Antibiotics after gallbladder surgery may be unnecessary

NCT ID NCT01015417

Completed Disease control Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether giving antibiotics after gallbladder removal surgery helps prevent infections in people with mild to moderate gallbladder inflammation. Over 400 adults took part, receiving either antibiotics or no medication after surgery. The goal was to see if antibiotics reduce surgical site or other infections within 30 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: amoxicillin clavulanic acid (Augmentin)
What this could lead to: If successful, this could show that antibiotics after gallbladder surgery are not needed for mild to moderate cases, reducing side effects and antibiotic resistance.
What could go wrong: This is a completed Phase 3 trial, but results may not apply to severe cases or patients with complications. The benefit of antibiotics may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute cholecystitis Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LITHIASIC CHOLECYSTITIS GRADE I OR II PREOPERATIVE AMOXICILLIN CLAVULANIC ACID FOR AT MOST 5 DAYS REQUIRED CHOLECYSTECTOMY SYMPTOMS LASTING FOR LESS THAN 5 DAYS

Contacts and locations

Locations

Centre Hopitalier Général

Grenoble, Auvergne-Rhône-Alpes, 38700, France
Centre Hospitalier

Longjumeau, Ile de Rance, 91161, France
Centre Hospitalier C.H.A.M.

Rang-du-Fliers, Hauts-de-France, 62180, France
Centre Hospitalier Cochin

Paris, Île-de-France Region, 75679, France
Centre Hospitalier Côte e Nacre

Caen, Basse Normandie, 14033, France
Centre Hospitalier Dupuytren

Limoges, Limousin, 87042, France
Centre Hospitalier Haut-Lévêque

Bordeaux, Aquitaine, 33604, France
Centre Hospitalier Jean-Verdier

Bondy, Île-de-France Region, 93143, France
Centre Hospitalier Louis Mourier

Colombes, Île-de-France Region, 92700, France
Centre Hospitalier Timone

Marseille, Province-Alpes Côte d'Azur, 13000, France
Centre Hospitalier de Saint-Germain en Laye

Poissy, Île-de-France Region, 78303, France
Centre de Chirurgie Viscérale et de Transplantation Centre Hospitalier Régional Universitaire

Strasbourg, Alsace, 67098, France
Centre hospitalier Lariboisière

Paris, Île-de-France Region, 75475, France
Centre hospitalier Universitaire

Angers, Pays de la Loire Region, 49933, France
Chirurgie Viscérale et Digestive

Rouen, Seine Maritime, 76031, France
Chirurgie viscérale et urologique Centre Hospitalier

Beauvais, Oise, 60021, France
Service de Chirurgie Digestive et Vasculaire. Centre Hopsitalier Universitaire

Besançon, Doubs, 25030, France
Service de Chirurgie Digestive et Viscérale

Paris, Île-de-France Region, 75020, France
Service de Chirurgie Digetsive Centre Hopsitalier Universitaire

Montpellier, Hérault, 34000, France
Service de Chirurgie Générale et Digestive. Centre Hospitalier Universitaire

Clermont-Ferrand, Auvergne, 63003, France
Service de Chirurgie Viscérale et Digestive

Amiens, Picardie, 80054, France