Primary bacterial infectious disease

This trial is testing two tuberculosis (TB) vaccines—VPM1002 and a repeat BCG vaccination—in pre-adolescents aged 8-14 who were vaccinated at birth. The goal is to see if these vaccines are safe and trigger a strong immune response in children both with and without HIV, and in th…

This early-stage trial is testing a new tetanus vaccine in 80 adults aged 18 and older. The study is randomized and double-blind, meaning neither participants nor doctors know who gets the new vaccine versus an existing one. The main goal is to check for side effects within the f…

This study tests an experimental mRNA vaccine (mRNA-1982) designed to prevent Lyme disease, which is spread by tick bites. About 350 healthy adults aged 18 to 70 will receive either the vaccine or a placebo to check for safety and immune response. The goal is to find the best dos…

This study tests a new vaccine called Shigella4V2 to see if it can protect people from shigellosis, a severe diarrheal disease. About 120 healthy adults will receive either the vaccine or a placebo and then be exposed to the bacteria in a controlled setting. The goal is to see if…

This Phase 3 trial tests the GamTBvac vaccine to prevent active pulmonary tuberculosis in adults aged 18 and older. The study includes people with and without a prior history of TB, comparing the vaccine to a placebo. Researchers will monitor how many participants develop active …

This study tests a new vaccine designed to protect against three common types of Salmonella bacteria that cause serious infections in Sub-Saharan Africa. The trial includes healthy participants ranging from adults down to young infants, and compares the vaccine to a placebo to se…

This study tests a new vaccine (iNTS-GMMA) designed to prevent severe Salmonella infections caused by two common strains. Researchers are giving the vaccine to healthy adults, children, and infants in Ghana to check if it is safe and triggers a strong immune response. The ultimat…

This large phase 3 trial is testing a typhoid conjugate vaccine (Vi-TCV) in 30,000 healthy children aged 9 months to 12 years in Malawi. Half get the typhoid vaccine, half get a meningitis vaccine for comparison. The goal is to see if the typhoid vaccine prevents blood-confirmed …

This study tests a new Lyme disease vaccine (VLA15) in about 200 healthy adults aged 18 to 44. Participants receive five shots over two years—four of the vaccine and one of salt water—to see if different timing schedules are safe and produce a strong immune response. The goal is …

This early-stage study tests a new vaccine called Ad5-105K to see if it is safe and triggers an immune response against tuberculosis (TB). About 36 healthy adults aged 18 to 49 who have been exposed to TB bacteria (but have no active disease) will receive either the vaccine or a …

This phase II trial tests a new tuberculosis vaccine called MTBVAC (BBV169) in 164 healthy adolescents and adults. Some participants get the new vaccine, others get the standard BCG vaccine. The study checks how safe the vaccine is and how well it triggers an immune response, aim…

This large study tests an experimental vaccine called M72/AS01E-4 to see if it can prevent tuberculosis (TB) in teens and adults. About 20,000 people will receive either the vaccine or a placebo. The goal is to find a safe and effective way to stop TB, a serious lung infection.

This study tests a two-dose vaccine designed to prevent diarrhea from two common types of Shigella bacteria in 8,000 children aged 6 months to 5 years in Bangladesh. Half the children get the vaccine, half get a placebo, and researchers track who gets sick over time. The goal is …

This study tests two experimental vaccines (BNT164a1 and BNT164b1) to see if they are safe and trigger an immune response against tuberculosis. About 500 healthy adults who have already received the BCG vaccine will receive three doses of either a vaccine or a placebo. The goal i…

This study tests a new vaccine called H107e/CAF®10b to prevent tuberculosis (TB). It is the first time this vaccine is given to people. The trial involves 140 healthy adults aged 18 to 45 and checks for side effects and how well the vaccine triggers the immune system. The goal is…

This study tests an anthrax vaccine called AV7909 in 220 healthy adults aged 18 to 65. The goal is to see how safe it is and how well it triggers the immune system, using two different dosing schedules and booster shots at 6 and 12 months. Participants will be monitored for side …

This phase 3 study tests a new vaccine (DTacP) that protects infants from diphtheria, tetanus, and whooping cough. Around 2,900 healthy babies aged 2-3 months will receive the vaccine to check its safety and how well it triggers immunity. The trial compares different schedules an…

This phase II trial is investigating whether higher doses of two tuberculosis (TB) drugs, rifampicin and pyrazinamide, can safely shorten treatment for people with mild to moderate pulmonary TB. The study compares drug levels and safety of this high-dose regimen against the stand…

This study tests a single booster dose of a combined vaccine against diphtheria, tetanus, and whooping cough (dTpa) in 85 healthy Japanese adolescents aged 11 to 13. Researchers will check if the shot triggers a strong immune response and monitor for side effects one month after …

This study tests whether a piece of donated aorta (the body's largest artery) can be used as a patch to repair severe windpipe or bronchial defects in children. The surgery is for kids who cannot have standard windpipe repair. Only 5 children will be enrolled, and the main goal i…

This phase 2 trial tests whether adding nicotinamide (a form of vitamin B3) to a standard three-drug regimen can safely and effectively treat drug-susceptible pulmonary tuberculosis. About 165 adults with newly diagnosed TB will receive one of two doses of nicotinamide plus the s…

This phase 2 trial tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) works better than the standard 26-week treatment for drug-susceptible tuberculosis. About 94 adults with TB will be randomly assigned to either the short r…

This study tests whether giving menstrual cups to economically vulnerable women in Kenya can lower rates of bacterial vaginosis (BV) and sexually transmitted infections (STIs). The cup is a reusable silicone device that collects menstrual blood and can be worn during sex. Researc…

This study tests a new combination of five oral drugs (bedaquiline, delamanid, levofloxacin, linezolid, and clofazimine) for treating multidrug-resistant tuberculosis (MDR-TB). The goal is to see if a shorter treatment course (16 to 40 weeks) can effectively cure the infection wi…

This study tests a digital package called CARE-TB to help people with tuberculosis take their medication as prescribed. The package includes video observation of pill-taking, digital reminders, telecounselling, and educational materials. Researchers will compare this approach to …

This Phase 2 trial tests whether a new drug called TBAJ-876, or the existing drug bedaquiline, combined with pretomanid and linezolid, can treat drug-sensitive tuberculosis faster and more effectively than the standard 6-month regimen. About 309 adults with newly diagnosed TB are…

This study tests a 4-session behavioral program to reduce alcohol use in 450 people with TB and HIV in India. Unhealthy drinking can worsen TB and HIV outcomes. The program is added to usual care, and researchers will check if it lowers alcohol use and improves health. The goal i…

This study tests whether a food supplement called Nyaditum resae® can reduce the gut problems caused by antibiotics used to treat tuberculosis (TB). About 48 adults with new, drug-sensitive TB will take either the supplement or a placebo alongside their regular TB medicines. The …

This study tests a drug called clofazimine for people with a chronic lung infection caused by Mycobacterium avium complex (MAC). The goal is to see if adding clofazimine to standard treatment helps clear the bacteria from sputum and improves walking ability and fatigue. About 102…

This study looks at whether having a nurse case manager helps people with multidrug-resistant tuberculosis (MDR-TB) and HIV complete their long treatment. About 3,600 patients in South Africa are involved. Half of the clinics have a nurse case manager to guide care, while the oth…

This study tests whether the antibiotic linezolid can effectively treat early syphilis in 24 adults. Participants have primary, secondary, or early latent syphilis, and some also have well-controlled HIV. The main goal is to see if linezolid reduces syphilis infection markers in …

This study tests a package of community support, family help, digital reminders, and healthcare worker training to improve how tuberculosis is found and treated in South Ethiopia. About 278 patients, family members, and health workers will take part. The goal is to see if this co…

This early-stage study tests a new lab-made antibody injection against tetanus in 68 healthy adults aged 18-60. The main goal is to check safety and side effects, not to treat or prevent tetanus directly. Participants receive a single shot and are monitored for several weeks.

This study tests a smartphone app and a tablet dashboard for community health workers to support people with both tuberculosis (TB) and HIV in South Africa. The app helps patients stay on track with their medications, while the dashboard alerts health workers if someone needs ext…

This study tests a 1-month course of three medicines (isoniazid, rifapentine, and vitamin B6) to treat latent tuberculosis in 25 adults with end-stage kidney disease who are candidates for a kidney transplant. The goal is to see if this shorter treatment is safe and easy to compl…

This study looks at how a medicine called BAT® works in children who have or may have been exposed to botulism toxin. The medicine is an antitoxin that helps stop the toxin from causing more harm. Researchers will take blood samples from up to 10 children to see if the dose is ri…

This study tests whether giving higher doses of a TB drug (rifampicin) plus an extra antibiotic (levofloxacin) for 14 days, with or without steroids, can help more people survive. It includes 732 adults with HIV who are hospitalized for TB that has spread beyond the lungs. The go…

This study is testing two tuberculosis (TB) prevention treatments in pregnant women who also have HIV. The goal is to see if these treatments are safe and how they interact with the HIV medication dolutegravir. About 252 pregnant women will take either a daily TB drug for one mon…

This study tests whether a once-weekly combination of two drugs (rifapentine and isoniazid) can safely prevent tuberculosis in children and teens with HIV who are already taking the antiretroviral dolutegravir. About 92 participants aged 3 months to 17 years will receive the TB p…

This study tests I-FALMIN, a supplement made from toman fish, in 112 adults with pulmonary tuberculosis and low albumin levels. Participants take the supplement or a placebo for one day alongside standard TB treatment. Researchers will check if albumin levels and body mass index …

This study tests whether two new 17-week drug combinations can treat pulmonary tuberculosis as effectively as the standard 6-month regimen. About 288 people with TB will receive one of three daily pill regimens. The goal is to see if shorter treatment can clear the infection fast…

This study tests whether adding methotrexate to standard steroid treatment can help people with a painful leprosy complication called ENL. 550 adults with active ENL will receive either methotrexate or a placebo alongside prednisolone. The goal is to see if methotrexate reduces t…

This phase 3 trial is testing a 6-month, all-oral combination of four drugs (bedaquiline, delamanid, linezolid, and levofloxacin or clofazimine) to treat rifampin-resistant tuberculosis in Chinese teenagers and adults aged 12 and older. The goal is to see if this shorter regimen …

This study is testing a new rapid blood test for syphilis that gives results from a fingerstick sample during a single clinic visit. About 600 adults attending a community health centre in Winnipeg will take part. Researchers want to see if this quick test is as accurate as stand…

This study evaluates a new blood test called Xpert Tropical Fever that can quickly detect several tropical diseases like malaria, dengue, and Zika from a small blood sample. Researchers will enroll 2,500 people with fever symptoms to see how accurate the test is compared to stand…

This study evaluates a new blood test that aims to directly detect the bacteria causing dormant tuberculosis (TB), rather than relying on the body's immune response. Current tests cannot tell if treatment worked or who will develop active TB, leading to unnecessary antibiotics. R…

This study evaluates a new PCR test (Bioneer Q-RFIA kit) for quickly and accurately detecting tuberculosis (TB) and resistance to key antibiotics. About 2,350 adults with TB symptoms will provide samples to see how well the test works compared to standard methods. The goal is to …

This study in Pakistan compares two new TB diagnostic tests (Pluslife MTBC and Ustar PortNAT) to the standard Xpert Ultra test. Researchers will collect tongue swabs and sputum from 6,100 people screened for TB. The goal is to see if the new tests are accurate, faster, and easier…

This study tests a new pill called TP-05 (lotilaner) to see if it can prevent Lyme disease in healthy adults who are often around ticks. The pill is already used in pets to kill ticks. Researchers will give either a low dose, high dose, or placebo to 700 volunteers and watch for …

This study tests whether taking doxycycline before potential exposure to STIs works better than taking it after exposure. 300 men who have sex with men will be randomly assigned to one of two groups and followed for 2 years. The goal is to see which approach better prevents chlam…

This study looks at better ways to find and prevent tuberculosis (TB) in people living with HIV. Researchers will test a new screening method and offer patients a choice of TB preventive medicines with extra support like text reminders. The goal is to improve TB detection and hel…

This early-stage study tests whether a single injection of a new antibody, JST-010, is safe in healthy adults aged 18 to 55. The goal is to prevent pneumonic plague, a rare but serious lung infection. Researchers compare the antibody to a placebo and monitor participants for one …

This Phase 3 trial tests whether a meningitis B vaccine (Bexsero) can prevent gonorrhea infections in men who have sex with men. 150 participants in Hong Kong will receive either the vaccine or a placebo. Researchers will compare infection rates and monitor safety.

This study tests whether taking two TB prevention drugs daily for one month works as well as taking them weekly for three months. It includes 1,000 people with HIV or those living with someone recently diagnosed with TB. The goal is to see which schedule more people complete and …

This study looks at whether taking activated charcoal can change certain blood test results, like osmolality and ethylene glycol levels. Eight healthy volunteers will take a dose of charcoal and have blood drawn over six hours. The goal is to see if charcoal causes false positive…

This study looks at HIV-negative people who get opportunistic infections—illnesses that usually only affect those with weak immune systems. Researchers want to find out if these patients have unusual antibodies that block a key immune signal. Up to 224 adults in Thailand and Taiw…

This study investigates whether taking rifampicin for latent tuberculosis increases the risk of antibiotic resistance in Staphylococcus aureus bacteria that naturally live on the skin. Researchers will compare people treated with rifampicin to those treated with isoniazid, taking…

This study investigates whether a blood test can detect the bacteria that cause tuberculosis (TB) in people with active TB and their asymptomatic household contacts. Researchers in Uganda will use several methods, including a DNA-based test, to look for TB bacteria in blood sampl…

This study tracks 56 follicular lymphoma patients to see how long their COVID-19 and other vaccine immunity lasts while they receive chemotherapy and maintenance therapy. Researchers will collect blood samples at several time points to measure immune responses. The goal is to und…

This study in India will test a low-cost urine check (IsoScreen) on 900 adults being treated for tuberculosis. The test detects whether they have taken their medication recently. Researchers want to see if the test can reliably find people who are missing doses, so that doctors c…

This study is tracking over 2,200 tuberculosis patients to see how the amount of TB drugs in their blood relates to how well the treatment works and whether they have side effects. By measuring drug levels, researchers hope to find ways to adjust doses for each person, especially…

This study looks at how tuberculosis (TB) medications travel through a mother's body, into her breastmilk, and to her nursing baby. Researchers will take blood and milk samples from 20 mothers and small blood samples from their infants at several time points after a dose. The goa…

This study tests whether AI-powered X-ray analysis and portable molecular tests can help find tuberculosis (TB) and COVID-19 cases in African communities where many cases go undetected. Over 26,000 adults will be screened using these tools, and researchers will measure how quickl…

This study looks at whether giving the BCG vaccine as a mist breathed into the lungs works better than the usual injection under the skin. It includes 36 healthy adults who have already had BCG, some with type 2 diabetes and some without. Researchers will measure immune responses…

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study looks back at the medical records of 150 children treated for tuberculosis at a French hospital. The goal is to see how many were cured, how many had problems, and why some treatments failed. By understanding these patterns, doctors hope to improve care for children wi…

This study aimed to see if the BCG vaccine, given as a skin injection, could stop the TB bacteria from growing in healthy adults. Researchers planned to vaccinate some volunteers and then expose them to a weakened form of TB six months later to measure protection. However, the tr…

This study tests the safety of a new tuberculosis vaccine called ID93/GLA-SE in 48 healthy adults, some of whom have had the standard BCG vaccine before. Researchers will also use an experimental method where a weakened form of TB bacteria is given as an aerosol to see how the im…

This study looks at whether taking an oral typhoid vaccine temporarily makes the gut more 'leaky' and how the immune system responds. Ten healthy adults will receive the vaccine and a low-dose aspirin challenge. Researchers will measure sugar levels in urine and immune cells in b…

This study was designed to see if taking activated charcoal could help clear certain blood thinners (rivaroxaban, apixaban) faster in patients needing an urgent procedure. It planned to enroll 140 adults and measure how quickly the drug left their blood. However, the trial was wi…

This study examines how the COVID-19 pandemic affected syphilis cases and their interaction with HIV. Researchers will review medical records of 240 adults diagnosed with syphilis in Italy between 2017 and 2025. The goal is to see if pandemic restrictions led to delayed diagnoses…