Massachusetts General Hospital

This study tests whether limiting calories before surgery can reduce wound complications in adults with soft tissue sarcoma of the leg. Participants will receive radiation therapy followed by surgery, and some will follow a calorie-restricted diet. The goal is to see if this appr…

This study tests whether meal replacements can help low-income adults who are overweight or have prediabetes or type 2 diabetes lose weight and lower blood sugar. Twenty participants will follow an intensive nutrition program for several weeks. Researchers will measure weight los…

This study tests a drug called sacituzumab govitecan, given before surgery, in people with localized triple-negative breast cancer. The goal is to see if it can eliminate all signs of cancer in the breast and lymph nodes at the time of surgery. About 260 participants will receive…

This study tests whether giving children (ages 8 to under 18) with newly diagnosed type 1 diabetes repeated doses of the BCG vaccine (normally used for tuberculosis) can improve blood sugar control and reduce insulin needs. The goal is to see if the vaccine can calm the immune at…

This study looks at whether adding nutrition counseling and stress management to standard medication can improve symptoms for people with active Crohn's disease or ulcerative colitis. About 160 adults will be split into four groups, each receiving different combinations of dietit…

This study tests whether the drug canakinumab can reduce inflammation in the blood vessels of people with a history of heart disease. Some participants have a specific gene change (TET2) that may increase inflammation. The study involves 120 adults and compares canakinumab to a p…

This study tests whether a special machine can revive fatty donor livers (30-60% fat) so they can be safely transplanted. About 200 adults on the liver transplant list will receive a treated liver. If successful, this could expand the donor pool and help more people get transplan…

This study looks at whether a blood test can detect tiny amounts of cancer left after surgery and standard chemotherapy in people with stage III colon cancer. If the test finds cancer, participants may get extra treatment like FOLFIRI or other drugs. The goal is to see if early t…

This early-phase study is testing whether combining two drugs (atezolizumab and bevacizumab) with targeted radiation (SBRT) is safe and tolerable for people with liver cancer that cannot be surgically removed. About 20 participants will receive the combination treatment. The goal…

This study is testing a precise type of radiation called proton beam therapy for children with neuroblastoma, a nerve cell cancer. The goal is to see if this treatment can control the disease while causing fewer long-term side effects than standard radiation. About 30 participant…

This study tests a combination of three drugs (venetoclax, obinutuzumab, and possibly acalabrutinib) in people with chronic lymphocytic leukemia or small lymphocytic lymphoma that has come back or not responded to prior treatment. The goal is to see if the treatment can eliminate…

This study tests a 12-week phone coaching program that uses positive psychology and motivational interviewing to help 280 heart failure patients improve their diet, exercise, and medication habits. Participants also receive text messages for up to 24 weeks. The goal is to see if …

This study looks at whether drinking instant coffee every day for 6 weeks can reduce liver fat and improve gut health in people who have finished treatment for stage I-III colorectal cancer. About 80 adults who completed surgery, chemo, or radiation at least 2 months ago will par…

This study looks at whether adding a special care program (GRACE) to regular annual check-ups can improve health and reduce hospital stays for older adults with multiple health issues. About 6,000 people aged 65 and older with complex needs will take part. The goal is to see if t…

This study tests a drug called talazoparib in people with metastatic breast cancer that has a BRCA1 or BRCA2 mutation in the tumor (not inherited). The goal is to see if the drug can slow or stop cancer growth. About 30 participants will take the pill and be monitored for tumor r…

This study tests whether the drug elranatamab, given after CAR T-cell therapy (idecabtagene vicleucel), can lower the chance of multiple myeloma worsening. About 32 adults with relapsed or treatment-resistant myeloma will take part. The goal is to see if this combination helps mo…

This study looks at whether using a smartwatch to track activity and body composition, along with exercise reminders, can help people maintain muscle mass and strength while taking GLP-1 medications like Ozempic or Mounjaro. About 100 adults who recently started or plan to start …

This study tests whether giving a sleep-promoting medication (dexmedetomidine) at night can prevent delirium—sudden confusion and disorientation—in older adults after heart surgery. About 1,800 patients aged 60 and older will receive either the drug or a placebo through an IV or …

This study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults who feel stressed. Researchers will use special scans to measure changes in artery inflammation. The goal is to see if managing stress can help control atherosclerosis…

This early-phase study tests two drugs, mezigdomide and talquetamab, in people with multiple myeloma that has come back or stopped responding to other treatments. The goal is to find the safest dose and see if the combination can control the cancer. About 25 adults will take part…

This study tests a device called RELiZORB that adds digestive enzymes directly to liquid food given through a feeding tube. It is for people who have trouble digesting food after pancreatitis. The goal is to see if it improves symptoms and quality of life. About 60 adults will ta…

This early-stage trial tests a drug called ASTX727 in people with a specific brain cancer (IDH-mutant glioma) that has come back or is growing. The main goal is to find the highest dose that is safe to give. About 18 adults will take part, and researchers will also track how long…

This study tests a combination of four drugs (isatuximab, belantamab mafodotin, pomalidomide, and dexamethasone) in 50 adults with multiple myeloma that has come back or stopped responding to prior treatments. The main goal is to see how many patients' tumors shrink or disappear.…

This study tests whether a high-intensity statin and a low-dose anti-inflammatory drug (colchicine) can slow or change the buildup of fatty plaque in the heart arteries. It includes 200 adults aged 40-75 with high genetic risk for heart disease but no symptoms. Participants get a…

This study is testing whether giving repeated doses of the BCG vaccine (traditionally used for tuberculosis) can help children aged 8 to 18 with type 1 diabetes. The goal is to see if it improves blood sugar control and reduces insulin needs. 150 participants will be followed to …

This study tests a tool called Savvy to help stroke survivors take their medication regularly. The tool includes short phone exercises, a weekly pill organizer, and text reminders. Researchers will compare medication adherence and blood pressure control between those using Savvy …

This study tests two treatments for people whose cancer has spread to the brain and is growing despite prior therapy. One group receives palbociclib alone; the other gets palbociclib plus pembrolizumab. The goal is to see if these drugs can shrink or stabilize brain tumors. About…

This study tests whether switching to a once-daily anti-rejection drug (Envarsus XR) helps preserve memory and thinking in older kidney transplant patients compared to staying on a twice-daily drug (Prograf). About 92 participants who are at least one year post-transplant will ta…

This study tests whether a daily pill called ivosidenib can help prevent acute myeloid leukemia (AML) from coming back after a stem cell transplant. About 75 adults with a specific IDH1 gene mutation will receive either the drug or a placebo. The goal is to see if the drug extend…

This study tests whether time-restricted intermittent fasting can reduce liver fat in non-obese adults (BMI 23-30) with non-alcoholic fatty liver disease (NAFLD). About 25 participants will follow a fasting schedule, and researchers will measure changes in liver fat using advance…

This study tests whether giving the inhaler Airsupra to adults in the emergency department, instead of usual care, can prevent asthma flare-ups and improve control over the next 3 months. About 1,860 people aged 18 to 54 with acute asthma will take part. The goal is to see if sta…

This study tests the safety of a drug called momelotinib given during and after a stem cell transplant for people with myelofibrosis, a type of bone marrow cancer. About 28 participants will receive the drug to find the highest safe dose. The goal is to control the disease and ma…

This study tests whether adding a new drug (liposomal irinotecan) to standard chemotherapy before chemoradiation can completely eliminate cancer in people with advanced esophagogastric cancer. About 40 adults with stage T3/4 or node-positive disease will receive the drug combo, t…

This study tests a device called the Tulavi Allay™ Nerve Cap, placed on cut nerve endings during finger amputation surgery, to prevent painful neuromas and chronic pain. About 20 adults who recently lost a finger due to injury will be enrolled. The goal is to see if the cap reduc…

This study looks at two ways to give fluids to people with cirrhosis who develop acute kidney injury. One method uses a special algorithm to guide fluid choice, while the other follows standard care. The goal is to see which approach is safer and works better. About 50 hospitaliz…

This study tests whether combining two targeted drugs, pemigatinib and afatinib, is safe and works against advanced solid tumors that have certain FGFR gene changes. About 70 adults whose cancers have not responded to standard treatments will take part. The goal is to find the be…

This study tests whether adding romosozumab to standard estrogen therapy improves bone density in girls and women aged 14-30 who have stopped menstruating due to intense exercise, stress, or an eating disorder. Participants receive either romosozumab or a placebo for 6 months, pl…

This study tests two types of radiation (proton or photon) given before surgery for retroperitoneal sarcoma, a rare tumor in the back of the abdomen. The goal is to find the highest safe radiation dose and see how well it controls the tumor. About 80 adults with this sarcoma will…

This study tests a new combination of two drugs (elranatamab and isatuximab) given as shots under the skin for people with multiple myeloma that has come back or not responded to at least two prior treatments. The goal is to see if the combination can shrink or control the cancer…

This study tests a drug called epcoritamab in people with a type of blood cancer called large B-cell lymphoma that has come back or not responded to treatment. Participants cannot have a stem cell transplant. The goal is to see if the drug can stop the cancer from growing for at …

This study compares two FDA-approved medication regimens to see which works better for improving bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will take one of the two drug combinations for 12 months. Th…

This study is testing proton radiation therapy in 100 adults with benign or slow-growing brain tumors. The goal is to see how well it controls tumor growth and how it affects quality of life and side effects. Participants receive targeted proton beams to the tumor area and are fo…

This study tests a drug called NPC-1 (made of two compounds) in 40 adults aged 55+ who have Alzheimer's disease, mild cognitive impairment, or subjective memory concerns. The goal is to see if NPC-1 is safe and can improve blood markers related to Alzheimer's brain changes. Parti…

This study tests a program called CHAMPION that helps overweight children with asthma manage their weight and breathing. Researchers want to see if doing the program online works as well as meeting in person. About 500 children aged 4 to 17 with asthma and a BMI in the 85th perce…

This study tests whether giving a low-dose anti-inflammatory drug (ketorolac) for just five days after orthopedic surgery can reduce the chance of patients still needing opioids six months later. About 458 adults with serious bone injuries will be randomly assigned to receive eit…

This study tests whether giving G-CSF (a drug that boosts white blood cells) during standard chemoradiation can help preserve brain structure and thinking abilities in people with a specific type of glioblastoma (MGMT-methylated). About 60 newly diagnosed patients will be randoml…

This study compares two common gout treatment strategies: one that aims to lower urate levels to a target, and another that treats symptoms as they occur. Researchers will track gout flares and quality of life over two years in 650 adults with gout. The goal is to find which appr…

This study tests whether freezing part of a growing tumor (cryoablation) combined with two immunotherapy drugs (ipilimumab and nivolumab) can help control advanced melanoma that stopped responding to prior treatment. About 37 adults with unresectable melanoma will receive the com…

This study tests whether combining tirzepatide (a weight-loss drug) with bimagrumab (an experimental drug) can help adults with obesity lose mostly fat instead of muscle and bone. About 63 participants will receive one of three treatments for 52 weeks, plus lifestyle advice. The …

This study tests whether combining three drugs—zanubrutinib, bendamustine, and rituximab—can achieve a very good partial response or better in people with untreated Waldenström macroglobulinemia, a rare blood cancer. About 55 participants will receive the combination therapy. The…

This early-phase study tests whether combining two immunotherapy drugs (botensilimab and balstilimab) with targeted radiation can help people with a specific type of colorectal cancer that has spread to the liver and hasn't responded to standard treatments. The study will include…

This study tests whether taking spironolactone for three months after delivery can improve blood pressure and heart health in women who had preeclampsia or gestational hypertension and were overweight before pregnancy. About 204 women will be randomly assigned to receive the drug…

This study tests a new therapy called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines two proven approaches—12-step support and motivational therapy—to see if it helps teens stay abstinent longer and reduce substance-related problems. About 294 par…

This study tests a new program called QUIT-AD that combines existing methods to help people with HIV or TB quit smoking. The program will be offered to 86 adults in Cape Town, South Africa who smoke daily. Researchers will check if the program is practical, well-liked, and helps …

This study tests a combination of three drugs (zanubrutinib, obinutuzumab, and sonrotoclax) in people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The main goal is to see if the treatment can make the cancer undetectable in the blood. Abo…

This study is testing a non-invasive device that stimulates the vagus nerve (a key nerve in the body) to see if it is safe and helpful for people who have had a brain bleed from a burst aneurysm. The device is placed on the neck and delivers gentle electrical pulses. Researchers …

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can stop the cancer from growing for at least 6 mo…

This study tests a program called ADELANTE for Latino adults with HIV whose virus is not well-controlled. Participants will either receive five sessions with a community health worker who helps solve problems, or five reminder phone calls. The goal is to see if the program helps …

This study looks at two ways to help people who have had a stroke lower their blood pressure. One way is checking blood pressure at home. The other adds group medical visits where people learn together. The goal is to see if combining both methods works better to prevent another …

This study looks at whether the drug eplerenone can improve blood flow to the heart better than another drug (chlorthalidone) in women who had preeclampsia during pregnancy and now have high blood pressure. About 90 women will take one of the two medications daily for 48 weeks. R…

This early-phase study tests an experimental drug called ziftomenib in adults with acute myeloid leukemia (AML) who have had a stem cell transplant. The goal is to find a safe dose and see if the drug can help prevent the cancer from coming back. About 22 participants will take t…

This study looks at people in Uganda and South Africa whose HIV medication (TLD) is no longer working well. Researchers will test different strategies to get the virus under control again. The goal is to find the best way to help these patients achieve undetectable viral levels.

This study looks at whether a 12-week home resistance exercise program can help transgender women and gender-diverse individuals starting estrogen-based hormone therapy maintain muscle mass and strength. Hormone therapy can increase the risk of muscle loss and weakness. The study…

This study tests if abatacept, a drug used for arthritis, can prevent serious heart problems in cancer patients who develop heart inflammation from immunotherapy. About 390 adults hospitalized with this condition will receive either abatacept or a placebo. The goal is to see if t…

This study looks at whether a medication called SGLT2 inhibitor, already used for diabetes and kidney disease, can improve blood flow to the heart in women with HIV who also have diabetes or kidney problems. About 80 women will be randomly assigned to health education alone or he…

This study looks for better ways to diagnose allergies to cephalosporin antibiotics, which are commonly used but can cause serious reactions. Researchers will test 300 adults who have had a possible allergic reaction to these drugs, using skin tests and carefully controlled drug …

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without sedation. About 30 adults who are healthy or have Lynch syndrome, Crohn disease, or inflammatory bowel disease will try it. The goal is to see if the capsule can get clear imag…

This study tests a special PET probe called [68Ga]CBP8 to see if it can detect tissue damage caused by radiation therapy in people with lung or pancreatic cancer. About 72 participants will get a PET scan before and 3-6 months after radiation. The goal is to find early signs of r…

This study is testing a new way to detect ovarian cancer earlier by looking at DNA from a uterine wash and proteins in the blood. Researchers will collect samples from 250 women before surgery for a suspected ovarian mass or as a preventive measure for those with BRCA mutations. …

This study tests an AI tool that looks at routine chest X-rays and medical records to find people at high risk for lung cancer. The AI alerts their doctor to discuss screening CT scans. The goal is to see if this alert increases the number of high-risk patients who get screened. …

This study is testing a new imaging tool called Brillouin microscopy to see if it can better diagnose corneal conditions like keratoconus and ectasia. Researchers will scan the corneas of healthy volunteers and patients with these conditions to compare their biomechanical propert…

This study tests whether injecting a near-infrared dye near a lung tumor can help surgeons see the tumor and the first lymph node it drains into during surgery. About 100 adults having lung surgery will receive the dye, and doctors will check if it safely improves tumor removal a…

This study explores whether a simple smell test can help detect early signs of Alzheimer's and other brain diseases. Researchers will have 250 adults with mild memory or behavior concerns, plus healthy older adults, take a 45-minute at-home smell test. The goal is to develop a lo…

This study is testing a new type of PET/MRI scan to see if it can give a complete picture of the liver in people with cirrhosis. The goal is to measure liver function, blood flow, and detect cancer or high blood pressure in the liver all at once. About 45 adults with cirrhosis wi…

This early-phase study tests a radioactive imaging agent called [68Ga]CBP8 to see if it can safely detect collagen buildup (scarring) in the lungs of people with pulmonary fibrosis and lung cancer. Researchers will compare scans from healthy volunteers and patients to see if the …

This study looks at whether molecules in saliva can help doctors quickly tell if heart failure is getting worse. Researchers will compare saliva samples from 90 people with stable or worsening heart failure. If successful, this could lead to a simple, painless test to predict hos…

This study tests whether a special dye called indocyanine green (ICG) can help surgeons see the edges of bone or soft tissue tumors during surgery. About 100 adults having tumor removal surgery will receive the dye, and doctors will use a camera to spot any leftover cancer cells.…

This early-stage study aims to find a reliable test for oxytocin deficiency in young people with hypopituitarism. Researchers will give a single dose of a hormone pill to 20 participants (10 with a related condition and 10 without) and measure oxytocin levels in blood and saliva.…

This early-phase study is testing a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately find clots anywhere in the body, including in the heart of people with atrial fibrillation. The study in…

This study is testing a special PET scan that uses a radioactive tracer to find collagen buildup in the lungs, which is an early sign of scarring. Researchers will compare scans from healthy relatives of people with pulmonary fibrosis and from patients with early lung abnormaliti…

This study looks at whether a special PET scan (flotufolastat F 18) can find prostate cancer that has come back in men with very low PSA levels (0.20 ng/mL or less) after their prostate was removed. About 50 men who had surgery for prostate cancer and now have a small rise in PSA…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if knowing their personal risk motivates them to make healthier lifestyle and diet changes that might …

This study tests whether using special air cleaners (HEPA filters) in elementary school classrooms can lower the amount of viruses in the air and reduce how often students, teachers, and their families get sick. About 200 children and adults from inner-city schools will take part…

This study aims to see if a long-acting injectable HIV prevention drug (cabotegravir) works well for adults who inject drugs. 100 participants will receive the shot along with support services. The main goal is to see how many people stick with the treatment for 7 months.

This study looks at whether giving HIV self-test kits and counseling to HIV-negative women after childbirth can help them and their male partners learn their HIV status and start PrEP (prevention) or antiretroviral therapy (treatment). About 120 women and their partners in South …

This study tests a program called Resilience Training for college students who have mild psychotic experiences, like unusual thoughts or perceptions. The goal is to see if this training can prevent the development of serious mental illness. Researchers will enroll 192 students ag…

This study tests whether eating more plants and less animal food can lower colorectal cancer risk. Forty adults who have had colon polyps removed will follow a diet education program. Researchers will measure changes in gut bacteria and bile acids linked to cancer.

This early-phase study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower biological markers linked to colorectal cancer risk. Researchers will measure changes in urine, blood, and gut bacteria in 20 adults aged 18–50 with a BMI between 27 and 40. The …

This study tests whether writing about a stressful childbirth experience for 15 minutes a day over three days can prevent post-traumatic stress disorder (PTSD) and improve bonding with the baby. Researchers are recruiting 136 women who recently gave birth at Massachusetts General…

This study tests a brain health program for adults aged 50 and older who have memory concerns but not dementia. The program helps participants make healthy lifestyle changes to lower their risk of dementia. Researchers want to see if the program is practical and satisfying for pe…

This study tests a brief group therapy called Resilience Training for Teens. It aims to prevent serious mental illness in high school students aged 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens will participate to see if the training hel…

This study is testing a program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program combines problem-solving support to address barriers like depression and anxiety. About 132 pregnant women at risk for HIV will participate…

This study tests a program called PrEP My Way, designed to help young women aged 16-24 in Kisumu, Kenya, continue using HIV prevention medicine. Participants can choose between a daily pill, a long-acting injection, or a vaginal ring, along with support from peers. The goal is to…

This study tests whether the drug ruxolitinib can reduce symptoms like fatigue, itching, and night sweats in people with low-risk essential thrombocythemia (ET) or polycythemia vera (PV) who have significant symptom burden. About 60 adults will take ruxolitinib and be monitored f…

This study tests a virtual sleep program for cancer survivors with chronic insomnia. About 198 participants will either receive the therapy or standard care. The goal is to see if the program reduces insomnia severity and improves mood and fatigue.

This study tests whether brief, online self-guided programs can help parents of children ages 2-7 better manage their child's anxiety. Parents are randomly assigned to one of three programs and report on their child's anxiety over 8 months. The goal is to see if these low-cost to…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study looks at whether tranexamic acid (TXA), a drug that reduces bleeding, can decrease fluid buildup and shorten the time surgical drains are needed after breast reduction surgery. About 160 adults having elective bilateral breast reduction will be randomly assigned to rec…

This study is testing a smartphone app designed to provide information and support to people with pancreatic cancer who are about to start treatment before surgery. About 50 participants will use the app to see if it is helpful and easy to use. The goal is to improve the patient …

This study tests a new program called WISH, which uses positive psychology exercises to help people with irritable bowel syndrome (IBS). Researchers want to see if the program is easy to follow and if it can improve symptoms and well-being. About 50 adults with IBS will either ta…

This study tests a special support program (BMT-CARE) for people caring for a loved one undergoing a bone marrow transplant. The goal is to see if the program improves the caregiver's quality of life and reduces their stress. About 800 caregivers will take part, and their well-be…

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists will learn several proven methods, like cognitive behavioral therapy and mindfulness, to help with anxiety, depression, pain, f…

This study looks at whether doing heated yoga or regular yoga can ease depression symptoms. Researchers will track mood changes in 120 adults with moderate depression using a standard questionnaire. Participants will attend yoga sessions and report how they feel over time.

This study tests a short counseling program for young adults (ages 25-39) with cancer and their caregiving partners. The goal is to see if the program helps them cope with stress and maintain their relationship. The study will enroll 20 couples and measure how many people join an…

This study tests whether breathing high doses of nitric oxide gas can help critically ill pneumonia patients on ventilators recover. About 34 adults will receive either the gas or a placebo for 5 days, and researchers will monitor safety and cure rates. The goal is to see if this…

This study tests a 10-week program called GetActive+ that combines gentle walking with mind-body techniques to help older adults (55+) with long-term muscle or joint pain. Two hundred participants will either join the program or continue their usual care. Researchers will measure…

This study tests whether a single dose of intravenous iron can improve exercise capacity in people with a type of heart failure (HFpEF) who also have low iron levels. About 66 adults with stable heart failure will receive either the iron infusion or a placebo. The main goal is to…

This study tests a program designed to help refugees and asylum seekers who have had a traumatic brain injury (TBI) and now struggle with thinking and memory. Researchers want to see if the program is practical and acceptable to participants. 50 people will be randomly assigned t…

This study tests whether adding a patient's own platelet-rich plasma (PRP) to standard arthroscopic hip labral repair surgery improves pain, function, and quality of life. Researchers will enroll 400 adults with torn hip labrums and compare outcomes between those who receive PRP …

This study tests a digital program called AMP-C for people who have both depression and cannabis use problems. About 80 adults will either use the AMP-C app or just track their symptoms. Researchers will check if the app helps reduce depressive feelings and cannabis use, and if p…

This study tests whether a nasal spray containing oxytocin, often called the 'love hormone,' can reduce binge eating in adults. Researchers will compare oxytocin to a placebo over 8 weeks in 60 people with binge-eating disorder. The goal is to see if it safely lowers binge freque…

This study tests a short, virtual program (6 sessions) designed to prevent long-term emotional distress in people recently diagnosed with young onset dementia (before age 65) and their care-partners. About 388 pairs will participate. The program focuses on building coping skills …

This study tests whether combining virtual reality (VR) with pleasant scents can help reduce pain and anxiety in people recovering from major heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR and scent therapy or standard care.…

This study explores whether watching guided acupuncture videos can help relieve nerve pain caused by chemotherapy in breast cancer survivors. About 20 people who have finished taxane-based chemotherapy will try this approach at home. The main goal is to see if the method is pract…

This study looks at whether a type of talk therapy for PTSD (Cognitive Processing Therapy) can also reduce the risk of heart disease. Researchers will measure inflammation and heart rate in 30 adults with PTSD who are at risk for heart problems. Half will receive the therapy righ…

This study is testing a new supportive care program called POISE for people with stage IV non-small cell lung cancer who are on targeted therapy. The program includes four visits with a specially trained palliative care clinician to help patients cope with uncertainty and manage …

This study tests whether turmeric, a common spice, can reduce pain and stiffness in people with thumb arthritis. Researchers will enroll 60 adults aged 40 and older with early-stage thumb arthritis. Participants will take turmeric and report changes in pain and daily function ove…

This study tests a new program called Sentinel that helps doctors provide extra comfort and support to patients getting a stem cell transplant. The program focuses on improving quality of life and managing symptoms during treatment. About 40 adults will take part to see if the pr…

This study tests two experimental drugs (siltuximab and erenumab-aooe) to see if they can safely reduce chronic pain in people with schwannomatosis, a rare condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will receive either the drug or a p…

This study tests a virtual cognitive behavioral therapy program designed to improve sleep for people with cirrhosis who also have insomnia. Ten adults with cirrhosis and sleep difficulties will try the program from home. The goal is to see if the program is practical and well-lik…

This study tests a group-based telehealth program called HORIZONS for adults who have chronic graft-versus-host disease after a stem cell transplant. The program is designed to help patients better manage their condition and improve their quality of life. Researchers will compare…

This study tests whether heated yoga or sauna sessions, combined with a mindfulness app, can help reduce symptoms of depression. Researchers will enroll 120 adults aged 18 to 65 who have at least moderate depression. Participants will be assigned to one of the two heat-based acti…

This study tests two different doses of a gel medicine (Purified Cortrophin Gel) given as a single shot to adults having a sudden, painful gout flare. About 150 people will rate their pain over a week to see which dose works better and is safe. The goal is to quickly ease severe …

This study tests a mobile app called PROMOTE designed to help lung cancer survivors improve their physical function, manage breathlessness and sleep problems, and adopt healthier habits. Researchers will enroll 250 people with stage I-III lung cancer who are starting treatment ai…

This study looks at whether adding coaching sessions can improve the effects of ketamine or esketamine treatment for people with treatment-resistant depression. About 20 adults who already get ketamine at Massachusetts General Hospital will try 12 coaching sessions. The goal is t…

This study tests whether a special exercise routine, done with or without a physical therapist's guidance, can improve muscle strength and walking ability in people with myotonic dystrophy type 2. About 24 adults will be randomly assigned to different schedules of supervised and …

This study tests a digital app called SHIFT designed to help stem cell transplant survivors improve their sexual health and quality of life. Researchers will compare the app to standard care in 300 adults who had a transplant at least three months ago and report sexual concerns. …

This study tests a new type of whole brain radiation that spares healthy tissue, aiming to improve quality of life and reduce symptoms for people with brain metastases. About 41 adults with solid tumors and brain metastases will receive this radiation plus a standard drug. The ma…

This study tests a support program for people recently diagnosed with a malignant brain tumor. The program includes a guide and one-on-one coaching sessions to help with coping. Researchers want to see if the program is practical and helpful for patients. About 50 adults from Mas…

This study tests whether a higher dose of omalizumab (a drug already used for allergies) can help people with food allergies tolerate larger amounts of trigger foods like peanuts, cashews, walnuts, eggs, or milk. About 30 adults with confirmed allergies will receive the drug for …

This study tests a self-guided digital app called DREAMLAND to see if it can improve quality of life and emotional well-being for adults with acute myeloid leukemia (AML) who are receiving intensive chemotherapy. About 200 participants will use either DREAMLAND or a standard well…

This study tests two resilience-building programs for cardiac arrest survivors and their caregivers. The goal is to reduce anxiety, depression, and emotional distress while improving quality of life. About 84 pairs (survivor plus caregiver) will participate in a series of session…

This study tests whether using a gentle brain stimulation device at home for four weeks can reduce ADHD symptoms and improve focus in adults. Sixty participants aged 18-65 with ADHD will use the device daily and complete questionnaires and computer tasks. The goal is to see if th…

This study tests tenapanor, a drug already approved for irritable bowel syndrome, as a treatment for constipation in people with cystic fibrosis. About 25 adults will take one 50 mg tablet twice daily for 4 weeks. Researchers will track bowel movements and use questionnaires to s…

This study tests a mindfulness-based program designed for older Black adults (age 50+) who have both chronic pain and mild depression. Participants will be randomly assigned to either the mindfulness program or a general health education program. The goal is to see if the mindful…

This study tests whether a combination of IV ketamine and nasal esketamine can safely reduce suicidal thoughts in people with severe depression. About 100 adults hospitalized for depression will receive the treatments over 24 weeks. The main goals are to see if the treatment is p…

This study tests if a newer sedative, remimazolam, works better than the standard drug propofol for people undergoing endoscopy (a tube camera procedure). The goal is to see which drug provides safer and more comfortable sedation. About 100 adults having planned endoscopy will ta…

This study tests whether a natural hormone called pregnenolone can improve depression and brain function in people living with HIV. About 120 adults with HIV and depression will take either pregnenolone or a placebo pill for several weeks, while continuing their usual antidepress…

This study is testing a special implant called IlluminOss to see if it can reduce pain and help people move better after pelvic fractures caused by cancer that spread to the bone or by aging. About 100 adults will receive the implant as part of their normal care, and they will fi…

This study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can help with depression and thinking problems after a traumatic brain injury. Ten adults with mild or moderate brain injury who are still depressed will take the combination f…

This study tests whether people with myeloproliferative neoplasms (a type of blood disorder) can stick with a 12-week program that teaches healthier eating and more physical activity. About 30 adults will take part. The main goal is to see if at least 70% of participants can comp…

This study looks at two standard treatments for frozen shoulder (adhesive capsulitis) in adults 18 and older. One group gets physical therapy plus steroid injections, the other gets injections followed by watchful waiting. Researchers want to see if physical therapy improves outc…

This study tests a 12-week remote program that combines positive psychology and motivational interviewing, plus text messages, to help 280 heart attack survivors who are not very active. The goal is to see if this approach increases moderate-to-vigorous physical activity compared…

This pilot study tests whether whole body hyperthermia — a sauna-like treatment — can reduce fatigue and other symptoms in people with Long COVID. Researchers at Massachusetts General Hospital will enroll 21 adults aged 18-65 who had COVID-19 at least 12 weeks prior. Participants…

This study tests whether an 8-week remote program combining positive psychology and motivational interviewing, plus text messages, can help 280 adults with type 2 diabetes increase their physical activity. Participants must currently be inactive and not using certain insulin. The…

This study tests whether a new type of laser (DFG laser) causes less pain and helps skin heal faster than the standard CO2 laser. About 23 healthy adults will receive both lasers on small skin areas and report their pain levels. Researchers will also take photos and use imaging t…

This study explores whether a mild electrical stimulation on the ear (called taVNS) can improve how the brain and stomach work together in people with functional dyspepsia (indigestion) or gastroparesis (slow stomach emptying). Researchers will use brain scans and stomach activit…

This study looks at whether adding palliative care (extra support for symptoms and stress) to usual cancer care can improve quality of life for adults with lymphoma, leukemia, or multiple myeloma who are receiving cell therapy. About 90 participants will be randomly assigned to e…

This study tests whether a digital sleep program (a mobile app and a wrist-worn activity tracker) can help older adults sleep better and protect their brain health after hip or knee replacement surgery. About 50 people aged 65 and older with mild insomnia will use the app before …

This study tests whether adding the drug tesamorelin to a home exercise program improves physical function in adults aged 50-80 with HIV who are sedentary and show early signs of frailty. Half of the 100 participants will get tesamorelin and half a placebo, all while exercising w…

This study tests a new approach to treat PTSD by weakening traumatic memories. Participants take propranolol (a blood pressure drug) before briefly recalling their trauma, sometimes in an unexpected way (like singing the story). The goal is to see if this 'mismatch' method reduce…

This study tests a self-guided writing program for adults with long-term muscle or joint pain who tend to catastrophize (expect the worst). Ten participants will complete writing exercises at home over several weeks. The goal is to see if the program is practical, acceptable, and…

This study tests whether bezafibrate, a drug used for high cholesterol, can safely improve depression in people with bipolar disorder. About 30 adults with bipolar depression will take bezafibrate alongside their usual mood-stabilizing medication for 8 weeks. Researchers will mon…

This study tests a behavioral health program called InSTILL for nursing home residents who feel depressed and their main support person. The program aims to help them cope with stress and build resilience. Researchers will compare the program to usual care and check if it is prac…

This study tests a five-session palliative care program designed for people with metastatic breast cancer and their caregivers. The goal is to help patients talk with their doctors about what matters most to them, while also managing symptoms. Researchers will enroll 400 particip…

This study tests a program called QuitVaping, which combines coaching and text message support, to help teens ages 14-18 quit vaping. About 400 teens who vape at least weekly will be randomly assigned to either the QuitVaping program or standard advice and resources. The main goa…

This study is testing whether cannabidiol (CBD), a non-intoxicating compound from cannabis, can reduce inflammation in the brain for people with chronic low back pain, with or without mild-to-moderate depression. About 80 adults will receive either CBD or a placebo for a period o…

This study tests a coaching program for pregnant or new-mom doctors in training. About 48 participants will either get coaching (one-on-one and group sessions) or not. Surveys over 7 months will measure burnout, well-being, and confidence. The goal is to see if coaching helps the…

This study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce chronic low back pain. Researchers will measure pain levels and brain activity in 80 adults aged 18-60 who have had low back pain for over 6 months. The goal is to see if tACS can c…

This early-stage study tests a new program designed to help older adults (65+) recover after ostomy surgery. The goal is to improve quality of life and make the recovery process easier. Researchers will interview participants and use questionnaires to see if the program is easy t…

This study is testing a smartphone app called TEC-S designed to help adults who have frequent suicidal thoughts. The goal is to see if the app is safe, easy to use, and can reduce the urge to die by suicide. About 20 adults living near Boston will use the app and report their fee…

This study tests whether a single IV dose of allopregnanolone (a natural brain chemical) can help people with chronic PTSD get more out of therapy. The drug may help the brain better process traumatic memories by either strengthening new learning or weakening old fear responses. …

This study tests a type of talking therapy (exposure-based CBT) for adults who have both functional dyspepsia (stomach pain or fullness after eating) and avoidant/restrictive food intake disorder (ARFID) with weight loss. The goal is to see if the therapy helps people eat more co…

This study looks at how well people tolerate laser treatment for port wine birthmarks using an FDA-approved 532 nm laser. Researchers want to compare the standard single high-energy pulse with a new approach using multiple low-energy pulses. Fifteen adults with non-facial port wi…

This study looks at bone health in teenagers with cystic fibrosis (CF) compared to healthy teens. Researchers will use MRI scans to measure bone marrow fat and other tests to check bone density. The goal is to understand why teens with CF may have weaker bones, which could lead t…

This study looks at bone health in teenagers who were recently diagnosed with Crohn's disease. Researchers will use MRI scans to measure fat in the bone marrow and compare it to healthy teens. The goal is to understand if Crohn's disease affects bone strength early on, which coul…

This study follows 10,000 breast cancer patients to detect arm swelling (lymphedema) early after treatment. Researchers use arm measurements and patient surveys to understand how swelling affects daily life and quality of life. The goal is to improve screening and outcomes by cat…

This study aims to understand how the brain processes language by recording brain activity from people with epilepsy who already have electrodes implanted for medical reasons. Researchers will compare these brain signals to computer models of language to see which models best mat…

This study is testing a simple device with motion sensors placed on a child's chest and belly to measure how well their breathing is coordinated. The goal is to see if it can detect breathing problems early, even before they are obvious to doctors. About 20 children aged 28 days …

This study aims to understand how the osteoporosis drug romosozumab changes bone cells over time. Researchers will study 16 postmenopausal women who are already prescribed this medication. The goal is to see if the drug increases early bone-forming cells but not later ones, helpi…

This study looks at whether a physical activity program can help improve hormone health and reduce diabetes risk in girls ages 8 to 12 who may be at higher risk for PCOS. Participants will either get a full program with coaching and messages or a lower-intensity version with mess…

This pilot study is testing whether connecting people who take medication for opioid use disorder to recovery community centers (RCCs) leads to better recovery outcomes. Researchers will compare two groups: one that visits an RCC and one that does other recovery activities. The s…

This study explores whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Participants will receive daily brain stimulation sessions ov…

This pilot study works with staff at community health centers to find better ways to increase colorectal cancer screening. Researchers will hold group discussions and analyze health records to see what strategies work best. The goal is to make it easier for people to get screened…

This study uses a non-invasive brain stimulation technique called rTMS to see how stimulating specific brain networks changes mood, thinking, and brain activity. Researchers will compare results from people with major depression and healthy volunteers. The goal is to understand h…

This study looks at 1,200 people with T-cell or NK-cell lymphoma to see how their genes affect their response to treatment. Researchers will use machine learning to find patterns that predict survival and whether the cancer comes back. The goal is to move toward personalized trea…

This study aims to create a test that tells doctors whether a donated liver is healthy enough to transplant. Researchers will take small tissue samples from livers before and after transplant surgery and analyze them to find markers of good function. The goal is to help more live…

This study is testing whether wearable devices like Fitbits and Apple Watches can help doctors catch complications early after heart or lung surgery. Researchers will use machine learning to analyze data from 1,200 patients to predict recovery quality and detect problems sooner. …

This study is testing a new imaging tool called OCT Vibrography that measures how stiff or flexible tissues like the cornea, skin, and gums are. About 90 healthy volunteers will have their tissues scanned with a special light-based device. The goal is to see if the tool is safe a…

This study tests whether showing a video about advance care planning at home helps people with life-limiting illnesses understand hospice care and document their medical wishes. About 500 adults with a one-year prognosis or less will be randomly assigned to watch the video or rec…

This study is for adults who have had a stroke (blood clot or bleeding in the brain). Researchers want to learn why some people develop memory and thinking problems after a stroke, while others do not. They will use brain scans, blood tests, and memory tests to find clues. The go…

This study looks at whether telling people their genetic risk for heart disease (called a polygenic risk score) helps them lower their cholesterol and improve their heart health over one year. About 500 adults aged 30-75 who are not on cholesterol medication will be randomly assi…

This study looks at how a gentle, noninvasive nerve stimulation on the ear affects the brain and stomach. Researchers will use brain scans and stomach imaging to measure changes in activity. The goal is to understand how this stimulation works in healthy people and those with sto…

This study collects blood samples from up to 1,000 adults with PSP, CBS, or MSA and their family members to search for genes linked to these rare brain disorders. Researchers will sequence participants' DNA to find known and new genetic variants. The goal is to better understand …

This study is testing a 9-session group program called Changing Lives and Changing Outcomes-9 for people with serious mental illness who have been in trouble with the law. The goal is to help them understand their mental health better and reduce their chances of future legal prob…

This study looks at whether low-dose CT scans are a good way to screen for lung cancer in Black individuals aged 50-80 who have smoked. Researchers want to see if this group will take part in screening and how well the scans find cancer. The goal is to improve early detection in …

This study uses a special MRI technique to look at the microscopic structure of the heart muscle in people at risk for heart failure. Researchers want to understand how heart muscle fibers change over time in conditions like heart attack and thickened heart walls. The goal is to …

This study looks at how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will use a special imaging technique (PET/MRI) to measure changes in the arteries and bone marrow. The goal is to …

This study is creating a large database of up to 5,000 children who received radiation therapy for cancer. Researchers want to compare proton beam therapy with standard photon therapy to see which causes fewer long-term side effects. Children under 22 treated at participating cen…

This study enrolls 2,000 Hispanic current or former smokers aged 50-80 who are not already getting lung cancer screening. Participants watch an educational video about screening and complete short surveys. The goal is to find out what stops people from getting screened and whethe…

This study works with clinics in Massachusetts to help people in underserved communities manage weight, get cancer screenings, and improve mental health. About 3600 adults who speak English or Spanish can join if they have obesity, are behind on colon or cervical cancer screening…

This study looks at how the liver's immune system responds to a chemotherapy drug called melphalan, given directly to the liver through a special procedure. Ten adults with eye melanoma that has spread to the liver will have small tumor samples taken before and after treatment to…

This study is testing whether low-intensity focused ultrasound (LIFUP) can help people with severe brain injuries who have not fully recovered consciousness. Researchers will measure changes in behavior and brain activity before and after the ultrasound sessions. The study involv…

This study aims to measure levels of a protein called fibrin in the brains of people with Alzheimer's disease and related dementias, compared to healthy volunteers. Researchers will use a special PET scan with a tracer called 64Cu-FBP8 to see if fibrin levels differ between group…

This study looks at whether giving emergency room patients with dental problems extra help—like lists of nearby dentists and social services, or even a navigator to assist them—can increase the number of people who actually go to a dental appointment. About 2,900 adults with unme…

This study aims to understand how the brain changes when people recover arm movement after a stroke. Researchers will enroll 50 people who had a stroke 3-6 months ago and have moderate to severe arm weakness. Participants will either receive intensive arm training or usual care, …

This study is observing 3,000 people with various types of heart failure to learn how the disease develops and progresses over time. Researchers will collect medical data, blood samples, and imaging to identify distinct groups of heart failure. The goal is to help doctors choose …

This study uses three types of brain scans (PET, MRI, and EEG) to see how epilepsy affects brain activity and energy use. Researchers will compare scans from 30 healthy adults and people with epilepsy. No treatment is given—the goal is simply to learn more about the condition.

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will look at problems like nausea, low blood pressure, and kidney injury. The goal is to improve fasting guidelines for the millions of people who have procedures each y…

This study looks at whether the natural bacteria in your gut are linked to mood changes after having a baby, including postpartum depression. Researchers will collect samples from 30 pregnant women before and after delivery to see if certain gut bacteria patterns relate to emotio…

This study tests two different educational programs to see which one helps adults with Neurofibromatosis 1 (NF1) and parents of children with NF1 get the recommended health screenings during their regular check-ups. Participants live in the U.S., do not visit a specialized NF cli…

This study looks at whether stopping tube feeding for at least 8 hours before a procedure (fasting) or continuing it until right before (not fasting) leads to better recovery in critically ill patients on breathing machines. About 1,072 adults in the ICU will be randomly assigned…

This study looks at brain activity related to speech in people with Parkinson's disease, essential tremor, or dystonia. Participants are already scheduled for deep brain stimulation (DBS) surgery. Researchers will record brain signals during speech tasks to better understand how …

This study looks at tiny particles called extracellular vesicles that are released from fat cells. Researchers want to understand how these particles carry signals that may affect the heart and liver, especially in people with obesity. About 100 adults having weight-loss surgery …

This study aims to understand why some people develop chronic pain after surgery by examining brain activity and sensory responses. Researchers will enroll 110 adolescents and adults who have had pain for at least 3 months following a surgery. The goal is to find better ways to m…

This study aims to find biological markers in spinal fluid and blood that could predict when prion disease will start in people who carry a genetic risk. Researchers will follow 150 adults aged 18-85 who have a family history of prion disease, along with some healthy volunteers. …

This early-phase study at Massachusetts General Hospital is testing a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. The study includes 40 people aged 50-80 with Parkinson's disease, multiple system …

This study tests a new swallowable capsule that takes detailed images of the esophagus and collects tiny tissue samples from areas that look abnormal. The goal is to see if this method can safely gather enough tissue for genetic analysis to better predict cancer risk in people wi…

This study tests whether a special video and support program (VIDEO-PEDS) helps parents and doctors have better conversations about treatment goals for children with cancer. About 567 parents of children aged 0-12 with any type of cancer will take part. The goal is to see if the …

This study looks at whether an online platform can help adults with neurofibromatosis 1 (NF1) who have low health literacy better understand their symptoms and care. Participants get personalized care letters and either educational videos or a call with a peer navigator. The goal…

This study looks at whether sleep and body-clock patterns can help predict delirium (sudden confusion) after major orthopedic surgery in adults aged 70 and older. Researchers will track sleep with a watch worn for two weeks before surgery and collect blood samples to check for Al…

This study is testing a new wireless capsule that you swallow to measure temperature inside your digestive tract. The goal is to see if it can help doctors find diseases like Crohn's disease. Ten healthy adults will take part to check if the capsule works correctly.

This study looks at whether suvorexant (Belsomra), a drug approved for insomnia, can lower brain activity related to cannabis use. Twenty adults who use cannabis daily or near-daily will take the medication for 14 days and have two brain scans. The goal is to see if the drug chan…

This study looks at how a person's genetic makeup influences their body's response to oral semaglutide, a medication used for type 2 diabetes. Researchers will give 125 people with normal to prediabetic blood sugar levels the drug for two weeks and measure changes in blood sugar …

This study is building a large database of health information from people with ALS and other motor neuron diseases. Researchers will collect details like symptoms, test results, and survival data during regular clinic visits. The goal is to help scientists better understand how t…

This study follows 40 people with Angelman syndrome over one year to see how their skills, brain activity, and sleep change. Participants visit the study site five times for tests and questionnaires, plus wear a sleep monitor at home. The goal is to better understand the natural …

This pilot study in 12 healthy volunteers aims to see if biological sex influences how quickly people recover from a sedative called dexmedetomidine. Researchers will also test whether a combination of brain stimulation and EEG can measure brain complexity during sedation without…

This study gathers opinions from patients, families, and doctors about using advanced brain scans and EEG to detect consciousness in people who appear unresponsive after severe brain injury. The goal is not to treat, but to understand what matters ethically when using these techn…

This study follows 500 infants who have a parent or sibling with celiac disease. Researchers collect stool and blood samples over time to track gut bacteria, gut health, and immune responses. The goal is to identify early signs that may predict who will develop celiac disease, wh…

This study tests a special care plan for people 65 and older who are having colorectal surgery. The goal is to see if this plan helps them recover better after leaving the hospital and reduces the chance of being readmitted. About 30 participants will take part to see if the prog…

This study is looking for easier ways to track muscle diseases like muscular dystrophy. Instead of taking small pieces of muscle (biopsies), researchers want to see if blood and urine samples, plus painless ultrasound and electrical tests on arms and legs, can give the same infor…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life. About 388 pairs (patient and caregiver) will take part. The program focuses on building resil…

This study tests whether brief smartphone messages, sent when a person reports suicidal thoughts, can help them use their safety plan and lower their immediate risk. About 185 adults hospitalized for suicidal thoughts will answer surveys up to 4 times daily and may receive a tail…

This study tests whether a gentle, non-invasive brain stimulation technique called rTMS can improve motivation, memory, and brain function in healthy older adults and people with very early Alzheimer's disease. Participants will receive daily stimulation sessions for two weeks, w…

This study talks to adults aged 45 to 54 who have never been screened for colorectal cancer, as well as health center staff, to learn what makes it easier or harder to get screened. Researchers will conduct interviews and surveys to identify barriers and find better ways to encou…

This study is testing a special PET/MR scan that uses a radioactive tracer to detect scar tissue in the gut of people with Crohn's disease. The goal is to see if the scan can accurately tell the difference between scarred (fibrotic) and inflamed strictures, which could help docto…

This study looks at how certain brain rhythms help us hold information in short-term memory. Researchers will use a gentle, noninvasive technique called tACS to adjust these rhythms in 32 healthy adults while they perform memory tasks. The goal is to understand how the brain work…

This study aims to understand how cannabis use and withdrawal affect depression and suicide risk in teenagers aged 12-18 who use cannabis daily or near-daily. Researchers will use smartphone surveys multiple times a day to track mood, cannabis use, and suicidal thoughts in real t…

This study is testing whether a non-invasive brain stimulation technique called tDCS can improve executive functions—like memory, attention, and decision-making—in people with various neuropsychiatric conditions. Researchers will enroll 600 adults with diagnoses such as traumatic…

This study uses a special PET-MR scan to measure a protein called HDAC in the heart. Researchers will compare HDAC levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how heart disease develops, not to provide treatme…

This study looks at whether a single session of mindfulness-based neurofeedback can change brain activity in teens who often get stuck in repetitive negative thinking. Researchers will compare 50 at-risk teens with 50 healthy teens to see if the training reduces overactivity in a…

This study looks at people who have developed new spine problems near a previous fusion surgery. It compares two surgical options: a simpler decompression surgery versus a more complex one that also extends the fusion. The goal is to find out which approach leads to better physic…

This study is testing whether giving patients pain medicine without opioids after major bone surgery is possible and works well. About 100 adults who had orthopedic surgery will either get the usual opioid prescription or an opioid-free plan. The main goal is to see if a larger s…

This study looks for markers in blood and urine that can show how active and severe myotonic dystrophy is. The goal is to find a less invasive way to measure the disease than taking a piece of muscle (biopsy). Researchers will compare samples from 215 people with and without the …

This study looks at how different parts of the brain talk to each other in healthy adults. Researchers will use safe, non-invasive methods like magnetic stimulation and brain wave recordings to measure these connections. The goal is to better understand normal brain function, not…

This study tests a new, compact imaging capsule that people swallow to take pictures of the esophagus. It includes up to 120 healthy volunteers and people with Barrett's esophagus, a condition that can raise the risk of esophageal cancer. The goal is to see if the capsule is safe…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of adults with stable heart disease. Participants must feel stressed and have a history of heart problems. Researchers will use special PET/MRI scans to measure changes in inflam…

This study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illness like psychosis or schizophrenia. Researchers will use surveys, daily check-ins, and brain scans to understand these connections. The goal is to…

This registry aims to learn how safe psychiatric medications (like antidepressants and ADHD drugs) are during pregnancy. Researchers will follow 5,000 pregnant women aged 18-45 who take these medications, collecting information on birth outcomes and infant health through the firs…

This study looks at how prolonged exposure therapy helps people with PTSD. Researchers will measure brain activity, stress responses, and symptoms before, during, and after 10 therapy sessions. The goal is to understand why the therapy works and who benefits most. 50 adults with …

This study tests a program called iDECIDE for about 300 middle and high school students who recently broke their school's drug rules. Instead of punishment, students take a course on drug effects, brain development, and marketing tactics. Researchers will check if it improves the…

This study is testing a blood test that looks for tiny pieces of prostate cancer cells floating in the bloodstream, called circulating tumor cells (CTCs). The goal is to see if the number and type of these cells can tell doctors more about the cancer and how it responds to surger…

This study is looking for immune markers that show whether a person is protected from cholera after vaccination or natural infection. About 1,200 healthy people aged 2 to 80 will receive either a cholera vaccine or a typhoid vaccine (as a control) and provide blood samples over t…

This study looks at whether telling people they have a high genetic risk for heart disease helps them improve their heart health over one year. About 200 adults aged 40 to 75 who have a high genetic risk but no current heart disease will take part. Half will learn their genetic r…

This study looks for markers in blood and urine that can show how active and severe Duchenne muscular dystrophy is. The goal is to find a less invasive way to track the disease instead of taking muscle biopsies. Researchers will compare samples from people with Duchenne or Becker…

This study looks at whether using a standard system to describe voice therapy sessions helps people with muscle tension dysphonia (a voice disorder caused by muscle strain) improve more. About 600 adults will receive standard voice therapy, but their therapists will use a special…

This study looks at spinal fluid and brain activity in people with myotonic dystrophy type 1 to find early signs of the disease. Researchers will compare fluid samples from affected and unaffected volunteers. No treatment is given; the goal is to better understand the condition a…

This study follows 100 active-duty Navy SEALs over 4 years to see if repeated exposure to blasts affects their brain health. Researchers will use brain scans and blood tests to look for early signs of injury. The goal is to create a test that can detect blast-related brain damage…

This study is for women aged 60 and older with newly diagnosed breast cancer who are scheduled for chemotherapy. Researchers want to understand how chemotherapy affects thinking skills and the brain over time. Participants will complete thinking tests and some may have brain scan…

This study looks at why some people don't get a follow-up colonoscopy after a positive FIT (stool) test for colorectal cancer. Researchers will test simple strategies to help more people complete the colonoscopy, especially in underserved communities. About 45 adults aged 45-75 f…

This study looks at whether blocking out noise from cars, planes, and trains with earplugs can reduce stress and lower the risk of heart disease. Researchers will study 26 adults who are bothered by noise or live in noisy areas and have heart disease risk factors. Participants wi…