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New peptide varnish could reverse white spots without drilling

NCT ID NCT07289932

ENROLLING_BY_INVITATION Disease control Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two different varnishes for treating white spot lesions, which are early signs of tooth decay common after braces. One varnish uses a self-assembling peptide to help rebuild enamel, while the other delivers calcium and phosphate. Thirty-eight people aged 15-25 will have each varnish applied to one side of their mouth, and the spots will be tracked for 9 months to see which works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Self-assembling peptide (P11-4) varnish and tri-calcium phosphate varnish
What this could lead to
If it works, this could offer a better way to reverse early tooth decay without drilling or fillings.
What could go wrong
This is a small, early-stage trial with only 38 people, so results may not apply to everyone. The treatments are compared to each other, not to a placebo, so we won't know if either is better than doing nothing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

enamel caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WHITE SPOT LESIONS

Contacts and locations

Locations

  • Ain-Shams University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.