Tooth disorder

This study tests whether 3D-printed composite resin fillings work as well as semi-direct composite resin fillings for cavities or damaged back teeth. About 60 adults aged 25 to 40 who need two similar fillings will get one of each type. Researchers will check for cracks, wear, an…

This study tests two methods of placing a bulk-fill composite filling material in cavities on the chewing surfaces of back teeth. One method places the material all at once, while the other builds it up in thin layers. Researchers will check how well each method holds up over tim…

This study tests a new dental filling made with coconut nanoparticles for children's baby teeth. Sixty children aged 5 to 9 with cavities will receive either the new coconut filling or a standard glass ionomer filling. Researchers will check the fillings' surface, shape, and how …

This study tests whether new plastic-like PEEK crowns work as well as standard metal crowns for children's back teeth after a common nerve treatment (pulpotomy). Sixty kids aged 5-9 got one PEEK crown and one metal crown on opposite sides of their mouth. Researchers checked gum h…

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This study tests four different ways to apply a new universal dental adhesive when fixing cavities on the side of teeth. Fifty patients will receive a total of 200 fillings, each using a different application method. The fillings will be checked every six months for four years to…

This trial tests four methods of activating the cleaning liquid during root canal treatment in adults aged 20 to 40 with an infected lower first molar. The goal is to see which method helps the infection at the root tip heal best after 12 months. Participants receive one-visit ro…

This study tests whether artificial intelligence (AI) can design dental crowns as well as a human technician. Forty adults with a damaged back tooth will receive either an AI-designed crown or a standard computer-designed one. Researchers will check for cracks, loosening, and ove…

This study compares three types of bioactive dental fillings for cavities in back teeth. Fifty-five healthy adults aged 18 to 50 with at least three cavities will receive each filling type in different teeth. Researchers will check how well the fillings hold up, their appearance,…

This study compares three materials used to treat deep cavities in children's baby molars: a standard dental cement (MTA), a bleeding-stopping liquid (ferric sulfate), and a new natural gel made from shellfish shells (chitosan). 165 children aged 5-8 will receive one of these tre…

This study compares a new injectable tooth filling material to a conventional one for treating cavities in back teeth (molars). About 120 people with cavities will receive one of the two fillings. Researchers will check how well the fillings hold up over time, looking at color, c…

This study tests whether applying 5-fluorouracil cream or Carnoy's solution after cyst removal lowers the chance of the cyst coming back. Fifty adults with odontogenic keratocysts in the jaw will be treated and followed for up to five years. The main goal is to see which method l…

This study compares two types of dental onlays (custom-made tooth covers) for treating decayed teeth. 164 adults will each receive one milled and one 3D-printed onlay to see which lasts longer over 10 years. The goal is to find out if the newer 3D-printing method is as good as th…

This study looks at two methods for placing glass ionomer fillings in the back baby teeth of 200 South African children aged 4-8. One method is done in a classroom using hand tools (ART), the other in a mobile clinic with standard equipment. Researchers will track how long the fi…

This study tests three different materials used to treat deep cavities in children's permanent molars that are still growing. The goal is to see which material best keeps the tooth alive and allows the root to finish forming normally. Sixty-nine children aged 7 to 10 will receive…

This study compares two ways of making dental onlays (custom tooth restorations) for damaged molars: milling from a solid block versus 3D printing. Thirty adults with cavities, broken teeth, or old fillings will receive either a milled or 3D-printed onlay. Researchers will check …

This study compares two types of dental cement used to place tooth-colored inlays (fillings) in cavities of back teeth. Fifty adults with large cavities or broken fillings will receive an inlay and be followed for 18 months to see which cement performs better in terms of strength…

This study tests a new high-strength ceramic material for dental crowns that can be made in a single appointment using a computer technique, avoiding the need for a temporary crown. 48 adults with a decayed, fractured, or poorly restored molar or premolar will receive the crown a…

This study compares three different dental adhesives used to fill non-carious cervical lesions, which are tooth defects not caused by cavities. Thirty healthy adults aged 18-55 will receive restorations using one of the adhesives, and the team will check how well they hold up aft…

This study looks at two materials, ferric sulphate and putty MTA, used to treat deep cavities in children's baby teeth. The goal is to see which one works better and is safer than a traditional chemical. Sixty healthy children will be treated and followed for up to a year to chec…

This study looks at how well a new type of tooth-colored ceramic (3D shaded zirconia) works for making dental crowns, onlays, and bridges in a single dental visit using a computer design and milling machine. About 82 adults aged 18 to 75 who need a crown or onlay on a back tooth …

This study tests two treatments made from a child's own blood—concentrated growth factor (CGF) and platelet-rich fibrin (PRF)—to help regrow the roots of a damaged permanent molar. Sixty children with an immature, infected lower first molar will receive one of the two treatments …

This study tests whether a gel containing silver diamine fluoride can stop cavities in preschool children as effectively as the standard liquid version. About 630 healthy children with at least one cavity will receive the gel or solution every six months for 30 months. The goal i…

This study is testing a new type of dental implant with a special surface (EK III NH) in 30 adults aged 20-80 who are missing teeth. Participants receive the implant and a temporary tooth replacement right away. Researchers will track how well the implant works over two years usi…

This study tests three non-drilling treatments—silver diamine fluoride, a self-assembling peptide, and fluoride varnish—to see if they can stop or reverse early cavities in children's baby teeth. About 90 kids aged 4-10 with early tooth decay will be randomly assigned to one of t…

This study looks at two ways to replace a missing lower molar with a dental implant. After the tooth is pulled and the bone heals for 12 weeks, some participants get a temporary crown right after implant surgery (immediate loading), while others wait 4 weeks before getting a temp…

This study tests three different fluoride treatments—silver diamine fluoride gel, a special fluoride varnish, and a standard fluoride gel—to see which one best stops early childhood cavities. Ninety healthy children with at least one active cavity will receive one of the treatmen…

This study tests whether placing omega-3 fatty acids inside a damaged tooth can help it regrow root length and dentin, compared to the standard method of inducing bleeding. Twenty patients aged 6 to 28 with immature permanent teeth that have died due to injury or decay will be tr…

This study tests a special tooth-colored filling called alkasite composite (Cention Forte) for baby molars that have had pulp treatment. Twenty-five healthy children with deep cavities received this filling. Researchers are checking how well the fillings hold up over time using s…

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve and placing a material on it) and an indirect pulp cap (leaving some decay and sealing …

This study tests whether a new tooth-colored crown (Bioflx) works as well as the standard metal crown for fixing severely decayed baby molars in children aged 4 to 10. Each child gets one of each type on opposite sides of the mouth, and researchers check durability, gum health, a…

This study tests a new way to lift the sinus floor using a special drill (Densah bur) guided by a surgical template, while placing a dental implant at the same time. Ten patients with missing upper back teeth and a shallow sinus will receive this procedure. The goal is to see how…

This study compares three modern dental materials used to treat deep cavities in children's permanent molars by preserving the tooth nerve. The goal is to see which material best helps the tooth root continue growing and reduces pain. About 48 healthy children aged 7 to 11 with o…

This study tests whether using a diode laser before placing a special filling material (Biodentine) helps preserve more healthy tooth and reduces staining compared to using Biodentine alone. 48 adults with deep cavities in permanent back teeth are being treated and followed with …

This study compares three dental procedures—pulpotomy, partial pulpotomy, and direct pulp capping—all using a material called MTA, to treat deep cavities in children's baby molars. The goal is to see which technique best preserves the tooth, prevents pain, and avoids infection. T…

This study tests three materials—amniotic membrane, mineral trioxide aggregate putty, and biodentine—for treating deep cavities in children's permanent molars that are still growing. The goal is to help the tooth root finish developing and avoid root canal or extraction. Seventy-…

This study compares two treatments for infected baby molars in children aged 3 to 8: a less invasive method using a triple antibiotic paste versus a standard root canal with a calcium hydroxide-iodoform paste. The goal is to see which approach better relieves pain, swelling, and …

This study tests three types of dental fillings—high-viscosity glass ionomer, bulk-fill composite, and conventional composite—in 110 adults with deep cavities. The goal is to see which material performs best and causes less irritation to the tooth's nerve. Participants are health…

This study compares a new calcium silicate-based sealer to the standard resin-based sealer for root canals in molar teeth. About 136 adults aged 18-65 with infected molars will receive one of the two sealers. The goal is to see which material leads to better healing and fewer sym…

This study tests whether a newer version of a blood-derived filling (Advanced Platelet-Rich Fibrin) helps bone and gums heal better than the standard version after a tooth is pulled and a dental implant is placed right away. Sixteen healthy adults with a badly decayed back tooth …

This study compares a new self-cured bioactive filling material to a standard one for treating deep cavities in back teeth. Twenty-five patients with two decayed molars will receive one of each filling, then be monitored for up to two years. Researchers will measure how well the …

This study tests two different varnishes for treating white spot lesions, which are early signs of tooth decay common after braces. One varnish uses a self-assembling peptide to help rebuild enamel, while the other delivers calcium and phosphate. Thirty-eight people aged 15-25 wi…

This study compares a new bioactive filling material to a standard resin composite for treating cavities. 31 adults with at least two cavities will receive both types of fillings and be monitored for up to 4 years. The goal is to see which material performs better in terms of dur…

This study looks at whether a special light-activated dye can kill more bacteria and reduce pain after root canal treatment. Fifty adults with infected teeth will receive either standard care or the light therapy. The goal is to see if this simple addition improves healing and co…

This study tested four different types of tooth-colored fillings (flowable resin composites) to see which works best for fixing cavities. Twenty-eight adults each received at least four fillings, and the fillings were checked over two years. The goal was to find out if newer, sel…

This study compares three types of dental filling materials for repairing non-carious cervical lesions (tooth damage not caused by cavities). Thirty-three adults with at least three such lesions will receive each material in different teeth. Over two years, dentists will rate how…

This study compared two types of tooth fillings for cavities between teeth. 23 adults received either a glass ionomer or a bulk-fill composite resin filling. The fillings were checked at regular visits over 4 years to see how well they held up. The goal was to find out which mate…

This study compares two materials—enamel matrix derivative and amniotic membrane—to standard blood-clot therapy for regenerating roots of non-vital immature permanent front teeth in children aged 7 to 12. The goal is to see which approach best promotes root growth, closes the ope…

This study looks at how well tooth-colored fillings hold up in baby molars that have had a pulpotomy (a procedure to remove infected pulp) compared to similar fillings in teeth without pulpotomy. About 40 healthy children aged 3-9 will be followed for 24 months. The goal is to se…

This study compares two methods of preparing the jawbone for dental implants: a newer technique called osseodensification and the conventional method. The goal is to see which provides better initial stability for the implant, which is important for long-term success. The study i…

This study tests three different dental cements used to attach prefabricated zirconia crowns to children's front baby teeth. Thirty-six children with cavities will receive crowns, and researchers will check crown retention, gum health, plaque buildup, and parent satisfaction at 1…

This study tests a collagen-based bone graft material (Bio-Oss Collagen) for sinus augmentation in people with bone loss and missing teeth. The goal is to see if it helps grow enough bone to support a dental implant. The study involves 36 adults who need a single implant in the u…

This study compares two types of tooth-colored fillings for cavities on the chewing surface of back teeth. One is a new injectable resin composite, and the other is a conventional composite. Over 24 months, researchers will check how well each filling stays in place, resists stai…

This study compares two types of tooth-colored filling materials for cavities between teeth. 54 healthy adults aged 18-60 received fillings using either a standard bulk-fill composite or a newer thermoviscous material. Researchers will check the fillings at 6 and 12 months for ho…

This study compares two materials used to make dental onlays (a type of tooth filling for molars): a high-performance polymer called BioHPP and a ceramic called lithium disilicate. Forty participants received onlays made from one of these materials. Researchers will evaluate how …

This study tests two new dental filling materials for cavities in back teeth. 65 adults with cavities or old fillings that need replacing will receive the new fillings and be checked for pain, function, and appearance over 5 years. The goal is to see if the materials are safe and…

This study tests a new dual-cure adhesive used to bond ceramic inlays and onlays to teeth. Researchers will check how often patients have tooth sensitivity after the procedure and how well the restoration holds up over time. 45 adults aged 18-65 with cavities in molars or premola…

This study tests whether a new nano-based paste (chitosan-coated silver nanoparticles) works better than a standard antibiotic paste for treating infected baby molars in children aged 4-8. The goal is to reduce pain, swelling, and infection, and to see which paste kills bacteria …

This study compares three different dental adhesives used to repair non-carious cervical lesions (tooth damage not caused by cavities). Eighteen adults with at least three such lesions will receive restorations using a flowable composite resin. The goal is to see which adhesive p…

This study tests two calcium silicate-based dental cements, Biodentine and NeoPutty, for treating irreversible pulpitis (severe tooth nerve inflammation) in adults. Sixty participants with deep cavities and spontaneous pain will receive a single-session pulpotomy, where the infla…

This study tests a blue dye called BlueCheck to see if it can find early tooth decay and track whether the decay is healing. Twelve adults will wear a special denture with pieces of human tooth enamel for 28 days. The dye's results are compared to standard dental tools to see if …

This study tests whether a new toothpaste can prevent enamel erosion better than a standard cavity-protection toothpaste. Eighty healthy adults will brush twice daily for 18 days with either the test or control toothpaste. Researchers will measure enamel loss on a small block wor…

This study tests whether specially designed videos can help parents of young children prevent early childhood cavities. The program uses motivational messages to encourage good oral health habits. Researchers are following over 1,200 families enrolled in the WIC program in Iowa, …

This study tests whether adding a special glass material to standard fluoride varnish can better prevent root cavities in adults over 60. Researchers will compare the two varnishes in 540 older adults over 36 months. The goal is to see which one reduces new cavities and helps sto…

This study tests two different dental sealants—a resin-based and a glass ionomer-based—on partially erupted permanent molars in children aged 10-15. The goal is to see which one lasts longer and prevents cavities better over one year. Forty healthy children will each get both typ…

This study tests simple educational programs for parents of children aged 9 months to 3 years. The goal is to see if these brief lessons can help prevent cavities and reduce behavior problems. Researchers will track dental records and behavior outcomes for 750 children.

This study tests a silver diamine fluoride (SDF) gel to prevent cavities in 1,500 healthy preschool children. The gel is applied every six months for two years and compared to standard fluoride varnish. The goal is to see if the SDF gel better protects teeth from decay.

This study tests whether using a fluoride-releasing composite resin for aligner attachments can prevent white spot lesions (early cavities) during clear aligner therapy. Twenty-four people aged 16-24 with mild crowding will have one side of their mouth get the fluoride resin and …

This study tests a program for children in Colombia that combines water filters with educational sessions for parents and kids to reduce high fluoride exposure. About 90 children from kindergartens will take part, with half getting the full program and the other half receiving st…

This study tests a program to reduce high fluoride exposure in children living in Huila, Colombia. The program includes installing water filters at kindergartens and teaching parents and kids about healthy habits. Researchers will measure fluoride levels in children's urine and p…

This study tests whether applying fluoride varnish to teeth can prevent white spot lesions in people undergoing clear aligner treatment. Twenty-five participants aged 16 to 24 with mild crowding will have one side of their mouth treated with fluoride varnish and the other side le…

This study tests a special tooth sealant that works even on wet teeth. Researchers will apply the sealant to 500 molars in 250 children aged 7-11, comparing how well it holds up when the tooth is dried for 3 seconds versus 15 seconds. The goal is to see if the sealant prevents ca…

This study aimed to see if chewing xylitol gum could prevent cavities in children aged 5 to 14 living in Ladakh, India. Participants would have chewed gum with either 100% or 22% xylitol daily for a school year. However, the study was withdrawn before any children enrolled, so no…

This study tests whether teaching children in Uganda how to brush their teeth, use fluoride varnish, and eat healthy foods can prevent cavities. About 610 school children aged 5-17 will be split into two groups: one gets the prevention program, the other does not. Researchers wil…

This study tests three approaches to prevent cavities in 180 children aged 6-7 in Karachi, Pakistan. One group brushes with fluoride toothpaste, another adds dietary advice, and the third also gets sealants on their back teeth. The goal is to find the most effective and affordabl…

This study tests two ways to activate a bleaching gel on teeth: using a laser or an LED light. Researchers want to see which method whitens better, causes less tooth sensitivity, and leaves teeth smoother. 45 adults aged 20-35 who want whiter teeth will take part in this single-s…

This study tests whether using a portable light device (photobiomodulation) at home for 8 minutes daily can reduce pain, root damage, and improve gum health in adults getting braces. Fifty patients aged 18–35 who need premolar extractions will use the device alongside standard br…

This study tests a new toothpaste designed to reduce tooth sensitivity. About 850 people with sensitive teeth will brush twice daily for 8 weeks. Researchers will measure pain from air puffs and gentle touch to see if the new formula works better than other toothpastes.

This study tests whether using cold or laser-activated fluids during a root canal can reduce pain and kill more bacteria than standard treatment. Sixty adults with an infected lower molar will receive one of four rinses: room-temperature, cold, heated, or laser-activated sodium h…

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days an…

This study tested two different ways of applying a whitening gel to see which causes less tooth sensitivity. Forty adults with darker teeth received two bleaching sessions one week apart. One group had the gel applied for 40 minutes straight, the other for two 20-minute sessions.…

This study tests different ways of applying a dental adhesive and filling material to see which method keeps fillings intact and stain-free for up to 5 years. Fifty adults with cavities or old fillings needing replacement will receive four different filling types. The goal is to …

This study tests whether taking vitamin D3 before a root canal can reduce pain afterward. Fifty-four adults with low vitamin D and painful tooth inflammation will receive either a single high dose, a three-day course, or a placebo. Pain levels and painkiller use will be tracked f…

This study compares two ways to restore a full upper jaw with dental implants: placing the permanent teeth right away versus waiting 6 weeks. Researchers want to see which timing leads to better implant stability and patient satisfaction. 24 adults with healed upper jaw tooth los…

This study tests whether adding low-level laser therapy and vitamin D3 supplements to standard braces can help move teeth faster and reduce pain. Fifty adults with crowded lower front teeth will be split into groups: braces alone, braces plus vitamin D, or braces plus both laser …

This study compares two treatments for severe tooth pain: vital pulp therapy, which tries to save the tooth's nerve, and standard root canal treatment, which removes it. Researchers will measure pain after 24 hours and one week, and check healing at 6 and 12 months using AI to re…

This study looks at two ways to clean root canals (rotary vs. reciprocating files) and whether rinsing with very cold saline (cryotherapy) reduces pain after the procedure. Sixty adults with infected but painless teeth will be randomly assigned to one of four groups. Patients wil…

This study looks at whether rinsing with a green tea extract (EGCG) during a tooth-saving procedure (pulpotomy) can lower pain and improve success rates in adults with severe tooth decay. 64 participants with deep cavities will receive one of two rinses and one of two filling mat…

This study tests two ways to clean a tooth during a root canal: laser-activated irrigation and passive ultrasonic irrigation. Researchers want to see which method leads to less pain and better quality of life afterward. 90 adults with infected or damaged permanent teeth are takin…

This study tested whether laser therapy, a remineralizing paste called Remin Pro, or both together can reduce pain from sensitive teeth. Twenty-five adults with at least four sensitive teeth received one of the treatments and reported their pain levels over 12 months. The goal wa…

This study looks at pain after root canal treatment in adults with a tooth condition called irreversible pulpitis. Researchers are testing three different sealers (materials used to fill the root canal) to see which one leads to the least pain and need for painkillers. 75 partici…

This study tests whether a special nano calcium fluoride varnish, a diode laser, or both together can reduce tooth sensitivity. Thirty adults with sensitive teeth will receive one of the treatments and rate their pain on a scale. The goal is to see which approach provides the bes…

This study looks at whether applying cold therapy (cryotherapy) during a pulpotomy—a procedure to save a decayed tooth—can lower pain and improve quality of life afterward. About 82 adults with severe tooth pain will be treated, and their pain levels and daily comfort will be tra…

This study tests whether adding tiny antibacterial particles called mesoporous silica nanoparticles to standard root canal medication can reduce pain and kill more bacteria. Forty-two adults with infected lower molar teeth will receive one of three treatments: standard medication…

This study tests whether a personalized digital coaching app, used with an electric toothbrush, helps adults brush twice daily for two minutes. 230 participants from California dental clinics will use the app for 19 weeks, receiving tailored feedback and reminders. The goal is to…

This study tests whether a 10% carbamide peroxide gel, used at home, can make white spot lesions on teeth less noticeable. About 67 adults with white spots on their front teeth will use the gel and report their satisfaction. The researchers will also check for side effects like t…

This study looks at different ways to clean a tooth during a root canal to see which causes the least pain and improves quality of life. 90 adults with a specific type of tooth infection will be randomly assigned to one of three irrigation methods. They will report their pain lev…

This study tests whether a single injection of dexamethasone (a steroid) near the tooth can reduce pain after root canal treatment for people with severe, irreversible tooth inflammation. 44 adults with this condition will receive either the steroid or a placebo (salt water) inje…

This study tests two medications—Chlorhexidine gel and Nitrofurantoin paste—placed inside the tooth during root canal treatment to see which one reduces pain between visits better. 220 patients with infected teeth will report their pain levels before treatment and again after 24 …

This study looks at whether using cold, hot, or ultrasound-activated rinsing solutions can lower pain and bacteria after a root canal. Sixty adults with painful tooth pulp inflammation will receive one of four rinsing methods. The goal is to find which approach works best for a m…

This study tests whether a virtual reality (VR) game can lower anxiety and pain in children aged 6 to 10 during their first dental treatment. Half of the 88 kids will wear VR glasses showing an interactive game that explains each step, while the other half gets the standard 'tell…

This study compares two types of dental cement used to attach crowns and bridges: a newer resin-modified glass ionomer cement and a conventional glass ionomer cement. The goal is to see which one causes less tooth sensitivity after the procedure. About 496 people aged 15 to 70 wi…

This study compares three types of dental onlays (a type of filling that covers part of a tooth) for treating cavities. It involves 36 adults who each need at least three onlays. The onlays are made using 3D printing, milling, or indirect resin composite. Researchers will check h…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study looks at how well different types of dentures and implant-supported dental devices help people chew and how they affect quality of life. Researchers will compare conventional dentures, mini-implant overdentures, and implant-assisted partial dentures in 240 adults. The …

This study looks at whether artificial intelligence can help dentists plan where to place dental implants in people who have lost all their lower teeth. Researchers will use old CT scans to compare AI-generated implant plans with plans made by expert dentists. The goal is to see …

This study looks at how the size of root canal preparation and the amount of remaining tooth structure affect the survival of treated lower molars. Sixty patients with infected pulp will receive either a conventional or conservative root canal preparation. Researchers will track …

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study surveys general dentists in two UK regions to understand their knowledge and use of silver diamine fluoride (SDF), a liquid that stops tooth decay without drilling or needles. Researchers aim to identify barriers like training gaps or cost that prevent wider use in chi…

This study checks how many teeth remain functional 10 years after root canal treatment using a sealer called Endomethasone N. Researchers will review records from 179 adults who had the treatment at least 5 years ago. The goal is to understand the long-term success and safety of …

This study compares two methods for measuring root canal length during root canal treatment: a manual technique using hand instruments and a machine-assisted mechanical technique. Both methods use electronic devices called apex locators to improve accuracy. About 104 adults needi…

This study looks at two common treatments for cavities in children's baby molars: ferric sulfate and sodium hypochlorite. Researchers will check how well each treatment worked by examining kids aged 4-9 during routine dental visits over 2 years. The goal is to see which agent lea…

This study looks at how two ways of cleaning cavities—removing all decayed tissue versus leaving some softer tissue near the nerve—change the types of bacteria left in the tooth. Researchers will take samples from 48 adults with cavities and analyze the DNA of the bacteria. The g…

This study looks at whether changing clear aligners every 7 days or every 14 days affects tooth root shortening and pain. Fifty-two adults with mild to moderate crowding are randomly assigned to one of two wear schedules. Researchers measure root length from X-rays taken before a…

This study reviewed 31 earlier studies to better understand how common impacted canine teeth are, where they get stuck, what causes it, and how to diagnose it. The review found that upper canine impaction affects about 1% to 7% of people, often toward the roof of the mouth. Commo…

White spot lesions are a common cosmetic problem during orthodontic treatment. This study tests whether placing the small composite attachments on the tongue side of clear aligners, instead of the front, reduces these spots. Fifty-two young adults with mild to moderate crowding a…

This pilot study is looking at whether dental erosion (loss of tooth enamel) could be a non-invasive biomarker for esophagogastric cancer and other cancers. Researchers will survey 174 participants (cancer patients and healthy volunteers) about diet, habits, and GERD symptoms, an…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study measures how hot the inside of a tooth gets when dentists shave off a tiny bit of enamel (a common step before braces). Researchers will test two different tools on 40 teeth from 30 people to see which method causes less heat. Keeping the tooth cool is important becaus…

This study follows 100 head and neck cancer patients receiving standard radiotherapy to see how their teeth, gums, and saliva change over time. Researchers measure gum health, tooth condition, and quality of life before and after treatment. The goal is to better understand these …

This study compares four different dental filling materials in 20 patients with cavities in their back teeth. The fillings are evaluated over 9 months for how well they hold up, look, and affect tooth health. The goal is to see if newer bioactive materials perform better than sta…

This study compares two methods of making 3D-printed dentures: scanning directly inside the mouth versus scanning a traditional mold. Eight people with no teeth will try both types of dentures to see which one stays in place better. The goal is to find out if the newer, more comf…

This trial tests three common ways to move the gums aside (gingival displacement) when taking impressions for dental crowns. 39 adults needing a single front tooth crown will receive one of three methods: a retraction cord, a retraction paste, or a cord plus hemostatic gel. Resea…

This study follows 80 adults who received dental restorations made with CAD/CAM digital technology to treat tooth wear. Researchers will check how well these restorations hold up over 5 years, looking at factors like breakage, wear, and patient satisfaction. The goal is to see if…

This study looks at two different types of lower dentures held in place by dental implants in adults aged 60-70. The goal is to see which design distributes bite force more evenly and stays more securely in the mouth. Researchers will use special devices to measure bite balance a…

This study looks at whether a person's genetic makeup influences how well a dental treatment called vital pulp therapy works for saving teeth with pulpitis (tooth nerve inflammation). Researchers will collect saliva from 96 participants to analyze specific genes, then track treat…

This study compares different types of dental tools (matrix systems) used to rebuild the shape of a tooth when filling large cavities. Ninety adults with large cavities on the side of a back tooth will receive a standard filling, and the quality of the filling's shape and contact…

This study compares five different ways of using dental adhesives to repair worn teeth near the gum line (called non-carious cervical lesions). Thirty-four adults each received multiple fillings using different adhesive methods. The fillings were then checked after two years for …

This study compares two techniques for placing dental implants in people with no teeth: fully guided (using a surgical guide) and partially guided. Sixteen participants will receive implants in both jaws, and researchers will measure how accurate the implant positions are and how…

This study looks at whether certain inflammation markers in the blood can predict how well dental numbing shots work and how much pain people feel after treatment. Researchers will analyze blood samples from 150 adults with tooth inflammation (irreversible pulpitis) and compare t…

This study compares four new single-shade universal resin composites to a conventional composite for filling class 2 cavities (between teeth). 45 adults will receive 180 fillings, which will be evaluated at 6 and 12 months by blinded dentists using standard criteria. The goal is …