New chemo combo shows promise for deadly bile duct cancer
NCT ID NCT05024513
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tested whether adding chemotherapy directly into the liver artery (hepatic arterial infusion) to standard bile duct drainage could help people with advanced perihilar cholangiocarcinoma live longer. The study enrolled 127 adults with inoperable cancer. One group received drainage plus the chemo drugs oxaliplatin and 5-fluorouracil, while the other group received drainage plus supportive care only. The main goal was to see if the chemo combination improved overall survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- oxaliplatin and 5-fluorouracil (chemotherapy drugs given directly into the liver artery)
- What this could lead to
- If this works, it could offer a new treatment option that extends survival for people with advanced bile duct cancer that cannot be removed by surgery.
- What could go wrong
- This is a phase 2 trial with 127 participants, so results are still preliminary. The chemotherapy may cause side effects like nausea, low blood counts, or liver problems, and the survival benefit may not be large enough to change standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Interventional Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),Peking University Cancer Hospital and Institute
Beijing, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a One-Two punch of heat and drainage tame inoperable bile duct cancer?
- Heat therapy before stenting may extend bile duct patency in cancer patients
- String-Attached stent may ease bile duct cancer surgery prep
- Personalized cancer care: new trial aims to improve outcomes in biliary cancer
- New stent technique may lower infection risk in bile duct cancer patients