Which tooth medication eases root canal pain better? new trial aims to find out

NCT ID NCT07198919

ENROLLING_BY_INVITATION Symptom relief Sponsor: Altamash Institute of Dental Medicine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two medications—Chlorhexidine gel and Nitrofurantoin paste—placed inside the tooth during root canal treatment to see which one reduces pain between visits better. 220 patients with infected teeth will report their pain levels before treatment and again after 24 and 48 hours. The goal is to help dentists choose the most effective option for patient comfort.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Chlorhexidine gel and Nitrofurantoin paste
What this could lead to: If it works, this could help dentists choose a better medication to reduce pain between root canal appointments, making treatment more comfortable for patients.
What could go wrong: This is an early-phase study with a moderate number of participants. Results may not apply to all patients, and pain relief may vary. No serious risks are expected, but individual responses differ.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for INTRACANAL MEDICAMENT are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

dental pulp necrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRACANAL MEDICAMENT

Contacts and locations

Locations

AIDM

Karachi, Sindh, 74500, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.