Could a vaccine speed up TB recovery?

NCT ID NCT05455112

Completed Disease control Sponsor: Archivel Farma S.L. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a therapeutic vaccine called RUTI in 41 adults with active pulmonary tuberculosis. Participants received either the vaccine or a placebo alongside their regular antibiotic treatment. The goal was to see if the vaccine could boost the immune system to kill bacteria faster and improve recovery without causing safety issues.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RUTI vaccine (a therapeutic vaccine made from fragments of tuberculosis bacteria)
What this could lead to: If successful, this could lead to a faster recovery from tuberculosis and reduce the risk of drug resistance.
What could go wrong: This is a small, early-phase trial (Phase IIb) with only 41 participants, so results may not apply to everyone. The vaccine is added to standard antibiotics, so its independent effect is unclear.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOSIS, PULMONARY

Contacts and locations

Locations

Hospital José Nestor Lencinas

Godoy Cruz, Mendoza Province, M5547, Argentina
Hospital de Clínicas Presidente Dr. Nicolás Avellaneda

San Miguel de Tucumán, Tucumán Province, T4001KKP, Argentina

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