New tetanus antibody drug shows promise in early trial
NCT ID NCT05625477
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested an experimental drug called TNM002 in 240 healthy Chinese adults to see if it can protect against tetanus as well as the standard treatment. Participants received a single injection of TNM002 at different doses, the standard tetanus antibody, or a placebo. The main goal was to measure whether TNM002 raised tetanus-fighting antibodies to protective levels. The trial is now complete, and results will show if this new drug is a safe and effective alternative.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- TNM002 injection (an experimental antibody)
- What this could lead to
- If successful, TNM002 could offer a new option to prevent tetanus after injury, potentially with fewer side effects or easier production than current treatments.
- What could go wrong
- This is an early-phase trial with only 240 participants, so results may not apply to everyone. The experimental drug may not work as well as existing tetanus shots, and allergic reactions are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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PKUCare Luzhong Hospital
Zibo, Shandong, China
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The First Affiliated Hospital of Shantou University Medical College
Shantou, Guangdong, China
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Wuxi People's Hospital
Wuxi, Jiangsu, China
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Yunnan Provincial Hospital of Traditional Chinese Medicine
Kunming, Yunnan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new vaccine shield older kids and adults from three deadly infections?
- Can a Five-Part vaccine bolster protection against three serious infections?
- Can a single shot keep tetanus at bay?
- Will a single DTP vaccine dose protect for a decade? study tracks antibodies
- Can a new tetanus shot offer stronger protection?
- Are adults in beijing still protected against tetanus? a study investigates