Massachusetts General Hospital

This early-phase study tests a cancer vaccine (PVX-410) alone or with an immunotherapy drug (durvalumab) in 22 women with stage II or III triple negative breast cancer who have completed standard treatment. The goal is to see if the vaccine is safe and can boost the immune system…

This early-phase study tests a vaccine called PVX-410, alone or with the immunotherapy drug pembrolizumab, in 20 women with metastatic triple negative breast cancer who have a specific genetic marker (HLA-A2+). The goal is to see if the vaccine safely boosts the immune system to …

This early-stage study tests a special treatment before a kidney transplant to train the body to accept the new organ naturally. The goal is to see if patients can eventually stop taking anti-rejection drugs. The study involves 20 adults receiving a first kidney transplant from a…

This study tests two targeted drugs, dabrafenib and trametinib, in 30 people with multiple myeloma that has returned or not responded to treatment. The goal is to see if these drugs can shrink the cancer. Participants must have measurable signs of myeloma. The study is in an earl…

This study tests whether a combination of two drugs, venetoclax and azacitidine, works as well as or better than standard chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML). About 172 participants will be randomly assigned to receive either the new combo or…

This study tested a combination of three drugs—pembrolizumab, trametinib, and dabrafenib—given for a short time to people with advanced melanoma that cannot be removed by surgery. The goal was to see if this shorter treatment could shrink or control tumors while allowing patients…

This study tests a precise type of proton radiation called IMPT for people with rare tumors of the spine, sacrum, or skull base (chordoma or chondrosarcoma). About 64 participants receive high-dose radiation, sometimes combined with surgery, to see if it controls the tumor while …

This early-phase study tests a new drug called sotatercept (ACE-011) combined with two standard treatments (lenalidomide or pomalidomide plus dexamethasone) in 33 adults with multiple myeloma that has returned or not responded to prior therapy. The main goal is to find the safest…

This study looks at whether a special blood test called TEG-PM can help doctors choose the right blood-thinning medication for people who have had leg artery surgery for peripheral artery disease (PAD). About 130 adults will have their blood tested before and after surgery, and t…

This study tests a drug called ribociclib combined with standard hormone therapy for people with ER-positive breast cancer. The goal is to see if the combination can clear tumor DNA from the blood and help control the disease. About 120 postmenopausal women with early-stage cance…

This study looks at how well two approved medications help strengthen bones in postmenopausal women who are at high risk for fractures. About 50 women will take one of the drugs for 12 months, and researchers will measure changes in hip bone density. The goal is to find which tre…

This study tests the drug niraparib in 20 people whose cancer has spread to the brain or spinal cord. The goal is to see if the drug can shrink or control these tumors. Participants must have mild or no symptoms from their brain metastases and not need increasing steroids or seiz…

This early-phase study tests whether giving focused radiation and two immunotherapy drugs before surgery can safely help treat liver cancer that can be removed. About 20 adults with resectable hepatocellular carcinoma will receive stereotactic body radiation therapy (SBRT) follow…

This study tests whether combining two immunotherapy drugs (durvalumab and tremelimumab) with radiation therapy can shrink tumors in people with advanced liver cancer or bile duct cancer. About 37 adults whose cancer cannot be removed by surgery or has spread will receive the tre…

This early-phase study tested the safety and best dose of adding bevacizumab to standard chemotherapy and radiation for people with soft tissue sarcoma that can be removed by surgery. The goal is to see if this combination can reduce the chance of the cancer returning after surge…

This early-phase trial tests whether fecal microbiota transplant (FMT) capsules are safe and feasible for people with auto-brewery syndrome (ABS), a rare condition where gut microbes turn carbs into alcohol. Eight adults with ABS will take antibiotics and a colon cleanse, then re…

This study tested the drug eribulin in 13 people with two rare cancers of the blood vessels: angiosarcoma and epithelioid hemangioendothelioma (EHE). The goal was to see if the drug could shrink tumors or stop them from growing. Participants had advanced disease that had already …

This study tests whether a higher dose of proton radiation can safely control high-grade meningiomas, which are aggressive brain tumors. About 21 adults with specific tumor types after surgery will receive intensity-modulated proton therapy (IMPT). The goal is to find the highest…

This study tests a combination of two drugs, alectinib and cobimetinib, in people with advanced ALK-positive non-small cell lung cancer. The goal is to find the safest dose and see how well the drugs shrink tumors. About 16 adults with stage IV cancer that has an ALK gene change …

This early-stage trial tests the safety and effectiveness of combining the experimental drug Ipatasertib with standard hormone therapy, with or without another targeted drug, in 77 postmenopausal women with advanced hormone receptor-positive (HR+) breast cancer that has spread. T…

This study compares four commonly prescribed medications for bipolar depression in over 2,700 adults. Participants receive one of three FDA-approved drugs or a combination therapy. The goal is to see which treatment leads to remission, meaning fewer depressive symptoms and better…

This study tests a combination of standard chemotherapy (cisplatin), an immunotherapy drug (pembrolizumab), and radiation therapy for people with vulvar cancer that cannot be removed by surgery. The goal is to see if this triple therapy can shrink or control the cancer better tha…

This study follows 500 people aged 6 months to 65 years with peanut allergy who are undergoing oral immunotherapy (eating small, increasing amounts of peanut protein). The main goal is to see how many can tolerate a daily maintenance dose of 300 mg peanut protein without symptoms…

This study tested the immunotherapy drug pembrolizumab in 26 people with high grade meningioma that came back or remained after treatment. The goal was to see if the drug could stop the tumor from growing for at least 6 months. Participants received pembrolizumab and had regular …

This study tests whether the oral drug Inqovi can reduce the chance of myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) coming back after a stem cell transplant. About 22 adults who have had a reduced-intensity transplant will take Inqovi as maintenance th…

This study aimed to see if giving the drug amiodarone for a short time after heart surgery could prevent a common complication called atrial fibrillation (an irregular heartbeat). The trial planned to include adults having heart surgery other than bypass, who had a normal heart r…

This study tested whether adding hydroxychloroquine (a malaria drug) to the standard targeted therapy erlotinib could delay or prevent drug resistance in people with advanced non-small cell lung cancer that has a specific EGFR mutation. About 76 participants received either erlot…

This study looks at the long-term safety and effectiveness of pomalidomide in people with hereditary hemorrhagic telangiectasia (HHT), a condition that causes frequent bleeding, especially from the nose. It follows 62 adults who previously took part in a clinical trial of pomalid…

This study tests a combination of four drugs (carfilzomib, lenalidomide, dexamethasone, and isatuximab) in 50 adults with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The goal is to see how many patients achieve a complete response after four trea…

This study tests whether a bone marrow transplant given after a kidney transplant can train the immune system to accept the new kidney without lifelong anti-rejection medication. About 20 adults aged 18-65 who already have a functioning kidney transplant will receive an experimen…

This study tests whether digoxin, a heart medication, is safe and can slow nerve damage in people with ALS. About 40 adults with early-stage ALS will take digoxin for 24 weeks. Researchers will monitor side effects and measure blood markers of nerve health.

This study tests whether transplanting gut bacteria from healthy people can treat confusion caused by advanced liver disease (hepatic encephalopathy). Researchers will find the best stool donors, then compare their stool to a placebo in 30 patients. The goal is to improve thinkin…

This study tests whether Truvada, an antiviral drug that fights Epstein-Barr virus (EBV), can reduce EBV levels in saliva and blood of 50 adults with multiple sclerosis (MS). Researchers also want to see if the drug is safe and tolerable for people with MS. The goal is to underst…

This study tests a combination of four drugs—elotuzumab, pomalidomide, bortezomib, and dexamethasone—in people with multiple myeloma that has returned or stopped responding to prior treatments. The goal is to see how many patients achieve at least a partial response and to monito…

This study tests whether repeated doses of the BCG vaccine (originally for tuberculosis) can lower blood sugar levels in adults with long-standing type 1 diabetes. About 150 participants will receive either BCG or a placebo over 5 years, with researchers tracking changes in HbA1c…

This study tests whether giving a precise dose of radiation directly to the tumor during surgery can help people with pancreatic cancer that has grown into nearby blood vessels. Participants had already received chemotherapy and standard radiation before the procedure. The main g…

This study tests an experimental drug called AZD6738 in adults with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) whose disease got worse after standard therapy. The main goal is to check the drug's safety and find the right dose. About 52 participants …

This study tests whether wireless body monitors can spot dangerous health problems in women during the first 24 hours after a C-section. Over 3,000 women at a hospital in Uganda wore a small sensor to track vital signs. The goal is to catch complications early and reduce maternal…

This study tests a combination of two drugs—sacituzumab govitecan and talazoparib—in people with metastatic triple-negative breast cancer that has spread. The goal is to see if the combo can shrink tumors and help patients live longer. About 75 adults with advanced disease are ta…

This early-phase study tests the drug niraparib given together with radiation therapy after surgery for triple negative breast cancer. It includes 21 patients who had residual disease after chemotherapy. The goal is to find the safest dose and see if the combination helps prevent…

This study tests whether a newer pacing method, left bundle area pacing (LBBAP), can better preserve heart function than standard right ventricular pacing in 100 adults with normal heart function who need a pacemaker. Participants must have a high-grade heart block and a healthy …

This study looks at whether proton beam radiation can safely treat germ cell tumors in the brain and spine while causing fewer side effects than standard photon radiation. About 45 participants aged 3 to 25 will receive proton therapy. The goal is to control the tumor and track b…

This phase 2 study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with radiation therapy can help control colorectal and pancreatic cancers that are either microsatellite stable or MSI-high. About 84 adults with these cancers will receive the treatment…

This study tests whether the drug ruxolitinib can help prevent acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) from coming back after a stem cell transplant. It includes older adults whose cancer is in remission. The goal is to improve survival and reduce complicat…

This study looks at whether two special diets—a liquid formula diet or the specific carbohydrate diet—can help people with active Crohn's disease or ulcerative colitis feel better. About 40 adults will choose one diet and follow it for 6 weeks, then return to normal eating. Resea…

This early-phase study tests a cancer vaccine (PVX-410) with two other drugs (citarinostat and lenalidomide) in people with smoldering multiple myeloma, a pre-cancer condition. The goal is to see if the combination is safe and can boost the immune system to control the disease. N…

This study tests whether adding losartan (a blood pressure drug) and nivolumab (an immunotherapy) to standard chemotherapy and radiation can improve surgical outcomes for people with localized pancreatic cancer. About 168 participants with borderline resectable or locally advance…

This study compares two common blood thinners—aspirin and low molecular weight heparin—to see which works better at preventing dangerous blood clots after surgery for bone or soft tissue cancer in the pelvis or leg. About 2,868 adults who have had or will have such surgery will b…

This study tests a custom-made drug (called an antisense oligonucleotide) designed specifically for one child with TUBB4A-related leukodystrophy, a rare genetic brain disease. The goal is to see if the drug is safe and can improve movement, development, and quality of life. Only …

This study tests whether adding infliximab (a drug used for arthritis) to standard immunotherapy can reduce serious side effects while still treating advanced melanoma. About 36 adults with stage 3 or 4 melanoma who haven't had prior treatment will receive either immunotherapy al…

This study tests a precise type of radiation called proton therapy for people with a non-cancerous brain tumor called vestibular schwannoma. The goal is to see if this treatment can preserve hearing and control tumor growth while causing fewer side effects than standard radiation…

This study tests the drug ruxolitinib for people who developed bronchiolitis obliterans syndrome (BOS), a type of lung scarring, after a stem cell transplant. The goal is to see if the drug can improve lung function or prevent further decline. About 50 participants will take ruxo…

This study tests a precise type of radiation called proton therapy for people with low-grade or certain grade 3 brain tumors (gliomas). The goal is to see if it can control tumor growth as well as standard radiation while causing fewer side effects by sparing healthy brain tissue…

This study aimed to see if adding two immunotherapy drugs (zimberelimab and domvanalimab) to standard chemotherapy was safe and effective for people with operable stomach or esophageal cancer. All participants would receive the combination before and after surgery. However, the s…

This study tests a text-message tool called REACH-Es to help Latino adults with type 2 diabetes take their medications as prescribed. About 70 participants will use the tool for a few months, and researchers will check if it's easy to use and helps with medication habits. The goa…

This study tests whether combining two drugs (niraparib and dostarlimab) with radiation therapy is safe and effective for people with metastatic triple-negative breast cancer that has not responded to immunotherapy or is PD-L1 negative. About 32 adults with this aggressive cancer…

This study tests a brain implant (deep brain stimulation) in 2 people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. The device sends electrical pulses to specific brain areas to help control symptoms. The goal is to reduce OCD seve…

This study tests a new combination of two drugs, lurbinectedin and doxorubicin, for people with advanced leiomyosarcoma, a rare soft tissue cancer. The first part finds a safe dose, and the second part compares the combination to lurbinectedin alone to see which works better. Abo…

This study looks at whether a special clinic with a team of experts can improve quality of life and reduce hospital visits for people with a mechanical heart pump (VAD). About 110 patients and their caregivers will take part. The goal is to see if this team approach helps patient…

This study looks at whether a small, single-lead ECG device used at home can help find people with undiagnosed atrial fibrillation (AF), a common heart rhythm problem. Researchers will use an AI tool to predict who might have AF and then check them with the handheld device. About…

This study tests whether a new type of PET/MRI scan can find endometriosis more accurately than current methods like ultrasound or MRI alone. About 60 adults with suspected endometriosis will get the scan before their planned surgery. The goal is to see if this approach can reduc…

This study looks at whether a simple, noninvasive adhesive patch can safely collect skin cells from children's suspicious moles and analyze them for genetic markers linked to skin cancer. Researchers will compare the patch's genetic results with standard biopsy findings in 100 ch…

This study tests a special imaging capsule that people swallow to take pictures of the esophagus. The goal is to see if it can accurately detect Barrett's esophagus, a condition that can lead to cancer. About 130 adults already scheduled for an endoscopy will swallow the capsule,…

This study tests whether artificial intelligence can help doctors diagnose functional gastrointestinal disorders (like IBS) more accurately. Researchers will use computer programs to analyze how 700 patients describe their symptoms during doctor visits and endoscopy procedures. T…

This study tests a new device called the LymphaTech scanner to see if it can accurately measure arm swelling (lymphedema) in 100 women treated for breast cancer. The scanner is compared to a standard tool called the Perometer. The goal is to find a quicker, easier way to screen f…

This study is testing a new, less invasive way to screen for Barrett's esophagus, a condition that can lead to esophageal cancer. Participants will swallow a small capsule with a camera that takes pictures of the esophagus. The goal is to see if this method is comfortable and wor…

This study compares two ways of providing HIV prevention medication (PrEP) to young people in South Africa. One group gets PrEP through standard clinic visits, while the other group receives home delivery and support. The goal is to see which method helps more people start and co…

This study looks at whether a single dose of the HPV vaccine can prevent HPV infection in women living with HIV who have already been vaccinated. About 778 women are taking part, and half get the vaccine right away while the others wait. Researchers will track infections and side…

This study tests whether adding a local antibiotic (tobramycin) directly into the wound, along with standard IV antibiotics, can lower infection rates after open fracture surgery. Open fractures have a high risk of infection because blood flow to the injured area is often poor. T…

This study looks at whether taking a daily aspirin can reduce the risk of colorectal cancer in people who have already had a precancerous polyp (adenoma) removed. Researchers will measure certain chemicals in the body that are linked to inflammation and cancer risk. The goal is t…

This study planned to test a mobile app designed to prevent depression and anxiety in pregnant women. The app would have provided behavioral tools and support to reduce the risk of mood disorders after childbirth. However, the study was withdrawn before any participants were enro…

This study looks at whether taking low-dose aspirin can lower the risk of colorectal cancer in people who have already had precancerous polyps removed. Researchers will measure changes in certain stem cell markers in the colon and other substances in the blood and urine. The goal…

This study tests whether a non-invasive brain stimulation technique called LIFUP can reduce negative thinking and mind-wandering in people with depression. Researchers will use brain scans to see if calming a specific brain region (the posterior cingulate cortex) helps people wit…

This study tests whether an 8-week online group program can help teens (ages 12-17) with neurofibromatosis type 1 or 2 better cope with stress and symptoms. Participants join live video sessions focused on building emotional, social, and physical resilience. The goal is to see if…

This study tested whether a safe, low-current brain stimulation device used at home could improve thinking problems like poor focus and slow thinking in people with long COVID. About 31 adults with persistent brain fog used the device for 4 weeks. The goal was to see if it could …

This study compares two virtual symptom management programs for adults aged 60 and older who have both chronic pain and early signs of memory decline. The goal is to see which program better improves physical function, thinking skills, and emotional well-being. Participants will …

This study looks at whether adding a palliative care team to standard leukemia treatment helps people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) feel better and have better end-of-life care. About 320 patients receiving non-intensive therapy will take par…

This study compares two treatments for a torn hip labrum in people aged 40 and older: arthroscopic surgery to repair the tear versus physical therapy. The goal is to see which approach better reduces pain and improves hip function. About 110 participants will be followed for up t…

This study looks at how common restless leg syndrome (RLS) is in women with X-linked adrenoleukodystrophy (ALD) and whether the drug pramipexole can reduce RLS symptoms. About 24 women will take part. The goal is to see if treating RLS improves sleep and walking ability.

This study looks at whether a 30-minute music session can help adults recover from heart surgery. Researchers will measure stress hormones, anxiety, pain, and vital signs in 120 patients. The goal is to see if music, a simple and safe activity, can improve early recovery after ca…

This study tests whether a non-invasive brain stimulation technique called RAVANS (a type of vagus nerve stimulation) can improve memory and thinking in older adults. Researchers will measure changes in memory tasks and other cognitive tests. The goal is to see if this safe, expe…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. The goal is to see if remote monitoring and home support can reduce emergency room visits and hospital stays. About 300 adults with certain cancers (like pancreat…

This study tests a special proton radiation method for children aged 3 to 18 with brain tumors that need radiation to the brain and spine. The new approach spares parts of the backbone to reduce side effects like low blood cell counts and slowed growth. Researchers will check if …

This study tests a mobile app called THRIVE-M designed to help people with multiple myeloma manage stress, fatigue, and overall well-being. About 120 adults with different stages of the disease will either use the app or receive usual care. Researchers will measure changes in qua…

This small pilot study is testing a mind-body program called HIPS for adults with chronic hip pain. The goal is to see if the program is practical and liked by patients, and to prepare for a larger future study. Five participants will try the program and give feedback.

This study tests a new program to help adults with lung cancer improve their quality of life after finishing cancer treatment. About 21 people will take part to see if the program is practical and acceptable. The goal is to support patients as they move from active treatment to r…

This study tests whether the drug larazotide can safely reduce Long COVID symptoms in 107 people aged 7 to 50. Participants take either the drug or a placebo four times a day for 21 days. The goal is to see if the drug helps with symptoms like fatigue, brain fog, and breathing tr…

This early-phase trial tests whether monthly injections of Kybella (a drug already approved for fat reduction) can safely shrink cutaneous neurofibromas—small, benign skin tumors—in people with Neurofibromatosis Type 1. Up to 15 adults will receive up to 6 monthly treatments, wit…

This study looks at whether auto-captioning glasses are useful and easy to use for adults with NF2-related schwannomatosis who have hearing loss. Eighteen participants will use the glasses as they wish for 12 weeks and then report their experience through online surveys and inter…

This study tests a 6-session virtual program called Future Self-BD for adults with bipolar disorder who want to quit smoking. Participants learn to vividly imagine positive future events that could happen if they stop smoking. The study aims to see if this approach is acceptable …

This study aimed to see if a tiny dose of buprenorphine/naloxone could help control pain after surgery in people who already take strong painkillers. It was designed for adults having orthopedic or general surgery. However, the study was withdrawn before any participants were enr…

This early-stage study tests a stimulant medication (methylphenidate, similar to Ritalin) given through an IV to people with severe brain injuries who are in a coma or minimally conscious state. The main goal is to check safety and find the right dose, not yet to prove it works. …

This study tests a special stress-reduction program for teens and young adults who have finished cancer treatment. The program teaches skills to manage stress and build resilience. Researchers want to see if it is practical and helpful for this group.

This study looks at whether bright light exposure can improve sleep and daytime alertness in people with Parkinson's disease. Researchers will measure sleep quality, daytime sleepiness, and other non-motor symptoms in 65 participants. The goal is to find a simple, non-drug way to…

This study tests a program designed to prevent eating disorder symptoms and body dissatisfaction in pregnant women who have had an eating disorder in the past. About 60 participants will either join the program or receive general health education. The goal is to see if the progra…

This study tests a brief educational and support program for adults who have just finished lung cancer treatment with the goal of curing their cancer. The program is designed to help improve quality of life and reduce fear of the cancer coming back. About 100 participants will be…

This study looks at whether unlicensed professionals can successfully give cognitive behavioral therapy (CBT) to patients in a general hospital. About 250 adults with conditions like anxiety, depression, OCD, or PTSD will take part. The goal is to see if this approach improves ps…

This study tests whether monthly laser treatments can safely shrink skin tumors in people with NF1. Ten adults will receive up to six treatments, and researchers will check for side effects and tumor reduction. The goal is to improve the look and feel of these bumps without major…

This study tests whether vedolizumab, given through an IV, can reduce symptoms like belly pain, nausea, and bloating in people with collagenous gastritis. Eleven participants will receive the drug, complete symptom surveys, and have two endoscopies with biopsies. The goal is to s…

This study tests whether a training method that limits blood flow to the leg muscles can improve strength and recovery after Achilles tendon repair. About 75 adults who had surgery for a torn Achilles tendon will be randomly assigned to receive this special training, a fake versi…

This study looks at ways to better support caregivers of children with tracheostomies after they leave the hospital. About 480 caregivers will be randomly assigned to either a standard discharge program or one with extra help. Researchers will check if the extra support reduces c…

This study aimed to compare two approaches to pain management after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would temporarily reduce their dose before and after surgery. The goal was to see which a…

This study tests different ways to deliver a proven sleep therapy (CBT-I) to cancer survivors who have chronic insomnia. About 80 adults who have finished primary cancer treatment will take part. The goal is to find the best approach to reduce insomnia and improve emotional well-…

This study tests a new web-based program called Face-Forward-Web for adults with chronic orofacial pain (pain in the face or mouth lasting more than 3 months). The goal is to see if the program is easy to use, acceptable to patients, and helpful in managing pain. Up to 20 partici…

This study looks at whether a telehealth palliative care program is practical and well-liked by people with moderate to severe chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. Ten adults will receive three video-based support sessions. The g…

This study compares two online treatments for depression: group yoga sessions and a type of behavioral therapy called Brief Behavioral Activation (BA). 518 adults with depressive symptoms will be randomly assigned to one of the two groups for 12 weeks. Researchers will track thei…

This study tests a mobile app called Horizons designed to help people with chronic graft-versus-host disease (GVHD) cope better and improve their quality of life. About 120 adults who had a stem cell transplant and now have moderate to severe chronic GVHD will use the app or rece…

This study looks at whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and quality of life in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for …

This study is developing and testing a program called Resilient Families (R-FAM) for parents whose babies are in the Neonatal Intensive Care Unit (NICU). The goal is to reduce emotional distress like depression, anxiety, and stress, and improve the couple's relationship. About 10…

This study compares two types of radiation therapy—proton beam therapy and IMRT—for men with low- or intermediate-risk prostate cancer. Both treatments aim to cure the cancer by targeting the prostate while sparing healthy tissue, but they may cause different side effects like bo…

This study tested whether resilience training delivered in a multi-user virtual reality setting is practical and well-received by people with mood, anxiety, or psychotic disorders. Researchers measured discomfort with others, emotion recognition, and personal space preferences. T…

This study tests a mobile app (CARE app) designed to support caregivers of people receiving a bone marrow transplant for blood cancer. The goal is to see if the app improves caregivers' quality of life and reduces stress. About 120 adult caregivers are taking part, and their well…

This study looks at whether infliximab can treat colitis (inflammation of the colon) caused by immunotherapy drugs in people with advanced skin cancer. About 42 participants will receive either infliximab or steroids to see which works better at stopping symptoms without needing …

This study tests a special program called Horizons for adults who have had a stem cell transplant and developed chronic graft-versus-host disease (GVHD). The program includes group sessions to help patients cope with symptoms, improve quality of life, and take their medications a…

This study tests if a parent-child therapy program can reduce anxiety in 2- and 3-year-olds who are very fearful or shy. About 90 families will take part in remote sessions. The goal is to see if the therapy helps children feel less anxious and keeps them well a year later.

This study was designed to test whether an informational website helps men with low-risk prostate cancer understand their treatment options and make more informed decisions. Researchers planned to measure patient knowledge and decision-making confidence using questionnaires. Howe…

This study looks for a blood test that can tell which patients with chronic lymphocytic leukemia (CLL) or multiple myeloma are at higher risk for infections. Researchers will use advanced lab methods to analyze blood samples from 150 adults. The goal is to help doctors prevent in…

This study aimed to find the best air pressure settings on a breathing machine for very obese patients to help them breathe on their own after a breathing tube is removed. It planned to test different pressure levels in about 20 patients. However, the study was withdrawn before a…

This study aimed to learn how the brain controls speech in people with Parkinson's disease who are getting deep brain stimulation (DBS). Researchers planned to record brain activity during DBS surgery while participants performed speech tasks. The goal was to gather data that cou…

This study looks at how a low dose of ketamine given through an IV can quickly improve depression and suicidal thoughts. Researchers will collect cells from the nose to study gene activity and use brain scans to see how ketamine changes brain connections. The goal is to find the …

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This study looks at whether an online platform can help older adults in Black communities stick with an 8-week exercise program. About 120 people aged 55 and older from churches or senior centers will take part. Researchers want to see if the online tool makes the program more ac…

This study follows 750 people who have already completed standard care for upper-arm bone or joint surgery. Researchers want to learn how well patients recover over the long term, including joint movement, pain, and daily function. The goal is to better understand uncommon injuri…

This study tests whether a special pressure-enabled catheter delivers radioactive tracer more precisely to liver tumors than a standard catheter. Twenty adults with liver cancer who are scheduled for radioembolization will receive both catheters during the mapping procedure. The …

This study follows 240 teenagers and young adults aged 13-21 to see how weight-loss surgery (gastric bypass or sleeve gastrectomy) impacts bone density and strength over two years. It compares those who have surgery with overweight teens who do not. The goal is to understand if t…

This study follows two small groups of pregnant women in Bolivia living above 3,500 meters: healthy women and those with complications like preeclampsia. Researchers measure heart function, blood vessel changes, and baby growth to understand how high altitude affects pregnancy. T…

This study looks at whether measuring tobacco smoke exposure in children during routine blood draws can help parents quit smoking. About 865 parents of young children are taking part. The goal is to see if this approach boosts quit rates and makes tobacco treatment part of regula…

This study aims to see if a special camera (tethered capsule OCT) can safely take detailed pictures of the esophagus in people with Parkinson's disease. Researchers want to find out if there are visible changes in the gut nerves of 20 participants compared to people without Parki…

This study tests a new, pill-sized camera on a string (OFDI capsule) that people swallow while awake to take detailed pictures of the upper small intestine. Researchers want to see if it's comfortable and works well in 108 volunteers, including healthy adults and people with celi…

This study tests a new, less invasive biopsy method called cryobiopsy to collect tissue samples from the small intestine. The goal is to see if it can replace standard forceps biopsy, which is too expensive and difficult to use in poor regions. If successful, this tool could help…

This study checks if a Samsung smartwatch can tell when someone has major depression. About 220 adults (135 with depression and 85 healthy) wear the watch for 3 months. The watch tracks heart rate, sleep, and steps, and participants answer daily surveys about their mood. The goal…

This study was designed to figure out why fractional CO2 laser treatment helps reduce pain and itch in burn scars. Researchers planned to take small skin samples from people with burn scars before and after laser treatment to look at nerve changes. The study was withdrawn before …

This study tests whether short, school-based conversations about alcohol can reduce drinking, cannabis, and nicotine use among high school students. About 21,000 teens across Massachusetts will take surveys over two years. The goal is to see if these programs work and can be deli…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if this device can effectively detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's diseas…

This study is creating a registry of 500 adults with functional GI disorders like IBS and chronic constipation. Researchers will collect medical information, diet and lifestyle details, and biological samples to identify genetic, microbial, and environmental factors linked to the…

This study follows 600 children and young adults (ages 2–25) who received radiation therapy for brain tumors or other cancers. Researchers want to understand how treatment affects their quality of life over time. The goal is to use this information to make future treatments bette…

This study looks at how different strengths and durations of a gentle brain stimulation technique called tDCS affect attention and brain waves in adults with ADHD. About 104 participants will complete attention tasks while their brain activity is recorded. The goal is to find the…

This early-stage study tests whether low-intensity focused ultrasound applied to the amygdala can change brain activity and improve mood in people with bipolar disorder. Twenty adults with bipolar I or II will receive the ultrasound while researchers measure brain scans and mood …

This study looks at how tiny electrical pulses to a deep brain area (the thalamus) change sleep-related brain waves. Researchers will work with 50 patients who already have brain electrodes for medical reasons. The goal is to learn how current brain stimulation therapies affect s…

This study was designed to find better ways to place deep brain stimulation (DBS) electrodes in patients with severe obsessive-compulsive disorder (OCD). The goal was to use brain scans to personalize targeting and improve symptom relief. However, the study was withdrawn before e…

This study tests a new imaging method called DBT-TOBI, which combines a 3D mammogram with a light-based scan, to see if it can predict how well breast cancer responds to chemotherapy before surgery. About 30 women with HER2+ or triple-negative breast cancer will get scans before …

This study aims to collect information from adults with hand or upper extremity problems to learn more about these conditions. No treatments or interventions are being tested. The goal is to better understand how these issues affect people's daily lives.

This study looks at whether a self-guided video program on a smartphone can help reduce stigma and mistrust around mental health care for Black adults who have depression or anxiety. About 90 people aged 18-45 who haven't seen a therapist or psychiatrist in the past year will tak…

This study looks back at medical records of 50 people with mucolipidosis type IV (MLIV) to understand how the disease progresses. Researchers will track when children reach or lose developmental milestones, how movement and vision change, and what brain scans show. No new treatme…

This study was designed to measure pressure inside the lungs of people with severe obesity using a small balloon in the esophagus and a CT scan. It aimed to compare these measurements between people with a BMI over 40 and those with a normal BMI. The study was withdrawn before en…

This study tests two virtual navigation programs designed to help adult survivors of childhood cancer better understand their health insurance, reduce worry, and lower financial burdens. About 529 participants will be randomly assigned to receive live coaching, a recorded version…

This study explores whether playing soft sounds during sleep can help normalize brain activity and improve memory in people with schizophrenia. Researchers will compare sleep and memory performance in 70 participants (healthy adults and schizophrenia patients) during two naps—one…

This study looks at fatty deposits called plaques that can build up in heart arteries and sometimes cause heart attacks. Researchers are using a new imaging method to see which plaques are 'vulnerable' and more likely to cause problems. About 320 people with coronary artery disea…

This study looks at how melatonin, a common sleep aid, affects sleep spindles—brain waves linked to sleep quality and attention—in 30 children with autism aged 12-18. Researchers aim to understand if melatonin boosts these brain rhythms and improves sleep. The goal is to identify…

This study aims to gather medical history and tissue or saliva samples from 100 people with a specific type of lung cancer called ALK+ non-small cell lung cancer. The goal is to create a registry that helps researchers understand the immune and genetic features of this cancer. Pa…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor can also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. However, the study was withdrawn before enr…

This study looks at whether doing therapy in the morning or late afternoon changes how well people with PTSD overcome fear. 52 adults will receive 10 sessions of prolonged exposure therapy via telemedicine, either right after waking or after 4 PM. Researchers will measure fear re…

This early-stage trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug reaches the tumor and how it affects cancer cells. The goal is to ga…

This study follows 500 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, for 3 years. Researchers use a tethered capsule endomicroscopy device to take detailed images of the esophagus. The goal is to measure how the affected area changes over…

This study follows 100 adults with Barrett's esophagus, a condition where the lining of the food pipe changes, to see how it develops over time. Researchers use a special pill-sized camera that patients swallow to take detailed pictures of the esophagus. The goal is to better und…

This study tests a new imaging method called OCT-NIRAF to see if it can predict how plaque builds up in heart arteries. About 40 adults with heart disease will get this special scan during a standard heart procedure, then a CT scan a year later. The goal is to learn if the new sc…

This study is creating a large collection of heart images (like CT scans and angiograms) from 1,000 people. The goal is to help researchers better understand atherosclerosis, a condition where arteries become clogged. No new treatments are being tested—this is purely about gather…

This study looks at how short bursts of noise played during sleep might help strengthen memory in people with epilepsy who have electrodes implanted in their brain. Researchers will measure brain activity and memory performance over several nights. The goal is to understand how s…

This study tests a 6-week program called Ready for Recovery that helps people prepare for surgery to fix an aortic aneurysm. Ten adults having elective surgery will take part to see if the program is practical and helpful. The goal is to see if this approach can improve readiness…

This study tests whether two new imaging devices—a tethered capsule and a thin nasal probe—can safely and comfortably take pictures of the small intestine in children with Environmental Enteric Dysfunction (EED), a gut condition linked to malnutrition. About 170 children and adul…

This study was planned to see if nitric oxide could help blood vessels work better in heart surgery patients with pre-existing blood vessel problems. It was an add-on to a larger trial and would have measured blood flow in the arm. However, the study was withdrawn before enrollin…

This study looks at whether giving patients extra decision-making tools helps them feel more satisfied and less conflicted about their treatment for common hand conditions like carpal tunnel syndrome or trigger finger. About 126 adults will be randomly assigned to receive either …

This study is testing a wearable sensor system to remotely monitor movement symptoms in people with Progressive Supranuclear Palsy (PSP) and related disorders. About 60 participants will wear a pendant sensor for 12 months to see if it's a practical way to track disease progressi…

This study looks at whether a blood test that detects tiny bits of tumor DNA can help doctors decide when it's safe to stop immunotherapy in people with advanced melanoma or non-small cell lung cancer. About 39 patients who have been on immunotherapy for at least a year and show …

This study was designed to test whether adding arm exercises to a standard osteoporosis medication could improve bone density in the wrist. It was planned for postmenopausal women at high fracture risk, but was withdrawn before enrolling anyone. No results are available.

This study looks at how transcranial magnetic stimulation (TMS) affects the brains of people with depression. Researchers use MRI scans to see changes in brain connections. About 54 adults who are already getting TMS as part of their care will take part. The goal is to understand…

This study aimed to see if a special camera capsule could diagnose Eosinophilic Esophagitis and Barrett Esophagus by taking pictures of the esophagus, instead of using a standard biopsy. The study was withdrawn before any participants were enrolled, so no results are available. I…

This study is testing a new, high-resolution imaging device that goes through the nose to look at the small intestine. Researchers want to see if healthy adults and pregnant women can tolerate the device and if it can clearly show gut features. The goal is to improve diagnosis of…

This study involves 1,000 adults who use special smell cards at home to measure their sense of smell. The goal is to see if these tests can reliably detect smell changes caused by COVID-19 and track recovery over time. Participants include people with known smell loss, those with…

This study looks at tiny pieces of genetic material (called extracellular RNA) in the blood of people with congestive heart failure. Researchers want to see if these RNA levels are linked to changes in heart structure and future heart problems. The study follows 400 adults who ar…

This study looks at whether using a laser before applying a medicated gel (NanoDOX) helps the medicine reach deeper into the skin and affects how wounds heal. About 12 healthy adults will receive the laser treatment and gel on small skin areas, then have biopsies to measure drug …

This pilot study tests whether allowing slightly lower blood pressure after heart surgery (permissive hypotension) is safe and can reduce the need for blood-pressure-raising drugs and shorten ICU stays. Researchers will compare this approach to usual care in 80 adults having elec…

This study tests a special camera capsule that people swallow to take detailed pictures of the esophagus. It includes healthy volunteers and people with eosinophilic esophagitis (EoE). The goal is to see if the capsule works well and is comfortable enough to use in the future.

This study planned to observe and compare different treatments for people hospitalized with Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis, severe skin reactions often caused by medications. The goal was to see which treatments helped stop the disease from spreading, spee…

This study looks at how methemoglobin (a form of hemoglobin) builds up and clears in healthy adults when they breathe high doses of nitric oxide gas. Ten volunteers aged 18-64 will inhale up to 300 parts per million of nitric oxide on and off while being closely watched. The goal…

This study looks at tiny pieces of RNA in the blood of 200 adults hospitalized with acute congestive heart failure. Researchers want to see if these RNA levels change as patients receive treatment to remove excess fluid, and whether they can help predict who will improve. The goa…

This study is testing a new way to take MRI pictures of the breast using a very low magnetic field. The goal is to see if this method can produce clearer images of breast cancers. About 40 people will take part, and the new images will be compared with standard mammograms, ultras…

This study looks at how common acquired pyruvate kinase deficiency is in people with certain blood cancers or pre-cancer conditions. Researchers will take a single blood sample from 100 participants to check for low enzyme activity or gene changes. The goal is to better understan…

This study tests whether showing a video decision aid to older adults in the emergency room helps them document their healthcare wishes. Researchers will compare advance care planning records between those who saw the video and those who did not. The goal is to see if the ER can …

This study looks at how the brain handles working memory in people with early psychosis. Researchers use a noninvasive technique called TMS (magnetic pulses on the scalp) along with brain scans to measure brain activity. The goal is to understand the brain circuits involved, not …

This pilot study tests an 8-week program called Move with Meaning, which uses text messages and audio sessions to encourage physical activity in adults aged 45-64 who are not very active. The study involves 30 participants and focuses on whether the program is easy to use and wel…

This study aimed to see if tying off extra veins (side branches) could help dialysis fistulas grow strong enough to use. It was designed for adults whose fistulas were not maturing properly. However, the study was withdrawn before enrolling any participants, so no results are ava…

This study looks at whether specific genes influence how people respond to a meal and a single dose of metformin, a common diabetes medication. Over 1,000 adults without diabetes will eat a special test meal and take metformin to measure changes in blood sugar and insulin. The go…

This study looks at how people with cancer-related pain take their long-acting opioid medications. The goal is to learn what works and what doesn't, so researchers can create a better way to manage cancer pain. About 150 adults who are already prescribed these pain medicines will…

This study was designed to see if giving nitric oxide gas during heart surgery changes levels of certain molecules linked to oxidative stress. It was an add-on to a larger trial and planned to include adults having elective heart surgery. However, the study was withdrawn before e…

This study aimed to see if quinine could be used as a marker to detect aspiration (leakage of fluids into the lungs) in critically ill patients on breathing machines. The plan was to collect samples from the mouth and windpipe to measure quinine levels. However, the study was wit…

This study looks at how problems with the body's internal clock (circadian rhythm) may cause REM sleep behavior disorder, where people physically act out their dreams. Researchers will measure sleep patterns and hormone levels in 30 adults recently diagnosed with the condition. T…

This study is testing a new imaging technology that can look at tissue samples from the stomach and intestines without destroying them. The goal is to see if this tool can help doctors detect diseases like inflammation or cancer more quickly and accurately. About 200 adults sched…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …

This study tests whether mild whole body hyperthermia (gentle heating) can reduce depression symptoms, and whether a drug that blocks an immune protein called IL-6 changes that effect. About 35 adults with major depression will receive either the drug or a placebo before the heat…

This study looks at 100 people with stage II or III breast cancer who are already getting radiation. It compares proton beam radiation to standard X-ray radiation to see which one causes less damage to the heart and lungs. The goal is to learn which type of radiation is safer, no…