Massachusetts General Hospital

This study tested a combination of two drugs—tivozanib and enzalutamide—in men with advanced prostate cancer that had stopped responding to standard hormone therapy. The goal was to see if adding tivozanib (which cuts off the tumor's blood supply) to enzalutamide could delay canc…

This study tested a drug called MBG453 in 10 people with lower-risk myelodysplastic syndromes (MDS), a bone marrow disorder. The goal was to see if the drug could improve blood cell counts and reduce the need for blood transfusions. The trial was terminated early, so results are …

This study tested whether breathing in nitric oxide gas could keep people with mild or moderate COVID-19 from getting sick enough to need a breathing tube. Researchers enrolled 62 hospitalized adults who were still breathing on their own. The trial was stopped early, so results a…

This small pilot study tested whether adding radiation therapy could help CAR T-cell treatment work better in people with lymphoma that did not respond to CAR T alone. Only 3 participants were enrolled before the study was stopped early. The main goal was to check safety and side…

This study tested a combination of two drugs, umbralisib and rituximab, as the first treatment for people with follicular lymphoma or marginal zone lymphoma. The goal was to see how many patients had their cancer completely disappear. The study was stopped early and included 18 a…

This study aimed to see if breathing in nitric oxide gas could protect healthcare workers from catching COVID-19 while caring for infected patients. It planned to enroll 470 workers but was stopped early with only 24 participants. The main goal was to compare how many people in t…

This study tested whether pramipexole, a drug for restless legs syndrome, could reduce symptoms of both restless legs and opioid withdrawal in people recovering from opioid use disorder. The goal was to help them feel better and stay in treatment. The study was planned for 75 adu…

This study aimed to see if naproxen sodium, a common anti-inflammatory drug, could reduce obsessive-compulsive symptoms in children with PANDAS, a condition linked to strep infections. The trial planned to enroll children aged 6 to 15 with new-onset OCD, but was terminated early …

This study tested a new cooling device to see if it could reduce pain during a skin treatment called radio-frequency microneedling. Six healthy women took part, and researchers measured their pain levels after different cooling times. The study was stopped early, so results are l…

This study looked at whether adding guanfacine (a blood pressure medication) to morphine could reduce pain sensitivity and tolerance in people with chronic neck or back pain. It involved 137 adults who had not taken opioids recently. The study was terminated early, so results are…

This small study looked at whether adding guanfacine to opioid painkillers could reduce the extra pain sensitivity that sometimes develops with long-term opioid use. It involved 8 adults with chronic neck or back pain who were already taking opioids. The study was stopped early, …

This study tested whether memantine, a medication for memory, could improve social skills in youth aged 8-18 with autism or nonverbal learning disorder. The trial was stopped early after enrolling only 25 participants. Researchers measured social improvement using clinician ratin…

This study tested a laser treatment to improve thick scars and scleroderma, a condition that hardens the skin. Researchers wanted to see if the laser could help the skin heal and look better. Only 6 people took part, and the study was stopped early, so results are limited.

This study tested whether a non-invasive brain stimulation technique called TMS could improve memory in older adults with mild cognitive impairment or early Alzheimer's disease. Only 4 people took part before the study was stopped. Researchers used brain scans to see if stimulati…

This study looked at two different ways to set a breathing machine for people with severe lung injury (ARDS). The goal was to see which method helps lungs work better and puts less strain on the heart. Only 2 people took part before the study was stopped early, so results are ver…

This study tested a special band called AirGo that monitors breathing in COVID-19 patients with respiratory failure. The goal was to see if the band could detect early signs of worsening breathing. The study included 25 adults hospitalized with COVID-19 who were breathing on thei…

This study aimed to understand how paresthesia-free spinal cord stimulation (PF-SCS) relieves chronic pain and affects sensation. Researchers planned to enroll 10 adults already using PF-SCS for chronic pain. The study was terminated early, so results are limited.

This study looked at how a gentle brain stimulation technique called tDCS affects thinking and behavior in children aged 10-17 with obsessive-compulsive disorder (OCD). The goal was to understand brain processes linked to OCD, not to treat it. The study was stopped early and incl…

This study looked at how healthy adults react to breathing air with less oxygen for several days. Researchers measured oxygen levels in the blood, red blood cell production, and lung pressure to understand the body's response. The goal was to learn about safety and basic body cha…

This study tested a personalized system that uses biosensors to adjust the work environment and help astronauts stay focused and perform well during long spaceflights. About 80 healthy adults aged 18 to 64 took part. The goal was to see if the platform could improve thinking and …