Can enamel proteins or amniotic membrane save Children's teeth?
NCT ID NCT07252167
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two materials—enamel matrix derivative and amniotic membrane—to standard blood-clot therapy for regenerating roots of non-vital immature permanent front teeth in children aged 7 to 12. The goal is to see which approach best promotes root growth, closes the open apex, and heals any infection. The trial is active but not recruiting, with 39 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- enamel matrix derivative and amniotic membrane
- What this could lead to
- If successful, this could offer a better way to regenerate tooth roots and reduce the need for extractions in children with damaged immature teeth.
- What could go wrong
- This is a small early-phase trial with only 39 participants, so results may not apply widely. The treatments are experimental and may not improve root growth or healing.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Al Azhar university
Cairo, Egypt