiotic called Lactiplantibacillus plantarum Dad-13, originally from buffalo milk curd, can improve gut health and physical performance in 30 adolescent athletes. Participants will take the probiotic and have their gut bacteria, inflammation markers, …

This Phase 2 trial tests a daily nail lacquer containing 2% tofacitinib for nail psoriasis. Ten adults with nail psoriasis will apply the lacquer at home for 26 weeks. Researchers will measure changes in nail appearance using the Nail Psoriasis Severity Index and quality of life …

This study tests a new topical gel containing 5% spironolactone against a standard 0.1% adapalene gel for treating acne. Forty people with mild to moderate acne will apply each gel to opposite sides of their face, allowing direct comparison. The goal is to see if the spironolacto…

This study tests whether daily red light therapy can prevent or reduce skin and mouth side effects in children aged 0-16 receiving radiation for cancer. About 248 kids will get a daily LED light treatment on the radiated area. Researchers will compare their side effects to those …

This study looks at whether using ketoconazole 2% shampoo for seven days works better than using it for three days to treat pityriasis versicolor, a common fungal skin condition that causes discolored patches. About 76 people aged 12 and older with confirmed infection will be ran…

This study tests a special care plan to help Chinese patients with advanced EGFR-mutated lung cancer who are taking the drug amivantamab. The plan focuses on preventing common side effects like blood clots, skin rashes, and infusion reactions. About 122 adults will join to see if…

This study tests whether an oral collagen supplement (Collagendep) can reduce vulvar dryness in 40 women with genital lichen sclerosus who are also receiving fat grafting. Participants take the supplement daily for 4 months. The main goal is to see if dryness improves, with secon…

This study tests whether a medicated cream called crisaborole works better than a placebo cream for people with mild to moderate eczema. About 270 people aged 12 to 50 will apply the cream twice daily for four weeks. The goal is to see if the cream can clear or nearly clear the e…

This study will test whether a gel containing dutasteride, a drug usually used for hair loss, can treat facial acne. Fifty adults with acne will apply the dutasteride gel to one side of their face and either a placebo or a standard triple-combination acne gel to the other side. R…

This study looks at whether a natural compound from licorice root, called glycyrrhetinic acid, can help calm irritated skin and repair the skin barrier. Researchers will apply a mild irritant to the skin of 30 healthy adults, then treat the area with a cream containing the compou…

This study tests whether a single 23-30 minute session of specially designed music or pink noise can reduce anxiety in adults with psoriasis. About 120 participants will listen at home using headphones. The goal is to see if audio therapy offers a quick, accessible way to manage …

This study looks at whether losing weight can make psoriasis treatments more effective in overweight or obese patients. About 70 adults with moderate-to-severe plaque psoriasis will either get standard care alone or standard care plus a personalized weight loss plan (diet, exerci…

This study tests whether a traditional Chinese herbal formula called Qibei Jiedu can prevent or ease the painful skin rash (radiation dermatitis) that often occurs during breast cancer radiotherapy. Sixty women with early-stage breast cancer will receive either the herbal drink o…

This phase 3 study tests an oral tablet called LW402 in 480 adults with moderate-to-severe atopic dermatitis (eczema). Participants will take either the drug or a placebo daily for 16 weeks. The goal is to see if LW402 can significantly improve eczema severity and skin clearance …

This study compares two prescription ointments, crisaborole and tacrolimus, for treating mild to moderate eczema (atopic dermatitis) in people aged 5 to 25. Researchers will measure how much the skin improves after treatment with each ointment. The goal is to find out which one w…

This study tests whether hypnotherapy can reduce pain and anxiety in children aged 6 to 18 during needle procedures like injections or blood draws. About 70 kids with conditions like juvenile arthritis or lupus will be randomly assigned to receive either hypnotherapy or standard …

This study compares a new emollient balm made from seawater (Relipid+) to a leading balm (Lipikar) for mild to moderate eczema in people aged 6 months to 70 years. The goal is to see if the new balm works just as well at reducing symptoms and improving skin health. Researchers wi…

This study tests if a cream made from diacerein can safely reduce psoriasis symptoms like redness and scaling. About 60 adults with mild psoriasis will apply the cream or a placebo twice a day for two months. Doctors will check their skin at several visits to see if the cream lea…

This study compares two skin-protective strategies—a fragrance-free emollient plus foam dressing versus a silicone-based barrier film—in 104 head and neck cancer patients receiving TomoTherapy. The goal is to see which approach better prevents or reduces painful radiation dermati…

This study tests an experimental capsule called QLS12010 in 160 adults with moderate-to-severe atopic dermatitis (eczema). The goal is to see if it reduces skin redness, itching, and rash better than a placebo over 16 weeks. Participants must have had eczema for at least one year…

This study tests a new cream called KR230109 for mild to moderate acne. About 180 people aged 18 to 40 will use the cream or a placebo for 12 weeks. The goal is to see if the cream safely reduces pimples and skin bumps better than no treatment.

This study tests whether a mouthwash containing sodium hyaluronate and Sh-Oligopeptide-85 can reduce pain and sores in people with oral lichen planus, a chronic inflammatory condition. Forty adults with painful mouth lesions will use either the test mouthwash or a standard cortic…

This study tests whether adding URGO FilmoCream Eczema to standard steroid cream works better than steroid cream alone for treating atopic dermatitis. Researchers will compare two similar eczema lesions on each of 44 adults—one treated with steroids only, the other with steroids …

This study looks at whether applying moisturizer while still in the shower or bath is better than applying it after towel drying for teens with eczema. Thirty participants aged 12-18 will try each method for one month and report which they prefer. Researchers will also measure sk…

This study tests whether a cream containing both testosterone and estrogen works better than estrogen alone to reduce pain during sex for women with vulvodynia. About 44 adult women with moderate to severe pain will use one of the two creams daily. The goal is to find a more effe…

This study compares a modern silver foam dressing to a traditional dry silver dressing for chronic wound infections. Researchers will track how much the wound shrinks in two weeks and how many wounds fully heal. The goal is to find which dressing works better and costs less for p…

This study tests whether letting patients report their symptoms online can help doctors schedule follow-up visits only when needed. About 250 adults with chronic skin conditions like eczema or psoriasis will either get standard fixed appointments or flexible scheduling based on m…

This study will collect information from medical records and routine clinic visits of 100 people in Egypt with hereditary angioedema (HAE) type I or II. The goal is to understand how the condition is diagnosed and managed in current medical practice. No new treatments are being t…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study looks at how muscle tiredness changes the way female volleyball players move their legs when landing on one foot. Researchers will use smartphone videos to measure hip, knee, and ankle motion in 35 athletes. The goal is to understand injury risks better, not to test a …

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …

This study looks at whether changing how much salt you eat can affect skin sodium levels and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet and take either sodium tablets or a placebo for several weeks. The goal is to see if this approach is practic…

This study tests a tiny microdevice, about the size of a grain of rice, that holds up to 20 different FDA-approved skin medications. Placed directly on the skin, it releases very small amounts of each drug to see how the skin reacts. The goal is to find out if this device can saf…

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This early-phase trial will test the safety and tolerability of a single injection of BW-41012 in 40 healthy adults aged 18 to 65. Participants will be randomly assigned to receive either the drug or a placebo, and researchers will monitor for side effects and measure how the dru…

This study looks at how often people develop allergic skin reactions to two different wound dressings used after open shoulder surgery: one made from silk protein and another from a medical glue mesh. About 350 adults having shoulder surgery will be randomly assigned to one dress…

This study in Côte d'Ivoire tests whether giving mothers a cash reward for breastfeeding until their child is 24 months old increases breastfeeding rates and improves child and maternal health. About 1,040 mothers will either receive the cash incentive or just educational materia…

This study looks at whether two substances in the blood, IL-6 and MMP-7, can help doctors diagnose and predict the course of a rare lung disease in children. Researchers will measure these markers in 60 children with immune-mediated interstitial lung disease and compare them to h…

This study tests a new imaging technique called full-field OCT to see if it can spot muscle inflammation faster than the usual method, which takes weeks. Researchers will compare both methods on muscle samples from 20 healthy adults and people with suspected myositis. The goal is…

This study explores whether short, AI-generated videos from a virtual doctor can help people with psoriasis stick to their topical medication routine. Fifteen adults will be split into three groups: weekly AI videos, weekly human doctor videos, or standard care (one follow-up vis…

This study looks at whether the placement of hand sanitizer in a doctor's office affects how much psoriasis patients trust their doctor and feel stigmatized. Researchers will observe doctors' hand hygiene habits and ask 250 patients to fill out questionnaires. The goal is to find…

This study looks at how two common psoriasis drugs, cyclosporine and methotrexate, affect a protein called IL-33 in the blood. Researchers will measure IL-33 levels and track psoriasis severity in 118 adults with moderate to severe psoriasis. The goal is to understand how these d…

This study is testing a new, non-invasive way to collect and analyze skin oil (sebum) using a simple adhesive patch called Sebutape. Researchers will recruit 200 people, including healthy volunteers and patients with acne, eczema, psoriasis, or seborrheic dermatitis. The goal is …

This early-stage study tests a single dose of an experimental drug called BW-20805-2 in 24 healthy adults aged 18 to 60. The main goal is to check for side effects and see how the drug moves through the body. Participants receive one injection under the skin and are monitored for…

This study looks at how body composition (like fat and muscle) and metabolism (how the body uses energy) are connected in adult and older Filipino athletes. Researchers will measure things like body fat, muscle mass, resting energy use, and fitness levels in 120 athletes and non-…

This study will follow 50 Costa Rican patients with moderate-to-severe atopic dermatitis (eczema) who are receiving advanced treatments like dupilumab or JAK inhibitors as part of their regular care. Researchers will collect information on patient characteristics, treatment patte…

This study creates a UK-wide registry for people with vitiligo, a skin condition causing white patches. It will track the safety and effectiveness of current treatments in up to 30 patients. The goal is to improve long-term care by collecting real-world data from dermatologists.

This study will look at the health records of 350 people with psoriasis in Costa Rica to find out how many also have conditions like obesity, diabetes, high blood pressure, heart disease, or psoriatic arthritis. Researchers want to understand how these problems relate to psoriasi…

This study will review medical records of 300 children under 18 with psoriasis in Costa Rica. Researchers want to learn about the children's symptoms, how severe the disease is, what other health problems they have, and what treatments they receive. No new treatments or tests are…

This study aims to develop and test an AI system that uses smartphone photos with a color card to measure redness in psoriasis lesions. Fifty adults with psoriasis will take weekly photos at home and have clinic photos taken. The goal is to see if this simple, low-cost method mat…

This observational study will follow 45 adults with severe plaque psoriasis to see how standard treatment affects their skin, dermoscopic images, and quality of life. Participants will be evaluated at the start and again after 12 and 24 weeks of treatment. The goal is to better u…

This observational registry will follow 50 patients with psoriasis or psoriatic arthritis who are receiving IL-23 inhibitors (guselkumab or risankizumab) as part of their routine care in Costa Rica. Researchers will track how well the drugs improve skin and joint symptoms and qua…

This study tests whether taking statins (a common cholesterol drug) can protect the heart and brain from the harmful effects of breathing bushfire smoke. Healthy adults aged 18-64 will be exposed to simulated smoke in a controlled setting, with some taking statins short-term (2 d…

This study creates a national registry for people with generalized pustular psoriasis (GPP) in Costa Rica. Researchers will collect information from about 50 patients to better understand the disease, how it progresses, and what treatments are used. The goal is to improve care fo…

This study looks at whether professional e-sports players are more physically fit than amateur players. Researchers will measure reaction time, endurance, and grip strength in 40 adults aged 18 to 30. The goal is to understand how different levels of gaming affect physical health…

This study will take high-resolution photos of the eyes of 950 people with psoriasis, eczema, or hives, plus healthy volunteers. Using artificial intelligence, researchers aim to find eye patterns linked to these skin conditions. The goal is to create a noninvasive tool for earli…

This study will look at 200 people aged 18 to 25 with mild, moderate, or severe acne, plus healthy volunteers, to understand how acne develops in Singapore's tropical climate. Researchers will analyze skin bacteria, immune responses, and use AI to grade acne from photos. The goal…

This study will test a new, gentle device that collects fluid from the skin of babies up to 6 months old. Researchers want to see if it's comfortable and can measure chemical signals that may explain why some babies get eczema. By comparing healthy babies and those with eczema, t…

This study looks at how certain immune cells, called MAIT cells, behave in people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will take skin and blood samples from 45 adults with HS and compare them to samples from people with other skin diseases. Th…

This study looks at whether a deep cleaning of the gums can improve symptoms in people with oral lichen planus, a chronic inflammatory condition affecting the mouth. Thirty participants will receive the cleaning and be monitored for changes in signs, symptoms, and immune cell lev…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at how caring for a child with mild to moderate eczema (atopic dermatitis) affects caregivers' work and family life. About 100 Canadian caregivers will answer questionnaires about missed work, reduced productivity, and family impact. The goal is to better underst…

This study looks at whether tongue and facial images can help doctors understand psoriasis better. Researchers will collect photos and lab data from 450 people with and without psoriasis. The goal is to find patterns that link Traditional Chinese Medicine signs to blood tests and…

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study will use a special headband that reads brain waves to see how adults with mild to moderate atopic dermatitis (eczema) respond to a single application of a marketed cream compared to plain water. Twenty participants will have their brain activity measured for signals re…

This study looks at whether people with oral lichen planus, a chronic mouth condition, have higher risks for heart problems or blood clots. Researchers will check blood samples from 55 adults for natural anticoagulant deficiencies and antiphospholipid antibodies. The goal is to b…

This study will measure 12 immune-signaling proteins (cytokines) in the blood of 125 people with vitiligo and healthy volunteers. The goal is to create a model that can predict when the disease will become active and how well a patient will respond to treatment. Currently, doctor…

This study aims to find biological markers (biomarkers) in blood, tears, and eye cells from 110 adults with seven rare eye diseases. Researchers will compare these markers between patients and healthy controls to see if they differ and if they relate to disease symptoms. The goal…

This study will measure three types of fats (ceramides and S1P) in the blood of 40 people with acne and 40 healthy volunteers. The goal is to see if these fats are different in acne patients and if they relate to acne severity. No treatment is given—just a blood draw. The results…

This study will examine 60 adults with psoriasis to understand why they often have higher rates of gum disease. Researchers will measure immune-related proteins and stress hormones in saliva and gum fluid, and also ask about appearance-related anxiety. The goal is to uncover biol…