Promising drug combo targets tough childhood cancers in adults
NCT ID NCT01858168
First seen Jan 10, 2026 · Last updated May 24, 2026 · Updated 19 times
Summary
This study tested the safety and best dose of a drug combination (olaparib plus temozolomide) in 49 adults with Ewing sarcoma or rhabdomyosarcoma that had come back or spread after standard chemotherapy. The goal was to find a dose that could be given safely and to see if the combination might help shrink tumors. This was an early-phase trial, so it focused on safety and dosing, not on proving the treatment works.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02215, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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St. Jude's Children's Research Hospital
Memphis, Tennessee, 38105, United States
Conditions
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