TB vaccine booster shows promise in speeding up recovery

NCT ID NCT04919239

Completed Disease control Sponsor: Archivel Farma S.L. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a therapeutic vaccine called RUTI in 140 people with tuberculosis (TB), including drug-resistant forms. Participants received either one dose of RUTI or a placebo alongside their standard TB medications. The goal was to see if the vaccine could help clear the TB bacteria from the lungs faster. Results are not yet available, but if successful, RUTI could become a tool to shorten TB treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RUTI vaccine (therapeutic vaccination)
What this could lead to: If it works, this could shorten tuberculosis treatment and help patients clear the bacteria faster, especially those with drug-resistant TB.
What could go wrong: This is a mid-stage trial with only 140 participants. The vaccine is an add-on to standard drugs, so its benefit may be small or not seen at all. Side effects from the vaccine are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multidrug-resistant tuberculosis pulmonary tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TUBERCULOSIS, PULMONARY

Contacts and locations

Locations

Agartala Government Medical College (AGMC)

Tripura, 799006, India
All India Institute of Medical Sciences (AIIMS)

New Delhi, 11002, India

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