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Could a single pill replace the shot for gonorrhea?

NCT ID NCT03959527

Completed Disease control Sponsor: Global Antibiotics Research and Development Partnership Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested a new antibiotic called zoliflodacin, taken as a single oral dose, against the standard treatment of an injection plus pills for uncomplicated gonorrhea. Over 1,000 participants were enrolled to see if the new pill works as well and is safe. If successful, it could offer a simpler, more convenient treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

zoliflodacin

What this could lead to

If successful, this could provide a simple, single-dose oral treatment for gonorrhea, reducing the need for injections and helping fight antibiotic resistance.

What could go wrong

The trial is completed but results are not yet widely available. The new drug may not be as effective as current treatments, and antibiotic resistance remains a concern.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

gonorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GONORRHEA

Contacts and locations

Locations

  • Bangrak STI Center

    Bangkok, 10120, Thailand

  • Bell Flower Clinic

    Indianapolis, Indiana, 46202, United States

  • Institute of HIV Research and Innovation

    Bangkok, 10330, Thailand

  • Institute of Tropical Medicine

    Antwerp, 2000, Belgium

  • Jefferson County Department of Health

    Birmingham, Alabama, 35233, United States

  • Louisiana State University Health Sciences Center

    New Orleans, Louisiana, 70112, United States

  • Masiphumelele Research Site

    Cape Town, 7975, South Africa

  • Ndlovu Research Centre

    Elandsdoorn, 0470, South Africa

  • Public Health - Seattle & King County STD Clinic

    Seattle, Washington, 98104, United States

  • Public Health Service (GGD) Amsterdam / STI Outpatient Clinic

    Amsterdam, 1018 WT, Netherlands

  • SAMRC Botha's Hill Clinical Research Site

    Bothas Hill, 3660, South Africa

  • SAMRC Tongaat Clinical Research Site

    Tongaat, 4400, South Africa

  • San Francisco Department Of Public Health City Clinic

    San Francisco, California, 94103, United States

  • Setshaba Research Centre

    Soshanguve, 0152, South Africa

  • Silom Community Clinic

    Bangkok, 10400, Thailand

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294-0006, United States

  • Wits RHI

    Johannesburg, 2001, South Africa

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