New pill shows promise for rare liver disease
NCT ID NCT03333928
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called HTD1801 in 59 adults with primary sclerosing cholangitis (PSC), a rare liver disease. Participants took either a low dose, a high dose, or a placebo for 18 weeks. The main goal was to see if the drug could lower a liver enzyme called ALP, which is a marker of liver damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HTD1801 (a drug taken as tablets)
What this could lead to
If it works, this could point toward a treatment to control PSC and improve liver health.
What could go wrong
This is an early Phase 2 trial with only 59 people, so results may not apply to everyone. The drug may not work better than placebo or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Arizona Liver Health
Chandler, Arizona, 85224, United States
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Arizona Liver Health
Tuscon, Arizona, 85711, United States
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Aspen Woods Clinic
Calgary, Alberta, T3H 0V5, Canada
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Cumberland Research Associates
Fayetteville, North Carolina, 28304, United States
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Florida Research Institute
Lakewood Rch, Florida, 34211, United States
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Fresno Clinical Research Center
Fresno, California, 93720, United States
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Gastro One
Germantown, Tennessee, 38138, United States
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Gastrointestinal Associates
Flowood, Mississippi, 39232, United States
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Keck School of Medicine of USC
Los Angeles, California, 90033, United States
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Mercy Medical Center
Baltimore, Maryland, 21202, United States
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Michigan Medicine University of Michigan
Ann Arbor, Michigan, 48109, United States
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Mount Sinai - Icahn School of Medicine
New York, New York, 10029, United States
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Pinnacle Clinical Research
Austin, Texas, 78746, United States
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Pinnacle Clinical Research
San Antonio, Texas, 78229, United States
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South Denver Gastroenterology, PC
Englewood, Colorado, 80113, United States
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Swedish Medical Center
Seattle, Washington, 98104, United States
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Toronto Centre for Liver Disease, Toronto General Hospital
Toronto, Ontario, M5G 2C4, Canada
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University of Colorado, Denver
Aurora, Colorado, 80045, United States
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University of Miami
Miami, Florida, 33136, United States
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University of Washington
Seattle, Washington, 98104, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
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Wake Forest Baptist Health
Winston-Salem, North Carolina, 27157, United States
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Walter Reed National Military Medical Center
Bethesda, Maryland, 20889, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale School of Medicine
New Haven, Connecticut, 06520, United States