Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Zapping the brain to tame bipolar mood swings?

NCT ID NCT03622749

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small pilot study tested whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) could help people with bipolar disorder regulate their emotions. Nineteen participants, including healthy controls, completed behavioral tasks measuring emotion regulation after receiving TMS. The study aimed to understand how the brain processes emotions in bipolar disorder, not to provide a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial Magnetic Stimulation (TMS)
What this could lead to
If successful, this could point toward a non-invasive brain stimulation technique to help people with bipolar disorder better manage their emotions.
What could go wrong
This is a very small pilot study with only 19 participants, so results may not apply to everyone. It is early research, and the main goal was to understand emotion regulation, not to prove a treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

19 people

The number who actually took part.

Started

Mar 2019

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients * Men and women * Ages 18-50 years * Patients diagnosed with bipolar I disorder (BD-I), current mood state euthymic. * On a stable psychiatric medication regimen for at least a month prior to and during study participation Healthy Controls: * Men and women * Ages 18-50 years * Without major psychiatric illness Exclusion Criteria: * Patients * Any change in psychiatric medications within a month prior to and during study participation * Legal or mental incompetency * Intellectual disability * Current manic (YMRS \> 12) or severe depressive episode (HAM-D-17 \> 5) * Substance use disorder (abuse or dependence) with active use within the last 3 months * Significant medical or neurological illness * Prior neurosurgical procedure * History of seizures * History of ECT treatment or clinical TMS within the past three months * Implanted cardiac pacemakers * Patients who have conductive, ferromagnetic or other magnetic-sensitive metals implanted in their head or neck, or are non-removable and within 30 cm of the treatment coil. These include: * Aneurysm clips or coils * Carotid or cerebral stents * Metallic devices implanted in the head (e.g. Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit, or ventriculo-peritoneal shunt) * Magnetically active dental implants * Cochlear/otologic implants * CSF shunts * Ferromagnetic ocular implants * Pellets, bullets, fragments less than 30 cm from the coil * Facial tattoos with metallic ink, permanent makeup less than 30 cm from the coil * Pregnant women Healthy Controls: * History of major psychiatric illness, including psychosis * Has a first-degree relative with psychosis * Active use of neuropsychoactive medications * Legal or mental incompetency * Intellectual disability * Substance use disorder (abuse or dependence) with active use within the last 3 months * Significant medical or neurological illness * Prior neurosurgical procedure * History of seizures * History of ECT treatment or clinical TMS within the past three months * Implanted cardiac pacemakers * Individuals who have conductive, ferromagnetic or other magnetic-sensitive metals implanted in their head or neck, or are non-removable and within 30 cm of the treatment coil. These include: * Aneurysm clips or coils * Carotid or cerebral stents * Metallic devices implanted in the head (e.g. Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit, or ventriculo-peritoneal shunt) * Magnetically active dental implants * Cochlear/otologic implants * CSF shunts * Ferromagnetic ocular implants * Pellets, bullets, fragments less than 30 cm from the coil * Facial tattoos with metallic ink, permanent makeup less than 30 cm from the coil * Pregnant women

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Bipolar disorder are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Martinos Center for Biomedical Imaging

    Charlestown, Massachusetts, 02129, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.