Biliary tract disorder

This Phase 3 study tests odevixibat, a daily pill, in 254 children with biliary atresia who recently had Kasai surgery. The goal is to see if the drug can prevent the need for a liver transplant or death. Children take either odevixibat or a placebo for up to 2 years, and researc…

This trial tests an experimental antibody drug called CM-101 in adults with primary sclerosing cholangitis (PSC), a rare liver disease. The drug targets a protein called CCL24 to potentially reduce inflammation and scarring. Participants receive either CM-101 or a placebo by intr…

This study tests a two-pronged chemotherapy approach for people with intrahepatic cholangiocarcinoma (a type of bile duct cancer) that cannot be removed by surgery. Participants receive chemotherapy directly to the liver through a surgically placed pump, plus standard chemotherap…

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This study tests the long-term safety of maralixibat, an oral medication, in children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease that causes intense itching. Participants who completed a prior study will receive maralixibat twice daily. Resear…

This study tested a combination of three drugs—camrelizumab, apatinib, and chemotherapy (gemcitabine plus cisplatin)—in 49 people with advanced biliary tract cancer that could not be removed by surgery. The goal was to see if the combo is safe and how well it shrinks tumors. Resu…

This completed Phase 2 trial tested whether the drug pentoxifylline can help people with jaundice caused by liver or bile duct problems. 45 adults took 400 mg of pentoxifylline twice daily for 3 months, alongside standard care. Researchers measured changes in antioxidant levels, …

This completed Phase 2 trial tested whether N-acetylcysteine (NAC), a common antioxidant supplement, can help people with jaundice caused by liver or bile duct issues. 44 adults took NAC twice daily for 3 months alongside standard care. Researchers measured changes in antioxidant…

This study looked at 410 patients with a bile duct infection (cholangitis) who had a procedure to drain the bile duct. It compared giving antibiotics for just 1 day versus the usual 4 to 7 days. The goal was to see if the shorter course is just as good at curing the infection, wh…

This study tested a new drug called MK-1200 in 13 people with advanced solid tumors, including stomach, esophageal, bile duct, and pancreatic cancers. The goal was to find safe doses and see if the drug could shrink tumors. The study is complete, but results are not yet available…

This study tested a drug called seladelpar in 96 adults with primary biliary cholangitis (PBC), a rare liver disease. Participants had not responded well or could not tolerate the standard treatment. The goal was to see if seladelpar could lower a key liver enzyme (alkaline phosp…

This trial tested a three-drug combination—chemotherapy infused into the liver, an immunotherapy drug (tislelizumab), and a targeted pill (regorafenib)—as a first treatment for 31 people with advanced bile duct cancer that couldn't be removed by surgery. The goal was to see how m…

This study tested the safety of a drug called maralixibat in 27 infants under 12 months old with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC), two rare liver diseases that cause bile buildup. The drug is given as an oral solution and aims to reduce bi…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study looked at 484 high-risk surgical patients with acute cholecystitis (gallbladder inflammation) who first received a standard drainage tube through the skin. Some then had a newer procedure using an endoscope to place a metal stent inside the gallbladder. Researchers com…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers like breast, ovarian, stomach, colorectal, brain, bile duct, or pancreatic cancer that had stopped responding to standard treatments. The goal was to see if the combo c…

This study looked at the long-term safety and effectiveness of a drug called A4250 (odevixibat) in 116 children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease. The children took the drug for up to 72 weeks. The study measured changes in bile acid …

This study tested a drug called saroglitazar magnesium in 196 adults with primary biliary cholangitis (PBC), a chronic liver disease. Participants either took the drug or a placebo to see if it improved liver function markers. The goal was to lower certain liver enzymes and bilir…

This study looked at whether a drug called Remaxol can help people with gallstones and a serious complication called obstructive jaundice. Obstructive jaundice happens when a gallstone blocks the bile duct, causing yellowing of the skin and eyes. The study involved 286 adults who…

This Phase 3 trial tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine and cisplatin) helps people with advanced bile duct cancer live longer. The study enrolled 158 Chinese adults with cancer that had spread or could not be removed by…

This study tested two different chemotherapy drug combinations in 92 people with advanced bile duct or gallbladder cancer that could not be removed by surgery. The goal was to see which combination better kept the cancer from growing for at least 6 months. Participants received e…

This Phase 2 trial tested a combination of three treatments—local chemotherapy delivered via beads into the liver, a targeted drug called apatinib, and an immunotherapy (PD-1 antibody)—in 20 patients with advanced bile duct cancer that had worsened after standard first-line chemo…

This phase 2 trial tests the drug utidelone in 126 people with advanced solid tumors (excluding breast, lung, and colorectal cancers) that have not responded to standard treatments. The study aims to see if the drug can shrink tumors and how safe it is. Participants receive utide…

This study tested a fish oil emulsion called Omegaven to treat liver disease in 36 children who depend on long-term intravenous (IV) nutrition. The goal was to lower bilirubin levels, a sign of liver damage. The treatment aims to control the disease and improve liver function.

This study tested a new way to reconnect the pancreas to the intestine during Whipple surgery for certain cancers. The new method uses a stent and wraps the connection with omentum (fatty tissue) to try to prevent leaks. 48 patients were split into two groups to compare the new t…

This early-phase trial tested an experimental drug called BAT8010 in 23 people with advanced or metastatic solid tumors who had no other standard treatment options. The main goals were to check safety, find the best dose, and see if the drug shows any sign of shrinking tumors. Pa…

This study tested a new cancer drug called brigimadlin (BI 907828) in 266 adults with advanced solid tumors that had spread or stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors. Brigimadlin is an MDM2 inhibitor tak…

This study tested the safety and effectiveness of atorvastatin (Lipitor) in 15 children with Alagille syndrome who had skin cholesterol deposits called xanthomas. The children took the drug for 6 months, and doctors graded the size and number of the lumps. The goal was to see if …

This study tested a technique where a balloon is used to widen the bile duct opening and clear stones during emergency gallbladder removal surgery. 100 adults with bile duct stones took part. After surgery, an MRI scan checked if all stones were gone. The goal was to see if this …

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine/cisplatin) helps people with advanced bile duct or gallbladder cancer live longer. Over 1,000 participants received either the combination or chemo plus a placebo. The goal…

This study tested a procedure called EUS-guided gallbladder drainage (EGBD) as an alternative to gallbladder removal surgery for 30 adults with acute cholecystitis (gallbladder inflammation). The goal was to see if it could safely resolve symptoms like fever and pain without need…

This early-stage study tested a new drug called cabotamig in 33 adults with advanced cancers of the digestive system (like colon, pancreas, or liver) that had stopped responding to standard treatments. The goal was to see if the drug is safe and how it affects the body and tumors…

This phase 2 study tested a combination of two drugs, durvalumab and SNDX-6352, in 5 people with advanced bile duct cancer that had not spread beyond the liver. Participants first received standard chemo or radiation therapy directly into the liver, then the drug combination. The…

This study tested whether sulfasalazine, a drug used for arthritis, can improve liver health and symptoms in people with primary sclerosing cholangitis (PSC) who also have inflammatory bowel disease. 32 adults across the US took either the drug or a placebo for a set time. Resear…

This study tested a combination of the targeted drug regorafenib with chemotherapy (mGEMOX) in 66 people with advanced bile duct cancer that could not be removed by surgery. The main goal was to find the safest dose and check for side effects. This is not a cure, but aims to cont…

This phase 2 trial tested the immunotherapy drug nivolumab (Opdivo) in 54 patients with advanced biliary tract cancer that had stopped responding to chemotherapy. The goal was to see if the drug could shrink tumors. While nivolumab is approved for other cancers, it is not yet app…

This study tested a new drug called CNP-104 in 42 adults with primary biliary cholangitis, a rare liver disease, who did not get better with standard treatments. The drug is designed to calm the immune system's attack on the bile ducts. The main goals were to check safety and see…

This study tested a combination of two experimental drugs, AK112 and AK117, with or without chemotherapy, in 154 people with advanced solid tumors. The goal was to see if the combo could shrink tumors and control the disease. The trial has finished, and researchers are now lookin…

This study tested an experimental drug called E7090 in 63 people with advanced bile duct cancer that has a specific genetic change (FGFR2 fusion). Participants had already tried chemotherapy without success. The goal was to see if the drug could shrink tumors. Results help determ…

This study tested a new oral drug called RLY-4008 in 490 adults with advanced bile duct cancer or other solid tumors that have specific FGFR2 gene changes. The drug is designed to block the FGFR2 protein, which can drive cancer growth. The trial aimed to find the safest dose and …

This study compared two surgical methods—laparoscopic (keyhole) and open surgery—for treating a rare cancer near the pancreas called periampullary adenocarcinoma. Forty patients were enrolled to see which approach led to fewer complications like pancreatic fistula. The goal was t…

This phase II trial tested the drug infigratinib in 17 adults with advanced or metastatic solid tumors that have specific FGFR gene mutations. The drug works by blocking overactive FGFR proteins that help cancer grow. The study measured how many patients' tumors shrank or stabili…

This early-phase trial tested an oral drug called AG-120 in 174 people with advanced solid tumors (including bile duct cancer, cartilage cancer, and brain tumors) that have a specific IDH1 mutation. The study first found a safe dose, then expanded to see how well the drug works. …

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goal was to find the safest dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 we…

This study tested a combination of an immunotherapy drug (nivolumab) and chemotherapy drugs (nanoliposomal-irinotecan, 5-fluorouracil, and leucovorin) in 34 people with advanced biliary tract cancer that had worsened after initial treatment. The goal was to see if the combo could…

This study tested whether a Medtronic pump and Codman catheter can safely deliver chemotherapy directly to the liver in 35 people with colorectal cancer or bile duct cancer that spread to the liver. The main goal was to check safety, including liver side effects and need for sten…

This study tested a new combination treatment for people with advanced liver cancer or bile duct cancer. The treatment combines an immunotherapy drug (SHR-1210) with either a targeted therapy (apatinib) or chemotherapy. The goal was to see if the combination is safe and can shrin…

This phase 3 study tested TAK-625 (maralixibat) in 7 Japanese children with Alagille syndrome, a rare genetic liver disorder. The goal was to see if the drug reduces bile acid levels and itching, and to find the best dose. Participants took the drug daily for up to 34 months, wit…

This Phase 2a trial tested an experimental oral drug called PLN-74809 in 121 adults with primary sclerosing cholangitis (PSC) and suspected liver fibrosis. The main goals were to check the drug's safety and how it moves through the body. Participants received either the drug or a…

This study compared miniinvasive (robotic or laparoscopic) Whipple surgery to the traditional open approach in 320 patients with pancreatic, bile duct, or ampulla of Vater cancers. The goal was to see which method leads to fewer complications like pancreatic leaks, bleeding, or i…

This phase 2 trial tested a combination of two drugs, pembrolizumab (Keytruda) and lenvatinib (Lenvima), in 27 people with advanced biliary tract cancer that had worsened after standard treatment. The goal was to see if the combination could shrink tumors. The study is now comple…

This study tested a combination of three drugs (capecitabine, lenvatinib, and tislelizumab) given after surgery to 65 adults with biliary tract cancer. The goal was to see if this treatment could help keep the cancer from coming back. The results focus on how long patients lived …

This study tracked side effects in 236 people with advanced biliary tract cancer who received IMFINZI (durvalumab) together with standard chemotherapy (gemcitabine and cisplatin). The goal was to see how often adverse reactions happen in everyday medical practice, outside of a co…

This study looked at 400 people with liver cirrhosis who had large or complex bile duct stones that couldn't be removed during a first procedure. Doctors placed either one or two plastic stents to help drain the bile and make stones easier to remove later. The goal was to find th…

This completed Phase 4 trial tested a new surgical technique during Whipple surgery for resectable periampullary tumors. The method uses an omental patch and surgical glue to reinforce the pancreatic connection, aiming to reduce leaks, bleeding, and stomach emptying problems. Thi…

This phase III trial tested whether adding nab-paclitaxel to the standard two-drug chemo (gemcitabine and cisplatin) helps people with newly diagnosed, advanced biliary tract cancers live longer. Over 450 patients took part. The goal is to see if the three-drug combo improves ove…

This study looked at 234 adults with a rare bile duct condition called congenital biliary dilation, which can lead to serious health issues if not treated properly. Researchers developed a new way to classify the disease based on surgery needs, aiming to guide doctors in choosing…

This study looked at whether placing a temporary plastic tube (stent) in the bile duct after removing gallstones helps prevent stones from returning while patients wait for gallbladder surgery. 200 adults with both gallbladder and bile duct stones took part. Half got the stent, h…

This study tested a new way to open the bile duct during an ERCP procedure. Instead of the standard pull-type cut, doctors used a special hooked knife (ASD) designed to cut only the circular muscle layer, potentially causing less damage. Over 1,500 patients were randomly assigned…

This phase 2 trial tested a combination of three drugs—chemotherapy delivered directly to the liver, a targeted pill, and an immunotherapy—in 25 people with advanced bile duct cancer that could not be removed surgically. The goal was to see if the combination could shrink tumors …

This study tested whether adding a liver-directed chemotherapy infusion (HAIC) to a standard drug combo (Gemox, lenvatinib, toripalimab) helps people with advanced bile duct cancer live longer without the disease getting worse. 96 patients took part. The goal was to see if the ex…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This phase 1 study tested an experimental drug called LY3039478 in 247 people with advanced or metastatic cancer, including lymphoma. The main goal was to find a safe dose and see how the drug affects the body. Researchers also looked for signs that the drug might shrink tumors.

This study compared robotic-assisted pancreatic surgery to the standard open approach for people with pancreatic and related tumors. Researchers wanted to see if robotic surgery could help patients recover faster after the operation. A total of 268 patients took part across multi…

This phase 2 trial tested whether adding chemotherapy directly into the liver artery (hepatic arterial infusion) to standard bile duct drainage could help people with advanced perihilar cholangiocarcinoma live longer. The study enrolled 127 adults with inoperable cancer. One grou…

This study looked at the long-term safety of a drug called maralixibat in 52 people with cholestatic liver disease, including Alagille Syndrome and other rare conditions. Participants had already taken maralixibat in an earlier study. Researchers tracked side effects and how well…

This study tested a drug called odevixibat (A4250) in 62 children with progressive familial intrahepatic cholestasis (PFIC) types 1 and 2, a rare liver disease that causes severe itching and bile buildup. The drug works by blocking the reabsorption of bile acids in the gut. The g…

This early-phase study tested whether adding fenofibrate to standard treatment (ursodeoxycholic acid) helps people newly diagnosed with primary biliary cholangitis, a chronic liver disease. Thirty adults participated to see if the combination could normalize liver enzyme levels a…

This first-in-human study tested a single dose of PVT201, a nanoparticle-based drug, in 24 people: healthy volunteers and patients with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC). The main goal was to check safety and how the drug moves through the …

This pilot study tested a highly targeted form of radiation called stereotactic body radiation therapy (SBRT) in 36 patients with pancreatic cancer that could not be removed by surgery or had come back after other treatments. The main goal was to see how safe the treatment was by…

This study tested a drug called HTD1801 in 59 adults with primary sclerosing cholangitis (PSC), a rare liver disease. Participants took either a low dose, a high dose, or a placebo for 18 weeks. The main goal was to see if the drug could lower a liver enzyme called ALP, which is …

This study tested a doctor-designed dose adjustment algorithm to prevent unplanned delays in FOLFOX chemotherapy for people with cancers of the colon, stomach, esophagus, and other digestive organs. 52 adults participated, and the goal was to see if the algorithm could keep treat…

This study looked at 304 patients with mild to moderate acute cholangitis, a serious bile duct infection. Researchers compared performing ERCP (a drainage procedure) within 24 hours versus waiting 24 to 48 hours. The goal was to see if faster treatment reduces deaths within 30 da…

This phase 2 trial tested a new chemotherapy combination (Nal-IRI with 5-FU and leucovorin) against a standard treatment (gemcitabine plus cisplatin) in 93 people with advanced biliary tract cancer that could not be removed by surgery. The study aimed to see which approach better…

This study tested a combination of three drugs—chemotherapy (mFOLFOX6), an immunotherapy (atezolizumab), and a targeted therapy (bevacizumab)—in 20 people with advanced bile duct cancer who had already received one prior treatment. The goal was to see if the combination could shr…

This study tested whether adding bezafibrate to the standard drug obeticholic acid helps people with primary biliary cholangitis, a rare liver disease. 72 adults took part, and researchers measured changes in a key liver enzyme over 12 weeks. The goal is to see if the combination…

This study looked at whether giving antibiotics after gallbladder removal surgery helps prevent infections in people with mild to moderate gallbladder inflammation. Over 400 adults took part, receiving either antibiotics or no medication after surgery. The goal was to see if anti…

This study tested a drug called ZW25 (zanidatamab) in 87 people with advanced or metastatic HER2-amplified biliary tract cancer that had worsened after standard chemotherapy. The goal was to see if the drug could shrink tumors and how long that effect lasted. The trial is now com…

This study tested whether injecting epinephrine around the bile duct opening, combined with a standard rectal anti-inflammatory drug, could reduce pancreatitis after ERCP—a common procedure to treat bile duct blockages. Over 500 adults with a first-time ERCP took part. The goal w…

This study tested two types of endoscopes used in ERCP, a procedure to treat bile duct and pancreas problems. One scope had a single-use plastic cover on its tip, while the other was a standard reusable scope. Researchers compared how well each worked and how often complications …

This study tested proton beam radiation, a highly targeted form of radiotherapy, in 83 people with liver cancer that could not be surgically removed. The goal was to see if this precise approach could control tumors while reducing damage to healthy tissue. Participants received d…

This study tested a new drug called zanidatamab (ZW25) combined with standard chemotherapy in 74 people with advanced HER2-positive cancers of the stomach, bile duct, or colon. The goal was to see if the combination is safe and shrinks tumors. Results will help decide if larger s…

This phase 2 trial tested colchicine, a drug usually used for gout, in 42 people with advanced liver cancer that could not be treated with curative intent. Participants took colchicine tablets daily in cycles of 4 days on, 3 days off. The study measured how long patients survived…

This early-phase trial tested an experimental immunotherapy called ELI-002 in 25 people with KRAS-mutated pancreatic, colorectal, lung, ovarian, or bile duct cancers who had signs of remaining disease after standard treatment. The therapy aims to train the immune system to attack…

This pilot study tested high dose rate brachytherapy, a type of internal radiation, in 43 patients with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could deliver the planned dose accurately. Participants received b…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at how well a special biopsy method called EUS-FNB can diagnose hard-to-reach tumors in the abdomen, such as those near the bile duct or small intestine. Researchers reviewed data from 131 patients who had this procedure over 10 years. The goal was to see if thi…

This study looked at different ways to take tissue samples from the bile duct during a procedure called ERCP. The goal was to see which method is most accurate for finding cancer. 327 adults with unclear bile duct narrowing took part. Researchers compared several biopsy technique…

This completed study tested a device called NvisionVLE® that helps doctors see bile duct details during a procedure called ERCP. Only 3 adults who had the procedure between 2017 and 2019 took part. The goal was to check if the device is safe and can better find abnormalities to g…

This completed study tested a new blood test that looks for tiny particles called exosomal microRNAs to detect intrahepatic cholangiocarcinoma, a rare and aggressive liver cancer. Researchers analyzed blood samples from 535 adults to see how accurately the test could identify can…

This study tested a new blood test called LyMIC that looks for tiny particles (exosomes) released by cancer cells. The goal was to see if it could accurately tell whether bile duct cancer has spread to nearby lymph nodes before surgery. Researchers analyzed blood samples from 230…

This study compares two ways to get tissue samples from a suspected hilar bile duct cancer: one using an endoscope with ultrasound guidance (EUS-FNA/B) and another using a scope to look directly into the bile ducts (ERCP with or without a special camera). Researchers will check w…

This study tested whether a wired magnetic capsule endoscopy system produces fewer airborne droplets than traditional endoscopy when checking for esophageal varices in people with biliary atresia. Fifty participants underwent either the capsule or standard procedure. The main goa…

This study tested a new radioactive tracer called [18F]FAPI-74 for PET scans in people with gastrointestinal cancers, including liver, bile duct, stomach, pancreatic, and colorectal cancers. The goal was to see if the tracer can accurately detect cancer cells by comparing scan re…

This study tested a new way to check gallbladder function using ultrasound after drinking special fatty acids. 100 adults with normal bile ducts took part. The goal was to see if this method can accurately measure how well the gallbladder squeezes and empties.

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This study tested how well a special MRI scan called LiverMultiScan can measure liver fat, iron, and scarring. 61 adults with various liver diseases had up to 6 scans on different machines. The goal was to see if the results are consistent when repeated on the same scanner or on …

This study tested whether a noninvasive device called FibroScan can accurately measure liver scarring (fibrosis) in children, potentially replacing the need for a liver biopsy. Researchers compared FibroScan results with biopsy results in 264 children aged 6 months to 18 years wi…

This large completed trial tested whether an AI system can help radiologists better diagnose liver tumors from CT scans. Over 10,000 adults with various liver conditions participated. The AI analyzed scans overnight, and a senior radiologist reviewed any differences between the A…

This study looked at whether a special ultrasound using gas microbubbles can predict how well bile duct cancer responds to targeted radiotherapy. The ultrasound can also pop these bubbles, which might make the cancer easier to treat. Sixteen adults with bile duct cancer took part…

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

This study tested whether a green dye injected into the blood can help surgeons see bile ducts better during gallbladder removal for acute cholecystitis, compared to the standard contrast dye. 156 adults with mild to moderate gallbladder inflammation took part. The goal was to se…

This study tested whether adding acupuncture to standard anti-nausea drugs could better prevent nausea and vomiting after laparoscopic gallbladder removal. 270 adults scheduled for surgery received either acupuncture plus standard drugs or standard drugs alone. The goal was to se…

This study looked at whether giving more IV fluids (aggressive hydration) during an ERCP procedure can prevent pancreatitis, a common complication. 126 adults having their first ERCP were randomly assigned to receive either standard or extra fluids. The goal was to see if extra f…

This study tests whether preserving the cystic artery during laparoscopic gallbladder removal can reduce complications like bleeding. Two hundred patients with symptomatic gallstones will be split into two groups: one where the artery is preserved and one where it is clipped or b…

This study looked at whether emergency gallbladder removal (laparoscopic cholecystectomy) can be performed as an outpatient procedure, meaning patients go home the same day. Researchers measured patient satisfaction using a simple scale. The study enrolled 25 adults with acute ch…

This pilot study tested a plastic stent with a retrieval string to drain bile in 40 people with resectable bile duct cancer. The goal was to see if the stent could safely reduce bile buildup before surgery. Researchers measured serious complications and how well the stent worked.

This study tested a new way to remove a stubborn gallbladder during keyhole surgery. When the gallbladder is too large or thick to pull out easily, surgeons often make a bigger cut, which can cause bleeding and pain. The new method uses three tiny star-shaped cuts around the open…

This study tested whether a nerve block called a TAP block can reduce pain after laparoscopic gallbladder removal. Sixty adults were split into two groups: one received the block plus standard painkillers, the other only standard painkillers. Researchers measured pain levels and …

This study tested whether a rectointercostal nerve block can reduce pain and the need for strong painkillers after laparoscopic gallbladder removal. 60 adults having elective surgery received the block as part of their pain management plan. The goal was to see if it lowers opioid…

This study tested a 10-week online wellness program for women with primary biliary cholangitis (PBC), a chronic liver disease that causes fatigue, itching, brain fog, and emotional distress. The program included guided breathing, meditation, gentle movement, and optional nutritio…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether listening to nature sounds while walking after gallbladder surgery could reduce anxiety, pain, and stress. Seventy adults who had laparoscopic cholecystectomy took part. Patients walked 50 meters while hearing nature sounds, then returned to bed. Their a…

This study looked at 121 patients with blocked bile ducts (biliary obstruction) to see which drainage method—endoscopic (through a scope) or percutaneous (through the skin)—led to a better quality of life. Researchers measured changes in mobility, self-care, pain, and anxiety. Th…

This study tested a personalized dose of a dye called indocyanine green (ICG) to help surgeons see bile ducts more clearly during emergency gallbladder removal. 21 patients with acute cholecystitis received a dye dose calculated from their MRI scans. The goal was to improve surgi…

This completed study tested a new painkiller called tegileridine in 150 adults who had gallbladder surgery. Participants received either the drug or a placebo through a vein, along with standard pain management. The goal was to see if tegileridine reduces pain and the need for ex…

This study looked at whether reducing noise during the start of anesthesia (when you go to sleep) can improve recovery after laparoscopic gallbladder removal. 105 adults having planned surgery were included. Researchers measured pain, nausea, vomiting, heart rate, blood pressure,…

This study tested two different nerve block methods to control pain after laparoscopic gallbladder removal. Sixty adults having elective surgery received either a modified thoracoabdominal nerve block or a standard abdominal plane block. Researchers measured recovery quality and …

This study looked at whether mindfulness exercises can lower stress and improve communication between patients with liver disease and their doctors. 56 adults took part, answering surveys about their stress, anxiety, and how well they felt they could share decisions with their he…

This study tested a new way to remove the gallbladder using a harmonic scalpel instead of metal clips to seal blood vessels and bile ducts. The trial involved 158 adults with gallstones who were scheduled for elective surgery. The goal was to see if the clipless method reduces su…

This study looked at whether a TAP block (a type of nerve block) can reduce pain after laparoscopic gallbladder removal. Sixty adults were split into two groups: one got the TAP block with numbing medicine after surgery, the other did not. Researchers measured pain levels and how…

This study tested a different surgical method (fundus-first) versus the standard method for removing difficult gallbladders in 174 adults. The goal was to see if the new method lowers the risk of bile duct injury, a serious complication. Participants had conditions like acute cho…

This study looked at whether adding dexmedetomidine to a common numbing medicine (bupivacaine) could improve pain control after laparoscopic gallbladder removal. Thirty adults having elective surgery were randomly assigned to receive either the combo or bupivacaine alone, sprayed…

This study tested whether using a needle to drain a swollen gallbladder during laparoscopic removal makes the operation easier and safer. 70 patients with acute cholecystitis, gallbladder mucocele, or empyema were randomly assigned to have their gallbladder drained or not. The go…

This study tested a drug called TAK-625 (maralixibat) in 5 Japanese children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease that causes severe itching. The main goal was to see if the drug reduces itching over 26 weeks. Researchers also checked sa…

This study tested whether aromatherapy foot massage can reduce pain, improve sleep, and speed recovery after laparoscopic gallbladder removal. 103 adults received two 10-minute foot massages with essential oils after surgery. Researchers measured pain, sleep quality, and recovery…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study looked at whether having a palliative care team work alongside surgeons improves quality of life for patients with gastrointestinal cancers like pancreatic or liver cancer. About 379 patients and their family members took part. The main goal was to see if this team app…

This study tested whether adding acupuncture at a specific point (GB34) to standard medical care could help people with mild gallbladder inflammation (acute cholecystitis). Thirty hospitalized adults received either acupuncture plus usual treatment or usual treatment alone. The g…

This study tested whether lidocaine, a common numbing drug, works as well as remifentanil (an opioid) for pain after laparoscopic gallbladder removal. 138 adults took part. The goal is to find effective pain relief with fewer opioid side effects.

This study tested whether showing patients a 10-15 minute video about post-surgery care (pain, diet, wound care, warning signs) before they leave the hospital helps them recover better after laparoscopic gallbladder removal. 92 adults took part, with half getting the video plus u…

This study tested whether using a stress ball before gallbladder removal surgery helps reduce patients' fear, anxiety, and stress while improving comfort. Ninety adults scheduled for laparoscopic gallbladder removal were randomly assigned to either use a stress ball or receive st…

This study looked at placing a small metal tube (stent) into the portal vein of 63 cancer patients whose vein was blocked by a tumor. The goal was to relieve serious symptoms like fluid buildup in the belly or bleeding in the gut. The procedure was done through a needle in the li…

This study tested two common painkillers, ketamine and lidocaine, to see which works better for pain after gallbladder removal. 76 adults were randomly assigned to receive one of the drugs right after surgery. Researchers measured their pain levels over the next 24 hours. The goa…

This study tested two common drugs, lidocaine and magnesium sulfate, to see which one works better for pain after gallbladder removal surgery. 168 adults received one of the two drugs during surgery, and their pain levels were checked at several points over 24 hours. The goal was…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This study tested different ways to control pain after laparoscopic gallbladder removal in 160 adults. Patients received either a TAP block (an injection into the abdominal wall muscles), local anesthetic at the incision sites, both, or no extra pain relief. The TAP block group r…

This study tested whether a TENS device (which sends mild electrical pulses through the skin) can help people recover after laparoscopic gallbladder removal. 140 adults were randomly assigned to receive TENS or standard care in the first 24 hours after surgery. Researchers measur…

This study tested two types of nerve blocks—Quadratus Lumborum (QL) and Erector Spinae (ESP)—to see which provides better pain relief after abdominal surgery. 100 adults having surgery for colorectal, prostate, or kidney cancer, or gallbladder removal, received one of the blocks …

This study investigates whether PET-CT scans can accurately measure the radiation dose delivered by radioactive spheres during a liver cancer treatment called radioembolization. Researchers will compare scans taken before and after the procedure in patients with liver tumors. The…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study reviewed medical records of 320 children with biliary atresia, a rare liver disease, treated at hospitals in the northeastern U.S. between 2012 and 2021. The goal was to find which factors lead to better outcomes, such as avoiding liver transplant or clearing jaundice.…

This completed study looked at 3000 patients having liver surgery to see if considering both medical and social factors could reduce how long they stay in the hospital. Researchers tracked things like complications and readmissions. The goal is to find ways to improve recovery an…

This study looked at whether the amount of three types of bacteria in stool samples is linked to gallbladder cancer risk. Researchers compared 230 South American patients with gallstones, some who had gallbladder cancer and some who did not. The goal was to confirm earlier findin…

This study looked at 120 South American patients with gallstones to confirm if certain bacteria in stool are linked to gallbladder cancer risk. Researchers measured three types of gut bacteria using advanced DNA sequencing. The goal was to validate earlier findings that these bac…

This study explored whether the Mallampati score, a simple visual check of the mouth, can help predict complications and patient satisfaction after laparoscopic gallbladder removal. Researchers studied 470 adults aged 20-50 with a BMI of 35 or less. The goal was to gather informa…

This study compared two methods of creating the first opening (pneumoperitoneum) in laparoscopic gallbladder removal: one through the belly button and one just below it. Researchers looked at how fast each method was, complications, pain, hospital stay, and cosmetic satisfaction.…

This study compared two ways to manage a patient's airway during laparoscopic gallbladder surgery: a video laryngeal mask and an endotracheal tube. Researchers measured how long each took to insert and checked breathing and pressure readings. The goal was to see if the video mask…

This study looked at 13 people aged 15 to 70 who had their gallbladder and bile duct stones removed. Right after surgery, doctors placed a small tube in the bile duct to measure pressure, then checked it weekly for six weeks. The goal was to understand how the bile duct heals and…

This study followed 159 people with metastatic colorectal, pancreatic, biliary, or esophageal cancers who were starting a new line of therapy. Researchers collected blood samples (tumor markers and liquid biopsies) and patient-reported quality-of-life data to see if these could p…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This completed Phase 1 study looked at how the drug seladelpar (Livdelzi) is processed in 24 people with primary biliary cholangitis (PBC) who also have liver impairment. Researchers measured drug levels in the blood and urine to see how the liver condition affects the drug. The …

This study tested a wearable sensor called ADAM to measure scratching and sleep patterns in 30 people with primary biliary cholangitis (PBC), a rare liver disease that often causes intense itching and poor sleep. Participants wore the sensor for 7 nights across four 7-day periods…

This study looked at 1435 patients with acute cholangitis (a bile duct infection) who had an ERCP procedure. Researchers analyzed bile samples to understand which bacteria were causing the infections and how resistant they were to antibiotics. The goal was to find patterns that c…

This study looked at whether using a special ultrasound probe (IDUS) during a procedure to remove bile duct stones can help predict if stones will come back. 248 adults at high risk for recurrence were randomly assigned to get IDUS or not. Researchers tracked stone return, need f…

This study looked at medical records of 729 people in Japan with biliary tract cancer that could not be removed by surgery. Researchers wanted to see if bile duct problems during first treatment affected how long patients could stay on that treatment. The study did not test any n…

This study looked at 130 patients with gallstones who had their gallbladder removed by keyhole surgery. Researchers compared the ultrasound results done before surgery with what the surgeon actually found during the operation. The goal was to see if ultrasound can predict when th…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study looked at 120 adults with breast, pancreatic, or biliary cancer to see if a new 3D measurement method (TDTP-RECIST) is better than the standard way (RECIST 1.1) for tracking tumor shrinkage before surgery. Researchers compared imaging results with actual tumor tissue r…

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study looked at 237 patients who had a single surgery to remove both their gallbladder and any gallstones stuck in the bile duct. Researchers wanted to see if the COVID-19 pandemic changed how safe or effective this procedure was. They found that the surgery remained a good …

This completed study looked at 169 patients with a type of liver cancer called intrahepatic cholangiocarcinoma. Researchers used MRI scans and machine learning to measure scar tissue and a protein linked to tumor growth. The goal was to see if these features could predict how lon…

This study tested a new artificial intelligence (AI) tool designed to help doctors safely drain an infected gallbladder in patients who cannot have surgery. The AI was used during an endoscopic ultrasound procedure to guide placement of a special stent. Researchers compared the A…

This pilot study looked at how two different diets affect people with primary sclerosing cholangitis (PSC), a rare liver disease. Twenty adults were randomly assigned to either a vegan/low-sulfur diet or the specific carbohydrate diet for 8 weeks, with support from dietitians. Th…

This study tested whether a blood test that looks at tiny particles called exosomes can find cancer that has spread but is not visible on scans in people with a type of bile duct cancer (intrahepatic cholangiocarcinoma). The goal was to help doctors know who needs stronger treatm…

This study tested new MRI and MRE techniques that let children breathe normally during scans, instead of holding their breath. The goal was to measure liver fat and stiffness more comfortably and accurately in kids with fatty liver disease. 135 children aged 6-17 took part, and t…

This study looked at whether two simple frailty questionnaires (G8 and VES-13) can predict serious side effects from chemotherapy in people 65 and older with gastrointestinal cancers. Researchers followed 72 patients receiving standard chemotherapy and checked their frailty, nutr…

This study followed 711 adults with primary biliary cholangitis (PBC) for 5 years to see how the disease is managed in everyday medical practice. Researchers collected data on treatments, lab results, and side effects, and also stored blood samples for future genetic research. Th…

This study looked back at the medical records of 609 people treated for gallbladder inflammation (cholecystitis) in Villavicencio, Colombia, between 2019 and 2022. The goal was to understand how quickly patients received care, what treatments they got, and how many had complicati…

This study followed 200 babies with biliary atresia who had Kasai surgery at different ages to see which timing gives the best chance of keeping their own liver healthy for two years. Researchers grouped babies by surgery age (from under 28 days to 120 days) and tracked how many …

This study tested a new single-use duodenoscope (aScope) in 59 patients at high risk of infection after ERCP, a procedure to treat bile duct problems. The goal was to see if the scope works well and to gather information on costs and complications. The results could help decide i…

This completed study used artificial intelligence to examine CT scans from 274 liver cancer patients who had already received radiation therapy. The goal was to find the radiation dose that causes a visible liver reaction, which could help doctors avoid liver injury in future tre…

This study looked at 360 patients who had gallstone removal surgery with a T-tube drain. Doctors compared a new continuous stitching method to the traditional interrupted stitch for closing the bile duct. The goal was to see which method is faster and just as safe. Results could …

This completed registry study gathered information from 159 people with biliary tract cancers, including gallbladder cancer. The goal was to create a detailed database of patient experiences, treatments, and quality of life to help guide future research. No new drug or treatment …

This study looked at 150 adults having gallbladder surgery to see if fatty liver disease (MAFLD) makes a special imaging technique less clear. The imaging uses a dye to help surgeons see bile ducts. Researchers found that fatty liver can reduce image quality and created a way to …

This study looked at whether two easy-to-use frailty checklists (FRAIL and FiND) can predict severe side effects from chemotherapy in adults aged 65 and older with gastrointestinal cancers. Researchers followed 84 patients who had already had surgery and were receiving standard c…

This completed study followed over 1,000 people who had an ERCP procedure to see if having chronic gallbladder disease increases the chance of complications like infection or inflammation. Researchers tracked issues such as post-ERCP cholecystitis, pancreatitis, and cholangitis. …

This study looked at 75 patients in Nepal who had bile duct stones removed using a reused Ambu aScope, a cheap disposable scope normally used for breathing tubes. The goal was to see if reusing it is safe and effective in low-resource settings where expensive scopes aren't availa…

This study looked at 128 people having gallbladder surgery to see if giving them extra oxygen before anesthesia (instead of using a mask to help them breathe) would reduce stomach bloating and sore throat. The researchers compared two groups: one that got mask ventilation and one…

This study looked at people with advanced solid tumors (like lung, bladder, or melanoma) who had been on immunotherapy for one year and whose disease was stable. Half stopped treatment and half continued. The goal was to see if stopping early affected how long until the cancer pr…

This study followed over 1,000 people whose bile ducts were found to be wider than normal by chance, without causing symptoms. Researchers collected data from 25 hospitals in China to learn how common this condition is, what types exist, and whether surgery helps prevent future p…

This study tracked over 700 people in Korea who were already receiving the cancer drug Imfinzi (durvalumab) for lung or biliary tract cancer. The goal was to see how safe and effective the drug is in everyday medical practice, not just in strict clinical trials. Researchers monit…

This study tested whether using a dye called indocyanine green along with infrared light helps surgeons see the bile ducts more clearly during gallbladder removal surgery. Over 600 adults having their gallbladder taken out were randomly assigned to either standard white light or …

This study looked at how patients recover after robotic surgery to remove part of the pancreas (pancreaticoduodenectomy). It included 91 adults with tumors in the pancreas or nearby areas. The main goal was to see how long they stayed in the hospital and how quickly they returned…

This study looked at over 121,000 procedures to remove gallstones from the bile duct using a scope (ERCP). Researchers wanted to see if the level of sedation given during the procedure affected whether stones were left behind. They found that deeper sedation might help the doctor…

This study looks at the genetic makeup of 1,500 people with Primary Biliary Cirrhosis (PBC), a rare liver disease, along with their close relatives. By comparing genes, researchers hope to find inherited factors that make someone more likely to develop PBC. The goal is to better …

This study looked at 559 patients who had their gallbladder removed laparoscopically to find out when surgical drains are truly needed. Drains are sometimes placed to prevent fluid buildup or infection, but many studies show they aren't always necessary. The goal is to help docto…

This study tested the EchoTip AcuCore, a needle used during endoscopic ultrasound to collect tissue samples from the pancreas, liver, and other organs. 183 adults with conditions like cancer or chronic pancreatitis took part. The main goal was to see if the needle could get a goo…

This completed study followed over 18,000 Taiwanese Buddhists to see if a vegetarian diet is linked to a lower risk of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers compared health records…

This completed study followed 44 adults who had Whipple surgery for cancers near the pancreas. Researchers measured changes in the remaining pancreas, including its size, metabolism, and nutrition levels, before surgery and at 3 and 6 months after. The goal was to learn how the b…