Could a single pill replace the shot for gonorrhea?

NCT ID NCT03959527

Completed Disease control Sponsor: Global Antibiotics Research and Development Partnership Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested a new antibiotic called zoliflodacin, taken as a single oral dose, against the standard treatment of an injection plus pills for uncomplicated gonorrhea. Over 1,000 participants were enrolled to see if the new pill works as well and is safe. If successful, it could offer a simpler, more convenient treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: zoliflodacin
What this could lead to: If successful, this could provide a simple, single-dose oral treatment for gonorrhea, reducing the need for injections and helping fight antibiotic resistance.
What could go wrong: The trial is completed but results are not yet widely available. The new drug may not be as effective as current treatments, and antibiotic resistance remains a concern.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gonorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GONORRHEA

Contacts and locations

Locations

Bangrak STI Center

Bangkok, 10120, Thailand
Bell Flower Clinic

Indianapolis, Indiana, 46202, United States
Institute of HIV Research and Innovation

Bangkok, 10330, Thailand
Institute of Tropical Medicine

Antwerp, 2000, Belgium
Jefferson County Department of Health

Birmingham, Alabama, 35233, United States
Louisiana State University Health Sciences Center

New Orleans, Louisiana, 70112, United States
Masiphumelele Research Site

Cape Town, 7975, South Africa
Ndlovu Research Centre

Elandsdoorn, 0470, South Africa
Public Health - Seattle & King County STD Clinic

Seattle, Washington, 98104, United States
Public Health Service (GGD) Amsterdam / STI Outpatient Clinic

Amsterdam, 1018 WT, Netherlands
SAMRC Botha's Hill Clinical Research Site

Bothas Hill, 3660, South Africa
SAMRC Tongaat Clinical Research Site

Tongaat, 4400, South Africa
San Francisco Department Of Public Health City Clinic

San Francisco, California, 94103, United States
Setshaba Research Centre

Soshanguve, 0152, South Africa
Silom Community Clinic

Bangkok, 10400, Thailand
University of Alabama at Birmingham

Birmingham, Alabama, 35294-0006, United States
Wits RHI

Johannesburg, 2001, South Africa

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