Tooth disorder

This study tests whether a procedure called full pulpotomy can successfully treat permanent teeth with irreversible pulpitis and apical periodontitis. Instead of removing the entire nerve like a root canal, full pulpotomy removes only the inflamed pulp from the crown, preserving …

This trial asks whether a minimally invasive root canal procedure can match the success of the traditional approach in treating lower molars with dead nerves and an infected root tip. Sixty adults aged 20 to 50 with such molars will be randomly assigned to receive either a conser…

This Phase 2 trial tests whether a topical drug called KH001 can preserve the pulp (nerve) inside teeth with deep cavities. Adults with deep dentinal caries will receive either KH001 or a placebo applied to the cavity. The study tracks how many people develop irreversible pulpiti…

This trial tests whether cold atmospheric plasma can match standard sodium hypochlorite irrigation for disinfecting root canals in teeth with dead nerves. Sixty adults with a single necrotic tooth will receive one of the two treatments. Researchers will compare post-treatment pai…

This trial compares two types of zirconia crowns—custom-made versus prefabricated—for restoring severely decayed baby molars after a pulpotomy (a procedure to save the tooth). Children aged 5-8 with deep cavities in their primary molars will receive one of the two crowns, and res…

This trial tests whether a one-bottle or a two-bottle HEMA-free dental adhesive works better for filling cavities on the front surfaces of teeth. About 50 adults with early to moderate cavities will receive a filling using one of the two adhesives. Researchers will check how well…

This trial compares two methods for removing black tooth stains in children aged 4 to 13. After an initial ultrasonic cleaning, one group receives a standard polish with paste and brush, while the other gets an air-polishing treatment using erythritol powder. Researchers will tra…

This study compares two ways to handle severely decayed front baby teeth in children aged 3 to 5: restoring them with zirconia crowns or simply extracting them. Researchers want to see which approach leads to better quality of life, parental satisfaction, child self-image, and sp…

This study compares toothpaste tablets to a standard toothpaste (Colgate Cavity Protection) for cleaning teeth and gums. Fifty adults will use one of the two products for six weeks. Researchers will measure plaque, gum inflammation, and cavities before and after the trial to see …

This study tests a 6-month nutritional program for adults aged 60–80 who wear complete dentures. Participants receive personalized dietary advice, meal plans, cooking workshops, and a mobile app. The goal is to see if the program improves diet quality, chewing ability, muscle str…

This study tests whether one or two applications of 38% silver fluoride can stop cavities in the baby teeth of children aged 4 to 6 years. Researchers compare a single treatment against two treatments given three months apart, and also measure how the children's oral health affec…

This study tests whether amla (Emblica officinalis), a medicinal plant, can replace standard sodium hypochlorite as a disinfectant during root canal treatment. The trial includes 66 people aged 18–50 with infected single-rooted front teeth. Researchers measure how well each solut…

This study compares two dental filling materials for cavities that form near the gum line (cervical lesions). One is a self-hardening composite, the other a flowable composite. Fifty adults will receive one of the two fillings and be checked over 18 months to see which stays in p…

This trial compares two types of rotary files designed for children's primary molars: Fanta AF Baby and EndoArt Pedo Blue. The goal is to see which system prepares root canals faster and with better filling quality during a pulpectomy (removing infected pulp). Thirty children age…

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This study compares 3D-printed resin crowns to standard stainless steel crowns for children's back teeth that have had pulp treatment. Twenty-six children aged 4 to 8 will receive one type of crown and be followed for a year. The goal is to see if the 3D-printed crowns lead to he…

This study compares two types of computer-designed and milled inlays—hard hybrid ceramic and resin composite—for repairing large cavities in vital back teeth. Fifty healthy adults aged 16 to 50 with a single molar needing a large filling will receive one of the two inlays. Resear…

This study compares two types of full dentures: 3D printed ones and milled ones. Researchers want to see which lasts longer and causes fewer problems over five years. Sixty-eight adults who need complete dentures will take part, and the main focus is how many dentures are still w…

This study compares two ways of making dental crowns for back teeth that have had root canals: 3D-printing from a ceramic-filled resin versus milling from a ceramic block. Sixty adults will receive one of these crowns and be checked for fractures, fit, and color over two years. T…

This study compares two treatments for severely damaged lower molars: a tooth-saving surgery called hemisection (removing the damaged root) versus replacing the whole tooth with a dental implant. Researchers will track 28 participants over 12 months to see which option leads to b…

This study tests whether applying a thin, clear surface sealant over tooth-colored fillings helps prevent discoloration and improves how long the filling lasts. Twenty-five adults with cavities in their back teeth will receive either a sealant or standard polishing. Researchers w…

This study tests whether a paste made from Salvadora persica (a plant used in traditional toothbrushes) mixed with zinc oxide can work as well as the standard material (MTA) for treating severe tooth inflammation. The trial involves 78 adults aged 18-40 with infected permanent mo…

This study looks at three types of dental cement used to attach zirconia crowns to young children's front teeth. About 120 healthy kids aged 2 to 7 with decayed or injured teeth will get crowns and be checked for up to 3 years. The goal is to see which cement holds the crown best…

This study compares rosemary extract to a standard material (MTA) for treating severe tooth pulp inflammation. Researchers will treat 100 adults with a damaged tooth, placing either rosemary extract or MTA directly on the pulp. They will then measure pain and healing over time to…

This study compares two treatments for severely damaged upper molars: root amputation (removing only the damaged root and keeping the rest of the tooth) versus replacing the whole tooth with a dental implant. Researchers will track pain, bone healing, and implant stability over 1…

This study tests if a new bioactive varnish can fix white spot lesions on teeth better than standard fluoride varnish. About 60 people aged 16-35 with at least four white spots will get one of the two varnishes. Researchers will check how well the spots heal and if tooth color im…

This study tests whether a robot can place dental implants more accurately than a computer-guided navigation system in the front upper jaw. Twenty-four adults needing an implant will be randomly assigned to one of the two methods. The main goal is to see which approach achieves b…

This study compares two types of dental fillings for cavities in the back teeth. Researchers will test a bulk-fill flowable resin against a submicron hybrid resin in 25 patients over 18 months. The goal is to see which filling performs better in terms of shape, comfort, and appea…

This study looks at how much denture teeth wear down over two years in people who have no natural teeth. It compares three types of teeth made with modern digital methods: 3D-printed, milled from a block, and standard prefabricated ones. The goal is to see which type resists wear…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This study tests a new type of tooth filling that sticks to the tooth without needing a separate bonding step. Researchers will compare it to the standard filling method in 75 adults with small to moderate cavities near the gum line. The fillings will be checked over 18 months fo…

This study compares three types of dental fillings—bioactive, nanohybrid, and bulk-fill—for treating cavities between teeth. Sixty adults with at least three cavities will receive each type of filling and be monitored for up to four years. The goal is to see which material holds …

This study will test a new injectable tooth filling material against a standard one for fixing cavities between baby molars in children aged 3 to 8. Fifty kids will get one of the two fillings, and dentists will check how well they hold up over a year. The goal is to see which fi…

This study compares mustard gel, made from black mustard seeds, to a standard dental material (MTA) for treating deep cavities in baby molars. 72 children aged 6-8 will receive one of the two treatments after the damaged nerve is removed. The goal is to see if mustard gel can kee…

This study will compare two treatments for cavities in children's back baby teeth. One uses a new injectable bioactive filling material, and the other uses the Hall Technique (placing a metal crown without drilling). About 50 children aged 3-8 with moderate cavities will be follo…

This study tests whether using plaque-disclosing dyes (like erythrosine) with a special light can kill more cavity-causing bacteria in children aged 3 to 7 years. Seventy-two kids at high risk for cavities will get either standard dental cleaning or cleaning plus the dye-and-ligh…

This study compares two types of tooth-colored fillings—injectable and packable—for cavities in children's back baby teeth. Researchers will check how well each filling holds up over time using dental exams and X-rays. The goal is to see if the injectable type, which may be easie…

This study will compare Bioflx crowns (a newer, tooth-colored material) with standard stainless steel crowns for children aged 6 to 9 who have had pulp treatment on their back baby teeth. The goal is to see how each crown affects bite force and the space between teeth, and how sa…

This study tests three special dental cements—Bio C Repair, Biodentine, and MTA—as treatments for irreversible pulpitis (nerve infection) in children's permanent molars. Sixty kids aged 6-10 will receive one of the materials after removing the infected pulp. The goal is to see wh…

This study compares a new cleaning solution made from ferumoxytol nanozymes to the standard treatment for root canal infections. About 72 adults with infected teeth will receive either the new solution or the usual one during their root canal procedure. Researchers will measure h…

This study will test four different dental filling materials in 92 children aged 4-8 who have cavities in their baby molars. The fillings include newer materials like Cention N and Stela, as well as standard options like Beautifil II and resin-modified glass ionomer. Researchers …

This study tests whether an antibiotic paste (LSTR) works as well as the standard filling (ZOE) for treating infected baby molars in children aged 4 to 10. 180 kids will be randomly assigned to one treatment and checked after 6 months for healing. The goal is to find a simpler, e…

This study tests whether a single rotary file system removes more bacteria from infected baby molars than traditional manual files. Thirty-four children aged 4 to 6 with irreversible pulpitis will have their root canals cleaned using one of the two methods. The main goal is to me…

This study compares two methods of moving canine teeth after premolar extraction: one with a minor surgical procedure (corticotomy) to speed movement, and one without. Sixty patients aged 12–30 will have their root length measured before and after treatment to see which method ca…

This study tests a new material made from treated dentin and calcium silicate for treating deep cavities that have reached the tooth's nerve. The goal is to see if it can keep the nerve healthy better than the current standard material. Fifty-six people aged 14 to 35 with deep ca…

This study will test whether 3D-printed fillings work as well as standard bulk-filled resin ones for large cavities in back teeth. About 50 adults aged 22 to 45 with deep decay in a molar will receive one of the two filling types. Researchers will check the fillings' strength, fi…

This study tests different sequences of minimally invasive dental treatments—like silver diamine fluoride, sealants, and fluoride varnish—plus a hygiene program, to see which works best for children aged 5 to 13 in schools. The goal is to reduce the number of kids who don't respo…

This study tests a new material called NeoPutty MTA against a standard chemical, formocresol, for treating deep cavities in children's back baby teeth. About 68 kids aged 4 to 9 will get one of the two treatments to save the tooth and prevent pain or infection. Researchers will c…

This study looks at how well a new type of dental filling (bioactive restorative system) works in people with controlled diabetes compared to those without diabetes. Fifty adults needing a filling in a back tooth will be followed for 18 months. Researchers will check for discolor…

This study tests whether graphene oxide can successfully treat decayed baby teeth that need pulp therapy. 126 children will be split into groups receiving graphene oxide, standard materials like MTA or zinc oxide, or a lesion sterilization technique. The goal is to see which appr…

This study tests whether heating sodium hypochlorite (a common disinfectant) inside root canals of dead teeth can kill more bacteria and reduce pain afterward. Thirty-six adults with a single dead tooth will receive one of two heating methods or standard cleaning. Researchers wil…

This study compares two treatments for irreversible pulpitis, a condition causing severe tooth pain. The standard treatment is a root canal, but researchers want to see if a less invasive procedure called pulpotomy works just as well. The study will involve 138 people and also lo…

This study tests if a less invasive procedure called partial pulpotomy using CGF (a blood concentrate) can control pain and inflammation in severely decayed permanent molars as well as standard root canal treatment. It will involve 60 adolescents aged 11-17 with intense tooth pai…

This study tests two cavity-stopping liquids in 60 children aged 3-5 with active tooth decay. One is a well-known treatment that turns cavities black; the other is a newer version that may avoid staining. Researchers will check which works better over 12 months, and ask parents a…

This study looks at whether an essential oil from Pelargonium graveolens (a type of geranium) can be used to treat deep cavities in children's baby teeth. The goal is to see if it works as well as current materials to relieve pain and prevent infection. Thirty children will recei…

This study tests whether a mouthwash made from moringa leaves can reduce dental plaque, bacteria, and early cavities as well as the standard chlorhexidine rinse. Researchers will enroll 90 adults with mild gum inflammation and moderate-to-high cavity risk. Participants will use e…

This study tests whether silver diamine fluoride or silver fluoride, sometimes with a special LED light, can stop early cavities in the back teeth of young adults. About 366 high-risk dental students will receive one of these treatments. The goal is to see which approach works be…

This study compares two types of dental glue used to attach braces to teeth. One is a traditional three-step system, the other a simpler two-step system. The goal is to see which causes less damage (white spots) to tooth enamel. Thirty-four teenagers will have each type of glue u…

This study tests whether a new bioactive filling material helps teeth repair themselves after deep cavities are removed. 66 adults with deep decay will get either the bioactive filling or a standard one. Researchers will check for new tooth layer formation and pain over 2 years.

This study compares the natural chewing stick Miswak to standard fluoride toothpaste for managing tooth sensitivity and preventing cavities in children aged 6-12 with a condition called Molar-Incisor Hypomineralization (MIH). MIH causes weak, discolored enamel that is prone to pa…

This study compares a new, easier-to-use tooth-colored filling material to a standard one for cavities between back teeth. Fifty adults aged 18-64 with cavities will receive one of the two fillings and be checked after 12 months for how well they hold up, look, and feel. The goal…

This study tests a new type of dental filling made with graphene, a super-strong material, for teenagers aged 10-16 who have weak enamel (a condition called MIH). The fillings are custom-made using a digital scanner and are meant to be more durable and less sensitive than standar…

This study looks at two methods for cleaning and filling infected baby molars in children aged 5-7. One method uses a manual tool, the other a rotating tool. The goal is to see which works better over a year. About 44 children will take part.

This study looks at whether applying cold (cryotherapy) during a pulpotomy—a procedure that removes infected nerve tissue from a tooth—improves the chance of saving the tooth. Researchers will compare treatment success in 140 healthy adults with deep cavities. Success means no pa…

This study compares two dental treatments for teeth with deep cavities and reversible pulpitis (early nerve inflammation). One treatment caps the exposed nerve directly, while the other removes a small part of the nerve before capping. The study will include 138 people aged 15-40…

This study compares three ways to handle the dental pulp (tooth nerve) after transplanting a wisdom tooth to replace a damaged molar. 360 people aged 18-40 will be randomly assigned to receive either standard root canal treatment weeks after surgery, a special root tip procedure …

This study tests whether shorter dental implants (6.3mm) work as well as standard ones (9mm) for people with low bone height in the upper jaw who need a sinus lift. Thirty-six adults will be randomly assigned to receive one of three implant types. Researchers will track complicat…

This study will test whether a liquid called silver diamine fluoride works as well as gentle fillings (atraumatic restorative treatment) for stopping cavities in children aged 2 to 5. About 156 kids from kindergartens will get one of the two treatments, and researchers will check…

This study compares two dental procedures for treating deep cavities in baby molars of children aged 6-8. One group gets a partial nerve treatment (pulpotomy) using a special cement, while the other gets a full root canal (pulpectomy) with a medicated paste. Researchers will trac…

This study will compare two dental filling materials—alkasite-based resin and nanohybrid composite resin—for treating cavities in the chewing surfaces of children's baby molars. About 50 children aged 4-6 will receive one of the two fillings and be checked at 3, 6, and 12 months …

This study tests a new root canal filling made from zinc oxide and ozonated olive oil against a standard material called Metapex in children aged 3-5 with cavities in their front teeth. Over 12 months, researchers will check for pain, swelling, and healing on X-rays. The goal is …

This study compares two dental procedures for treating infected baby molars in children aged 4 to 8. One method removes only the infected part of the tooth's nerve (pulpotomy), while the other removes the entire nerve (pulpectomy). The goal is to see if the simpler pulpotomy work…

This study looks at how different 3D-printed materials affect gum health and restoration success in teeth with deep cavities that need margin elevation. Researchers will treat 48 patients and check their teeth at 6 and 12 months using dental and gum health scores. The goal is to …

This study tests whether natural substances like grape seed extract and glycyrrhizin can replace antibiotics in a procedure to revive dead permanent teeth in children aged 7-13. The goal is to restore blood flow and promote root growth while reducing pain and infection. The trial…

This study compares two cavity removal methods in 144 adults with deep cavities and reversible pulpitis (tooth nerve inflammation that can heal). One method removes all decay, the other leaves some near the nerve. Researchers will check pain, tooth vitality, and X-rays over 12 mo…

This study tests how mouth rinses made with monk fruit or Splenda affect saliva acidity and levels of cavity-causing bacteria. 90 healthy young adults (ages 20-24) with no active cavities will rinse with one of the sweetener solutions. Saliva samples will be checked before rinsin…

This study tests whether a special silver liquid (silver diamine fluoride) can stop tooth decay in elderly people living in nursing homes. Sixty participants will either get the silver treatment or a placebo, and their teeth will be checked after 6 and 12 months. The goal is to i…

This study tests whether different fluoride treatments—like varnishes, solutions, and mousse—can stop root cavities from getting worse in adults over 44. About 136 participants in Switzerland will use these products at home or get them applied by a dentist twice a year. The goal …

This study tests whether a gel made from a patient's own blood (platelet-rich fibrin) can help regenerate the inner part of infected or dead teeth in adults. 57 participants will receive either the gel or a standard blood-clot treatment. The goal is to see if the gel reduces infe…

This study compares a new material made from eggshells (calcium hydroxyapatite) to a standard one (calcium hydroxide) for protecting the nerve in deep cavities. Fifty-four adults with reversible pulpitis will receive one of the two materials after cavity cleaning. Researchers wil…

This study tests whether a less invasive dental procedure called full pulpotomy can heal infected molars as well as root canals. Researchers will treat 128 adults with deep cavities and compare healing in teeth with and without infection at the root tip. If successful, it may off…

This study tests two ways to improve gum tissue around dental implants in adults with missing teeth. One method uses a collagen membrane from cows, the other uses a small piece of tissue from the roof of the mouth. The goal is to see which approach leads to healthier gums and bet…

This study will test three different materials—hyaluronic acid, TheraCal, and MTA—used to treat deep cavities in children's baby molars. Sixty-six kids aged 4 to 8 will receive one of the treatments, and researchers will check for pain, swelling, and X-ray changes over 12 months.…

This study will test two types of dental cement—bioactive and resin—to see which one works better for putting zirconia crowns on children's front teeth. Sixty kids with cavities in at least two baby teeth will get crowns, and researchers will check how well the crowns stay on, if…

This study compares artificial intelligence analysis of dental photographs to standard clinical exams for detecting white spot lesions—early signs of tooth decay. Researchers will train AI models (YOLO and Mask-RCNN) on 329 labeled images from adult patients at Cairo University D…

This study will check if smartphone photos, 3D dental scans, and a special fluorescent light can accurately detect early cavities in people who have finished braces. Thirty participants aged 11 to 46 with early white spots on their teeth will be followed for three months. Researc…

This study looks at whether two substances in the blood of a tooth's pulp—IL-8 and presepsin—can help dentists tell the difference between a tooth infection that can heal on its own and one that needs a root canal. Researchers will collect pulp blood samples from 50 patients with…

This study will compare three methods for testing whether a tooth's nerve is alive (vital) or dead (nonvital): laser Doppler flowmetry, cold testing, and electric pulp testing. About 150 people who need root canal treatment will receive all three tests before treatment. The goal …

This study tests a handheld scanner that uses safe near-infrared light to find early cavities without radiation. Fifty adults scheduled for a tooth extraction will get an extra 5-minute scan before their procedure. The scanner's results will be compared to standard X-rays and vis…

This trial tests whether sending oral health tips via WhatsApp to mothers, in addition to standard face-to-face advice, improves their knowledge and their children's toothbrushing habits. Mothers of children aged 3 to 6 will receive either usual education alone or with 16 additio…

This trial tests whether swabbing toddlers' teeth with povidone iodine can prevent tooth decay and reduce cavity-causing mouth germs. Children aged 1 to 3 will have their teeth swabbed weekly for the first month and then monthly, with some also receiving a daily probiotic. The st…

This trial tests whether a silver nanoparticle mouthwash can reduce cavity-causing bacteria in children as effectively as chlorhexidine, but without the staining and taste issues. About 96 children aged 6–12 at high risk for cavities will rinse twice daily for 14 days. The study …

This trial tests whether cleaning the chewing surfaces of children's teeth with a fine erythritol powder spray (Guided Biofilm Therapy) before applying a protective sealant helps the sealant stay in place longer than the standard rotary-brush polishing. Each child aged 6–10 will …

This trial tests whether a fluoride-releasing adhesive used to attach braces can prevent white spot lesions—early signs of decay—on teeth. About 40 adolescents getting braces will have standard adhesive on one side of their upper jaw and the fluoride sealant on the other. After 3…

This study tests whether applying povidone iodine (a disinfectant) to toddlers' teeth before fluoride varnish prevents cavities better than fluoride varnish alone. About 393 children aged 6-24 months with healthy teeth or early white spots will be followed to see which approach r…

This study tests if using a diode laser before applying a tooth-colored sealant helps it stick longer and prevent cavities better. About 111 young adults aged 17-22 will get sealants on their back teeth, with or without laser pre-treatment. Researchers will check sealant retentio…

This study tests whether motivational interviewing — a supportive, patient-centered conversation style — can help mothers adopt better oral care habits for their infants, preventing early childhood caries. Researchers will enroll 228 mother-infant pairs in Malaysia, with half rec…

This study will test a new self-sticking dental material against a standard sealant to see which better prevents cavities in children's permanent molars. About 88 healthy kids aged 6-8 with high cavity risk will take part. The goal is to find out which material stays on teeth lon…

This trial asks whether a newer 'bulk-fill' composite filling causes less tooth sensitivity after cavity repair than the traditional layer-by-layer method. Dentists often apply standard fillings in thin layers to avoid shrinkage gaps, but bulk-fill materials can be placed in thic…

This study compares two ways of numbing a child's tooth for a root canal on a baby molar: a computer-controlled system that delivers anesthetic slowly and steadily, versus a traditional injection. The goal is to see which method causes less anxiety and pain in children aged 6 to …

This trial tests whether taking a single dose of diclofenac potassium before dental treatment can improve the numbing effect of local anesthesia and reduce pain after the procedure. Adults with severe tooth pain from irreversible pulpitis in lower molars will receive either 50mg,…

This trial compares two different file systems used during root canal treatment for infected lower molars. The goal is to see whether a newer, minimally invasive single-file system leads to less pain after the procedure than the standard Wave One Gold system. Adults with a specif…

This study tests whether a 3% hypertonic saline (saltwater) rinse, used at the end of a root canal procedure, can reduce pain and inflammation better than the standard 0.9% saline rinse. Forty adults with painful tooth inflammation will receive one of the two rinses, and their pa…

This trial investigates whether a single injection of dexamethasone, a steroid, given before a root canal can lower pain during the procedure. It includes adults with severe tooth pain from symptomatic irreversible pulpitis. Participants receive either dexamethasone or a placebo,…

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This study looks at whether using a cold saline rinse after ultrasonic cleaning during a root canal can lower pain afterward. Adults with an inflamed tooth nerve will get either ultrasonic cleaning alone or followed by a cold saline flush. Pain levels are tracked for three days a…

This study tests two simple treatments for tooth sensitivity caused by worn enamel: a blue diode laser and a bioactive glass powder. Thirty adults with two similarly sensitive teeth will each receive both treatments (one per tooth) to see which works better. The goal is to find a…

This study tests whether three different desensitizing toothpastes can reduce tooth sensitivity in people with braces. About 200 adults aged 18-40 with mild to moderate sensitivity will use one of the toothpastes or a placebo for 8 weeks. The goal is to see if the special toothpa…

This study tests whether a special adhesive filled with strontium-doped bioactive glass-ceramic can reduce tooth sensitivity. 142 adults with sensitive teeth will receive a single application of either the new adhesive or a standard one. Pain levels will be checked right after an…

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study compares two dental varnishes—one with fluoride and one without—to see which better reduces tooth sensitivity. Sixty-six adults with sensitive teeth will have each varnish applied to different teeth and rate their pain over time. The goal is to find a simple, effective…

This study will test a 16% carbamide peroxide gel used at home in custom trays for 90 minutes daily over six weeks. Ten adults with healthy gums and no prior whitening will have their tooth color measured by a special device and report how their quality of life changes. The goal …

This study compares three different root canal sealers—AH Plus, ProRoot Bio Sealer, and BC Sealer ion+—to see which one leads to the least pain after treatment. About 135 adults with irreversible pulpitis in a lower molar will be randomly assigned to one of the three sealers. Pat…

This study compares two ways to remove cavities in children's baby molars: a special gel that softens decay, versus scraping by hand. The goal is to see which method causes less pain and is more acceptable to kids. Twenty-eight healthy children aged 5 to 9 will take part, and the…

This study tests whether a gel made from the Libidibia ferrea plant can reduce tooth sensitivity after professional whitening. Seventy-five adults will receive either the experimental gel, a standard desensitizing gel, or a placebo before bleaching with hydrogen peroxide. Partici…

This study tests whether a new type of root canal filling material (bioceramic nano-coated gutta-percha with a bioceramic sealer) causes less pain and swelling after treatment compared to the standard material (gutta-percha with a resin sealer). About 30 adults aged 20-55 with a …

This study will compare two types of root canal sealers, NeoSealer Flo and CeraSeal, in 30 adults needing root canal treatment for painful tooth inflammation. The goal is to see which sealer causes less pain after the procedure and less leakage of material beyond the tooth tip. P…

This study tests four different ways to clean infected root canals to see which one reduces bacteria and pain the most. Forty adults with tooth infections will be randomly assigned to one of the cleaning methods. The goal is to find a better way to disinfect teeth while making th…

This study tests whether a gel made from propolis (a bee product) can reduce tooth sensitivity after professional whitening. 66 adults will receive either propolis gel, a standard desensitizer, or a placebo before bleaching. Their pain and color change will be tracked for two wee…

This study compares two self-ligating bracket systems (Damon Ultima and Pitts 21 Pro) in 40 people with mild-to-moderate crowding. Researchers will measure treatment time, pain, root resorption, and alignment quality to see if one system works better. The goal is to find which br…

This study tests a gel called Cariclast that softens tooth decay, allowing dentists to remove cavities without a drill. It will involve 24 children aged 4-7 with cavities in their back baby teeth. The goal is to see if this method causes less pain and is more accepted by kids tha…

This study looks at whether using different root canal tools (TruNatomy vs ProTaper Gold) and different sealers (AH Plus vs TotalFill BC) can reduce pain after a root canal. About 144 adults with a tooth infection will take part. They will rate their pain at several times over a …

This study tests whether applying a dipotassium oxalate gel before placing a filling can reduce tooth sensitivity afterward. 64 adults with sensitive tooth cavities will be randomly assigned to get the gel or standard treatment. Pain is measured at 24 hours, 7 days, and 30 days u…

This study compares two ways of using an anti-inflammatory drug (ketorolac) during root canal treatment: one at room temperature and one chilled. The goal is to see if the cold version reduces pain better after the procedure. Sixty adults with tooth infections will be enrolled, a…

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This study tests whether special scaffolds placed inside a tooth after removing the infected pulp can lower pain and improve healing. About 36 adults with a painful, infected lower molar will be treated and followed for up to a year. The goal is to find a better way to save the t…

This study compares a 1% melatonin gel to a standard calcium hydroxide paste placed inside the tooth after root canal cleaning. It aims to see which one better reduces pain, lowers bacteria, and affects a certain protein linked to healing. The trial will involve 50 adults with a …

This study compares two ways of doing a pulpotomy (a type of root canal) for adults with a painful, infected tooth. Half the treatments will use a special dental microscope, and half will not. The goal is to see if the microscope helps the tooth heal better over time. Fifty healt…

This study compares two ways of applying cold inside a tooth during a root canal to see which reduces pain better. Ninety adults with a painful, inflamed tooth nerve will be randomly assigned to receive either ice sticks, a cold spray, or no extra cold treatment. Patients will ra…

This study compares two treatments for dentin hypersensitivity (tooth sensitivity). One group gets a special varnish (CPP-ACPF) alone, the other gets the varnish plus a low-level laser treatment. 70 adults with sensitive teeth will rate their pain before and after. The goal is to…

This study tests a new rinse called Triton during root canal treatment for dead teeth. It aims to see if it kills more bacteria and causes less pain afterward than the standard rinse. Thirty-six adults with infected lower molars will take part. The results could help dentists cho…

This study tests whether using a special rotary file (a spinning tool) causes less pain after a baby tooth root canal than the traditional manual file. Fifty children aged 4 to 6 with an infected baby molar will be randomly assigned to one of the two methods. Parents will rate th…

This study looks at whether using a special rotating tool (rotary file) instead of a hand tool (manual file) during a baby molar root canal (pulpectomy) makes children behave better. It will include 54 children aged 4-6 who need this treatment. The main goal is to see if the rota…

This study tests whether applying cold (cryotherapy) to the gums right after a numbing shot can make root canal treatment less painful. About 100 adults with an infected lower premolar tooth will be randomly assigned to receive standard numbing methods with or without the cold tr…

This study compares two different medicines placed inside a tooth during a root canal to see which one is better at killing bacteria and reducing pain afterward. About 52 adults with infected single-root teeth will take part. The goal is to find which treatment leads to less disc…

This study tests whether using a dental operating microscope during a pulpotomy (a partial root canal) reduces pain and improves quality of life afterward. 82 adults with deep cavities and tooth nerve pain will be randomly assigned to get the procedure with or without the microsc…

This study tests a new gel that dissolves tooth decay without drilling, aiming to reduce patient anxiety. Eighty adults with cavities in lower molars will be randomly assigned to either the gel or a standard drill. The main goal is to see which method causes less pain and discomf…

This study aims to find out which of two root canal sealers causes less pain after treatment. Sixty adults with tooth nerve inflammation will have root canals and then rate their pain over two days. The goal is to improve patient comfort and recovery.

This study compares two ways to clean a tooth's root canal (step-back vs step-down) to see which one leads to less pain afterward. About 110 adults with a dead nerve in a single-root tooth will be randomly assigned to one method. Pain levels will be tracked for a week using a sim…

This study compares two methods for fixing cavities in children's back teeth: the Hall Technique (a less invasive approach) and traditional stainless-steel crowns. Researchers will measure bite force, jaw changes, and child comfort in 22 kids aged 6-9. The goal is to see if the g…

This study compares two single-dose pain relievers—piroxicam and prednisolone—given before a root canal to see which one reduces pain better afterward. Sixty adults with an inflamed tooth nerve and infection will take one of the drugs right before treatment. The goal is to find a…

This study compares a single-shade flowable composite resin to a multi-shade composite for filling cavities in back teeth. Thirty adults with at least four cavities will receive both types of fillings and be followed for five years. Researchers will check how well the fillings ma…

This study will test if a technique called 'apical patency'—gently passing a small file just past the root tip during cleaning—can reduce pain after a root canal. 48 adults with a dead nerve and infection in a back molar will be randomly assigned to receive either this technique …

This study will compare two treatments—low-level laser therapy and hyaluronic acid gel—to see which helps children's gums heal better after removing a badly decayed first permanent molar. Thirty-six children aged 6 to 10 will receive one of the treatments right after extraction. …

This study looks at two ways of cleaning a tooth's root canal to see which one causes less pain afterward. It involves 72 adults with a specific type of tooth nerve pain in their front teeth. Participants will have their root canals cleaned using one of two methods, then rate the…

This study tests whether applying Gluma desensitizer before a filling can reduce tooth sensitivity afterward. Sixty adults with cavities in their back teeth will be randomly assigned to get either the desensitizer plus a standard filling or just the standard filling. Their pain r…

This study compares a computer-controlled injection device (Starpen) to a standard syringe for numbing and extracting upper baby molars in 38 children aged 6-8. The goal is to see if the new device causes less pain during the injection. Children will rate their pain using a faces…

This study aims to find biological markers in saliva, mouth rinse, blood, or tissue that could help identify and predict the course of oral cancer, gum disease, and tooth decay. Researchers will collect health information and samples from 4,000 adults with these conditions and he…

This study looks at how common cavities are in the first permanent molars of 6- to 7-year-old Egyptian children and whether diet and tooth-brushing habits play a role. Researchers will examine 272 children's teeth and ask parents about their child's eating and oral hygiene routin…

This study looks at whether GLP-1 receptor agonists like semaglutide and tirzepatide, used for weight loss, change saliva composition and increase tooth wear. Researchers will measure saliva calcium, pH, flow rate, and dental erosion in 40 adults before and 3 months after startin…

This study looks at whether having insomnia before dental surgery leads to more pain afterward. Adults getting teeth pulled will be grouped by their sleep quality and will report pain levels using questionnaires. The goal is to see if poor sleep makes recovery harder.

This study looks at saliva from people with osteoporosis to measure certain immune markers and an enzyme called MMP-8. Researchers also check participants' dental cavities. The goal is to better understand how osteoporosis might affect oral health. No treatments are given—only sa…

This study looks at how well 3D-printed resin fillings hold up in back teeth with large cavities. Researchers will compare two different ways of shaping the tooth before placing the filling. Fifty adults will be followed for 18 months to see which design leads to fewer cracks or …

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This study aims to create a patient decision aid for young people aged 11-18 who are missing one or both upper front teeth, a condition affecting 1 in 50 people. Researchers will interview patients and their parents, and hold focus groups with clinicians, to understand what matte…

This study tests how well three different toothpastes repair early tooth damage (enamel lesions) in 30 healthy adults aged 18-70. Participants wear a removable mouth device with human enamel pieces for 14 days per toothpaste, with breaks in between. Researchers measure mineral ga…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study looks at whether getting complete dentures for the first time changes how anxious patients feel about dental visits. Researchers will measure anxiety in 70 adults who have lost all their teeth at two points: when they first get impressions made and when they receive th…

This study aims to understand why some teeth fail to erupt (come in) properly. Researchers will look at dental records and test for changes in the PTH1R gene in 50 patients with eruption problems. The goal is to improve diagnosis and distinguish between different causes, such as …

This study asks 200 practicing midwives in Germany about their role in oral health for pregnant women and young children. Through an anonymous online survey, researchers will learn how confident midwives feel giving dental advice, what barriers they face, and what training they n…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study looks at how stainless steel crowns placed on weak permanent molars (due to a condition called MIH) affect a child's bite and jaw function. Forty-six children will have their teeth scanned before, right after, and up to 3 months after crown placement. The goal is to un…

This observational study will collect pulp tissue from 1,200 adults during routine dental procedures like root canals or extractions. Researchers will analyze the tissue to understand the immune and inflammatory response at the molecular level. The goal is to see if current diagn…

This study compares a new digital denture-making technique (Easdent) with the traditional method for people who need full dentures. Twenty adults will receive both types of dentures, and researchers will measure chair time, number of visits, and patient satisfaction. The goal is …

This study will test five different types of tooth-colored fillings (bulk-fill composites) in 70 adults who need a cavity filled. The fillings use different technologies, like heating or sound waves, to see which one works best. Dentists will check the fillings right after placem…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This study looks at inflammation inside the tooth's inner tissue (dental pulp) in people with painful pulpitis compared to healthy individuals. Researchers will measure specific inflammation markers in saliva, gum fluid, and pulp tissue to see if they reflect the level of inflamm…

This observational study looks at whether eating lots of ultra-processed foods (like chips, soda, and packaged snacks) is linked to cavities and gum disease. Researchers will track the diets and oral health of 200 adults aged 18 to 65. No treatments or changes are given—just care…

This study will follow 75 adults who need root canal treatment or retreatment at a hospital dental clinic in Rome. Researchers will check how well the teeth heal using X-rays and symptom reports over up to 5 years. The goal is to understand success rates and how factors like over…

This study looks at how two types of dental cement used to attach stainless steel crowns affect gum health in 45 children aged 6-10. Researchers measured gum inflammation and certain immune markers before and one week after placing the crowns. The goal is to see if one cement cau…

This study looks at 1,200 preschool children to understand why some get severe tooth decay. Instead of just looking at teeth, researchers will also study family stress, parenting burnout, children's sleep, and diet. The goal is to create a tool that predicts which kids are most a…

This study looks at how well a special type of dental filling called Giomer works in people with and without diabetes. Researchers will place fillings in cavities on the tooth neck and check them over 18 months to see if they stay in place and prevent new decay. The goal is to un…

This study looks at whether sending short dental health videos through WhatsApp can improve how much 10-12 year old children in Cairo know about taking care of their teeth, and whether it changes their brushing and eating habits. About 150 children will take part, with one group …

This study looks at people with Enamel Renal Syndrome, a rare genetic condition that causes calcium deposits in the body, leading to kidney and blood vessel problems. Researchers will measure kidney function and test how the body handles calcium, phosphate, water, and acid. The g…

This study looks at certain proteins (aquaporins and IL-8) in the fluid and tissue of healthy teeth and teeth with a painful, inflamed nerve (irreversible pulpitis). Researchers will collect samples from 70 adults during routine root canal treatment to compare protein levels. The…

This study aims to find genetic links between certain dental issues (like missing or extra teeth) and eye or skin conditions. Researchers will collect DNA from 5 orthodontic patients with these dental problems and a family history of eye or skin issues. They hope to identify shar…

This study looks at 58 children with deep cavities in their baby molars. Dentists will perform a pulpotomy (removing the infected nerve and sealing the tooth) and measure levels of cytokines—substances that signal inflammation—in the pulp. The goal is to see if these levels can p…