Massachusetts General Hospital

This study tested an experimental drug called MBG453 for adults with a lower-risk form of myelodysplastic syndromes (MDS), a type of bone marrow disorder. The drug was designed to help the body's own immune system recognize and attack the abnormal blood cells. The trial was for p…

This study tested if combining two drugs, tivozanib and enzalutamide, could better control advanced prostate cancer that had stopped responding to standard hormone therapy. It aimed to see if the combination could delay cancer growth longer than enzalutamide alone. The trial was …

This study tested a two-drug combination as the first treatment for people newly diagnosed with certain slow-growing blood cancers called follicular lymphoma or marginal zone lymphoma. The goal was to see if adding the experimental drug umbralisib to the approved drug rituximab c…

This study tested whether inhaling nitric oxide gas could prevent mild or moderate COVID-19 from progressing to severe disease requiring a ventilator. It involved 70 hospitalized patients who were still breathing on their own. The goal was to see if this early treatment could red…

This study tested whether adding the drug guanfacine to morphine could help people with chronic back or neck pain. The goal was to see if guanfacine could prevent two common problems with long-term opioid use: increased pain sensitivity (where pain feels worse) and needing higher…

This small, early-stage study tested whether adding a short course of radiation therapy could help control lymphoma that did not fully respond to CAR-T cell therapy. The goal was to see if radiation could improve the body's immune response against the cancer and work together wit…

This study aimed to see if healthcare workers could be protected from catching COVID-19 by inhaling nitric oxide gas, which has shown antiviral effects against similar viruses. It planned to enroll 470 workers to compare those receiving the gas treatment with those who did not. T…

This study tested whether a medication called memantine (brand name Namenda) could help improve social skills in children and teens with autism spectrum disorder and similar conditions. Participants aged 8-18 took the drug or a placebo for 12 weeks. The goal was to see if the med…

This study tested a laser treatment to see if it could improve the look and feel of raised scars and scleroderma, a condition that causes skin to harden and tighten. Researchers enrolled a small group of adults with these skin conditions to receive the laser treatment. The goal w…

This study tested whether a medication called pramipexole, commonly used for Restless Legs Syndrome (RLS), could help people recovering from opioid addiction. Researchers wanted to see if reducing RLS and withdrawal symptoms would help participants start and stay in their addicti…

This study tested whether naproxen sodium (the medicine in Aleve) could reduce obsessive-compulsive symptoms in children with PANDAS, a condition where strep infections trigger sudden neuropsychiatric problems. It was a small, controlled trial comparing the drug to a placebo pill…

This study tested whether lower-intensity settings on spinal cord stimulators could still effectively relieve chronic pain. Researchers secretly switched 10 patients with implanted devices to lower settings to see if their pain returned. The goal was to better understand how thes…

This study tested whether adding the blood pressure medication guanfacine to standard opioid treatment could reduce a specific side effect where opioids actually make people more sensitive to pain over time. It involved 120 adults with chronic back or neck pain who were already t…

This study aimed to understand the safety and body's response to breathing low-oxygen air for an extended period. Six healthy volunteers stayed in a hospital setting for seven days, breathing air with reduced oxygen for five of those days. Researchers closely monitored their vita…

This study aimed to understand how a mild, non-invasive brain stimulation technique affects specific thinking processes in children and teens with obsessive-compulsive disorder (OCD). Researchers tested the stimulation on two different brain areas and compared it to a fake (sham)…

This study aimed to find the best way to set ventilator pressure for patients with severe lung failure (ARDS). Researchers compared two standard techniques to see which one improved oxygen levels while putting less strain on the heart. The study was terminated early after enrolli…

This study tested a special wristband called the AirGo to monitor the breathing patterns of hospitalized COVID-19 patients who were breathing on their own. The goal was to see if the band could detect patterns that signal a patient's breathing is getting worse and might require a…

This study tested whether using magnetic pulses to stimulate specific brain areas could improve memory in older adults with very early signs of Alzheimer's disease. Researchers used brain scans to see how the stimulation changed brain network connections and gave memory tests to …