New drug ZW25 shows promise for rare bile duct cancer
NCT ID NCT04466891
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested a drug called ZW25 (zanidatamab) in 87 people with advanced or metastatic HER2-amplified biliary tract cancer that had worsened after standard chemotherapy. The goal was to see if the drug could shrink tumors and how long that effect lasted. The trial is now complete, and results will help determine if ZW25 could become a new treatment option for this hard-to-treat cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Zanidatamab (ZW25)
- What this could lead to
- If successful, this could provide a new targeted treatment option for people with HER2-positive biliary tract cancer who have few alternatives.
- What could go wrong
- This is a single-arm, phase 2 study with only 87 participants, so results are preliminary. The drug may not work for everyone and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advent Health Cancer Institute
Orlando, Florida, 32804, United States
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Affiliated Tumor Hospital of Harbin Medical University
Harbin, 150081, China
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Affiliated Zhongshan Hospital of Fudan University
Shanghai, 200032, China
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Anhui Provincial Hospital
Hefei, 230001, China
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Asan Medical Center Hospital
Seoul, 05505, South Korea
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Beijing Cancer Hospital
Beijing, 100142, China
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Centro de Cáncer Nuestra Señora de la Esperanza
Santiago, 8330032, Chile
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City of Hope National Medical Center
Duarte, California, 91010, United States
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Corporacio Sanitaria Parc Tauli
Sabadell, 08208, Spain
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Département De Médecine
Villejuif, 94805, France
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Département Oncologie Gastro-entérologie CHRU de Poitiers La Miletrie
Poitiers, 86000, France
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Fondazione del Piemonte per l'Oncologia (IRCCS)
Candiolo, 10060, Italy
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Gyeongsang National University Hospital
Jinju, 52727, South Korea
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Hopitaux de La Timone
Marseille, 13385, France
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Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
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Hospital Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Doce de Octubre
Madrid, 28041, Spain
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Hospital Universitario Reina Sofia
Córdoba, 14004, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hubei Cancer Hospital
Wuhan, 430079, China
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Hunan Cancer Hospital
Changsha, 410013, China
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Huzhou Central Hospital
Huzhou, 313000, China
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Imperial College Healthcare NHS Trust
London, W12 0HS, United Kingdom
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Institut de Cancerologie et d'Hematologie Hopital Morvan - CHRU de Brest
Brest, 29200, France
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Istituto Clinico Humanitas
Milan, 20089, Italy
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Istituto Nazionale Dei Tumori
Milan, 20133, Italy
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Istituto Oncologico Veneto - I.R.C.C.S.
Padova, 35128, Italy
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Jilin Cancer Hospital
Changchun, 130012, China
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Jinhua Central Hospital
Jinhua, 321000, China
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
Nanjing, 210008, China
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Oncologie médicale Hopital Jean Minjoz
Besançon, 25030, France
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Peking Union Medical College Hospital
Beijing, 100730, China
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Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
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Pusan National University Hospital
Pusan, 49241, South Korea
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Radiomed (Clinica Alemana de Temuco)
Temuco, 645, Chile
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Royal Free London NHS Foundation Trust
London, NW3 2QG, United Kingdom
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Samsung Medical Center
Seoul, 06351, South Korea
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Seattle Cancer Care Alliance
Seattle, Washington, 98109, United States
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Seoul National University Bundang Hospital
Seongnam, 13620, South Korea
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Seoul National University Hospital
Seoul, 03080, South Korea
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Severance Hospital Yonsei University Health System
Seoul, 03722, South Korea
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Shandong Provincial Third Hospital
Shandong, 250031, China
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Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, 310016, China
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The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 06591, South Korea
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The First Affiliated Hospital of Zhejiang University
Hangzhou, 310003, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, 450052, China
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The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, 510080, China
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The First Hospital Of Lanzhou University
Lanzhou, 730000, China
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The Oncology Institute of Hope and Innovation
Whittier, California, 90603, United States
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The Third Affiliated Hospital of the Chinese PLA
Shanghai, 200081, China
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Tianjin Medical University Cancer Institute and Hospital
Tianjin, 300060, China
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Universitario Germans Trias i Pujol
Barcelona, 08916, Spain
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University College London Hospitals (UCLH)
London, NW1 2PG, United Kingdom
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University of Arizona Cancer Center
Tucson, Arizona, 95724, United States
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University of California Los Angeles
Santa Monica, California, 90404, United States
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University of Maryland Greenebaum Cancer Center
Baltimore, Maryland, 21201, United States
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University of Texas MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of Texas Southwestern Medical Center - Hospital
Dallas, Texas, 75390, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Weifang People's Hospital
Weifang, 261000, China
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West China Hospital
Chengdu, 610041, China
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Winship Cancer Institute, Emory University
Atlanta, Georgia, 30322, United States
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Zhejiang Cancer Hospital
Hangzhou, 310022, China
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Zhejiang Provincial People's Hospital
Hangzhou, 310014, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can freezing tumors boost immunotherapy in hard-to-treat bile duct cancers?
- Triple attack on bile duct cancer: chemo, targeted drug, and immunotherapy aim to make the inoperable operable
- Can two targeted drugs boost chemo against a rare Bile-Duct cancer?
- Liver tumors targeted directly: old pump, new drug
- Chemo, immunotherapy, and targeted radiation join forces against bile duct cancer
- Chemotherapy sprayed directly into the abdomen: a new attack on stubborn cancers