Simple Anti-Inflammatory may curb opioid dependence in trauma patients
NCT ID NCT06201676
First seen Oct 31, 2025 · Last updated May 18, 2026 · Updated 30 times
Summary
This study tests whether giving a low-dose anti-inflammatory drug (ketorolac) for just five days after orthopedic surgery can reduce the chance of patients still needing opioids six months later. About 458 adults with serious bone injuries will be randomly assigned to receive either standard pain care or standard care plus ketorolac. The goal is to see if early, short-term use of this NSAID lowers long-term opioid use and improves pain management.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Conditions
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