Primary bacterial infectious disease

This study tested a 9-month treatment plan for people with multidrug-resistant tuberculosis (MDR-TB) in Gabon. The goal was to see if this shorter regimen could cure the disease with fewer side effects. 23 patients aged 15 and older took part, and the study tracked how many were …

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This study tested an experimental gonorrhea vaccine in healthy adults aged 18 to 50. The goal was to see if the vaccine is safe and can prevent gonorrhea infections. Over 1,000 participants received either the vaccine or a placebo (salt water shot) and were monitored for side eff…

This early-stage trial tested a new vaccine (CJCV2) designed to protect against Campylobacter infection, a leading cause of foodborne illness. Fifty-nine healthy adults received three different doses of the vaccine, with or without an immune-boosting adjuvant (ALFQ). The main goa…

This study tested a new vaccine (VLA15) to prevent Lyme disease, a tick-borne illness. About 12,500 healthy people aged 5 and older in high-risk areas received either the vaccine or a placebo. The goal was to see if the vaccine safely reduces Lyme disease cases compared to no vac…

This study tested a new vaccine called VLA15 to prevent Lyme disease, which is spread by tick bites. Researchers gave the vaccine or a placebo to 625 healthy people aged 5 to 65. The goal was to check safety and how well the vaccine triggers an immune response. Results showed the…

This study tested whether a new Lyme disease vaccine (VLA15) is safe for healthy children ages 5 to 17. Over 3,500 kids received either the vaccine or a placebo (saltwater shot) and were monitored for about 2 years. The main goal was to check for side effects like pain, redness, …

This Phase 3 trial tested a new anthrax vaccine called AV7909 in nearly 3,700 healthy adults. The vaccine aims to protect people after they have been exposed to anthrax bacteria. Results showed that AV7909 produced a strong immune response and was safe, similar to the current lic…

This large study tested a typhoid conjugate vaccine called TyphiBEV in over 72,000 people aged 1 to 30 years in Vellore, India. The goal was to see if the vaccine reduces the number of confirmed typhoid fever cases in vaccinated communities compared to unvaccinated ones. The tria…

This completed study tracked over 10,000 people in Thailand who received the Boostagen® vaccine, which protects against tetanus, diphtheria, and whooping cough. Healthcare workers reported any side effects to see how safe the vaccine is in everyday use. The study also looked at p…

This study tested an experimental vaccine called H56:IC31 in 831 adults who had just finished treatment for tuberculosis (TB). The goal was to see if the vaccine could lower the chance of TB coming back. Participants were randomly assigned to get either the vaccine or a placebo, …

This completed study checked the safety of the Hexaxim vaccine in 713 infants aged 2 months and older in South Korea. Researchers tracked side effects like injection site reactions, fever, and crying after routine vaccination. The goal was to confirm the vaccine's safety in every…

This phase 2 trial tested the oral cholera vaccine Vaxchora in 34 healthy adults to see how well it triggers protective antibodies and immune cells. Participants received a single dose, and researchers measured antibody levels, B cells, and T cell responses. The goal is to unders…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tested a new Shigella vaccine in 200 healthy African infants to see if it can prevent severe diarrhea. The vaccine was given in two doses, and researchers measured immune responses and safety. The trial is now complete, and results will show whether this approach is pr…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study tested a new vaccine called BK1310 in 370 healthy infants to see if it safely protects against several serious diseases: Hib, diphtheria, pertussis, tetanus, and polio. The vaccine was compared to existing vaccines. The goal was to check how well the infants' immune sy…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This study tested a booster dose of the DTaP vaccine (BK1301) in 446 adolescents aged 11-12 who had already received the standard childhood series. The goal was to confirm the vaccine boosts immunity against diphtheria, tetanus, and pertussis (whooping cough) safely. Results show…

This early-stage trial tested two experimental vaccines (BNT164a1 and BNT164b1) against tuberculosis in 120 healthy adults who had never been exposed to TB or received the BCG vaccine. The main goal was to check safety and find the best dose. Participants received three doses of …

This study tested a new vaccine designed to protect against two types of Salmonella bacteria that cause serious infections like typhoid fever and invasive nontyphoidal Salmonella disease. The trial involved 155 healthy adults in Europe and Africa who received three doses of the v…

This study tested a new combination vaccine called Shan6™, which protects against six diseases (diphtheria, tetanus, whooping cough, hepatitis B, Hib, and polio) in healthy infants and toddlers in Thailand. The trial involved 460 participants and compared Shan6™ to a similar 5-in…

This study tested two new mRNA vaccine candidates designed to prevent Lyme disease. It involved 807 healthy adults to see if the vaccines were safe and if they triggered a good immune response against the bacteria that causes Lyme. The study compared different doses of the vaccin…

This study looks at whether giving the Tdap vaccine every 3 months for a year is safe for healthy plasma donors. Normally, this vaccine is given once every 10 years. The goal is to see if more frequent vaccination produces high levels of tetanus antibodies in the plasma, which co…

This study compares two ways of making sure people with tuberculosis (TB) take their medicine correctly: traditional in-person observation by a healthcare worker versus electronic observation using live video or recorded videos on a computer or phone. The trial involves 216 TB pa…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This study tested the drug delamanid in 37 children with multidrug-resistant tuberculosis (MDR-TB), some of whom also had HIV. The goal was to see how the drug works in the body, check for side effects, and find the right dose. Children took delamanid along with their regular TB …

This study tested a single booster dose of a recombinant botulinum vaccine in 25 healthy adults who had already been vaccinated against botulism for work. The goal was to see if the booster safely raises their antibody levels enough to donate plasma for making BabyBIG, a treatmen…

This study tested an experimental drug called GSK3036656 in combination with other tuberculosis medications in 127 adults with newly diagnosed, drug-sensitive pulmonary TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to s…

This completed study tested whether adding AC-134, a dietary supplement, to a low-protein diet helps protect kidney function in people with chronic kidney disease. Researchers measured kidney function, protein in urine, and waste products in the blood of 100 adults aged 20-90 wit…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tested a new drug called VR-AD-1005 for treating severe diarrhea caused by cholera. The drug aims to reduce fluid loss and the need for antibiotics, which could help fight antibiotic resistance. 150 adults with cholera took part, and researchers measured stool output a…

This study tested whether the antibiotic ciprofloxacin works as well as doxycycline for treating plague, a serious bacterial infection. Only 5 people in Uganda took part, and they were randomly assigned to one of the two drugs. The goal was to see if ciprofloxacin could be a good…

This completed Phase 1/2 trial tested a new lab-made antibody called SNA02-48 for treating tetanus in 255 Chinese adults. The study compared SNA02-48 to the standard treatment (human tetanus immunoglobulin) to see if it is safe and how well it works. The goal is to find a more re…

This study looked at whether a booster dose of typhoid vaccine given 5-6 years after the first shot still works in children. Researchers measured immune responses and side effects in 147 children in Burkina Faso. The goal is to understand how long protection lasts and if boosters…

This trial tested a new 4-month combination of three drugs (OPC-167832, delamanid, and bedaquiline) against the standard 6-month treatment for drug-susceptible pulmonary tuberculosis. 122 adults with newly diagnosed TB took part. The goal was to see if the shorter regimen is safe…

This study tested a single dose of the drug pretomanid in 32 children with rifampicin-resistant tuberculosis (TB). The goal was to see how the drug moves through the body and whether it is safe when added to their regular TB treatment. The children were monitored for 48 hours aft…

This study looked at how to best dose two medicines, rifapentine and isoniazid, for children aged 0-12 with latent (hidden) tuberculosis infection. The goal was to find a dose that works as well as in adults to prevent the infection from turning into active TB. The study included…

This study tested whether charcoal-infused toothbrushes remove plaque and stains better than regular nylon toothbrushes. Thirty-six Egyptian adults brushed twice daily for 4 weeks with standard toothpaste. Plaque and stain levels were measured at the start and end. The goal is to…

This study tested two different doses of the antibiotic linezolid, combined with three other drugs (bedaquiline, delamanid, and clofazimine), in 138 people with drug-resistant pulmonary tuberculosis. The goal was to see which dose worked better at clearing the infection and was e…

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This study tested whether adding bedaquiline to two standard antibiotics (clarithromycin and ethambutol) helps clear a stubborn lung infection called MAC lung disease. 129 adults who had not responded to previous treatment took part. The main goal was to see if the new combinatio…

This study tested whether taking a higher dose of the drug rifampin for 2 months is as safe and effective as the standard 4-month dose for treating latent tuberculosis (TB) infection. Over 1,300 adults and children aged 10 and older with latent TB were randomly assigned to receiv…

This study tested a once-daily combination of three HIV drugs (tenofovir, emtricitabine, and efavirenz) in 70 adults with both HIV and tuberculosis. Participants had not taken HIV medication before and had been on TB treatment for less than three months. The goal was to see if th…

This study looked at whether adding metformin, a diabetes drug, to standard tuberculosis (TB) treatment is safe and tolerable for people also living with HIV. 112 adults with TB and HIV took either standard TB medicines alone or with metformin for 11 weeks. Researchers monitored …

This early-phase trial tested whether an injection made from human umbilical cord cells (called secretome) can help heal chronic skin ulcers in people with leprosy. 27 adults with ulcers that had not healed with standard care received the injection and were followed for 12 weeks.…

This study tested whether injecting the antibiotic gentamicin directly into swollen lymph nodes helps people with cat scratch disease recover faster. 75 participants received either the injection or a placebo, along with standard oral antibiotics. The goal was to see if the injec…

This study looked at whether giving two antibiotics together (meropenem and azithromycin) helps children with drug-resistant typhoid fever get better faster than using just one. 90 children aged 6 months to 5 years with confirmed typhoid took part. The main goal was to see how qu…

This study tested whether a vaccine already approved for meningitis B (Bexsero) can also protect against gonorrhea infection. Healthy men aged 18–35 received either the meningitis vaccine or a placebo, then were exposed to the gonorrhea bacteria in a controlled setting. The goal …

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested whether taking two antibiotics instead of three is just as effective for treating a lung infection called MAC, while causing fewer side effects. 474 adults with MAC lung disease were randomly assigned to receive either two or three drugs for 12 months. The goal …

This study tested whether adding an inhaled antibiotic (ALIS) to standard oral antibiotics helps adults with a new diagnosis of a hard-to-treat lung infection caused by MAC bacteria. About 425 adults took part. The main goal was to see if the combination improved breathing sympto…

This study tested whether a combination of two antibiotics (azithromycin and cefixime) works better than azithromycin alone for treating uncomplicated typhoid fever in South Asia. Over 2,100 patients took part across Bangladesh, India, Nepal, and Pakistan. Researchers measured tr…

This study tested whether a stronger tuberculosis (TB) treatment could save more lives in people with HIV and very weak immune systems. Over 1,300 hospitalized patients received either the standard TB drugs or an intensified version with higher doses of two key medicines, plus a …

This study tested a therapeutic vaccine called RUTI in 41 adults with active pulmonary tuberculosis. Participants received either the vaccine or a placebo alongside their regular antibiotic treatment. The goal was to see if the vaccine could boost the immune system to kill bacter…

This study tested a therapeutic vaccine called RUTI in 140 people with tuberculosis (TB), including drug-resistant forms. Participants received either one dose of RUTI or a placebo alongside their standard TB medications. The goal was to see if the vaccine could help clear the TB…

This study tested two different antibiotics—clarithromycin or moxifloxacin—alongside standard drugs to treat a rare lung infection caused by M. xenopi bacteria. Researchers tracked whether patients' sputum samples became bacteria-free after 6 months. The goal was to find the more…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This early-phase trial tested replacing the standard drug cyclophosphamide with bendamustine after a half-matched bone marrow transplant in 50 patients with various blood cancers. The goal was to see if this change could reduce side effects like graft-versus-host disease while st…

This study tested an experimental drug called SPR720 in 25 adults with a chronic lung infection caused by Mycobacterium avium complex (MAC). The goal was to see if the drug can reduce bacteria in sputum and is safe compared to a placebo. Participants took the drug or placebo by m…

This phase 3 trial tested a new antibiotic called zoliflodacin, taken as a single oral dose, against the standard treatment of an injection plus pills for uncomplicated gonorrhea. Over 1,000 participants were enrolled to see if the new pill works as well and is safe. If successfu…

This study tested a new HIV medication (Biktarvy) taken twice daily in 122 adults who also have drug-sensitive tuberculosis (TB) and are on standard TB treatment. The goal was to see if the new pill can control HIV just as well as the current standard treatment. The study measure…

This study tested a new oral treatment called LMN-101, made from spirulina, to see if it can prevent or control Campylobacter infection. Healthy volunteers took LMN-101 or a placebo for two days, then were exposed to the bacteria. The goal was to check safety and how well the tre…

This small pilot study tested a drug called 3,4-diaminopyridine (FIRDAPSE) in 3 people with severe botulism who needed a ventilator to breathe. The goal was to see if the drug could improve nerve signals and breathing. Because only 3 people took part, the results are very prelimi…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested an experimental drug called TNM002 in 240 healthy Chinese adults to see if it can protect against tetanus as well as the standard treatment. Participants received a single injection of TNM002 at different doses, the standard tetanus antibody, or a placebo. The m…

This phase IIb trial tested an experimental antibiotic called delpazolid, added to a standard three-drug regimen (bedaquiline, delamanid, moxifloxacin), in 76 adults with newly diagnosed, drug-sensitive pulmonary tuberculosis. The main goals were to check safety and how the drug …

This completed trial tested whether zinc and selenium supplements could boost the immune system of tuberculosis patients. Researchers gave 90 adults with pulmonary TB either fortified cookies or a supplement called Myrin P Fort, and measured changes in body measurements, blood co…

This study tested a combination of three drugs—bedaquiline, pretomanid, and linezolid—in 109 people with extensively drug-resistant TB (XDR-TB) or multi-drug resistant TB (MDR-TB) that didn't respond to other treatments. Participants took the drugs for 6 to 9 months. The goal was…

This study looked at how safe and tolerable the drug bedaquiline is for children and teens with rifampin-resistant tuberculosis, including those also living with HIV. Fifty-four participants received bedaquiline along with their regular TB treatment for 24 weeks. Researchers meas…

This completed Phase 2 trial tested two antibiotics, levofloxacin and ciprofloxacin, in 360 children aged 1-12 with typhoid fever. The goal was to see which drug resolves fever faster within 5 days. Children were randomly assigned to one of the two drugs and monitored in the hosp…

This study compares a new rapid point-of-care test for chlamydia, gonorrhea, and mycoplasma genitalium to standard lab testing. The goal is to see if the faster test helps doctors give the right antibiotics on the same day, reducing unnecessary or missed treatments. Participants …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new skin test called C-TST to find latent (hidden) tuberculosis infections in 300 adults in Indonesia who were close contacts of TB patients. Participants received both the skin test and a standard blood test (IGRA) to see how well the new test worked. The goa…

This study tested a new skin test called EC to see if it can accurately diagnose tuberculosis (TB) infection in adults aged 65 and older. Researchers compared EC with a standard TB skin test (TB-PPD) and a blood test (T-SPOT) in 780 participants, including TB patients and healthy…

This study tested three rapid, point-of-care HIV tests to see how well they work compared to standard lab tests. Researchers enrolled 224 adults at high risk for HIV in Baltimore. The goal was to see if faster results help more people start treatment or prevention the same day.

This study looked at whether measuring TB DNA in fluid from around the lungs (pleural fluid) can quickly and accurately diagnose tuberculosis. Researchers tested fluid from 329 adults with lung fluid buildup. The goal was to see if this DNA test works better than standard tests, …

This study tested a rapid fingerstick test that checks for both HIV and syphilis at the same time in pregnant women visiting prenatal clinics in Guatemala. The goal was to see if this quick, on-the-spot screening would lead to more women being diagnosed and treated during pregnan…

This study tested a new rapid blood test called SeroSelectTB to see if it can diagnose active tuberculosis (TB) faster than current methods. Over 9,000 adults in South Africa, Tanzania, and Ethiopia who were unwell and suspected of having TB or pneumonia took part. The goal is to…

This study evaluated a new stool-based test (qPCR) to diagnose tuberculosis (TB) in children under 8 and people living with HIV. Researchers in Mozambique, Eswatini, and Uganda tested nearly 2,000 participants to see if the stool test could improve TB detection rates compared to …

This study checked how well a new rapid test (Reveal TP) detects syphilis compared to standard lab tests. About 600 adults visiting a Vancouver STI clinic took part. The goal was to see if the quick finger-prick test is accurate enough for routine use.

This study looked at whether a bronchoscopy (a thin, flexible tube with a camera) can help diagnose tuberculosis in the airways of people whose usual sputum tests came back negative. 63 adults with suspected lung TB took part. The goal was to catch the disease earlier and more ac…

This study aimed to create a quick, simple test to diagnose tuberculous meningitis (TBM) in children. TBM is a severe form of TB that affects the brain and is hard to detect with current methods, especially in places with limited resources. Researchers tested 51 inflammatory mark…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study involved 603 hospitalized children aged 2 to 59 months with severe acute malnutrition in Uganda and Zambia. Researchers tested various diagnostic methods—including chest X-rays, lab cultures, and symptom checks—to develop a score that helps doctors decide whether a chi…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This completed study tested several tuberculosis (TB) diagnostic tools in over 14,000 people across seven countries. The goal was to find tests that are accurate enough to use in local clinics, without needing special lab equipment. Researchers looked at a simple blood test for C…

This study looked at better ways to screen teenagers (ages 15-21) for chlamydia and gonorrhea when they visit emergency departments. Researchers compared offering STI tests to everyone versus only to those with certain risk factors. The goal was to find the most effective and cos…

This study tested a new diagnostic method (mass spectrometry) to detect Lyme disease bacteria in skin biopsies from 84 people with early Lyme rash (erythema migrans). The new method was compared to standard PCR and culture tests. The goal was to see if the new technique could ide…

This study tested a strategy of using rapid, point-of-care diagnostic tests for sexually transmitted infections (STIs) in pregnant women attending antenatal clinics in Zimbabwe. Over 1,000 women were offered testing for chlamydia, gonorrhea, trichomoniasis, syphilis, and hepatiti…

This study tested two new tools for diagnosing tuberculosis (TB): a software that analyzes chest X-rays (CAD4TB) and a blood test that measures C-reactive protein (CRP). Researchers enrolled 1,400 adults with TB symptoms in Lesotho and South Africa. They compared these tests to s…

This study tested two ways to find tuberculosis (TB) in communities in Lesotho and South Africa. One method used a chest X-ray analyzed by computer software (CAD4TB). The other added a finger-prick blood test (CRP) for people whose X-ray results were unclear. Both methods were fo…

This study tested whether a smartwatch app called Hyfe can accurately count how often people cough. Researchers compared the app's cough counts to manual counts from audio recordings in 31 adults with various cough-related conditions. The goal is to see if the smartwatch can be a…

This trial evaluates whether a hospital-based remedial vaccination strategy can improve Tdap-IPV (tetanus, diphtheria, pertussis, polio) vaccination rates in adults aged 65 and older in the Sarthe region of France. Participants are randomly assigned to receive either the remedial…

This study tested whether adjusting the dose of a tuberculosis (TB) prevention drug based on a person's genetic makeup could improve treatment. Researchers enrolled 78 people and used a quick genetic test to guide the dose of isoniazid. The goal was to see if this personalized ap…

This study tested whether taking the tuberculosis prevention drug isoniazid for 36 months instead of the usual 6 months could better prevent TB in adults with HIV. Nearly 2,000 participants in Botswana were randomly assigned to either short or long treatment. The goal was to see …

This completed study tested a new public health pack to find and prevent tuberculosis (TB) early in people living with someone who has TB. Over 7,400 participants in Thailand were involved. The pack included active screening, treatment for active TB, and preventive therapy for th…

This study tested a pop-up clinic inside a van for women who inject drugs and exchange sex in north Seattle. The goal was to see if offering HIV prevention pills, addiction medications, and quick STI testing in a convenient location would help more women start and stay on these t…

This study tested an experimental vaccine (G03-52-01) in 622 healthy adults to see if it could safely protect against botulinum toxin, the poison that causes botulism. Participants received either the vaccine or a placebo, and researchers measured side effects and immune response…

This study tested whether using an antibacterial mouthwash every day could lower the chance of getting gonorrhea in the throat. Researchers recruited 89 HIV-positive and HIV-negative men at high risk. Participants gargled with either Listerine or a placebo mouthwash daily. The st…

This study tested whether giving a full 3-month supply of TB preventive medicine directly in the community helps more people finish their treatment compared to standard clinic visits. Researchers enrolled 301 adults in South Africa who were at risk for TB, including those with HI…

This study tested a short in-class education program to teach children aged 7-12 how to prevent Lyme disease. The program covered personal protection, early detection, and reducing ticks around homes. Researchers compared Lyme disease cases and prevention behaviors between groups…

This study tested a mobile program called Comunică to help Romanian gay and bisexual men reduce HIV risk and heavy drinking. 300 participants used their phones or laptops to complete surveys and eight one-hour sessions with a counselor or by reading health information. The progra…

This study tested whether a supervised exercise program can improve heart and lung function and quality of life in people with lasting lung damage from tuberculosis. 60 participants were split into an exercise group and a control group. The goal was to see if physical training he…

This study tested several non-drug methods—like a textured plastic device called ShotBlocker, a vibrating ice pack (Buzzy), and a skin-tapping technique—to reduce pain from injections in children aged 4 to 6. 120 kids in a pediatric emergency department took part. The goal was to…

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This study tested a special way to give intramuscular injections to children aged 6-12. Instead of the usual method, nurses used a precise ventrogluteal technique with a 90-degree angle and quick needle insertion and removal. The 90 children were split into two groups: one got th…

This study reviews the medical records of people who were hospitalized in French intensive care units (ICUs) for severe botulism poisoning. Botulism is a rare but serious illness caused by a toxin that can paralyze muscles. The goal is to describe what happened to these patients,…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This pilot study looked at how well the antibiotic azithromycin kills Mycobacterium avium complex (MAC) bacteria in the lungs during the first 14 days of treatment. Ten adults with MAC lung disease took azithromycin daily, and researchers measured bacterial levels in their sputum…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study examined whether the standard dose of isoniazid, a key tuberculosis drug, is right for all adults. Researchers measured drug levels in 112 patients to see if some were getting too much or too little. The goal was to understand how individual differences in drug process…

This study tested a new drug called MK-7762 in 119 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo in single or multiple doses. The goal was to check for side effects and measure drug levels in the blood, not t…

This study looked at how a new drug called OPC-167832 is processed by the liver when taken with other common medicines. Twenty-four healthy adults took part to see if certain drugs slow down or speed up the breakdown of OPC-167832. The goal was to gather safety information, not t…

This study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…

This study looked at how immune cells in the lungs respond to tuberculosis (TB) proteins in 17 adults—some with latent TB (no symptoms) and some never exposed. Researchers used a thin tube to deliver the protein directly into the lung and collected cells to measure immune reactio…

This study looked at how many people with cirrhosis in French general hospitals were vaccinated against diseases like hepatitis, flu, and COVID-19. Researchers surveyed 742 patients to see if they were up to date on their shots. The goal was to find gaps in vaccination coverage s…

This study tested whether a virtual reality (VR) room called VR CAVE can teach community health nursing skills as effectively as a physical mock home. 150 final-year nursing students practiced home visits for patients with COPD and tuberculosis in both settings. Results showed bo…

This study tested whether bringing a portable TB test (Gene Xpert) directly to people in crowded communities helps find and treat more TB cases than the usual method of waiting for people to visit a clinic. Over 3,500 adults in South Africa took part. The goal was to see if this …

This completed study monitored over 14,000 hospital patients for multidrug-resistant organisms (MDROs) by taking rectal swabs and tracking bloodstream infections. Researchers analyzed the bacteria's genetics and how they resist antibiotics, aiming to understand how resistance eme…

This study surveyed 418 respiratory doctors in the Asia-Pacific region to understand how they diagnose tuberculous pleuritis, a type of TB that affects the lining around the lungs. The goal was to see which tests are used, how available they are, and how doctors decide to start t…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study tested a simple way to get more HIV patients in South Africa the medicine that prevents tuberculosis (TB). Instead of doctors having to choose to prescribe it, the new approach made TB prevention the standard option, requiring doctors to actively opt out if they didn't…

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This study explored why some people with latent (inactive) tuberculosis (TB) are more likely to develop active TB. Researchers looked at 626 people in South India to see how malnutrition, diabetes, and worm infections might change the body's response to TB. Participants gave bloo…

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study looked at ways to prevent tuberculosis (TB) in Malaysian prisoners, many of whom also had HIV, opioid addiction, or hepatitis. Researchers compared a standard 40-week TB prevention treatment with a shorter 12-week option. The goal was to see which approach worked bette…

This completed study looked for tuberculosis (TB) cases in 5,694 people who had already finished a COVID-19 vaccine trial. Participants had physical exams, blood tests, and tongue swabs to find TB and study related biomarkers. The goal was to understand how common TB is in this g…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This study looked at why some people infected with TB bacteria get sick while others don't. Researchers in India studied 120 household contacts of TB patients, comparing those who were malnourished or had parasitic worms. They provided food and deworming medication to see how the…

This study looked at whether exposure to PFAS chemicals (found in some water supplies) can weaken the body's immune response to the tetanus and diphtheria booster vaccine. Twenty adults from a community with known PFAS exposure received the vaccine and had blood and saliva sample…

This study tested a new method to evaluate tuberculosis (TB) drugs and vaccines in 20 healthy adults. Researchers used a harmless version of the TB bacteria (BCG) to see how the body fights it and how treatments work. The goal was to create a faster, safer way to test new TB trea…

This study looked at whether adding a fiber supplement (inulin) to a low-fiber diet could increase helpful gut bacteria and improve the immune response to a typhoid vaccine. Sixty healthy adults with low fiber intake took either inulin or a placebo for five weeks, and all receive…

This study used a special PET scan to track how the tuberculosis drug pretomanid moves through the body. Ten people with or without TB received a tiny radioactive version of the drug, and the scanner measured where it went. The goal was to see how much drug reaches infected areas…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study tested whether a pay-it-forward approach—where one person's donation covers testing for the next person—could increase gonorrhea and chlamydia testing among men in China. Over 1,200 men who had sex in the past year but hadn't been tested recently took part. The goal wa…

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and their newborns. Researchers measured drug levels in blood and vaginal fluids to see if dosing needs to change during pregnancy and after birth. Over 1,500 women took p…

This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal…

This study tested two ways of giving anesthesia gas (sevoflurane) during kidney stone surgery. One method used a very low gas flow (minimal-flow), the other a slightly higher flow (low-flow). In 62 adults, the minimal-flow approach used less anesthesia drug while keeping patients…

This study tested a smartphone app called Hyfe Cough Tracker to see if it can accurately count coughs in people with lung conditions like COPD, asthma, or COVID-19. Researchers compared the app's cough counts to patients' own reports and expert listening. The goal was to improve …

This study looked at whether providing nutritional support to people being treated for tuberculosis (TB) improves their outcomes. Researchers compared TB patients in Benin, who receive food baskets and meals, to similar patients in Togo, who do not get systematic nutritional supp…

This study looked at how HIV and tuberculosis (TB) medications are processed in the bodies of pregnant women and new mothers. Researchers measured drug levels in the blood of 205 women during pregnancy and after delivery to see if standard doses are effective. The goal was to gat…

This completed study looked at 141 people being treated for tuberculosis (TB) to see if intestinal parasites or poor nutrition made their recovery harder. Researchers checked stool samples for parasites and measured weight gain and treatment success. Some participants received nu…

This study tested a new way to find people exposed to tuberculosis (TB) in Cali, Colombia. Instead of relying only on in-person visits, researchers used a mobile phone chatbot and a simple oral (mouth) test that people could do at home. The goal was to see if this approach was pr…

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…

This completed Phase 3 study measured how high doses of the tuberculosis drugs rifapentine and moxifloxacin move through the body in 53 adults with TB. Participants gave multiple blood samples to track drug levels. The goal was to understand the best doses to kill TB bacteria whi…

This study followed 603 pregnant women in South Africa to see if infections or bacteria in the vagina are linked to how early they give birth. Researchers tested for sexually transmitted infections, yeast, and other germs at the start of pregnancy and again at 30-34 weeks. The go…

This study looked at 350 patients who had surgery (decortication) to treat severe lung infections called empyema, including cases caused by tuberculosis and drug-resistant bacteria. The goal was to understand the types of germs causing these infections and how they affect recover…

This study looks at whether a listeria infection around the time of birth can lead to long-term thinking or behavior problems in children. Researchers will compare 53 children who had the infection with a control group using standard tests. The goal is to understand the role of t…

This study tested a new AI system (Janus Pro 1B-CXR) designed to help radiologists interpret chest X-rays. The AI was developed using public data and evaluated in 296 patients with suspected chest diseases. Researchers compared report quality, reading time, and agreement between …

This study tested whether people with active tuberculosis can use a smartphone app to send videos of themselves taking their medication, instead of going to a clinic for direct observation. Researchers enrolled 51 patients in Switzerland and measured how many agreed to use the ap…

This study looked at whether giving the anthrax vaccine AV7909 along with common antibiotics (ciprofloxacin or doxycycline) changes how the body processes those antibiotics. 210 healthy adults received the vaccine and antibiotics on a set schedule. The goal was to see if the vacc…