Massachusetts General Hospital

This study tested a 4-month program where community health workers provided nutrition education and support to 60 primary care patients with high blood pressure and food insecurity. The goal was to see if adding nutrition help to existing blood pressure coaching was feasible and …

This study tested the safety and best dose of a drug combination (olaparib plus temozolomide) in 49 adults with Ewing sarcoma or rhabdomyosarcoma that had come back or spread after standard chemotherapy. The goal was to find a dose that could be given safely and to see if the com…

This study tested a program called Positive Minds-Strong Bodies Enhanced for older adults from minority groups who have depression, anxiety, or physical limitations. The program combines mental health support with physical exercises to help prevent disability. Over 400 participan…

This early-phase study tested the drug regorafenib in 16 adults with advanced blood cancers like acute myeloid leukemia (AML) that had stopped responding to other treatments. The main goal was to find the safest dose and see how the drug affects cancer-related cell signals. While…

This study tested the drug D-cycloserine in one person with a rare genetic form of hereditary spastic paraplegia, a condition that causes muscle stiffness and movement problems. The goal was to see if the drug could safely reduce harmful fat-like substances in the body and slow d…

This study tested a two-step approach for people with advanced bladder cancer that has spread. First, doctors freeze some tumors (cryoablation), then give an immunotherapy drug (pembrolizumab or avelumab) to help the immune system attack remaining cancer. Only 9 people took part,…

This study tested whether a high dose of calcitriol (a form of vitamin D) alone can improve blood phosphate levels and bone health in 16 people with X-linked hypophosphatemia (XLH), a genetic condition that causes weak bones and poor growth. Participants took calcitriol for one y…

This study tested adding a precise type of radiation (SBRT) to standard targeted therapy for people with stage IV non-small cell lung cancer that has specific gene changes (EGFR, ALK, or ROS1). The goal was to see if this combination could delay the cancer from spreading to new a…

This study tested a new radiation schedule (once a week for 5 weeks) in 10 people with B-cell lymphoma that had come back or not responded to treatment. The goal was to see if this approach is practical and has fewer side effects before patients receive CAR T-cell therapy. The st…

This study tested whether offering financial rewards helps homeless smokers quit. 184 adults who were currently or formerly homeless received smoking coaching, a prescription for a quit-smoking drug, and some also got cash rewards for staying smoke-free. Researchers checked if th…

This early-phase study tested two drugs, bortezomib and lenalidomide, in 22 adults whose acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) came back after a stem cell transplant. The main goal was to find the safest dose and see if the combination could reduce cancer…

This early-phase study tested a newer, more precise type of proton radiation (pencil beam scanning) combined with standard chemotherapy for anal cancer. The goal was to see if this approach is practical and can reduce side effects by better targeting the tumor and sparing healthy…

This study tested a combination of two immunotherapy drugs, ipilimumab and nivolumab, in 18 adults with leptomeningeal metastases—cancer that has spread to the fluid and lining around the brain and spinal cord. The main goal was to see how long participants lived and what side ef…

This study tested different ways to deliver HIV treatment to people in South Africa who had a detectable viral load or were not engaged in care. The goal was to see which approach helped the most people achieve viral suppression at 18 months. The study enrolled 874 adults and com…

This study tested whether giving a heart medication (amiodarone) before surgery plus a small surgical cut in the heart lining can prevent a common irregular heartbeat after heart surgery. About 242 adults having bypass surgery took part. The goal was to see if this combo reduces …

This study tested a drug called pembrolizumab in 21 people with recurrent respiratory papillomatosis (RRP), a condition where non-cancerous growths come back in the throat, windpipe, or lungs. The goal was to see if the drug could shrink these growths and reduce the need for freq…

This study tested a probiotic called INF108F in 20 breastfed infants with a food allergy that causes bleeding in the gut. The goal was to see if the probiotic could improve the balance of gut bacteria and reduce symptoms like reflux and fussiness. The study is complete, but resul…

This study looked at whether a dedicated clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure, including those with reduced or preserved pumping function, took part. The goal was to see if the clin…

This study tested a program to help HIV-positive men who have sex with men (MSM) and struggle with substance use feel less shame and stigma about their health. The goal was to help them stay engaged in HIV care. Fifty participants tried the program, and researchers checked if it …

This study tested whether a drug called denosumab can improve bone density in women with anorexia nervosa, who often have weak bones. Thirty women received either denosumab or a placebo for 12 months, and some continued with another bone medication for an additional year. The goa…

This study tested a precise type of radiation called proton beam therapy for people with cancer that spread to the liver. 92 adults with 1 to 4 liver tumors received this treatment. The goal was to see if it could stop tumor growth and cause fewer side effects than standard radia…

This study tested whether the drug ritlecitinib can protect people with celiac disease from gut damage and symptoms when they eat gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. T…

This pilot study tested whether ibutamoren, a drug that boosts growth hormone, can reduce fat buildup in the liver of people with nonalcoholic fatty liver disease (NAFLD). Twelve generally healthy adults with NAFLD took the drug for 6 months. Researchers measured changes in liver…

This study tested whether adding lenalidomide to a standard chemotherapy regimen (MEC) could help adults with acute myeloid leukemia (AML) that either did not respond to initial treatment or came back after treatment. The trial enrolled 41 people aged 18 to 70. The main goal was …

This study tested whether denosumab, a drug used for osteoporosis, can prevent the rapid bone loss that often happens after weight-loss surgery. It included 36 postmenopausal women and men aged 50 or older who were planning either gastric bypass or sleeve gastrectomy. Participant…

This study looked at whether a precise type of radiation called proton beam therapy can control liver cancer that cannot be surgically removed. It included 83 adults with liver cancer. The goal was to see if this treatment can kill cancer cells while causing fewer side effects th…

This study tested whether blocking a hormone called aldosterone and boosting another called BNP can reduce early heart damage in people with HIV. 39 adults with well-controlled HIV and signs of early heart strain took part. The goal was to see if this approach could lower inflamm…

This small pilot study looked at whether giving free e-cigarettes to smokers who hadn't quit after lung cancer screening could help them smoke fewer regular cigarettes. Fifteen people who still smoked were offered e-cigarettes for 4 weeks and then followed for another 4 weeks. Th…

This study looked at how the drug ocrelizumab changes brain inflammation in people with multiple sclerosis (MS). Researchers used special brain scans to measure inflammation before and after one year of treatment. The study included 22 adults with relapsing-remitting or progressi…

This study tested the drug enasidenib as a maintenance therapy after stem cell transplant in 23 people with IDH2-mutant acute myeloid leukemia or chronic myelomonocytic leukemia. The goal was to find the safest dose and see if it could help prevent the cancer from coming back. Pa…

This study tested the drug baricitinib, currently used for arthritis, in 17 people with Alzheimer's disease, ALS, or early memory problems. The goal was to see if the drug could reach the brain and reduce inflammation linked to these diseases. Participants took the drug for 24 we…

This study tested the drug ivosidenib as a maintenance therapy to prevent relapse in people with IDH1-mutated blood cancers (like AML, MDS, or CMML) after a stem cell transplant. 18 adults aged 18-75 took part. The goal was to find the safest dose and see if it could help keep th…

This early-phase study tested a combination of two drugs—oral decitabine and durvalumab—in 13 adults with head and neck cancer that had stopped responding to standard immunotherapy. The goal was to see if the combination could boost the immune system to fight the cancer again. Th…

This study tested a drug called tesamorelin in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The drug aims to boost growth hormone levels, which may reduce liver fat and inflammation. Researchers measured liver fat with special scans and biopsies to see if the tr…

This study tested whether a newer blood thinner (rivaroxaban) is safer and more cost-effective than the standard drug warfarin for patients who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new irregular heartb…

This study tested a program called iSTRIVE to help people with HIV who also use opioids or stimulants stay engaged in their HIV care. The program taught emotion regulation and communication skills, and included video check-ins for taking medication. The goal was to see if the pro…

This study tested a drug called denosumab in 55 people with multiple myeloma and severe kidney problems. The goal was to see if it could help control bone damage caused by the cancer. Researchers measured changes in bone turnover markers and watched for side effects like low calc…

This study tested whether breathing in nitric oxide gas helps COVID-19 patients on ventilators get more oxygen into their blood. The trial included 200 adults in intensive care units. Researchers measured changes in oxygen levels after 48 hours of treatment.

This study tested a combined bone marrow and kidney transplant from a partially matched family donor for 10 people with both a serious blood disorder and chronic kidney disease. The goal was to treat both conditions with one donor, potentially reducing the need for lifelong anti-…

This early study tested a powerful mix of chemotherapy drugs (FOLFIRINOX) along with radiation before surgery for people with gastroesophageal junction cancer. The goal was to see if patients could complete the full treatment plan. 25 adults took part, and researchers tracked sid…

This early-phase study tested the safety of adding nilotinib, a drug that targets a specific growth signal in chordoma cells, to standard radiation therapy for people with high-risk chordoma. The goal was to find the highest safe dose of nilotinib when combined with radiation. Tw…

This study looked at whether giving a special research e-cigarette to people who are on medication for opioid use disorder and smoke cigarettes could help them smoke less. 41 adults who were stable on buprenorphine and not ready to quit smoking were randomly assigned to get the e…

This study tested a chemotherapy pill (TAS-102) combined with targeted radiation for people with colorectal cancer that has spread to the liver. The goal was to find the safest dose and see how well the combination controls tumor growth. About 52 adults with 1 to 4 liver tumors t…

This study tested whether a rapid 30-minute test for gonorrhea and chlamydia helps doctors treat patients with symptoms of urethritis or cervicitis more effectively than the current standard. About 100 adults took part, providing samples during their clinic visit. The goal was to…

This study looked at over 5,000 people aged 45-75 who were overdue for colorectal cancer screening. Participants received either a FIT or Cologuard test in the mail to complete at home. The goal was to see which test more people actually finished, helping improve screening rates …

This early-phase study tested whether losartan, a common blood pressure medication, could prevent early heart damage caused by radiation therapy in breast cancer patients. Five women with left-sided breast cancer took losartan during their standard radiation treatment. Researcher…

This study tested whether giving a decision support tool to adults aged 45-75 before their primary care visit helps them complete colorectal cancer screening. Over 9,200 average-risk participants were involved. The tool was part of a routine pre-visit questionnaire and aimed to h…

This study tested whether helping fathers get involved during pregnancy and the first year of life can prevent rapid weight gain and obesity in babies. Over 650 families from diverse backgrounds took part. The program provided extra support to parents, focusing on healthy eating,…

This study tested a program to prevent obesity in mothers and children from pregnancy through age 2. It involved over 1,600 families at community health centers in Boston, focusing on healthy eating, physical activity, sleep, and addressing social needs. The goal was to reduce ob…

This study tested whether giving nitric oxide during heart-lung bypass surgery could prevent acute kidney injury in 250 adults at high risk due to blood vessel problems. Participants received either nitric oxide or a placebo during surgery. The goal was to see if the treatment re…

This study tested two culturally adapted HIV prevention programs for African-born women living in the Boston and New York City areas. One program was one-on-one, the other was a group program. The goal was to see which approach works better at increasing condom use and PrEP use. …

This study tested whether offering HIV prevention pills (PrEP), birth control, and STI testing in hair salons could make it easier for women in Umlazi, South Africa to get care. About 436 women took part, with some salons offering services and one serving as a comparison. The goa…

This study tested a virtual group program to help parents of children with learning or attention problems feel less stressed. About 28 parents took part, either in a mind-body resiliency group or a health education group. The goal was to see if the program was easy to use and hel…

This study tested a non-invasive device that sends mild electrical pulses to a nerve in the ear to see if it can reduce chronic low back pain. Researchers measured pain levels and physical disability in 70 adults over several weeks. The goal was to find a drug-free option that co…

This study tested whether a smartphone app called Healthy Minds Program could help reduce stress in people caring for a loved one with dementia. About 93 stressed caregivers used either the Healthy Minds app or a wellness podcast app for a few weeks. The main goal was to see if u…

This study tested a program that combines positive psychology and motivational interviewing to help people who had weight loss surgery become more physically active. Twelve adults who had surgery 6-12 months earlier and were not very active took part. The program aimed to see if …

This study tested a program called CONTINUUM for people with advanced cancer leaving the hospital. Within three days of going home, patients had a video visit with a specialized nurse to support their transition. The goal was to see if this extra support helps patients feel more …

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to higher quit rates comp…

This study tested whether atomoxetine, a drug used for ADHD, can help reduce hyperactivity, inattention, and impulsivity in children and teens with autism. Sixty participants received either the drug or a placebo for 8 weeks. The goal was to see if the drug could improve these sp…

This study tested a mind-body program called 'Recovering Together after Cardiac Arrest' for survivors and their caregivers. The goal was to see if the program was feasible and helpful for reducing emotional distress. 14 survivor-caregiver pairs participated in a mix of in-person …

This study tested a non-invasive brain stimulation method called tACS in 17 people with early to moderate Alzheimer's. The goal was to see if daily sessions over 2-4 weeks could safely reduce amyloid and tau buildup in the brain and improve memory and thinking. Participants recei…

This study tested two stress and symptom management programs delivered through live video for adults with neurofibromatosis (NF1, NF2, or schwannomatosis). The goal was to see if these programs could improve physical and mental quality of life. 228 participants who reported diffi…

This study looked at whether strengthening a small thumb muscle (first dorsal interosseous) can help people with thumb osteoarthritis. 160 adults who already use a thumb splint were enrolled. Researchers measured pinch strength and pain levels after 12 weeks of the strengthening …

This study tested whether a 12-week cognitive behavioral therapy (CBT) group program is practical and well-liked by older adults (50+) living with HIV. The program aimed to help participants better handle stress related to aging and HIV, and encourage healthy behaviors like physi…

This study tested whether a non-invasive brain stimulation technique called TMS could improve language in people with primary progressive aphasia (PPA), a condition that slowly destroys the ability to speak and understand language. Ten adults with different types of PPA received …

This study tested whether a special type of heated yoga (hyperthermic yoga) can help reduce symptoms of depression. 80 adults with mild to moderate depression were randomly assigned to either take yoga classes twice a week or join a waitlist. Researchers measured how acceptable a…

This study tested a nurse-led program to improve quality of life for 50 adults with cancer who are in early phase clinical trials. The program included regular check-ins, symptom monitoring, and team meetings led by a clinical research nurse. The goal was to see if the program wa…

This study tested a computer-based program that combines mental exercises and relaxation techniques for people with mild cognitive impairment (MCI), a condition that causes slight but noticeable memory and thinking problems. The program was designed to be used at home, making it …

This study tested whether a non-invasive brain stimulation technique called TMS could reduce symptoms of obsessive-compulsive disorder (OCD) in 26 adults. Participants received either real TMS or a sham (fake) treatment over six weeks, and researchers measured changes in OCD seve…

This study tested whether having a peer mentor through video chats and texts could help reduce depression in older adults, especially those with low income or from ethnic minority groups. 34 participants aged 50 and older with mild depression were assigned to receive 8 weekly vid…

This study tested a psychological program to help caregivers of cancer patients receiving a stem cell transplant. 100 caregivers took part, and the program aimed to improve their quality of life and mood. The approach involved teaching coping skills through several sessions.

This study tested a light-based treatment called transcranial photobiomodulation (tPBM) to see if it could safely reduce autistic traits in children and teens with ADHD. 38 participants aged 9 to 17 received the treatment. The goal was to improve social skills and ADHD symptoms, …

This study tested whether a package of extra support—including a smart sleep bassinet, wearable breast pump, 24/7 online perinatal care, and a faculty mentor—could improve wellbeing and reduce burnout in pregnant trainee doctors. 156 pregnant residents and fellows from four hospi…

This small pilot study tested a mindfulness-based therapy adapted for older Black adults (age 50+) who have both chronic pain and early memory decline. The goal was to see if the program could improve quality of life and reduce how much pain interferes with daily activities. Nine…

This study tested a new program called 'Improving Life with CF' at five cystic fibrosis (CF) centers. The program helps doctors regularly check for and treat common problems like pain or stress, and provides education for patients and families. Over 600 people with CF took part t…

This study looked at 20 adults with short bowel syndrome who receive nutrition through a tube at home. Researchers compared giving the nutrition during the day versus at night to see if it improved sleep quality and blood sugar levels. The goal was to find a simple change that co…

This study tested a program that combines mind-body skills (like deep breathing and relaxation) with a Fitbit activity tracker to help people with long-term pain. 82 adults with chronic pain took part in weekly sessions and wore the device. The goal was to see if the program was …

This study tested a 20-session therapy program for children ages 4 to 7 who were at risk for anxiety disorders. The program included sessions for parents and children together. Out of 65 children, those who received the therapy showed much greater improvement in anxiety symptoms …

This study looked at whether omega-3 fatty acids can reduce inflammation and improve depression in people whose depression hasn't improved with standard antidepressants. 14 adults with treatment-resistant depression were randomly given either omega-3 or a placebo for 12 weeks. Re…

This study tested a new program called MASC (Mindful and Self-Compassionate Care Program) to help caregivers of people with Alzheimer's or related dementias manage stress. 82 caregivers took part in a pilot study to see if the program was feasible and helpful. The program teaches…

This study tested a new way to help people with long-term low back pain. It combined virtual reality (VR) with guided imagery of acupuncture, without using real needles. 31 adults with chronic pain tried it. The goal was to see if people would stick with the treatment, how satisf…

This study tested whether laser treatment or a simple punch biopsy (removing a tiny piece of scar tissue) improves burn scars better than no treatment. Seventeen adults with burn scars each had three small areas on one scar treated differently: one with laser, one with punch biop…

This study tested a new, non-invasive treatment called transcranial photobiomodulation (tPBM) for adults with autism spectrum disorder. Over 8 weeks, 41 participants received either the light therapy or a placebo to see if it was safe and could improve social and behavioral sympt…

This study tested two natural supplement combinations—omega-3 plus inositol versus N-acetylcysteine (NAC)—to see if they could help children and teens (ages 5-17) with emotional ups and downs. Over 6 weeks, 27 participants took one of the two treatments. The goal was to find a ge…

This study tested whether learning three skills to manage negative emotions and getting smartphone reminders to practice them can reduce how often and how intensely people feel emotional distress and suicidal thoughts. 41 adults with recent suicidal thoughts or a suicide attempt …

This study looked at 60 adults with trigger finger to compare two surgical treatments: the standard open release and a newer ultrasound-guided method. The goal was to see which approach helps people get back to daily activities faster with less pain. Participants were followed fo…

This small pilot study tested a mindfulness-based therapy adapted for older Black adults (age 50+) who have both chronic pain and depression. The goal was to see if this approach could improve quality of life and reduce pain interference. The study enrolled 12 participants and me…

This early-phase study tested whether cooling the skin before and during laser or injection treatments for neurofibromatosis type 1 (NF1) skin bumps can reduce pain. Thirteen adults with NF1 each received treatment on one cooled site and one non-cooled site. The main goal was to …

This small pilot study tested a new mind-body program to help female colorectal and anal cancer survivors improve their sexual well-being. Six women who had finished initial cancer treatment took part in group sessions. The goal was to see if the program was acceptable and helpfu…

This study tested if cognitive-behavioral therapy (CBT) plus nutrition counseling helps children and teens aged 10-18 with Avoidant/Restrictive Food Intake Disorder (ARFID). 53 participants completed the trial. The goal was to reduce fear of new foods and improve eating habits.

This study tested a smartphone-based breathing exercise (heart rate variability biofeedback) to help people with substance use disorder. 120 adults in early recovery used the app to practice slow breathing for 15 minutes daily. Researchers measured whether the app helped reduce c…

This study looked at whether a psychological treatment can help people who get stuck in repetitive negative thinking, like worries, mental rituals, or depressive rumination. 65 adults with OCD, generalized anxiety, or major depression took part. The goal was to see if treatment c…

This study tested a program to help stem cell transplant survivors who have sexual problems. About 230 adults who had a transplant at least three months earlier took part. The program aimed to improve sexual function, quality of life, and mood. Results were measured using patient…

This study tested a program that helps advanced cancer patients recover at home after a hospital stay. The program uses remote monitoring of symptoms, vital signs, and weight, along with home visits and nurse calls to manage any issues. The goal was to see if this approach is pra…

This study looked at whether a virtual mind-body program called SMART-3RP can help caregivers of cancer survivors feel more resilient and less distressed. About 94 people (cancer survivors and their caregivers) took part. The program was compared to an online support group to see…

This pilot study tested a program called PROWESS that uses fitness trackers and coaching to help Black and Hispanic men with prostate cancer exercise more while on hormone therapy. The goal was to reduce treatment side effects and improve quality of life. Fourteen men participate…

This study tested a new 3-session mind-body pain management program called PACE CF for adults with cystic fibrosis (CF). The program was delivered via telehealth by a member of the CF care team. The goal was to see if the program was acceptable and feasible for participants, and …

This study tested a smartphone app called SiS-H designed to help people with HIV quit smoking. 66 participants used either SiS-H or the standard QuitGuide app for 8 weeks. The goal was to see if the new app is easy to use and helps people smoke less.

This small pilot study tested whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) could help people with bipolar disorder improve their emotion regulation. Nineteen participants, including both patients and healthy controls, completed…

This study tested a short, web-based program for parents of children with anxiety who are waiting for cognitive behavioral therapy (CBT). The program aims to reduce how much parents accommodate their child's anxiety, which can make anxiety worse. 47 parents of children aged 5-12 …

This study looked at whether a program to improve physical fitness, nutrition, and sleep before surgery is possible for older adults with esophageal cancer. Fifteen patients aged 65 and older took part after finishing chemotherapy or radiation. The goal was to see if patients wou…

This study tested different doses of light therapy to see which works best for improving sleep in people with Parkinson's disease. 203 participants received either bright white or dim red light at different times of day. The goal was to find the most effective way to ease sleep p…

This study tested a short, nurse-led program to help breast cancer survivors who were hesitant or delayed in starting hormone therapy. The program aimed to support patients in making informed decisions. The study enrolled 35 women and measured how feasible and acceptable the prog…

This study tested whether a mind-body walking program is practical and helpful for adults with long-term muscle or bone pain. About 92 people took part, comparing the walking program to a health education class. The goal was to see if people would join, stick with it, and find it…

This pilot study looked at whether providing overnight infant care (respite) could help new mothers with substance use disorder get better sleep and feel better. 41 mothers living in residential treatment programs took part. The goal was to see if this approach is feasible and ac…

This study looked at how a nerve stimulation device (like a gentle zap on the neck) combined with stress-reduction training affects the brains of people with migraine. Researchers compared brain scans and inflammation levels in 193 adults with migraine and healthy volunteers. The…

This study looked at whether adding medical marijuana to a 24-week support program helps adults with long-term pain reduce their opioid painkiller dose and improve pain. 87 people on high-dose opioids took part. The goal was to see if marijuana could make it easier to lower opioi…

This study looked at whether adding a palliative care team (focused on symptom relief and emotional support) to usual cancer care improves quality of life for people with acute myeloid leukemia (AML). Researchers compared two groups of 160 hospitalized adults with high-risk AML. …

This study tested a program called MASC, designed to help caregivers of people with Alzheimer's disease manage stress. It taught mindfulness, self-compassion, and behavioral management skills through group training. The study included 13 caregivers and focused on whether the prog…

This study tested a stress management and resilience-building program for nurses who care for people with HIV in South Africa's public clinics. The program taught coping skills through group sessions. Researchers wanted to see if nurses found the program helpful and practical, an…

This study looked at whether it is safe for people with HIV to receive an organ transplant from a deceased donor who also had HIV. Researchers followed 13 HIV-positive transplant recipients to track their survival, organ rejection, and HIV progression. The goal was to gather info…

This study looked at how a gentle nerve stimulation device (tVNS) affects the brain's stress response in people with major depression. Researchers tested 62 adults, comparing active stimulation to a sham (fake) version while scanning their brains. The goal was to see if the effec…

This study looked at whether firefighters have different lung scan results compared to non-firefighters, and if a blood test can help predict lung cancer risk. Researchers enrolled 734 current and retired firefighters to compare their low-dose CT scans with those of matched contr…

This study followed 155 children who had proton radiation for brain or central nervous system tumors. Researchers measured changes in thinking skills, behavior, and use of special education services one year or more after treatment. Parents and children filled out questionnaires …

This study tested a 4-session program designed to teach resiliency skills to medical interpreters working in cancer care. 28 interpreters from three hospitals took part. The main goal was to see if the program was feasible and acceptable, and to measure changes in stress and resi…

This study looked at data from nearly 1,800 patients who had a heart attack to find out what causes plaque erosion in the arteries. Researchers combined information from previous studies and new datasets from around the world. The goal is to better understand why plaque erosion h…

This study looked at whether playing soft sounds during a nap can change brain activity and help memory. Thirty healthy adults took a nap in the lab while their brain waves were recorded. They practiced a finger-tapping task before and after sleep to see if the sounds helped them…

This study looked at whether a gentle, non-invasive brain stimulation technique called tDCS can temporarily improve attention and impulse control in adults with ADHD. Researchers compared 83 people with and without ADHD using computer tasks that measure focus and decision-making.…

This study looked at how surgery might affect the brain in people with moderate-to-severe sleep apnea. Researchers used brain scans and memory tests before surgery, two days after, and six months later. They also checked for signs of confusion after surgery and measured inflammat…

This study tested whether shining a special near-infrared light on the head (called transcranial photobiomodulation) can improve thinking, memory, and mood in healthy adults. Researchers enrolled 80 volunteers aged 18-25 or 65-85. Participants received either the light treatment …

This study tested whether a special PET/CT scan can measure inflammation in deep vein thrombosis (DVT) and predict who will develop post-thrombotic syndrome (PTS), a chronic condition causing leg pain, swelling, and ulcers. Researchers followed 51 patients for up to 2 years after…

This study tested a new way of caring for young adults (ages 18-30) with type 1 or type 2 diabetes as they move from pediatric to adult diabetes clinics. 45 participants were split into two groups: one received the new collaborative care model, the other received usual care. Rese…

This study looked at 159 people with advanced colorectal, pancreatic, biliary, or esophageal cancers to see if simple blood tests (tumor markers and liquid biopsies) and patient-reported symptoms could predict whether the cancer would get worse. Researchers compared changes in th…

This study tested a new type of microscope called Spectrally Encoded Confocal Microscopy (SECM) to see if it can take clear images of pigmented skin spots like moles. Sixteen healthy adults with moles on their forearms had their skin scanned. The goal was simply to check image qu…

This study tested a simple, inexpensive device called the Augmented Infant Resuscitator (AIR) that attaches to standard breathing equipment for newborns. The device gives real-time feedback to birth attendants on their ventilation technique, aiming to improve their skills and con…

This study tested whether a gentle electrical current applied to the scalp (transcranial electrical stimulation) can improve performance on a challenging computer task that requires quick thinking and hand-eye coordination. 44 healthy adults with advanced degrees completed the ta…

This study used brain imaging techniques like MEG, EEG, and MRI to explore how the brains of people with autism spectrum disorder process sensory information. 85 participants aged 14 to 32 took part. The goal was to better understand the neural basis of autism, not to test a trea…

This study looked at how different electrical stimulation settings affect abnormal brain activity in people with epilepsy. Researchers tested settings from animal studies against those used in clinics. The goal was to find which settings best reduce spike-ripple brain waves. 28 p…

This study tested a new computer app designed to help doctors and nurses give the right medications during surgery. Forty anesthesia clinicians used the app or the usual method on a manikin (a fake patient) in a simulation. The goal was to see if the app made the process faster a…

This study tested whether adding a special care model (GRACE) to regular annual wellness visits helps older adults with complex health needs. Researchers worked with 110 people aged 65 and older to see if this approach is practical and could reduce hospital stays. The goal was to…

This study tested whether combining acupuncture with a gentle brain-stimulation technique (tDCS) can improve chronic low back pain more than either treatment alone. 116 adults with long-term back pain received one of four treatment combinations for a month. Researchers used brain…

This study looked at how video-guided acupuncture imagery changes brain activity in people with knee osteoarthritis. 125 participants had brain scans before and after treatment to understand the mind-body connection. The goal was to learn more about how imagery and acupuncture wo…

This study looked at how a hormone called kisspeptin changes the body's response to sugar. Sixteen healthy adults received kisspeptin or a placebo and then drank a sugary solution. Researchers measured insulin and blood sugar levels to understand kisspeptin's effect on metabolism…

This study explored whether analyzing social media messages (like WhatsApp and Instagram) can help identify young women at risk for HIV. Researchers collected 6 months of messages from 400 women aged 18-24 in Kisumu, Kenya, and used AI to look for patterns linked to HIV risk. The…

This study looked at whether a low dose of ketamine, a drug often used for anesthesia, could help stimulate breathing in critically ill patients who are on a breathing machine (ventilator). Researchers measured airflow and brain activity in 15 adults in the ICU. The goal was to u…

This study tested a communication program for adults undergoing fecal ostomy surgery. Researchers worked with 25 patients and 4 clinicians to see if the tool was easy to use and helpful. Participants filled out surveys at the start and four weeks later. The goal was to improve su…

This study created a database of 40 volunteers, including both healthy individuals and those with autism spectrum disorder (ages 14-32). The goal was to make it easier to recruit participants for future research on autism and other developmental disorders. No treatment was given;…

This study tested a new program to help caregivers and people with dementia who receive medical care at home. Researchers worked with two home-care practices to see if the program was practical and well-received. The goal was to improve quality of life and reduce caregiver stress…

This study looked at 76 adults with depression to understand why some people get better with a placebo (a fake treatment). Researchers used brain scans and other tests to find clues. The goal is to help design better treatments and clinical trials in the future.

This study looks at how the skin heals after taking many very small skin samples (micro-biopsies) instead of one large piece. The goal is to reduce pain, infection, and scarring from skin grafts used for burns or injuries. Eight healthy adults having tummy tuck surgery took part,…

This pilot study tested whether the BCG vaccine (used for tuberculosis) can change certain markers in the blood and spinal fluid of healthy older adults. Researchers measured immune responses and Alzheimer's-related proteins in 20 participants aged 55-80. The goal was to gather e…

This study followed 10 people with late onset Tay-Sachs disease for 6 months to learn how the condition changes over time. Researchers measured balance, coordination, and brain chemicals. The goal was to gather information that will help design better clinical trials for future t…

This study tested a special camera system that uses near-infrared light to help surgeons see blood flow during minimally invasive surgery for lung or esophagus conditions. 38 adults participated. The goal was to see if this imaging tool could help surgeons identify important anat…

This study developed a new questionnaire called the Down Syndrome Health Instrument (DHI) to measure health in people with Down syndrome. Researchers worked with over 750 caregivers, individuals with Down syndrome, and doctors to create and test the tool. The goal is to help iden…

This study tested a 10-week program that combines positive psychology and motivational interviewing to help people increase physical activity after bariatric surgery. 58 adults who had surgery 6-12 months earlier and wanted to be more active took part. The program was found to be…

This study looked at whether a blood test can predict how prostate cancer responds to the drug abiraterone. Researchers collected blood samples from 40 men with advanced prostate cancer before and during treatment. They measured proteins in rare tumor cells found in the blood to …

This study tested two group-based brain health programs in 60 older adults who had memory concerns and lifestyle risk factors for dementia. The goal was to see if the programs were practical, well-liked, and helpful. Researchers measured satisfaction, participation rates, and ear…

This study tested whether women with different types of gestational diabetes respond differently to meals with varying amounts of carbs, protein, and fat. Nineteen pregnant women with gestational diabetes wore a continuous glucose monitor and ate two different test meals. The goa…

This study looked at whether a non-invasive brain stimulation technique called TMS can help people with bipolar disorder regulate their emotions. Researchers used brain scans and special tasks to measure emotional control in 56 participants. The goal was to understand how TMS aff…

This study tested whether a full-scale trial is possible for a new approach to manage recurrent pain in children with severe neurologic impairment. 54 children and their parents participated, with some receiving the PQ-ResPOND intervention (a web-based survey system plus a pallia…

This study tested whether using computer predictions and camera monitoring could help prevent falls in hospital patients. Over 5,000 adult patients and their nurses took part across three hospital units. Each unit used a different fall prevention method: a risk alert system, came…

This study looked at how deep brain stimulation (DBS) influences the way people approach or avoid difficult decisions. Researchers tested 13 adults with DBS implants for severe depression or OCD, plus epilepsy patients with temporary brain electrodes. Participants played a comput…

This study looked at whether having a skin doctor (dermatologist) see patients within 24 hours of being admitted to the hospital for cellulitis (a skin infection) helps them get better faster. About 246 adults took part, and researchers compared those who got a dermatology consul…

This completed study looked at how blood sugar levels affect sleep in 30 adults with cystic fibrosis-related diabetes. Participants wore devices at home for 10 days to track glucose and sleep patterns. The goal was to see if this type of remote monitoring is feasible and to gathe…

This study looked at how a gentle brain stimulation technique called tDCS affects fear learning in 86 people with obsessive-compulsive disorder (OCD). Researchers measured skin responses and brain waves to see if stimulation helped participants better unlearn fear. The goal was t…

This study tested a smartphone app that gives people real-time reminders to use their safety plan and coping strategies when they report having suicidal thoughts. 103 adults who were hospitalized for suicidal thoughts or behaviors took part. The goal was to see if the app was eas…

This study looked at how playing sounds during sleep affects brain activity and memory in children with Rolandic epilepsy. Researchers used brain scans and memory tests to understand which brain circuits are involved. The goal is to find new ways to treat childhood epilepsy. The …

This study looked at how the brains of fibromyalgia patients and their acupuncturists work together during treatment. Using special brain scans, researchers measured if matching brain activity leads to better pain relief. The goal was to understand the connection, not to test a n…

This study looked at whether the COVID-19 vaccine triggers a strong immune response in people with multiple myeloma or Waldenstrom's macroglobulinemia. Researchers measured antibody levels 28 days after the final vaccine dose in 146 participants. The goal was to understand vaccin…

This study tested a before-school exercise program called BOKS in three schools in Revere, MA. About 188 children aged 5 to 14 took part. Researchers measured changes in body mass index, thinking skills, and quality of life to see if the program helped.

This study looked at how inherited genes influence the way people respond to two common diabetes medications, metformin and glipizide. Over 1,000 adults at risk for or with type 2 diabetes took part. Researchers measured blood sugar and insulin levels after taking the drugs to se…

This study used brain imaging to understand how a low dose of the sedative dexmedetomidine reduces pain. Seventeen healthy adults received the drug while researchers measured changes in brain fluid flow. The goal was to learn more about the drug's pain-relieving effects, not to t…

This study surveyed 714 breast cancer survivors to understand their experiences with COVID-19 vaccination, focusing on lymph node swelling. Researchers wanted to know if this common vaccine side effect causes extra worry or risk of lymphedema in patients who had lymph node surger…

This study followed 344 infants who have a brother or sister with autism from birth to age 3. Researchers collected blood, stool, urine, and saliva samples to look for early signs of autism. The goal was to find biological markers that could help predict autism and lead to earlie…