CNS demyelinating autoimmune disease

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This study looked at 144 people with aggressive relapsing multiple sclerosis to compare two treatment plans over three years: monthly natalizumab infusions versus a six-month course of mitoxantrone followed by another immune-modulating drug. Researchers measured cost-effectivenes…

This early-phase trial tested a new treatment for relapsing-remitting multiple sclerosis (RRMS) that uses a patient's own red blood cells. The cells are coated with specific peptides and given back to the patient to teach the immune system to stop attacking the body. The study in…

This study tested whether a dietary supplement called propionic acid is safe and helpful for people with multiple sclerosis (MS). Twenty-two adults with stable MS took propionic acid capsules alongside their usual MS medications. Researchers measured nerve damage markers and thin…

This study followed 134 adults in Italy with active secondary progressive multiple sclerosis who were prescribed siponimod (Mayzent) as part of their routine care. Over 36 months, researchers measured how many patients experienced a confirmed worsening of disability or cognitive …

This completed Phase 3 trial tested the oral drug dimethyl fumarate (Tecfidera) against an injected interferon in 156 children aged 10 to 17 with relapsing-remitting multiple sclerosis. The main goal was to see if the drug could prevent new brain lesions and control the disease s…

This study looked at over 2,600 people with multiple sclerosis to compare two drugs: Kesimpta and Ocrevus. Researchers used insurance claims data to see which drug led to fewer relapses and lower healthcare costs. The goal is to help patients and doctors choose the best treatment…

This study tested a treatment called extracorporeal photopheresis (ECP) in 15 people with multiple sclerosis. ECP is a procedure that filters a person's blood, treats it with light, and returns it to the body. The goal was to see if it is safe and if it can improve walking, hand …

This study looked at whether it is safe for people with multiple sclerosis to receive their natalizumab (Tysabri) infusions at home instead of at a hospital. Researchers compared serious side effects, quality of life, and costs over one year in 295 patients. The goal was to see i…

This study followed 107 adults in Switzerland with relapsing multiple sclerosis who were already taking Kesimpta (ofatumumab) as part of their routine care. Researchers tracked how many patients had no signs of disease activity, including relapses, new brain lesions, or worsening…

This early-phase trial tested a new drug called VIS171 in 61 people: first in healthy volunteers, then in patients with autoimmune diseases. The main goal was to check safety and how the body processes the drug. No results on whether it actually helps the disease are available ye…

This study looked at how well ofatumumab works in 562 people with relapsing multiple sclerosis who switched from other drugs (fumarates or fingolimod) because their disease was still active. The main goal was to see how many relapses they had per year. Researchers also tracked si…

This study tested an online self-management program designed to help people with multiple sclerosis prevent falls. The program was developed with input from patients and covers various fall risk factors. 45 adults with MS participated to see if the program was easy to use and hel…

This Phase 3 study tested whether ofatumumab, a monthly injection, works better than standard first-line disease-modifying therapies (like glatiramer acetate or interferon) in people newly diagnosed with relapsing multiple sclerosis. The main goal was to see if more patients coul…

This study tested a monthly injection of ofatumumab in 180 people with very early relapsing-remitting multiple sclerosis (MS). The goal was to see if the drug could stop all signs of disease activity—like relapses, disability worsening, and new brain lesions—over 18 months. Resea…

This study tested an experimental drug called BIIB091, alone or combined with an approved MS drug (diroximel fumarate), in 127 people with relapsing multiple sclerosis. The goal was to check safety and see if it reduces brain inflammation on MRI scans. Participants took pills twi…

This study followed 1,710 people with relapsing or primary progressive multiple sclerosis who were prescribed ocrelizumab (Ocrevus) as part of their normal care. Researchers tracked symptoms like fatigue, mobility, and cognition, as well as side effects, to see how well the drug …

This study looked at how well ocrelizumab works in Black and Hispanic patients with relapsing multiple sclerosis (MS). About 179 participants received the drug and were monitored for relapses, disability progression, and brain lesions over 48 weeks. The goal was to see if the tre…

This study looked at whether people with relapsing multiple sclerosis can safely switch from an intravenous (IV) anti-CD20 antibody treatment to a self-injected drug called ofatumumab. 111 adults took part, and researchers tracked their brain scans and side effects for a year. Th…

This study looked at how well and how safely the drug fingolimod (Gilenya) works for people in China with relapsing multiple sclerosis (RMS), a condition where the immune system attacks the nerves. Over 24 months, 98 participants took a daily 0.5 mg pill. The main goal was to see…

This study tested the drug ofatumumab in 99 Chinese adults with relapsing multiple sclerosis (RMS). The goal was to see if monthly injections could reduce the number of relapses and monitor for side effects. Participants received the drug for 12 months, and researchers tracked re…

This early-stage trial tested a new cell therapy called DUOC-01, made from donated umbilical cord blood, in 20 adults with primary progressive multiple sclerosis (PPMS). The cells were injected into the spinal fluid to see if it was safe. Researchers also looked for early signs o…

This Phase 3 trial tested whether the oral drug tolebrutinib can delay disability progression in people with primary progressive multiple sclerosis (PPMS). 767 adults with PPMS received either tolebrutinib or a placebo. The study measured time to confirmed disability worsening ov…

This completed study looked at how well cladribine tablets work in everyday practice for people with relapsing multiple sclerosis (MS) who had a poor response to other oral or infusion treatments. Researchers tracked 291 participants over 24 months, measuring relapse rates and pa…

This study looked at how ocrelizumab, a standard MS medication, changes brain inflammation in 22 people with multiple sclerosis. Researchers used special PET and MRI scans to measure inflammation before and after one year of treatment. The goal was to see if the drug reduces harm…

This completed study in Spain looked at 310 people with relapsing multiple sclerosis who were taking ofatumumab (Kesimpta®). Researchers wanted to see how well the drug reduced relapses and how safe it was in everyday medical practice. The study collected information from medical…

This phase 2 trial tested a liquid suspension of gold nanocrystals, called CNM-Au8, in 33 people with relapsing multiple sclerosis. The goal was to see if the treatment could improve energy metabolism in brain cells, measured by a special MRI scan. Participants took the drug by m…

This completed Phase 2 trial tested whether combining two common drugs—metformin (for diabetes) and clemastine (an antihistamine)—can help repair the protective lining of nerve cells in people with relapsing-remitting multiple sclerosis. The 70 participants continued their usual …

This study followed over 1,000 people with multiple sclerosis who had already taken ocrelizumab in earlier trials. Participants received a 600-mg infusion every 24 months for two years. Researchers tracked disability progression, relapse rates, and safety to see if the drug remai…

This phase 3 study tested the safety and tolerability of diroximel fumarate (Vumerity) in 136 East Asian adults with relapsing forms of multiple sclerosis. Participants took the drug for up to 48 weeks, and researchers monitored side effects, lab results, and drug levels in the b…

This study tested an experimental oral drug called PIPE-307 in 182 adults with relapsing-remitting multiple sclerosis (MS). Participants took either a low or high dose of PIPE-307 or a placebo daily for about 30 weeks, alongside their usual MS medication. The goal was to see if t…

This study tested the long-term safety of the drug SAR442168 in 125 people with relapsing multiple sclerosis who had already completed a previous study. Researchers monitored side effects and checked brain scans for disease activity over about 4.5 years. The goal was to see if th…

This study tested whether a person's own stem cells (called HB-adMSCs) could improve quality of life for people with multiple sclerosis. Twenty-four adults with relapsing-remitting MS received either the stem cells or a placebo through six infusions over a year, while continuing …

This study looked at how a common gene mutation (ABCG2) affects the levels and side effects of the MS drug teriflunomide in 82 Chinese patients. Participants took teriflunomide 14 mg daily for 24 weeks. The goal was to see if the mutation changes drug exposure and safety, which c…

This phase 2 trial tested clemastine fumarate, a common allergy medicine, to see if it could repair damaged nerves in people with relapsing-remitting multiple sclerosis. Fifty participants took either the drug or a placebo for several months. The study measured nerve signals in t…

This phase 2b trial tested an experimental oral drug called SAR442168 in 130 adults with relapsing multiple sclerosis. The goal was to find the best dose to reduce new active brain lesions seen on MRI scans. Participants took the drug or a placebo for 12 to 16 weeks, and research…

This study followed 450 people with relapsing-remitting multiple sclerosis (RRMS) in Germany who were already prescribed ozanimod (Zeposia). Over three years, researchers collected data on how long patients stayed on the drug, its effect on quality of life, and any side effects. …

This study looked at a device called GLOBAFFIN that filters antibodies from the blood to help people with autoimmune diseases. It involved 34 adults and measured how much harmful antibodies were removed and if patients felt better. The goal was to see if the device is safe and wo…

This study tested whether a tablet-based eye-tracking device (ETNA-MS) can accurately estimate disability levels in people with Multiple Sclerosis. Sixty adults with MS took eye-tracking tests, and the device's estimates were compared to standard neurologist assessments. The goal…

This study tested whether special wearable sensors can detect early walking and balance problems in people with multiple sclerosis (MS). Researchers compared 70 participants (MS patients and healthy volunteers) as they walked on a platform with sensors. The goal was to see if the…

This study looked at whether a 6-minute walk test done over a short 6-meter distance is a valid and reliable way to measure walking ability in people with multiple sclerosis. Twenty-one adults with MS participated. The goal is to see if this shorter version works as well as the s…

This study tested two different MRI scanning methods to see which better detects the 'central vein sign' in the brains of people with multiple sclerosis (MS). The central vein sign is a marker that helps doctors diagnose MS more accurately. Sixty adults with early-stage MS underw…

This study tested two different MRI sequences to see which one better detects active inflammatory lesions in the brains of people with multiple sclerosis (MS). 180 adults with known central nervous system inflammatory disease who needed an MRI after a recent clinical event took p…

This study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…

This study looked at whether proteins in spinal fluid can help doctors tell the difference between multiple sclerosis (MS) and other brain diseases, and also predict how MS will progress. Researchers analyzed spinal fluid samples from 161 people with MS using a special test calle…

This trial investigates whether a non-invasive technique called transcranial direct current stimulation (tDCS) can help with fatigue, depression, anxiety, and cognitive problems in people with multiple sclerosis (MS). tDCS uses a weak electrical current applied to the scalp to ge…

This study tested whether bright light therapy could help people with multiple sclerosis who have trouble sleeping. 27 participants used a light box at home. The goal was to see if it was safe and if it improved sleep and daily function.

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study tests whether adding task-oriented training—like walking on different surfaces, climbing stairs, and reaching for objects—to standard aerobic and strength exercises can improve functional mobility, balance, and fatigue in people with relapsing-remitting multiple sclero…

This study explores whether a 9-month online mind-body exercise program is practical and acceptable for people with multiple sclerosis (MS) living in Portugal and Spain. The program combines physical fitness, Pilates, Tai-Chi, mindfulness, and relaxation in small group sessions v…

This study compares two gentle exercise programs—tai chi and square stepping—in women with multiple sclerosis. Researchers want to see if these activities improve knee joint awareness, leg strength, and fatigue. About 39 women aged 20-45 with mild MS will participate, helping to …

This study tested an eight-week visually-guided gait training program in 40 people with multiple sclerosis. The training combined eye movement exercises with precision walking and obstacle avoidance to improve balance and mobility. Researchers measured balance, walking ability, a…

This study tested whether adding probiotics (found in yogurt and yeast tablets) to standard therapy could improve fatigue, quality of life, mood, and inflammation in 60 people with relapsing-remitting multiple sclerosis. Participants were randomly assigned to take probiotics or n…

This study looked at whether 8 weeks of low-load leg exercises with a blood flow restriction cuff is safe and doable for people with multiple sclerosis who have moderate to severe walking problems. Sixteen adults with MS took part, doing exercises like knee extensions and hip lif…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This study tested a 4-month remote exercise program designed for African-Americans with multiple sclerosis living in rural areas. 121 participants were randomly assigned to either the exercise program or a stretching control group. The goal was to see if the program could improve…

This completed pilot study looked at whether a placebo treatment — sham TENS combined with positive verbal suggestions — could reduce fatigue in people with relapsing-remitting multiple sclerosis. 36 participants were enrolled. The main goal was to measure motor performance (numb…

This study tested whether using the ABLE Exoskeleton—a robotic walking aid—once a week for a year could help people with multiple sclerosis maintain their physical and mental health. Nineteen adults with MS took part in weekly 60-minute gait training sessions and were evaluated e…

This study tested whether a home-based program combining motor imagery (mentally practicing movements) and action observation (watching videos of movements) could help people with multiple sclerosis improve balance, walking, and fatigue. Twenty-nine adults with MS participated in…

This study tested a 6-week program that combines home exercises with fun, game-like balance activities (like stepping on colored circles and Twister-inspired moves) for people with multiple sclerosis. Thirty participants were split into two groups: both did home exercises, but on…

This study explores whether a powered exoskeleton—a wearable robot—can help people with moderate to severe walking problems due to multiple sclerosis (MS) exercise and walk better. Twenty-four participants will either use the exoskeleton or do standard exercises with a fitness in…

This study tested whether plasma exchange (a blood-filtering treatment) helps people with multiple sclerosis who have severe flare-ups that don't get better with steroids. Thirty-eight adults took part, and researchers compared real plasma exchange to a sham procedure. The main g…

This study tested whether L-carnitine, a natural supplement, can reduce fatigue in people with multiple sclerosis (MS). About 60 adults with MS who had significant fatigue took either L-carnitine or a placebo, then switched. The goal was to see if L-carnitine improved fatigue sco…

This study looked at whether high-intensity walking exercise can help reduce fatigue and improve walking in people with multiple sclerosis (MS). Twelve adults with MS who had walking problems and significant fatigue took part. Researchers measured changes in fatigue, walking spee…

This study tested whether adding Dynamic Neuromuscular Stabilization (DNS) exercises to standard pelvic floor muscle training can improve bladder control in women with multiple sclerosis. Twenty-four women aged 28-54 completed an 8-week program, with half doing pelvic floor exerc…

This study tested a home-based telerehabilitation system for veterans with multiple sclerosis. The system provided exercise instructions and tracked daily logs to help improve balance and mobility. Fifty-one participants used the system to see if it was feasible and acceptable, w…

This study tested whether acupressure, a technique where pressure is applied to specific points on the body, can help people with multiple sclerosis (MS) manage pain, fatigue, and sleep problems. Researchers enrolled 90 adults with relapsing-remitting MS who had moderate to sever…

This study tested whether a high-intensity virtual reality boxing program is safe and feasible for people with multiple sclerosis. Five participants used a VR headset to exercise for 10 minutes twice a week over 8 weeks, alongside their usual therapy. Researchers measured side ef…

This study tested whether MitoQ, a dietary supplement, can reduce fatigue in people with multiple sclerosis. 45 participants took either 20 mg, 40 mg, or a placebo daily for 12 weeks. Researchers measured changes in fatigue using a standard survey. The goal is to find a safe, sim…

This study tested whether a robotic walking system called Atalante could help people with multiple sclerosis walk better. Sixty participants were randomly assigned to either use the robot or receive standard physical therapy for 8 weeks. The main goal was to see if the robot impr…

This study tested whether a 12-week exercise program using coordinated arm movements could improve brain function and movement in people with progressive multiple sclerosis (MS). Five adults with progressive MS did the exercises three times a week. Researchers measured brain acti…

This study tested a robotic exoskeleton called Atalante to see if it is easy and safe for people with multiple sclerosis (MS) to use. 15 adults with MS who had trouble walking tried the device. The goal was to see if the suit could help them walk better and if they liked using it…

This study tested two types of nerve stimulation—one using tiny needles (PENS) and one using skin pads (TENS)—to see if they could improve hand function in people with multiple sclerosis. 28 participants received a single session of stimulation, and their hand dexterity, strength…

This study tested whether partial-body cryotherapy (standing in a very cold chamber for 2-3 minutes) could help reduce fatigue in people with multiple sclerosis during a rehabilitation stay. 43 participants received either real cryotherapy at -120°C or a sham version at -30°C ove…

This study tested a digital group program called 'Fewer Falls in MS' for people with multiple sclerosis who had fallen in the past year. 240 participants either joined the 8-session online program or received a brochure. Researchers tracked falls and other outcomes over 12 months…

This study tested whether applying shock wave therapy to the soles of the feet could improve balance and walking in people with multiple sclerosis (MS). Fifty-four participants received the therapy three times a week for six weeks. Researchers measured changes in foot sensation, …

This pilot study tested two different computerized brain training programs that also involve light physical activity, like reaching or stepping, in people with multiple sclerosis who have memory or attention problems. The goal was to see if these programs could improve thinking s…

This study tested an 8-week online program to help people with multiple sclerosis (MS) improve their problem-solving and coping skills. The goal was to see if the program was easy to use and if it helped reduce anxiety and depression. Thirty adults with MS in Lebanon took part. T…

This study tested whether a low-histamine version of the Mediterranean diet could help people with relapsing-remitting multiple sclerosis (MS) feel better. 51 adults were split into three groups: one followed the low-histamine Mediterranean diet, another a standard Mediterranean …

This study tested whether mat and reformer Pilates can improve balance, walking, and postural control in people with multiple sclerosis. Thirty participants were split into mat Pilates, reformer Pilates, or a control group, training twice a week for eight weeks. Researchers measu…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested whether pelvic floor strengthening or relaxation exercises, done at home via video calls, could help women with multiple sclerosis who have bladder control problems. Twenty-four women were split into three groups: strengthening, relaxation, or both. They exercis…

This study tested whether an Arabic mobile app could help people with multiple sclerosis (MS) improve their self-care and quality of life. 74 adults with MS used the app or received usual care for 3 months. Researchers measured changes in self-care habits and well-being using sta…

This study tested whether repeated electrical brain stimulation could improve mental health and cognitive function in people with multiple sclerosis (MS). Fifty-three adults with MS received either real or fake stimulation in a double-blind setup. Researchers measured changes in …

This study tested two online programs designed to help people with multiple sclerosis manage spasticity (muscle tightness) in their legs. Participants attended two video classes that included education and stretching exercises. The goal was to see if these programs could reduce t…

This study looked at whether adding cognitive behavior therapy (a type of talk therapy) to supervised Pilates exercises could improve balance, walking, and fatigue in people with multiple sclerosis. 90 adults with mild to moderate MS took part. The goal was to see if combining me…

This study tested whether a mind-body program called amygdala insula retraining, along with lifestyle changes, can help people with multiple sclerosis feel better. 132 participants were split into groups receiving the program, lifestyle changes, or usual care. The goal was to see…

This completed study tested whether the MIND diet—a mix of Mediterranean and DASH diets—could improve fatigue, quality of life, and brain fog in 62 adults with multiple sclerosis. Participants followed either the MIND diet or a traditional healthy diet for 3 months, with weekly o…

This study tested a 16-week home exercise program called SPIN for people with multiple sclerosis who use a wheelchair. Twenty-four participants were randomly assigned to either the exercise program or a wellness program. Researchers checked if the program was safe, doable, and li…

This study tested whether watching 3D virtual reality videos of hand and arm movements could improve upper limb function in people with multiple sclerosis (MS). Thirty-two participants with recent MS and moderate disability completed six weeks of training. Researchers measured ha…

This study tested whether a safe, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) could reduce fatigue in people with multiple sclerosis (MS). Ten adults with MS-related fatigue used a home-based tDCS device. The goal was to see if i…

This study compared two ways of delivering exercise programs to people with relapsing-remitting multiple sclerosis: live online sessions with a therapist versus pre-recorded videos. Sixteen participants completed a 12-week program focusing on strength, core stability, and stretch…

This study tested whether a 5-week program of positive psychology exercises—like writing a gratitude letter or recalling a past success—could help people newly diagnosed with multiple sclerosis feel more hopeful and happy. Thirty participants were split into two groups: one start…

This completed study tested a new physical therapy program called deep sensory assisted rehabilitation in 40 people with multiple sclerosis. The program added exercises with a weighted vest (4-6 kg) to standard rehab, aiming to improve sensation, walking, and balance. Researchers…

This study looked at whether 8 weeks of aerobic exercise can improve movement and daily function in people with Multiple Sclerosis (MS). 30 adults with MS were randomly placed into an exercise group or a control group. The exercise group showed significant improvements in walking…

This study looked at how aerobic exercise on an elliptical trainer or a treadmill affects walking, balance, and stability in people with moderate multiple sclerosis. Thirty adults with MS completed the exercise programs. The goal was to see which machine might improve gait and wa…

This study tested whether a 4-month exercise program done at home could help Hispanic/Latino adults with multiple sclerosis (MS) improve their physical function, manage symptoms, and feel better overall. Participants worked with coaches via video calls and compared results to a c…

This study tested whether teaching pelvic floor muscle exercises using a health belief model can help women with multiple sclerosis who have bladder leakage. Forty-six women participated, with one group learning the exercises and the other continuing usual care. Researchers measu…

This study tested whether laughter yoga—a practice combining laughing exercises and breathing techniques—can reduce fatigue, improve sleep quality, and boost psychological well-being in people with multiple sclerosis. Forty MS patients participated, with one group doing laughter …

This study tested whether people with Multiple Sclerosis (MS) could take a probiotic drink daily for 12 weeks. 29 participants drank 70ml of the probiotic each day and completed online questionnaires, cognitive tests, and provided stool samples. The main goal was to see if the ap…

This study tested whether adding mental imagery (imagining movements) or action observation (watching movements) to standard physical therapy could help people with multiple sclerosis. 48 adults with MS took part. The goal was to see if these techniques improve walking distance, …

This study looked at whether a water-based exercise program (hydrotherapy) could help improve balance and reduce fatigue in people with multiple sclerosis. 26 adults with relapsing-remitting MS took part in 16 hydrotherapy sessions. Researchers measured changes using the Berg Bal…

This study looked at whether two types of talk therapy—cognitive behavioral therapy (CBT) and relaxation training—could improve mood and thinking in people with relapsing-remitting multiple sclerosis. 140 participants with mild to moderate disability were randomly assigned to one…

This study tested whether special leg exercises could improve balance, walking, and fatigue in people with multiple sclerosis (MS). Twenty-six adults with MS did either the special exercises or standard leg strengthening for six weeks. The goal was to see if these exercises could…

This study tested whether mild electrical pulses to nerves in the leg and lower back can help women with multiple sclerosis who have overactive bladder symptoms like sudden urges and leaks. Forty-two women received the stimulation over several sessions. The goal was to see if it …

This study tested whether personalized dietary advice from a dietitian helps people with multiple sclerosis (MS) get more calcium in their diet. 182 MS patients who could still walk were split into two groups: one received one-on-one dietitian sessions, the other got a standard a…

This study looked at whether three types of cognitive behavioral therapy (CBT) delivered online could help reduce fatigue in people with multiple sclerosis. 21 adults with MS and chronic fatigue tried relaxation training, behavioral activation, or cognitive therapy. The goal was …

This study tested how easy it is for people with multiple sclerosis (MS) to use a mobile app called MeTime MS. The app guides users through self-acupressure, a technique that involves pressing on specific points on the body to help with fatigue and pain. Ten adults with MS who ha…

This study looked at whether practicing two tasks at the same time (like walking while talking) can improve balance, walking, thinking, and tiredness in people with multiple sclerosis (MS). 26 people with MS took part. The training focused on everyday activities to see if it made…

This study tested whether a single session of moderate cycling combined with virtual reality could improve processing speed in people with multiple sclerosis who have mild-to-moderate mobility disability. Twenty-three participants completed one bout of exercise while using differ…

This study tested whether a program that combines talk therapy, brain training, and healthy lifestyle advice is practical and helpful for people with conditions like mild traumatic brain injury, multiple sclerosis, long COVID, or mild cognitive impairment. Fifteen participants we…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study tested whether wearing a virtual reality headset during botulinum toxin injections could lower stress and pain in adults with muscle spasticity. Forty-two participants chose calming audio-visual content while getting their shots. Researchers measured heart rate variabi…

This study tested whether adding a mild electrical stimulation device to standard swallowing therapy helps people with multiple sclerosis who have trouble swallowing. 136 participants were randomly assigned to receive either real electrical stimulation or a sham device alongside …

This completed study tested whether a new type of electrical stimulation, called spatially distributed sequential stimulation, works better than standard stimulation for people with upper motor neuron disease. Ten adults with stable symptoms used both methods while cycling. Resea…

This completed study tested whether an artificial intelligence (AI) app could help people with multiple sclerosis (MS) improve their strength through home-based exercise. Fifty-eight adults with MS followed a 20-week strength training program, with one group using the AI app for …

This study tested whether a combination of mild brain stimulation (tDCS) and computer-based cognitive training could improve memory, attention, and brain flexibility in people with multiple sclerosis. Forty-five adults with relapsing-remitting MS took part. The goal was to see if…

This study looked at whether an 8-week yoga program or standard physical therapy helps more with fatigue, balance, walking, and quality of life in people with multiple sclerosis. Twenty participants were split into two groups, each meeting three times a week for an hour. The goal…

This pilot study tested whether a voice therapy program called LSVT-Loud, usually done in a clinic, can be delivered effectively via video calls for people with multiple sclerosis (MS). Twenty participants with MS who had voice problems received the therapy either at home or in t…

This study tested whether methylphenidate, a drug used for ADHD, can reduce the mental exhaustion that affects up to 95% of people with multiple sclerosis. Thirty-six adults with MS took both the drug and a placebo for four weeks each, without knowing which they were getting. The…

This study tested whether gabapentin and memantine can reduce the speed, size, and frequency of involuntary eye movements (nystagmus) in people with oculopalatal tremor, a condition caused by brainstem damage. Seven adults took each drug separately, and researchers measured eye m…

This study tested two drugs, gabapentin and memantine, in 10 people with multiple sclerosis who have a constant eye shaking called pendular nystagmus. The goal was to see if either drug could reduce the eye movement and improve vision and quality of life. Each person tried both d…

This study looks at how good or poor sleep quality influences quality of life, depression, and fatigue in people with multiple sclerosis. Researchers will survey about 121 adults with MS to measure their sleep patterns and link them to these health outcomes. The goal is to better…

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

This study tested a new risk score that combines genetic and environmental factors to predict multiple sclerosis (MS). Researchers studied 181 people, including MS patients and their close relatives. The goal was to see if this score could identify who might develop MS in the fut…

This study looked at whether asking people with multiple sclerosis (MS) to do two things at once — like walking while thinking — can uncover balance problems that standard tests miss. Researchers studied 24 people with mild MS and low disability. The goal was to see if this dual-…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study aims to understand how satisfied both doctors and patients are with current multiple sclerosis (MS) treatments in everyday medical practice. Researchers will collect information from 261 patients and their physicians across several countries, including the UK, France, …

This study followed 115 people with relapsing-remitting multiple sclerosis for up to 5 years to see if early damage to the spinal cord could predict later walking difficulties. Researchers used MRI scans and walking tests to track changes. The goal was to better understand how ea…

This study looked at how people with multiple sclerosis and their natural caregivers (like family members) feel about the quality of care they receive. Researchers surveyed over 1,000 participants to understand their expectations and experiences. The goal was to create a tool tha…

This study used a quick, painless eye scan called OCTA to compare blood flow in the optic nerve between 54 people with multiple sclerosis and healthy volunteers. The goal was to see if MS changes optic nerve blood vessels and if measuring this could help doctors track the disease…

This study used advanced MRI scans to look at energy use in the brains of 40 people with multiple sclerosis and 15 healthy volunteers. The goal was to see if energy problems in brain cells can predict nerve damage over two years. Researchers hope this will help understand how MS …

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study looked at 320 people whose brain scans showed signs that sometimes lead to multiple sclerosis (MS), even though they had no symptoms. Researchers analyzed blood and spinal fluid samples to find biological markers that could predict whether these silent signs would turn…

This study tested whether smartphone communication and a special questionnaire could help confirm MS relapses without requiring an in-person visit. Researchers worked with 150 people with relapsing-remitting MS to see if this approach improves patient satisfaction and care. The g…

This study followed 307 people with relapsing multiple sclerosis in Germany who had recently switched to the drug Kesimpta (ofatumumab) from another treatment. Researchers collected information on why patients made the switch and how many doses they missed over one year. The goal…

This study collected blood, saliva, and eye fluid samples from 343 people with uveitis, an inflammatory eye disease that can cause vision loss. Researchers aimed to learn which genes and other factors might lead to the disease and affect treatment response. Participants were foll…

This completed study tracked 42 women with multiple sclerosis who became pregnant around the time they received LEMTRADA infusions. Researchers aimed to measure rates of miscarriage and birth defects to better understand the drug's safety during pregnancy. The study did not test …

This study looked at how people with autoimmune diseases like multiple sclerosis or blistering skin conditions respond to COVID-19 vaccines while on B-cell depleting therapies. Researchers measured antibody levels and T-cell activity over time to understand vaccine effectiveness …

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This completed study looked at 65 people with multiple sclerosis to find specific scores on walking and balance tests that could tell who is at risk of falling. Participants walked on a special mat and stood on a balance platform under different conditions. The goal is to help do…

This completed study looked at 75 people with relapsing-remitting multiple sclerosis (RRMS) who were taking the medication Aubagio. The goal was to see if virtual reality tests and real-world tasks could better detect cognitive (thinking) problems in everyday life compared to sta…

This study tested a short, computerized cognitive assessment in 421 French-speaking adults with multiple sclerosis and healthy controls. The goal was to see if a brief battery of computer tests can reliably detect early cognitive issues, like slowed thinking and memory problems, …

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This study used brain scans to understand why some people with multiple sclerosis have trouble with social thinking, like reading emotions or intentions. Researchers compared 35 MS patients to healthy volunteers using MRI while they performed social tasks. The goal was to see whi…

This study examined a type of immune cell called 4BL B cells in people with multiple sclerosis (MS) and compared them to healthy controls. Researchers wanted to see if these cells are more common in MS and might contribute to inflammation. The study involved 125 participants and …

This study looked at whether a multiple sclerosis (MS) drug called Ofatumumab (Kesimpta) can make immune cells less toxic to brain cells. Researchers took blood samples from 40 people with relapsing-remitting MS before and after 6 months of treatment. They tested if the chemicals…

This completed study at Brigham and Women's Hospital used special PET scans to look at brain inflammation and chemical activity in 10 people with multiple sclerosis. The goal was to understand what causes the severe fatigue many MS patients experience. Researchers measured brain …

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…

This completed study looked at 361 people recently diagnosed with multiple sclerosis to see if experiencing 'flow' (being fully absorbed in an activity) and mindfulness are linked to better mental health. Participants filled out online questionnaires about their mental health, an…

Fatigue is a major problem for people with multiple sclerosis (MS), but its cause is unknown and there is no good treatment. This completed study looked at 34 adults with MS to see if a type of immune cell (cytotoxic CD4+ T cells) is linked to how tired they feel. Researchers mea…

This study checked how the multiple sclerosis drug ocrelizumab passes from mother to baby during pregnancy. Researchers measured B cell levels in 70 infants whose mothers took the drug around the time of pregnancy. The goal was to see if the drug affects the baby's immune system …

This completed study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and to understand what factors increase that risk. Researchers …

This study looked at 102 people with multiple sclerosis to see how sleep quality relates to fatigue, body awareness, and arm and leg function. Participants were grouped by good or poor sleep, and their abilities were measured with tests like walking speed and a heartbeat counting…

This study looked at whether eye movements can help measure how severe multiple sclerosis (MS) is and how it affects thinking. 120 adults with MS had their eye movements tracked and compared to standard disability and cognitive tests. The goal was to build a database and train co…

This study looked at whether eye movements can help measure how severe multiple sclerosis (MS) is and how well the brain is working. Researchers tracked the eyes of 200 people with MS while they did tasks on a screen. The goal was to train computer programs to find patterns in ey…

This study looked at 40 people with multiple sclerosis to see if muscle loss (sarcopenia) is linked to weaker breathing muscles and lung function. Participants did breathing tests and grip strength measurements in a single session. The goal was to understand the connection, not t…

This completed study looked at how women with multiple sclerosis (MS) respond to high-intensity interval training and strength training at different points in their menstrual cycle. Fifteen women with MS and 15 without MS took part in exercise sessions and reported their satisfac…

This completed study from Cairo University looked at whether people with multiple sclerosis (MS) are more likely to have gum disease. Researchers examined 293 Egyptian adults with MS using standard dental check-ups. The goal was to see if there is a link between MS and periodonta…

This study looked at how the COVID-19 pandemic changed the way people with multiple sclerosis (MS) reported and managed their relapses. Researchers compared 51 patients who had a relapse during the first wave of the pandemic (April–June 2020) with those who had a relapse during t…

This study looked at 46 people with progressive multiple sclerosis who have more weakness on one side of their body. Researchers used MRI scans to see how damage in the brain and spinal cord relates to muscle strength in each limb. The goal was to better understand what causes ph…

This study looked at how well people with relapsing multiple sclerosis (RMS) follow their Kesimpta (Ofatumumab) treatment plan. Researchers used data from the MSGo patient support app to track when doses were taken. They also compared how patients felt (reported symptoms) with th…

This completed study looked at how neuropsychological problems (like trouble with thinking or emotions) affect how people with multiple sclerosis explore their surroundings and start walking. Researchers used eye-tracking glasses and motion analysis to measure walking patterns in…

This study analyzed MRI scans from 732 people with primary-progressive multiple sclerosis who took part in the ORATORIO trial. Researchers wanted to see if ocrelizumab changes a part of the brain called the choroid plexus, which may be involved in inflammation. The study was obse…

This completed study involved 15 people with relapsing-remitting multiple sclerosis who were already taking alemtuzumab. Researchers measured anti-drug antibodies in their blood over 24 months to see if these antibodies affect treatment or cause infusion reactions. The goal was t…

This study tested a new way to deliver the drug ozanimod using a skin patch instead of oral capsules. 24 healthy adults either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checked for skin reactions to see if the patch works well …

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide movements, making tasks like grabbing a drink easier. 21 adults who use power wheelchairs and have trouble with everyday tasks took part. They compared the new …

This study tested a French version of a questionnaire that measures physical activity levels in people with physical disabilities. Fifty participants with conditions like stroke, multiple sclerosis, or Parkinson's disease filled out the questionnaire twice, two weeks apart. The g…

This study looked at how the drug cladribine affects the immune system in people with multiple sclerosis (MS). Researchers analyzed blood samples from 77 MS patients and healthy donors to understand the drug's anti-inflammatory effects. The goal was to learn more about how cladri…

This study compared traditional pencil-and-paper tests with virtual reality tasks (like driving simulations and a virtual supermarket) to assess attention and executive function in 60 people with relapsing-remitting multiple sclerosis. The goal was to see if VR can better detect …

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This study looked at how the oral medication cladribine changes different types of immune cells in people with relapsing-remitting multiple sclerosis (RRMS). Ten participants provided blood and spinal fluid samples over 96 weeks to track changes in B cells, T cells, and other imm…

This study followed 10 adults with relapsing multiple sclerosis for 9 months to see how the drug ofatumumab affects microglia, the brain's immune cells. Researchers used special PET scans and blood tests to track changes. The goal was to understand how the drug works in the brain…

This study looked at fatigue in 60 people with multiple sclerosis (MS) to compare how patients describe their tiredness with results from physical and cognitive tests. Researchers used questionnaires, walking tests, grip strength, and balance assessments to get a fuller picture o…

This completed study enrolled 300 people with multiple sclerosis who were taking beta-interferon. Researchers compared the genes of those who developed liver injury to those who did not, aiming to find genetic markers that predict this side effect. No new drug or treatment was te…

This study looked at how much of the multiple sclerosis drug ocrelizumab gets into breastmilk and whether it affects babies' immune cells. Twenty-six breastfeeding mothers with MS or clinically isolated syndrome took part. Researchers measured drug levels in breastmilk and checke…

This study tested whether a technique called compressed sensing can speed up a specific type of brain MRI (QSM) without losing image quality. 82 people, including some with multiple sclerosis, had extra scan sequences added to their routine MRI. The goal was to see if the faster …

This study looked at 94 people with relapsing-remitting multiple sclerosis to better understand why standard MRI scans often don't match a person's actual walking ability. Researchers used advanced MRI to measure damage in brain and spinal cord pathways important for movement and…

This study tested whether a modified version of the O'Sullivan Functional Balance test is a reliable way to measure balance in people with multiple sclerosis (MS). 44 volunteers with MS completed several balance and walking tests. The goal is to give clinicians a simple, fast too…

This study compared 101 people with multiple sclerosis to healthy volunteers to see if they can recognize positive emotions like joy and enthusiasm. Participants completed questionnaires and tests to evaluate their ability to identify emotions from faces and voices. The goal was …

This completed survey looked at whether healthcare professionals and people with multiple sclerosis (or their caregivers) understand the safety steps needed when using the drug Mayzent (siponimod). Over 300 participants from Europe answered questions about proper use, side effect…

This study looked at how well the Pfizer COVID-19 vaccine triggers an immune response in 196 adults with weakened immune systems (due to conditions like kidney transplant, cancer, or HIV) compared to healthy adults. Researchers measured antibody levels and their ability to neutra…

This study looked at whether a specific serotonin receptor, called 5-HT7, could be used as a biomarker for multiple sclerosis (MS). Researchers measured the receptor on different blood cells from 100 people, including those with MS and healthy volunteers. The goal was to better u…

This study tested how different lower-limb prostheses and orthoses affect movement during daily life. Twenty participants with lower-limb amputation or drop foot wore each device for a period while sensors tracked their walking. The goal was to compare devices and improve how we …

This study looked at how high doses of vitamin D change immune cells in 56 healthy adults over 3 months. Researchers used advanced lab tests to measure different types of immune cells before and after treatment. The goal was to better understand vitamin D's effects on the immune …

This study looked at 46 people who had a first episode of optic neuritis (inflammation of the optic nerve). Researchers used special MRI scans to measure the length of the damaged nerve area and then checked how much vision-related nerve loss occurred one year later. The goal was…

This study looked at breathing problems in 70 people with severe multiple sclerosis (MS). Participants had sleep and lung tests to check for breathing muscle weakness. The goal was to better understand how MS affects breathing, not to test a new treatment.

This study tested whether personalized walking training based on detailed 3D movement analysis works better than standard walking therapy. 63 people with spinal cord damage from injury or multiple sclerosis took part. The goal was to see if customizing exercises to each person's …

This study involved 32 adults with arm weakness from stroke, multiple sclerosis, or spinal cord injury. Researchers measured how much force patients could voluntarily produce in their arms and used that data to build mathematical models. The goal is to use these models to improve…

This completed study followed 134 people with a first episode of neurological symptoms (clinically isolated syndrome) to develop better ways to detect nerve damage early. Researchers used MRI scans and eye exams to monitor changes over time. The goal was to help doctors decide wh…

This completed study looked at 369 adults with multiple sclerosis (MS) in Libya to understand how long it takes to get diagnosed, who receives advanced treatments, and how disability levels are affected. Researchers used data from a national MS registry at two hospitals. The goal…

This study examined 100 people who had brain MRI findings suggesting possible multiple sclerosis (MS) but no symptoms yet. Researchers measured four new biomarkers in their spinal fluid and blood to see if these could predict who would later develop MS. The goal was to improve ea…

This completed observational study followed 367 people with relapsing-remitting or active secondary progressive multiple sclerosis who were taking Kesimpta for the first time. Researchers tracked side effects and how well the drug worked in everyday use. The goal was to gather re…

This study reviewed medical records of 800 multiple sclerosis patients to see if gender, race, or socioeconomic status affected how quickly they started Ocrelizumab or how well it worked. Researchers looked at relapse rates and MRI changes over 12 to 24 months. The goal was to id…

This study followed 168 women with Multiple Sclerosis who were pregnant or planning pregnancy. Researchers collected information through phone interviews every three months during pregnancy and tracked the baby's growth for up to three years after birth. The goal was to understan…

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This study investigated why humans swing their arms during walking, a common but poorly understood movement. Researchers had 25 participants, including healthy individuals and those with conditions like stroke or Parkinson's disease, walk on a force-sensing treadmill. They measur…

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This completed study measured two proteins in the blood—neurofilament light chain and GFAP—that can signal nerve damage. Researchers compared 15 people with atypical MS, 30 with typical MS, and 15 healthy controls to see if these markers differ. The goal was to better understand …

This study looked at 104 people with relapsing-remitting multiple sclerosis (RRMS) who switched their disease-modifying therapy to ozanimod. Researchers tracked why they switched (e.g., lack of effectiveness, side effects) and how the switch was done. The goal was to understand r…

This early-stage study gave a single oral dose of a radioactive form of the experimental drug SAR442168 to 6 healthy men. Researchers measured how much of the drug was excreted in urine and stool, and how it moved through the bloodstream. The goal was to understand the drug's met…

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This study looked at whether the L Test, a walking test that involves turning, can reliably measure how well people with multiple sclerosis (MS) walk while also doing a mental task. Fifty adults with mild to moderate MS completed the test under single and dual task conditions. Th…

This completed study surveyed 134 adults with multiple sclerosis who were starting treatment with either Kesimpta or the newer subcutaneous (under-the-skin) version of Ocrevus. The goal was to compare how patients felt about their first injection, including any pain, redness, swe…

This completed Phase 1 study tested how two common drugs—gemfibrozil (for cholesterol) and rifampicin (an antibiotic)—affect the levels of tolebrutinib, an experimental oral drug for multiple sclerosis. Thirty healthy men aged 18 to 45 took tolebrutinib alone and then with each o…

This study looked at how different types of exercise affect the brain and body in people with multiple sclerosis (MS). Twelve participants tried traditional aerobic exercise, virtual reality (VR) aerobic exercise (using the game Beat Saber), and standard exercises. Researchers me…

This study looked back at medical records of 606 people with secondary progressive multiple sclerosis (SPMS) in Russia who were taking siponimod. Researchers wanted to understand patient characteristics and how the drug was used in everyday practice. The study collected data from…

This study looked at whether multiple sclerosis (MS) and its treatments affect a woman's egg supply. Researchers measured a hormone called AMH in blood samples from over 800 women with MS or a related condition. The goal was to see if disease activity or medications impact ovaria…

This completed study looked at how depression affects the ability to recognize emotions in people with multiple sclerosis (MS). Researchers used EEG, heart rate monitoring, and questionnaires to compare emotion recognition in MS patients with and without depression, as well as he…

This study tested whether robotic training that adjusts errors based on each person's abilities can improve motor learning in healthy adults and people with neurological conditions like stroke. Over 250 participants performed arm tasks with robotic devices while researchers measu…

This study checks if a questionnaire about bladder symptoms works well for Turkish-speaking people with multiple sclerosis. Researchers asked 71 participants to fill out the Core Lower Urinary Tract Symptoms Score and compared it to another bladder questionnaire. The goal is to m…

This study looked at 39 people with multiple sclerosis who have chronic vision problems. Researchers used eye exams, scans, and electrical tests to see if the vision loss is caused by nerve scarring (demyelination) or nerve cell death (degeneration). The goal is to better underst…