Triple-Drug cocktail shows promise for tough bile duct cancer
NCT ID NCT05052099
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a combination of three drugs—chemotherapy (mFOLFOX6), an immunotherapy (atezolizumab), and a targeted therapy (bevacizumab)—in 20 people with advanced bile duct cancer who had already received one prior treatment. The goal was to see if the combination could shrink tumors or control the disease. The drugs were given every two weeks until the cancer worsened, side effects became too severe, or the patient chose to stop.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- A combination of chemotherapy (mFOLFOX6), an immunotherapy drug (atezolizumab), and a targeted therapy (bevacizumab), all given by IV.
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced bile duct cancer who have already tried one line of therapy.
- What could go wrong
- This was a small, early-phase study (20 people) with no comparison group. The combination may cause significant side effects, and it is not yet known if it works better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clínica Universidad de Navarra
Pamplona, 31008, Spain
-
Universitätsklinikum Essen
Essen, North Rhine-Westphalia, 45147, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a smart drug home in on Hard-to-Treat cancers?
- Can a new immunotherapy combo shrink Hard-to-Treat tumors?
- Can two targeted drugs boost chemo against a rare Bile-Duct cancer?
- New drug cocktail aims to outperform standard immunotherapy in bile duct cancer
- Liver cancer registry aims to uncover new biomarkers from thousands of patients
- Triple-Drug cocktail targets Hard-to-Treat biliary cancers