New drug aimed at slowing liver damage in rare bile duct disease
NCT ID NCT04480840
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2a trial tested an experimental oral drug called PLN-74809 in 121 adults with primary sclerosing cholangitis (PSC) and suspected liver fibrosis. The main goals were to check the drug's safety and how it moves through the body. Participants received either the drug or a placebo for up to 24 weeks. The study is complete, but results on effectiveness are not yet available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PLN-74809 (an experimental oral drug)
What this could lead to
If successful, this could point toward a treatment that slows liver damage in people with primary sclerosing cholangitis.
What could go wrong
This is an early Phase 2a trial focused on safety and drug levels, not yet on effectiveness. The drug may not work or could have side effects.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PRIMARY SCLEROSING CHOLANGITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
(G.I.R.I) GI Research Institute
Vancouver, British Columbia, V6Z 2K5, Canada
-
Amsterdam UMC
Amsterdam, 1105 AZ, Netherlands
-
Aspen Woods Clinic
Calgary, Alberta, T3H 0V5, Canada
-
Baylor College of Medicine - Advanced Liver Therapies
Houston, Texas, 77030, United States
-
Bon Secours Liver Institute of Hampton Roads
Newport News, Virginia, 23602, United States
-
C.H.U. Hautepierre
Strasbourg, 67200, France
-
CHU Grenoble Alpes - Hôpital Michallon
Grenoble, 38043 CEDEX 9, France
-
CHU de Lille service MAD
Lille, 59037, France
-
California Liver Research Institute
Pasadena, California, 91105, United States
-
California Pacific Medical Center Research Institute
San Francisco, California, 94109, United States
-
Centre Hépato-Biliaire - Hôpital Paul-Brousse
Villejuif, 94800, France
-
Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM)
Montreal, Quebec, H2X 0A9, Canada
-
Charité University Medicine Berlin
Berlin, 13353, Germany
-
Department Gastroenterology, Hepatopancreatology and Digestive Oncology CUB Hôpital Erasme
Brussels, 1070, Belgium
-
Duke University Medical Center
Durham, North Carolina, 27710, United States
-
Erasmus University Medical Center
Rotterdam, 3015 GD, Netherlands
-
Florida Research Institute
Lakewood Rch, Florida, 34211, United States
-
Ghent University Hospital
Ghent, 9000, Belgium
-
Henry Ford Health System
Novi, Michigan, 48377, United States
-
Indiana University Health University Hospital
Indianapolis, Indiana, 46202, United States
-
John Radcliffe Hospital/Oxford University Hospital
Headington, Oxford, OX3 9DU, United Kingdom
-
King's College Hospital NHS Foundation Trust, Denmark Hill
London, SE5 9RS, United Kingdom
-
Leiden University Medical Center
Leiden, 2333 ZA, Netherlands
-
Liver Institute Northwest
Seattle, Washington, 98105, United States
-
Liverpool Hospital: Department of Gastroenterology and Hepatology
Liverpool, New South Wales, 2170, Australia
-
London Health Sciences Centre-University Hospital
London, Ontario, N6A 5A5, Canada
-
Massachusetts General Hospital Gastroenterology Liver Center
Boston, Massachusetts, 02114, United States
-
McGill University Health Centre
Montreal, Quebec, H4A3J1, Canada
-
McMaster University Medical Centre
Hamilton, Ontario, L8N 3Z5, Canada
-
Medical University of Vienna Div. of Gastroenterology and Hepatology
Vienna, A-1090, Austria
-
Medizinische Universität Graz
Graz, 8036, Austria
-
Norfolk and Norwich University Hospitals NHS Foundation Trust
Norwich, Norfolk, NR4 7UY, United Kingdom
-
Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104, United States
-
Piedmont Atlanta Hospital
Atlanta, Georgia, 30309, United States
-
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
-
Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
-
Saint Antoine Hospital/ Hepatology Department
Paris, 75012, France
-
Schiff Center of Liver Diseases/University of Miami
Miami, Florida, 33136, United States
-
Sir Charles Gairdner Hospital
Nedlands, Western Australia, 6009, Australia
-
St. Vincent's Hospital
Melbourne, Victoria, 3065, Australia
-
Stanford University School of Medicine
Redwood City, California, 94063, United States
-
The Alfred
Melbourne, Victoria, 3004, Australia
-
The Ottawa Hospital
Ottawa, Ontario, K1H 8L6, Canada
-
Toronto Centre for Liver Disease (TCLD), University Health Network, Toronto General Hospital
Toronto, Ontario, M5G 2C4, Canada
-
UZ Leuven
Leuven, 3000, Belgium
-
Universitair Ziekenhuis Antwerpen
Edegem, 2650, Belgium
-
University Hospital Erlangen
Erlangen, 91054, Germany
-
University Hospital Heidelberg
Heidelberg, 69120, Germany
-
University Hospitals Birmingham NHS
Birmingham, B15 2GW, United Kingdom
-
University Medical Center Hamburg -Eppendorf/ I. Dept of Medicine
Hamburg, 20246, Germany
-
University of Alberta Hospital - Walter C. Mackenzie Health Sciences Centre
Edmonton, Alberta, T6G 2X8, Canada
-
University of California San Francisco
San Francisco, California, 94143, United States
-
University of California, Davis Medical Center
Sacramento, California, 95817, United States
-
University of Chicago Medical Center
Chicago, Illinois, 60637, United States
-
University of Michigan
Ann Arbor, Michigan, 48109, United States
-
Universitätsmedizin Mainz, I. Med. Klinik
Mainz, 55131, Germany
-
VCU Health Clinical Research Services Unit
Richmond, Virginia, 23298, United States
-
Vanderbilt Digestive Disease Center
Nashville, Tennessee, 37232, United States
-
Westmead Hospital
Westmead, New South Wales, 2145, Australia
-
Yale School of Medicine
New Haven, Connecticut, 06511, United States