Eye disorder

Researchers are testing a gene therapy called rAAV2/4.hRPE65 in people with Leber congenital amaurosis or severe early-onset retinal degeneration caused by mutations in the RPE65 gene. The treatment delivers a working copy of the gene directly into one eye through a single inject…

Researchers are testing a single injection of SKG0106, an experimental gene therapy, in Chinese adults aged 50 and older with wet age-related macular degeneration. The trial aims to find out whether the treatment is safe and how the body responds to it. Participants receive one i…

This trial tests a gene therapy for people with a rare inherited eye disease called Leber congenital amaurosis, caused by mutations in the RPE65 gene. A harmless virus is used to deliver a working copy of the gene into cells under the retina. The goal is to restore vision with a …

This study tests whether transplanting healthy bacteria from the eye's surface can help people with moderate to severe dry eye. Forty participants will either receive the bacteria transplant or a fake procedure. Researchers will measure changes in eye discomfort and surface damag…

This study tests whether a steroid injection given during retinal detachment surgery can replace the usual course of antibiotic and steroid eye drops afterward. About 168 adults with a first-time retinal detachment will receive either the injection or standard drops. The goal is …

Researchers compare two versions of corneal crosslinking to treat progressive keratoconus or corneal ectasia, conditions where the cornea thins and bulges. Both use riboflavin eye drops and ultraviolet light, but one delivers the light faster and more intensely. The trial measure…

Researchers are studying aflibercept (Eylea), an anti-VEGF drug given as an injection into the eye, in adults aged 50 and older with wet age-related macular degeneration. Everyone in the trial receives three monthly loading doses over 12 weeks. The team uses detailed retinal scan…

This study tests an experimental drug called AVD-104, given as an eye injection, for people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The trial involves 300 participants and aims to see if the drug is safe and can slow …

Researchers at Tanta University are testing whether a high-dose version of the eye injection aflibercept (8 mg) can improve vision in people with diabetic macular edema or retinal vein occlusion that has not responded well to earlier anti-VEGF treatments. The study enrolls 60 adu…

Researchers compare two approaches for proliferative diabetic retinopathy, a condition where abnormal blood vessels grow in the retina and can cause vision loss. One group receives standard pan-retinal laser photocoagulation alone. The other receives the same laser treatment plus…

Researchers are testing whether adalimumab biosimilars combined with immunosuppressive drugs work as well as corticosteroids combined with immunosuppressants for adults with noninfectious intermediate, posterior, or panuveitis. The trial enrolls about 128 people aged 18 to 70 who…

Researchers compare two ultraviolet light protocols for corneal cross-linking in people with progressive keratoconus. One is the standard Dresden protocol, and the other is an accelerated custom-fast method that uses a mathematical model to set the light intensity and time. Both …

This Phase 3 trial tests dazodalibep, a drug given by IV, in 651 people with moderate-to-severe Sjögren's syndrome. The goal is to see if it reduces disease activity and improves symptoms like dryness and fatigue. Participants receive either the drug or a placebo, and researchers…

Researchers compare two corticosteroid treatments for inflammatory macular edema, a condition where swelling in the center of the retina blurs vision. Adults with the condition receive either a subconjunctival injection of triamcinolone or an intravitreal implant of dexamethasone…

This study tests a new drug called zifibancimig for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The drug is given either as an eye injection or through a small implant placed in the eye that releases the drug over time. The trial involv…

This trial tests a treatment called Melphalan/HDS for people whose eye melanoma has spread to the liver. The approach delivers high-dose melphalan, a chemotherapy drug, straight into the liver through a device system while limiting exposure to the rest of the body. Researchers wa…

This phase 2 study tests a new treatment plan for diabetic macular edema, a condition that causes vision loss. Instead of waiting for severe swelling, patients receive two dexamethasone implants 12 weeks apart, then additional injections only as needed. The goal is to improve vis…

This study tests whether a combination eye drop (netarsudil/latanoprost) can improve vision and reduce corneal thickness in people with glaucoma and a condition called pseudophakic bullous keratopathy, where the cornea swells after cataract surgery. Half of the 50 participants re…

This trial tests whether a modified soft contact lens placed on the cornea during vitrectomy, a surgery for retinal disease, keeps the surgical view clearer than the standard method of intermittent saline irrigation. Researchers randomly assign 46 participants to receive either t…

This trial tests a new dissolvable plug placed in the tear duct that releases tacrolimus, an anti-inflammatory drug, to treat moderate to severe dry eye. Adults aged 18 to 75 with dry eye will receive either the tacrolimus plug in one of two sizes or an approved dissolvable plug …

This trial compares two versions of a surgery called external dacryocystorhinostomy, which creates a new drainage path for a blocked tear duct. Half of the participants receive the standard surgery, while the other half receive the surgery plus a piece of amniotic membrane placed…

This completed Phase 4 trial tested whether adding a second drug (B55R2) to standard treatment (B55R1) works better for people with non-proliferative diabetic retinopathy, an early stage of diabetic eye disease. 52 adults with mild to severe disease took either the combination or…

This study tested whether adding a light-activated dye (rose bengal) to standard antibiotic or antifungal eye drops could improve vision in people with severe corneal infections. About 330 adults in India and Brazil with fungal or amoeba infections received either standard drops …

This trial tests an implant called OTX-TIC, which is placed inside the eye and slowly releases travoprost, a drug that lowers eye pressure. The study includes adults with open-angle glaucoma or ocular hypertension, a condition of high pressure in the eye. Participants receive eit…

This study follows adults who had cataract surgery with Clareon Vivity or PanOptix intraocular lenses, which are designed to restore vision at multiple distances. Researchers will track visual acuity and watch for complications like lens dislocation or retinal detachment over sev…

This trial compares two surgical procedures for people with primary open-angle glaucoma whose eye pressure stays high despite maximum medication. One group receives deep sclerectomy with scleral bed fenestration, a modified drainage surgery, while the other receives trabeculectom…

This study tested an experimental drug called RZ402 in 94 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. The goal was to see if the drug is safe and can reduce swelling in the retina and improve eyesight compared to a placebo. Par…

This study looks at how well a biosimilar drug called Yesafili works for people with wet age-related macular degeneration (AMD). About 54 participants will switch from the standard drug Eylea to Yesafili. Doctors will check vision and eye health to see if the biosimilar is a safe…

This study tests whether a home eye-scanning device can improve care for people with wet age-related macular degeneration (AMD) who are switching to the medication faricimab. Participants will scan their own retinas at home several times a week, and the images will be sent to the…

This study tests whether pneumatic retinopexy, a procedure that injects a gas bubble into the eye, can successfully reattach a detached retina without traditional surgery. Researchers will follow 33 adults with a specific type of retinal detachment for two years, tracking how oft…

This Phase 3 trial tests whether RGN-259, an eye drop containing thymosin beta 4, can reduce the signs and symptoms of dry eye. About 700 adults with a history of dry eye will use the drops four times a day for two weeks, or a placebo. Researchers will measure changes in corneal …

This trial tests whether combining two different types of artificial lenses during cataract surgery improves vision compared to using the same lens in both eyes. Half of the 50 participants will receive a standard monofocal lens in both eyes, while the other half will get a monof…

This trial tests whether an oral medication called linsitinib can help people with active, moderate to severe thyroid eye disease, a condition that causes eye bulging and inflammation. Participants take either linsitinib or a placebo twice daily for 24 weeks. The main goal is to …

This study tests whether special glasses called DIMS lenses can slow the worsening of nearsightedness (myopia) in children as well as low-dose atropine eyedrops do. About 242 children aged 6-12 with myopia will wear either DIMS lenses or regular glasses plus use atropine drops ni…

This study tests whether ketorolac, an anti-inflammatory eye drop, can reduce inflammation in the eyes of people with diabetic retinopathy and slow the disease. About 164 adults with type 2 diabetes will use either the active drop or a placebo for up to 3 years. Researchers will …

This trial tests whether providing free reading glasses to textile workers aged 35 and older with presbyopia (age-related difficulty seeing close up) can improve their work productivity. Workers at a garment factory in India will be randomly assigned to receive glasses or not, an…

This trial tests whether providing free reading glasses to textile workers aged 30 and older with presbyopia (age-related difficulty seeing close up) helps them stay employed longer. Over 1,200 workers in India will either receive glasses or not, and researchers will track how ma…

This trial compares two surgical techniques for removing a pterygium, a fleshy growth on the eye's surface that can distort vision. Researchers are testing whether using a piece of the patient's own conjunctiva (the clear tissue covering the eye) or a preserved amniotic membrane …

This early feasibility trial tests a new retinal implant called PRIMA in 5 people with advanced dry age-related macular degeneration who have lost central vision. The device is surgically placed in the eye to stimulate remaining retinal cells. Researchers are checking if it is sa…

This trial is testing whether a piece of the patient's own eye tissue, called Tenon's capsule, can help close large or recurrent macular holes—tears in the center of the retina that can blur or distort vision. During standard vitrectomy surgery, the tissue is harvested and placed…

This trial investigates whether a sterile gauze infused with natural plant extracts can reduce bacteria on the eyelid margin in people with bilateral anterior blepharitis. Each participant receives the plant-based gauze on one eye and a standard gauze on the other, allowing direc…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This clinical trial is testing whether an investigational eye drop called STN1010904 can improve vision in people with Fuchs endothelial corneal dystrophy (FECD), a condition that damages the cornea's inner layer and can lead to blurry vision. The study will compare two different…

This study tests whether daily low-dose atropine eyedrops (0.01%) can slow the progression of myopia (nearsightedness) in children aged 5 to 12. Participants receive either atropine or placebo drops for two years, followed by six months off treatment to see if any benefit lasts. …

This study tested a drug called faricimab (VABYSMO®) against an existing treatment (ranibizumab) for people with vision loss caused by abnormal blood vessels growing in the back of the eye due to severe nearsightedness. The trial involved 280 participants who received either fari…

This study tested SYD-101 eye drops in 852 children with nearsightedness (myopia). The goal was to slow the worsening of vision over time. Children used the drops daily for up to 3 years. The study measured how much their eyesight changed, aiming to reduce the risk of serious eye…

This trial investigates whether adding a dexamethasone implant (Ozurdex) to standard aflibercept (Eylea) injections can better control diabetic macular edema that has not responded to anti-VEGF therapy alone. Adults with persistent retinal swelling will receive either the combina…

This study tests a new preservative-free eye drop combination (QLS-111-FDC) to lower eye pressure in people with open-angle glaucoma or ocular hypertension. About 60 adults with mild to moderate disease will receive the treatment. The goal is to see if it safely reduces eye press…

This phase II trial tests whether combining pembrolizumab (an immunotherapy) with lenvatinib (a targeted therapy) can control metastatic uveal melanoma, a rare eye cancer that has spread. About 51 adults are enrolled in two groups: those who have never taken Tebentafusp and those…

This study tested an experimental drug called tinlarebant in 104 teenagers with Stargardt disease, a genetic condition that causes progressive vision loss. The goal was to see if the drug could slow the growth of damage in the back of the eye. Participants took the drug or a plac…

This trial tests a new type of intraocular lens, the CT LUCIA 621P, designed to improve vision after cataract surgery. The lens has a special shape that may correct vision more precisely than standard lenses. Researchers will measure how well people see at distance and intermedia…

This trial investigates how well a new multifocal intraocular lens, the AT ELANA, improves vision in people having cataract or refractive lens exchange surgery. About 69 participants will receive the lens in both eyes and be followed for 12 months to measure visual sharpness and …

This study examines how wearing Ortho-K contact lenses overnight changes the optical quality of the cornea in children and young adults aged 8 to 21 with mild to moderate nearsightedness and astigmatism. Participants wear the lenses for 8–10 hours each night, and researchers meas…

This early-stage trial tests an experimental drug called Kamuvudine-8 (K8) for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 30 participants receive eye injections of K8 and are monitored for 26 weeks to check s…

This trial compares two ways to correct nearsightedness: implanting a small lens inside the eye (EVO+ ICL) and reshaping the cornea with a laser (LASIK). Researchers are measuring how well each procedure improves vision, as well as side effects like glare, dry eye, and night visi…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This study compares two ways of creating scleral tunnels during flanged intrascleral intraocular lens (IOL) fixation surgery, a procedure used when the eye's natural lens support is missing or damaged. Researchers are testing whether making the tunnel horizontally (parallel to th…

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This study investigates whether a non-invasive light treatment called photobiomodulation can improve vision and slow vision loss in people with dry age-related macular degeneration (AMD). Participants receive either active light therapy or a sham (inactive) treatment over 12 mont…

This study tests two types of light therapy—low-level light and intense pulse light—to kill Demodex mites that cause eyelid inflammation (blepharitis). 88 adults with confirmed mite infections will receive one of four treatments: sham, blue light alone, IPL alone, or both. All wi…

This study tests whether progressive addition lenses (PALs), like bifocals without a visible line, can slow the progression of low myopia (nearsightedness) in children who have certain focusing traits. About 118 children with low myopia and specific vision characteristics were ra…

This study tests whether injections of ranibizumab, a drug that blocks abnormal blood vessel growth, can help clear bleeding inside the eye in people with diabetes. The bleeding, called diabetic vitreous hemorrhage, can blur or block vision. Participants receive the injection and…

This study tested whether cleaning the eyelids with wipes containing chlorhexidine can treat blepharitis caused by Demodex mites. 106 adults with the condition used the wipes twice daily for four weeks. Researchers measured mite counts and eyelash debris before and after treatmen…

This phase 3 study tests whether the drug ianalumab can reduce disease activity in people with active Sjogren's syndrome. About 275 adults with the condition will receive either ianalumab or a placebo shot under the skin. The main goal is to see if the drug improves symptoms and …

This study follows people with two inherited eye conditions—choroideremia and X-linked retinitis pigmentosa—who previously received gene therapy. Researchers monitor their safety and vision over several years to see if the treatment remains safe and helps preserve sight. Particip…

This study tests whether NPI-001 tablets can safely slow or stop vision loss in people with Usher syndrome, a rare genetic condition that causes blindness and hearing loss. About 49 adults will take either the study drug or a placebo for 24 months. The main goal is to see if the …

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This study looked at whether placing a tiny device called iStent during cataract surgery helps lower eye pressure in people with primary open-angle glaucoma. Researchers compared 80 patients who got the implant plus cataract surgery to those who had cataract surgery alone. The go…

This study examines how well a biosimilar (a lower-cost copy) of the drug ranibizumab works for diabetic macular edema, a condition that causes vision loss in people with diabetes. Researchers will review medical records of 60 adults who received at least one injection of the bio…

This phase 3 trial tested a new type of corneal cross-linking that does not require removing the surface layer of the eye. It involved 398 people aged 8 to 45 with keratoconus, a condition that thins and bulges the cornea. The treatment uses riboflavin eye drops and ultraviolet l…

This phase 3 trial tested a new way to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The treatment uses special eye drops and ultraviolet light to strengthen the cornea without removing its outer layer. 396 people aged 8 to 45 took part …

This completed study tested a special lens called HAL for people with nearsightedness (myopia). 88 participants wore either the HAL lens or a standard single vision lens. Researchers measured reading speed and how well they could see at different distances and contrasts. The goal…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This study tested two types of advanced glasses—lenslet spectacles and violet filter glasses—against standard single-vision lenses to see if they could slow the worsening of nearsightedness (myopia) in 90 people aged 8 to 20. Participants wore the glasses during all waking hours …

This study tested a higher dose (8 mg) of the drug aflibercept against the standard dose (2 mg) in 892 adults with macular edema from a blocked retinal vein. The goal was to see if the higher dose works as well or better while allowing fewer injections. Participants received inje…

This study tests whether a graft made from a patient's own or donor stem cells can repair the cornea's surface in people with limbal stem cell deficiency, a condition that causes pain, scarring, and vision loss. A small biopsy of limbal tissue is taken from a healthy eye or donor…

This study tested the long-term safety and effectiveness of pegcetacoplan in 792 people with geographic atrophy, a form of advanced dry age-related macular degeneration that causes vision loss. Participants had previously been in earlier pegcetacoplan trials. The goal was to see …

This completed trial tested the ELIOS System, a device used during cataract surgery to lower eye pressure in adults with mild-to-moderate open-angle glaucoma. The study enrolled 318 participants and measured how many achieved a 20% or greater drop in eye pressure without medicati…

This study tests a drug called faricimab (VABYSMO) in people with diabetic macular edema, a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. Participants receive injections of faricimab into the eye every four weeks. The goal is t…

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested a combination of two drugs, sitravatinib (a pill) and tislelizumab (an IV infusion), in 16 people with a rare eye cancer (uveal melanoma) that had spread to the liver. The goal was to see if the combo could shrink liver tumors better than current treatments. Par…

This study tested the safety of a drug called maralixibat in 27 infants under 12 months old with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC), two rare liver diseases that cause bile buildup. The drug is given as an oral solution and aims to reduce bi…

This early-stage trial tested a new gene therapy called FLT201 in 10 adults with Gaucher disease type 1. The therapy uses a harmless virus to deliver a working copy of the gene that produces a missing enzyme. The main goal was to check safety and see if the treatment can boost en…

This study looked at whether adding bifocal glasses to daily atropine eye drops works better than atropine alone to slow down nearsightedness (myopia) in children. 210 kids aged 4-16 with worsening myopia took part. The main goal was to measure changes in their vision prescriptio…

This early-stage study tested a new drug, VP-001, given as an injection into the eye to see if it is safe for people with a rare genetic eye disease caused by a PRPF31 mutation. Seventeen adults took part. The main goal was to check for side effects, not to measure vision improve…

This study tested a new eye medication called PRO-169 against a standard drug (ranibizumab) for people with diabetic macular edema, a condition that causes vision loss in people with diabetes. About 509 adults with diabetes took part, receiving injections into the eye over one ye…

This Phase 2 trial tested a drug called CFZ533 (iscalimab) in 273 adults with Sjögren's syndrome, an autoimmune disease causing dryness, pain, and fatigue. Participants received either the drug or a placebo for 24 weeks. The study measured changes in disease activity and symptoms…

This study tested an oral drug called AZ-3102 in 13 people with GM2 gangliosidosis (Tay-Sachs or Sandhoff disease) or Niemann-Pick type C disease. The main goal was to check safety and how the drug moves through the body over 12 weeks. It was a randomized, double-blind, placebo-c…

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This study tested a new way to seal the small cuts made in the eye during cataract surgery. The technique, called posterior flap hydration, uses a special cannula to add fluid to the back of the wound. Researchers checked how tight the seal was right after surgery and looked at t…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested whether eye drops made from a patient's own blood or from donated umbilical cord blood can improve dry eye disease. Eighty adults with dry eye from conditions like Sjogren's syndrome or after using glaucoma drops were randomly assigned to one of the two types of…

This study tested a small implant called Supraflow v2.2 in 57 adults with open-angle or narrow-angle glaucoma. The implant is placed inside the eye to help drain fluid and lower eye pressure. The goal was to see if it safely reduces pressure and the need for daily eye drops over …

This study tested a minimally invasive surgery called GATT in 30 children who developed glaucoma after cataract surgery. The procedure aims to lower eye pressure by improving fluid drainage inside the eye. Researchers measured changes in eye pressure and the number of glaucoma me…

This phase 2 trial tested the drug darovasertib in 15 people with high-risk uveal melanoma (a rare eye cancer) who were scheduled for eye removal surgery. Participants took the drug for up to 4 weeks before surgery, and some continued for 6 months afterward. The main goals were t…

This study compared two types of tube shunts (Baerveldt 350 and Ahmed ClearPath 250) in 80 adults with glaucoma that was not controlled by other treatments. The goal was to see which device lowers eye pressure better and is safer. Both implants are used to drain fluid and protect…

This study tested a new anti-infective eyedrop called SCH1 in 30 adults with acute infectious conjunctivitis (pink eye). Participants received either the active eyedrop or a placebo. The goal was to see if the drug could completely clear redness and discharge. The trial is comple…

This Phase 3 trial tested a gene therapy called GS010 in 98 people with Leber hereditary optic neuropathy (LHON), a genetic condition that leads to rapid vision loss. Participants received injections of the therapy or a placebo into both eyes. The study measured changes in vision…

This study looked at whether faricimab injections can help people with diabetic retinopathy, a diabetes-related eye disease. Over 12 months, 60 patients received the treatment and doctors measured changes in the back of the eye. The goal was to see if the drug could reduce abnorm…

This Phase 2 trial tested whether Humira (adalimumab), a drug used for arthritis, can help people with Netherton syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. Eleven patients received six injections over three months, followed by thre…

This study tested a tiny implant called the PRIMA Bionic Vision System in 5 people with advanced dry age-related macular degeneration who had lost central vision. The implant is placed under the retina and uses electrical stimulation to replace damaged light-sensing cells. The go…

This phase 3 trial tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. The study enrolled 174 people with moderate-to-severe non-proliferative diabetic retinopathy but without swelling in the center…

This study tested a new eye drop called QLS-111 in 37 people with normal tension glaucoma, a type of glaucoma where eye pressure is not high but vision still gets damaged. The goal was to see if QLS-111 is safe and can lower eye pressure better than a standard drop called timolol…

This study tested whether a higher dose (8 mg) of the drug aflibercept, given every 16 weeks, works as well as the standard dose (2 mg) given every 8 weeks for Chinese people with diabetic macular edema (DME), a diabetes-related eye condition that causes vision problems. 333 part…

This study tested a new, less invasive surgery called MIMS for people with glaucoma. The goal was to see if it lowers eye pressure as well as traditional surgery but with fewer side effects. 23 adults with glaucoma took part. The results will help doctors understand if MIMS is a …

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study tested a drug called faricimab in 179 people with non-proliferative diabetic retinopathy, a condition where diabetes damages blood vessels in the eye. The goal was to see if the drug could improve blood flow in the retina over 48 weeks. Participants received either mon…

This study tested a toric intraocular lens implant in 40 children aged 6 to 17 with cataracts and astigmatism (a condition where the eye is shaped like a football). The goal was to see if this special lens could improve vision better than standard surgery. All children had catara…

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whet…

This study looked at how well a special lens implant, called the Visian Toric ICL, works over two years for people with nearsightedness and astigmatism. A total of 125 participants received the implant, which sits behind the iris. The main goal was to see if the lens stays in pla…

This study tested special glasses called C.A.R.E. lenses in 100 children aged 6-12 with nearsightedness. The lenses have rings that change how light hits the eye to slow down eye growth. After 12 months, researchers measured changes in eye length and prescription strength to see …

This study followed 62 people with Leber Hereditary Optic Neuropathy (LHON), a rare inherited eye disease that causes vision loss, for up to 5 years after they received a single gene therapy treatment called GS010. The goal was to see if the treatment remained safe and if any vis…

This phase 3 trial tested a single injection of GS010 gene therapy in 39 people with Leber Hereditary Optic Neuropathy (LHON) who had vision loss for 6 months or less. The treatment aims to improve vision by delivering a working copy of the ND4 gene to the eye. Results measured c…

This study tested a one-time gene therapy injection, GS010, in 37 adults with Leber Hereditary Optic Neuropathy (LHON), a genetic condition that causes rapid vision loss. Participants had vision loss for 6 to 12 months before treatment. The goal was to see if the therapy could im…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study tested whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the eye could slow the progression of advanced dry age-related macular degeneration (AMD). Fourteen people with advanced dry AMD received three PRP injections…

This study looked at whether early surgery (vitrectomy) or waiting with ultrasound monitoring is better for people with sudden, dense bleeding inside the eye. The goal was to see if early surgery could lower the chance of the retina detaching. Only 8 adults with recent bleeding f…

This study looked at the long-term safety of efgartigimod in 24 adults with primary Sjögren's syndrome who had already completed a prior trial. Efgartigimod works by lowering certain antibodies that may drive the disease. The main goal was to track side effects over 48 weeks, wit…

This study tested an experimental drug called KUS121, given as an eye injection, for people who suddenly lost vision due to a blocked artery in the eye (central retinal artery occlusion). The goal was to see if the injection could improve vision better than a sham procedure. The …

This study tested the drug sorafenib (Nexavar) in 32 adults with uveal melanoma that had spread to other parts of the body. The goal was to see if the drug could stop tumors from growing for at least 24 weeks. Sorafenib is already used for other cancers, and researchers wanted to…

This study looked at 30 people with Vogt-Koyanagi-Harada (VKH) disease, a rare autoimmune condition that causes eye inflammation and can lead to vision loss. Researchers compared two initial treatments: oral prednisolone (steroid pills) and steroid injections near the eye. They c…

This study looked at 83 people with diabetes and early-stage eye disease. It compared having laser treatment in one session versus four sessions to see which approach better controls the disease and reduces the risk of swelling in the center of the eye. The main goal was to measu…

This study looked at the long-term safety of faricimab, a medicine injected into the eye, for people with diabetic macular edema (DME). About 1,500 patients who had completed earlier studies received faricimab at personalized intervals. The main goal was to track side effects, no…

This study followed 30 uveitis patients who received a fluocinolone acetonide implant to control eye inflammation. Researchers used advanced imaging (OCT, OCTA, fluorescein angiography) to track changes in inflammation over 12 months. The goal was to see if imaging could better m…

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study tested whether tocilizumab, a drug that blocks inflammation, can help people with primary Sjögren's syndrome—an autoimmune disease causing dry eyes, dry mouth, pain, and fatigue. Researchers gave 110 participants either tocilizumab or a placebo to see if it could reduc…

This study tested a special intraocular lens (Vivity EDOF) in 10 adults who had cataracts and mild keratoconus, a condition that thins and bulges the cornea. All participants received the lens in both eyes during standard cataract surgery. The goal was to see if the lens could pr…

This study tested whether eating one avocado and one cup of mango daily for 8 weeks could improve blood vessel health and thinking in 82 adults with pre-diabetes. Participants were randomly assigned to either a diet including these fruits or a matched control diet. Researchers me…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This study tested a small device called the Hydrus Microstent in 217 adults with open-angle glaucoma that was not well controlled with other treatments. The goal was to see if the implant could safely lower eye pressure. After 12 months, many patients had a significant drop in ey…

This study tested whether special glasses (DIMS) are as good as overnight contact lenses (Ortho-K) at slowing myopia progression in children aged 6-12. Ninety kids wore either the glasses or the lenses for 18 months. The main goal was to see if the glasses were not worse than the…

This study tested a personalized treatment plan using the drug brolucizumab for people with a specific eye condition called polypoidal choroidal vasculopathy (PCV). The goal was to see if adjusting the treatment schedule based on each person's needs could maintain or improve visi…

This clinical trial tested a new treatment called AURN001 for people with corneal edema, a condition where the cornea swells due to damaged cells. The treatment is a single injection into the eye that combines donor corneal cells with a drug to help them work. The study involved …

This study tested ACTH gel, given as a shot under the skin, in 28 people with non-infectious uveitis (eye inflammation not caused by an infection). The goal was to see if it is safe and can help control inflammation. Participants received one of two doses, and researchers tracked…

This study looked at the long-term safety of a drug called maralixibat in 52 people with cholestatic liver disease, including Alagille Syndrome and other rare conditions. Participants had already taken maralixibat in an earlier study. Researchers tracked side effects and how well…

This study looked at whether taking omega-3 supplements for 6 months can improve blood flow in the eyes of people with mild to moderate diabetic retinopathy, a common diabetes complication. Researchers measured tiny blood vessels in the retina using a special camera. The goal was…

This study tested whether adding a light-based treatment (photodynamic therapy) to the standard drug ranibizumab could reduce the number of eye injections needed for wet macular degeneration. Sixty adults over age 50 with the condition took part. The goal was to see if the combin…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study tested a new drug called EYE103, given as an injection into the eye, for people with diabetic macular edema (DME) or wet age-related macular degeneration (NVAMD). The trial had two parts: first, checking safety at increasing doses in about 12 people, then comparing two…

This study tested an eye drop called OXERVATE in 37 adults with stage 1 neurotrophic keratitis, a condition where the cornea loses feeling and doesn't heal properly. The treatment was given for 8 weeks, and patients were followed for 24 weeks to see if the cornea healed safely. T…

This study tested a new drug called FYB203, which is a biosimilar (a close copy) of the existing medication Eylea, for people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The trial involved 434 participants and compared how well FYB203 worked v…

This completed Phase 4 study tested how much of the drug aflibercept gets into the bloodstream when a high dose (8 mg) is injected into both eyes of adults with diabetic macular edema or wet age-related macular degeneration. Fifty-one participants received the injections and had …

This study tests a daily pill called ALK-001, a modified form of vitamin A, to see if it can slow the growth of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 300 people with the condition took either the drug or a place…

This study looked at the long-term safety of faricimab, a drug injected into the eye, for people with wet age-related macular degeneration (AMD). Over 1,000 participants who had completed earlier studies received faricimab at personalized intervals. The main goal was to track sid…

This phase 2 trial tested a new drug called EYP-1901, given as an eye injection, for people with wet age-related macular degeneration (AMD). The goal was to see if it works as well as the standard treatment, aflibercept (Eylea), but with fewer injections. 161 participants receive…

This extension study tested the safety and tolerability of two doses of iscalimab in 206 people with Sjögren's syndrome who had already completed a prior study. Participants received weekly injections for three weeks, then bi-weekly doses. The goal was to see if the drug is safe …

This study tested whether an eye injection called brolucizumab works as well as laser treatment for people with proliferative diabetic retinopathy, a serious eye condition caused by diabetes. 689 participants received either the injection or laser, and researchers measured vision…

This Phase 2 study tested an experimental drug called SAR441344 in 84 adults with primary Sjögren's syndrome, a condition causing dry eyes, dry mouth, and fatigue. Participants received either the drug or a placebo by injection over 12 weeks. The goal was to see if the drug could…

This study tested an eyedrop called TP-03 in 39 people with meibomian gland dysfunction (a common cause of dry eye) linked to Demodex mites. The goal was to compare two dosing schedules (twice vs. three times daily) for safety and effectiveness. The results could lead to a new tr…

This study followed 20 people with progressive keratoconus for one year after they received either a standard 30-minute or a faster 10-minute corneal cross-linking treatment. The goal was to see how well each method stopped the disease from getting worse and improved eye shape an…

This study compared two different dosing schedules of brolucizumab (Beovu) in 52 people with wet age-related macular degeneration (AMD) who had not responded well to previous treatment. Participants received the drug as an eye injection either on a fixed schedule or with adjustme…

This early-phase trial tested whether it is safe and feasible to give patients their own immune cells (called tumor infiltrating lymphocytes, or TIL) directly into the liver artery. Eight adults with melanoma that had spread to the liver received the TIL infusion along with chemo…

This phase 2 trial tested a new drug called OCS-05 in 36 people with acute optic neuritis, a condition that inflames the optic nerve and can cause vision loss. Participants received OCS-05 or a placebo alongside standard steroid treatment for five days. The main goal was to check…

This study tested three biologic drugs—adalimumab, anakinra, and tocilizumab—in 112 people with severe, treatment-resistant uveitis, an inflammatory eye disease that can cause blindness. Participants received one of the drugs for 16 weeks. The goal was to see which drug best redu…

This study tested the enzyme replacement drug imiglucerase (Cerezyme) in 12 Chinese patients with Gaucher disease type 3, a rare genetic disorder that affects the brain and body. Participants received the highest approved dose (60 units per kilogram) every two weeks for one year.…

This study tested two ways to treat keratoconus, a condition where the cornea thins and bulges. One method removes the cornea's outer layer before treatment, while the other keeps it intact and customizes the light pattern. Researchers followed 135 adults for 24 months to see whi…

This study tested whether a steroid implant (Ozurdex) or anti-VEGF injections (Avastin, Lucentis, or Eylea) work better to prevent worsening of diabetic macular edema after cataract surgery. Sixteen adults with diabetes and pre-existing eye swelling received one treatment before …

This phase 3 trial tested whether a new eye drop called NCX 470 can lower eye pressure better than the standard drop latanoprost in people with open-angle glaucoma or ocular hypertension. About 696 participants used one drop in each eye every evening for up to 12 months. The stud…

This small study tested ustekinumab, a drug that calms the immune system, in 16 adults with Behçet disease. The goal was to see if it could reduce mouth ulcers and eye inflammation. The trial is complete, but because it's early and small, we don't yet know if the drug will become…

This study tested the drug adalimumab against a placebo in 34 children with juvenile arthritis and active eye inflammation (uveitis) that wasn't controlled by steroid drops or methotrexate. The goal was to see if adalimumab could reduce eye inflammation after two months. After th…

This early safety study tested a bioengineered corneal implant called LinkCor in 20 adults with advanced keratoconus, a condition that thins and bulges the cornea. The implant is placed inside the cornea to flatten it and improve vision, without needing human donor tissue. Resear…

This study tested the safety of aflibercept, an already-approved eye injection, in 100 Indian adults with diabetic macular edema (DME). Participants received injections every 4 weeks for 5 months, then every 8 weeks for a total of 48 weeks. The main goal was to track any side eff…

This phase 2 trial tested a new way to deliver dexamethasone directly to the back of the eye using tiny microspheres (OXU-001) compared to the standard Ozurdex implant. The study enrolled only 3 adults with diabetic macular edema to check safety and how well the treatment is tole…

Researchers are studying whether cell-free RNA in saliva can work as a non-invasive liquid biopsy to help diagnose Sjögren's disease. The trial compares saliva from people with Sjögren's disease against saliva from people with dry-eye and dry-mouth symptoms who do not have the di…

Researchers at the University of Salerno are testing whether an artificial intelligence system can grade glaucoma severity from standard visual field tests as reliably as an expert ophthalmologist. The study follows about 50 adults with glaucoma or suspected glaucoma who have vis…

Researchers are studying how measurements from two different optical coherence tomography (OCT) machines compare when scanning the back of the eye. The trial includes 338 adults with diabetes and diabetic macular oedema. Participants receive OCT scans on both a Heidelberg Spectra…

Researchers in Denmark are screening teenagers with Down syndrome for keratoconus, a condition that thins and bulges the cornea and can blur vision. The study uses corneal tomography to measure how common keratoconus is at different ages in this group. The goal is to find the bes…

This study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…

This study is testing whether a blood test can tell apart the DNA from a vanishing twin and the living twin in pregnancies where one twin stops developing. The goal is to improve non-invasive prenatal screening for chromosome conditions like trisomy 21, 18, and 13 in the survivin…

This study tested a new method called metagenomic deep sequencing (MDS) to find the cause of eye infections. 100 adults with suspected infectious uveitis or endophthalmitis were randomly assigned to have their doctors receive MDS results or not, in addition to standard tests. The…

This trial compares a telemedical device called Occyo One to the standard slit lamp exam for detecting complications after cataract surgery. About 365 patients scheduled for cataract surgery will have their eyes imaged with Occyo One before and after surgery. A remote ophthalmolo…

This study tested whether a high-resolution eye scan called SD-OCT can diagnose glaucoma more accurately than standard methods. Researchers compared 109 people with and without glaucoma using the scan. The goal was to see if this technology could catch the disease earlier, before…

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

This study tested two new devices that automatically measure vision in children aged 6 to 16. The devices use special lenses that adjust themselves, avoiding the need for eye drops that dilate the pupils. Researchers compared the results from 43 children to the standard dilation …

This study tested an artificial intelligence (AI) system called Retina4IRD that helps doctors diagnose inherited retinal diseases, which are rare eye conditions that can cause vision loss. The AI looks at eye images and patient information to suggest which gene might be causing t…

This study tested whether special MRI scans can better detect signs of central retinal artery occlusion (CRAO), also known as an eye stroke. Researchers enrolled 63 adults with CRAO and performed detailed brain and eye imaging. The goal was to find imaging clues that help diagnos…

This study looked at whether a new, high-resolution MRI can help doctors more accurately and confidently diagnose the cause of optic disc swelling (a sign of various eye or brain problems). Researchers used these detailed scans on 197 adults with optic disc swelling to see if the…

This study tested a device called RETeval that measures how the retina responds to light. Researchers collected data from 664 people, both with and without retinal disease, to create a reference for normal eye function. The goal is to improve diagnosis of retinal conditions.

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This study tested whether a device called MAIA, which measures light sensitivity in the retina, can predict when intermediate age-related macular degeneration (AMD) progresses to the advanced stage. Researchers followed 182 people who already had advanced AMD in one eye and inter…

Researchers tested an artificial intelligence program that analyzes retinal images to diagnose several nerve and brain conditions, such as optic neuropathy and brain tumors. The study used data from 693 patients with confirmed diagnoses. The goal is to create a fast triage tool f…

This trial tests whether training female community health volunteers to diagnose and treat corneal abrasions can prevent corneal ulcers across many villages. Volunteers treat eye scratches with antifungal and antibiotic ointments three times a day for three days. Researchers comp…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tested whether injections of aflibercept (Eylea) into the eye could prevent the development of wet age-related macular degeneration (AMD) in people at high risk. 128 participants with early signs of AMD in one eye and wet AMD in the other eye received either Eylea or a…

This early-stage trial tested an experimental eyedrop called INV-102 in 84 adults with moderate dry eye disease. The study had two parts: first, checking safety at different doses, and second, seeing if the drops improve eye dryness symptoms after two weeks. Participants used the…

Researchers are testing an experimental eyedrop called INV-102 in adults with acute infectious keratoconjunctivitis, a common eye infection that causes redness and discharge. The Phase 2 trial randomly assigns participants to receive either INV-102 or a vehicle drop for one week,…

Researchers are testing an experimental eyedrop called INV-102 in adults with moderate to severe dry eye disease. The trial compares INV-102 with a vehicle drop over four weeks of repeated dosing. The main goal is to see whether INV-102 reduces corneal damage, measured by a stand…

Researchers are testing two eye drops that contain hyaluronic acid and amino acids in people with dry eye syndrome. Adults with moderate to severe dry eye receive the 0.30% drop, while those with mild dry eye receive the 0.15% drop. The study measures changes in eye surface stain…

Researchers compare kalifilcon A daily disposable toric contact lenses with Ultra for Astigmatism lenses in adults who already wear soft contacts and need astigmatism correction. Each participant wears both lens types for about one week each, in random order. The study measures h…

This study tests a new artificial tear called ABBV-444 against an existing brand, Refresh Optive, in 250 adults with dry eye disease. Participants use the assigned eye drops for 90 days. The goal is to see if the new formula improves eye comfort and surface health better than the…

This study tests a device called Rexon-Eye that uses low-level electrical current to treat dry eye disease. Researchers will also analyze tear proteins to see how they change with treatment. The trial involves 75 adults with dry eye and aims to understand both the device's effect…

Researchers at King Saud University tested whether a four-week yogic eye exercise program reduces symptoms of computer vision syndrome in female university students. All 36 participants performed a 13-minute sequence of relaxation and eye-strengthening exercises three days a week…

Researchers at the Philippine Eye Research Institute studied a surgical technique called a sub-incisional pocket (SIP) for sealing the small corneal incisions made during cataract surgery. The study reviewed records from 35 adults who had routine phacoemulsification with a clear …

This study tested a new type of daily disposable contact lens for people with astigmatism. 281 contact lens wearers tried the lenses to see how well they corrected vision, stayed in place, and felt comfortable. The goal was to make sure the new lenses are safe and work well for e…

Researchers are testing whether perceptual learning, a computer-based training that aims to improve how the brain processes visual information, can help people with stable keratoconus see better with their glasses. The study enrolls people aged 9 and older whose best corrected vi…

This study tests a laser treatment for people with bothersome eye floaters that make vision blurry or distracting. Researchers will measure how vision, eye structure, and quality of life change after the procedure. The study involves 50 adults with floaters caused by certain eye …

This trial tests whether low-dose atropine eye drops can reduce excessive tearing (epiphora) in adults. Participants use one of two strengths (0.005% or 0.01%) in their affected eye(s) for one week. The study compares how well each dose works and monitors for any side effects.

Researchers are testing whether insulin eye drops help the cornea heal faster and reduce pain after corneal collagen cross-linking, a procedure used to treat keratoconus. In this paired-eye study, each participant receives insulin drops in one eye and standard drops in the other,…

This study compares a clinic-based thermal device (MiBo Thermoflo) to standard warm compresses for treating dry eye caused by meibomian gland dysfunction. About 42 adults who haven't improved with warm compresses will be randomly assigned to either three sessions of MiBo therapy …

Researchers are testing tivanisiran sodium eye drops in adults with dry eye disease to see if the drops are safe when used once daily for a year. About 300 participants will receive either the tivanisiran drops or a vehicle drop, which is a solution without the active ingredient.…

This study will test how comfortable and clear TOTAL30 Multifocal contact lenses feel after wearing them for up to 16 hours. About 36 adults who already wear multifocal contacts will rate their comfort and vision at several points during the day over one month. The goal is to see…

This trial tests whether playing different types of music during retinopathy of prematurity (ROP) eye exams can reduce pain and improve comfort in premature infants. ROP exams are necessary but can be painful and stressful for babies. Researchers will compare pain and comfort sco…

This study tested two types of daily disposable contact lenses for people with astigmatism to see which one felt more comfortable. 134 adults wore each lens for one week and rated their comfort. The goal was to find out which lens provided longer-lasting comfort and a better over…

This study compares two lubricating eye drops—Systane PRO PF and Thealoz Duo—to see which one better relieves dry eye symptoms. About 100 adults with dry eye will use each drop for 4 weeks, one twice a day and the other four times a day. The goal is to find out if they work equal…

This study tested how comfortable two different daily soft contact lenses feel right after putting them in. 45 adults who already wear contacts and have mild to moderate nearsightedness rated each lens on a 0-100 comfort scale. The goal was to see if one lens feels better than th…

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study tested whether a numbing gel (lidocaine) works as well as a needle injection for pain relief during pterygium surgery. 41 adults having pterygium removal took part. The goal was to see if the gel causes less pain and eye dryness after surgery.

This study tested an eye drop (POS) in 200 adults who had poor night vision after LASIK or similar eye surgery. The goal was to see if the drops could help them see better in dim light, reducing problems like glare and halos. Participants used the drops for 15 days and had their …

This completed Phase 3 trial tested whether phentolamine eye drops (Nyxol) can improve near vision in people with presbyopia, the age-related loss of ability to focus on close objects. 569 adults aged 45 to 64 used the drops or a placebo once daily for 8 days. The main goal was t…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the real surgery. About 260 adults scheduled for cataract surgery will either use VR glasses to experience the sights and…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the actual surgery. Sixty adults scheduled for cataract surgery will either watch the VR video or receive standard care. …

This trial tests whether adding nepafenac eye drops before and after surgery for epiretinal membrane (a wrinkle on the retina) can help the eye heal faster. Sixty adults with this condition will either receive the drops plus standard care or standard care alone. Researchers will …

This study tests whether wearing a compression dressing for 24 hours after upper eyelid blepharoplasty (eyelid lift) reduces swelling, bruising, and pain. Each participant has both eyelids operated on; one eye gets the dressing, the other does not. Masked observers assess recover…

This Phase 3 trial tested Nyxol eye drops, alone or with low-dose pilocarpine, in 333 adults aged 40–64 with presbyopia (age-related difficulty seeing up close). The goal was to improve near vision without losing distance vision. Participants received drops and were measured afte…

This study is testing whether eye drops made from cord blood plasma can relieve symptoms of moderate to severe dry eye disease better than standard artificial tears. Researchers will compare the cord blood drops combined with cyclosporine to a control treatment of hyaluronic acid…

This pilot study compares two sedation approaches for cataract surgery: one uses oral medication to reduce anxiety, the other uses a placebo. The goal is to see which approach leads to higher patient satisfaction and better recovery. The study involves 23 adults aged 60 and older…

This completed study tested whether taking anti-aging compound capsules twice daily for four weeks could reduce eye fatigue and discomfort in 25 healthy adults aged 20 to 60. The capsules contained a mix of botanical extracts, omega-3s, vitamins, and minerals. Researchers measure…

This study tested whether using Systane PRO eye drops consistently for 30 days can relieve symptoms of dry eye disease and improve daily functioning. Thirty-three adults with mild to moderate dry eye took part. The main goal was to see if their eye comfort scores improved from th…

This study tested the TearCare MGX system, a device that applies heat to the eyelids, for treating dry eye caused by meibomian gland dysfunction. 21 adults with dry eye symptoms received the treatment, comparing a standard version with one that includes an extended warming hold. …

This study checked the safety and effectiveness of the CorVision microlens, a tiny implant placed in the cornea to help with presbyopia (age-related difficulty seeing up close). About 95 people who had the implant in an earlier study came back for a single 4-year follow-up visit.…

This study tested an eye drop called LNZ101 to help people with presbyopia (age-related trouble seeing up close) read without glasses. 469 adults aged 45-75 received the drops, and researchers measured how many gained clear near vision without losing distance vision on the first …

This study tested whether a nasal spray containing varenicline (OC-01) can improve tear film quality and reduce dryness in people with dry eye disease. Fifty adults used either the active spray or a placebo. Researchers measured tear film changes and symptom scores shortly after …

This study looked at whether a melt tablet containing midazolam and ketamine works as well as IV sedation for keeping people calm and pain-free during cataract surgery. Over 1,100 adults aged 55-80 took part. Researchers measured sedation levels, pain scores, and whether extra pa…

This study tested whether giving EXACYL before surgery can reduce bleeding during and after jaw realignment surgery. 157 adults took part in a double-blind, placebo-controlled Phase 3 trial. The goal was to see if the drug makes surgery safer and more comfortable.

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study tested a new antiseptic called IRX-101 against the standard povidone-iodine in 155 people receiving eye injections for retinal disease. The goal was to see if IRX-101 reduces pain and corneal damage after the injection. Researchers measured safety and corneal staining …

This study tested whether a smartphone meditation app (Calm Health) could help reduce anxiety and depression in 100 adults with non-infectious uveitis, an inflammatory eye disease. Participants used the app and reported their symptoms. The goal was to see if digital mindfulness c…

This study looked at whether regular aerobic exercise, like walking, can reduce fatigue in women with primary Sjögren's syndrome. Forty-five women participated in a 16-week program. Researchers measured changes in fatigue, mood, and physical fitness.

This study tested a new contact lens designed to help people with presbyopia (age-related blurry near vision) see clearly at both far and close distances, potentially reducing the need for bifocals or reading glasses. 78 adults aged 45 to 70 who already wear soft contact lenses t…

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study tested a special lens implanted during cataract surgery to see if it improves vision at far, middle, and close distances. Thirty adults with cataracts received the lens in both eyes. Researchers measured their vision and satisfaction 1 and 3 months after surgery.

This Phase 2 study tested three different dosing schedules of Lagricel Ofteno eye drops (sodium hyaluronate 0.4%) in 141 people with mild to moderate dry eye. Participants used the drops either twice, four times, or six times a day. The main goal was to see which schedule best im…

This study tested a special type of artificial lens (TECNIS Eyhance IOL) in 62 adults aged 45-75 who had cataract surgery. The goal was to see how well the lens helps people see clearly at different distances, from close up to far away. Researchers measured vision at nine distanc…

This Phase 3 trial tested LNZ101 eye drops in 229 people aged 45-75 with presbyopia, a condition that makes it hard to see up close. The drops combine aceclidine and brimonidine to temporarily improve near vision. The main goal was to see if participants could read three lines be…

This study tested three different eye drops (Humylub Ofteno PF, Hyabak, and Lagricel Ofteno PF) in 182 people with mild to moderate dry eye. Participants used the drops four times a day for 30 days. The main goal was to see if Humylub was as good as the others at reducing dry eye…

This study looked at whether a structured counseling session over the phone before cataract surgery could lower patients' anxiety and improve their recovery. 128 adults scheduled for cataract surgery took part. Half received the extra phone counseling, while the other half got st…

This phase 2 trial tested two strengths of rhNGF eye drops against a placebo in 317 adults with moderate-to-severe dry eye disease. Participants used the drops three times a day for 4 weeks, followed by 4 weeks of monitoring. The goal was to see if the drops could improve dry eye…

This early-phase study tested the safety of PRO-201 eye drops (a low-dose atropine solution) in 29 healthy adults aged 18 to 35. The main goal was to see if the drops cause unexpected side effects or light sensitivity. Researchers also checked vision, eye pressure, and comfort. T…

This study looked at how two light-based treatments—intense pulsed light (IPL) and low-level light therapy (LLLT)—work for dry eye disease caused by clogged oil glands. Twenty-six participants received four treatment sessions, with one eye getting IPL plus LLLT and the other gett…

This study tested whether Ectoin allergy nasal spray and eye drops can relieve symptoms of hay fever (runny nose, sneezing, itchy eyes) better than a placebo. 46 adults with ragweed allergies were exposed to pollen in a special chamber. Researchers measured symptom scores and nas…

This early-stage study tested the safety of eye drops made from stem cell secretions in 9 adults with chronic corneal surface disease that did not improve with standard treatments. The drops were given in increasing doses to find the safest amount. Researchers checked for side ef…

This Phase 3 trial tested SI-614 eye drops, a modified form of sodium hyaluronate, against placebo in 232 adults with dry eye disease. Participants used the drops four times daily for 84 days. The study measured changes in eye surface staining (a sign of damage) and daily symptom…

This early-stage study tested a new eye gel called PRO-165 to see if it is safe and tolerable for people with dry eyes. 32 healthy adults used either the new gel or a standard lubricating gel. The goal was to check for side effects and comfort, not to cure dry eye.

This study tested whether giving two types of light therapy (intense pulsed light and low-level light therapy) before laser eye surgery can help prevent dry eyes afterward. 62 people who were already scheduled for laser vision correction took part. The goal was to see if these tr…

This study tested a low-level light therapy mask on 98 adults having cataract surgery. The mask was used one week before and one week after surgery to see if it could prevent or reduce dry eye symptoms. Researchers measured dry eye symptoms, tear stability, and eye surface health…

This study tested two different lens approaches for cataract surgery: one group got two different extended-depth-of-focus lenses (one in each eye), and the other got the same trifocal lens in both eyes. The goal was to see which caused fewer halos and better vision. 36 adults hav…

This study tested a new gel called PRO-149 used during cataract surgery to protect the eye. 36 adults with age-related cataracts received either the new gel or a standard gel during their operation. The main goal was to check safety by measuring changes in eye cell count and pres…

This study tested whether Total 30 contact lenses can help people who previously stopped wearing contact lenses because of discomfort or dryness. Sixty adults aged 18 to 40 who had worn reusable lenses for at least a year but quit within the past two years were refitted with Tota…

This Phase 3 study tested cenegermin (Oxervate) eye drops against a placebo in 85 adults with severe dry eye caused by Sjogren's syndrome, who were already using cyclosporine drops. The goal was to see if cenegermin could increase tear production and reduce eye discomfort over 4 …

This study tested a new type of lens (EDOF) for people having cataract surgery, comparing it to a standard lens. The goal was to see if the new lens could improve vision at different distances while being safe. 250 adults aged 45 and older with cataracts took part, and the result…

This study tested whether listening to music through headphones during cataract surgery could reduce anxiety and prevent high blood pressure. Over 300 patients took part, with some listening to music and others wearing silent headphones. The goal was to see if a simple, non-drug …

This study tested whether letting patients pick their own aromatherapy scent (lavender, geranium, lemongrass, or sandalwood) could lower anxiety before eye surgery. 64 adults undergoing short eye procedures chose their preferred scent or received an odorless placebo patch. Resear…

This study tested a six-month personalized coaching program for glaucoma patients who struggle to use their eye drops regularly. 236 participants received either coaching or standard care. The program used motivational interviewing and tailored education to help patients overcome…

This study tested how well DAILIES TOTAL1 daily disposable contact lenses work for people with myopia (nearsightedness) who use digital devices for at least 8 hours a day. 41 adults rated their comfort, dryness, and vision clarity after a day of screen use. The goal was to see if…

This study tested a device called TearCare against another device, LipiFlow, in 235 adults with dry eye disease caused by blocked oil glands. The goal was to see if TearCare safely improves tear quality and eye comfort. Participants received one treatment session, and researchers…

This study tested a gentle light treatment (low-level light therapy) given before and after Femto-LASIK eye surgery. 61 adults without prior dry eye received either real light therapy or a sham treatment. Those who got the real treatment had more stable tears and fewer dry eye sy…

This Phase 2 trial tested OCS-01 eye drops in 153 adults who had cataract surgery. The drops aim to reduce eye inflammation and pain. Participants received either a once-daily or twice-daily dose of OCS-01 or a placebo. The study measured how many people had no signs of inflammat…

This study looked at whether starting supportive care early, alongside standard cancer treatment, helps patients with metastatic uveal melanoma feel more supported. 162 adults with advanced eye cancer that had spread were randomly assigned to get either standard oncology visits o…

This pilot study tested a device that gently stimulates the inside of the nose to see if it can improve tear production in people with Sjogren's syndrome. 26 participants used either the active device or a sham (fake) device for 6 weeks, then everyone used the active device for a…

This study follows 61 people who previously used the REVISYON SDS 100 device for mild-to-moderate cataract. Researchers will check for side effects and measure vision changes over about 20 months. No new treatment is given; the goal is to see if the device stays safe and works we…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This completed study looked at how well different eye tests can track changes in retinitis pigmentosa (RP), a group of blinding eye diseases. Researchers tested 49 people with RP and healthy volunteers using exams like vision tests, retinal imaging, and electrical signal recordin…

This study explores whether things a mother is exposed to during early pregnancy might cause uveal coloboma, a rare eye condition present at birth. Researchers will survey mothers of affected children and compare their answers to historical data. The goal is to identify possible …

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study looked at the natural bacteria in the gut of 131 adults with and without uveitis, an inflammatory eye disease. Researchers collected stool and blood samples and performed eye exams to see if differences in gut bacteria are linked to eye inflammation. No treatment was g…

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

Researchers at Nantes University Hospital are studying how the immune system behaves in adults with Gaucher disease. The study collects one blood sample from each participant to measure macrophage activity and immune cell profiles. The goal is to understand how different parts of…

This study reviewed medical records of 523 people with severe glaucoma who had one of two surgeries: trabeculectomy or Ahmed glaucoma valve implantation. Researchers wanted to see which factors, like early eye pressure control, were linked to central vision loss after surgery. Th…

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and a…

This observational study follows about 236 adults with diabetic macular edema (DME) who did not respond well to anti-VEGF injections and are now starting treatment with a dexamethasone implant (DEX-I). The implant slowly releases steroid medication into the eye. Researchers will …

Researchers are following 110 people aged 1 to 65 who have homocystinuria caused by a missing or faulty CBS enzyme. The study observes how the condition changes over time under standard care, without testing any new treatment. Participants give blood samples, complete quality-of-…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study uses advanced PET brain scans to measure dopamine, acetylcholine, and tau protein levels in people with GBA gene mutations, both with and without Parkinson's disease. Researchers also analyze typing patterns on a computer or touchscreen to detect subtle motor changes. …

This study looks at X-linked juvenile retinoschisis (XLRS), a rare inherited eye disease that causes vision loss in young males. Researchers will examine 351 participants, including affected males and female carriers, using eye exams, retinal photos, and genetic tests. The goal i…

This trial tests two different soft toric contact lenses, Acuvue Oasys for Astigmatism and Air Optix for Astigmatism, to see how much they rotate on the eye. Researchers will measure lens rotation in adults with astigmatism who have never worn contacts, using a special microscope…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looks at whether the thickness of a layer inside the eye (the choroid) can predict how well a gentle laser treatment works for glaucoma. Researchers will measure eye pressure and choroid thickness before and after the laser procedure in 20 adults with glaucoma. The goa…

This study looks at how different doses of the antibiotic doxycycline affect antibiotic resistance in people with ocular rosacea, an inflammatory eye condition. Researchers will compare a low anti-inflammatory dose (40 mg daily) with a standard antibiotic dose (200 mg daily) and …

This study examines tear fluid for signs of inflammation in people with glaucoma who receive different treatments. Researchers will measure certain proteins in tears and eye pressure before and after treatment. The goal is to see if these tear markers can predict how well a treat…

This trial asks whether using a 3D visualization system during cataract surgery helps surgeons operate more smoothly in people with high myopia (very nearsighted eyes). It compares the 3D system to a traditional optical microscope, measuring how often the surgeon needs to adjust …

This study investigates whether using a lower, more natural eye pressure during cataract surgery reduces trauma to the cornea compared to traditional high-pressure methods. The Active Sentry device helps maintain stable pressure by sensing changes in the eye. Researchers will mea…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study compares three different methods for prescribing eyeglasses in people with keratoconus, a condition that thins and bulges the cornea, causing blurry vision. The goal is to see if the best method depends on the shape of the cornea, as measured by corneal topography. Res…

This study investigates whether measurements from eye imaging devices can predict the tilt (misalignment) of an artificial lens implanted during cataract surgery. Researchers will use OCT and Scheimpflug cameras to measure the eye before and after surgery in about 110 adults. The…

This study follows 103 adults with a genetic eye condition called retinitis pigmentosa caused by EYS mutations. Researchers will track changes in vision and eye structure over 4 years. The goal is to better understand how the disease progresses so that future clinical trials can …

This study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…

This study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…

This completed study observed 572 patients with neovascular age-related macular degeneration or diabetic macular edema who were already receiving brolucizumab injections. Researchers collected routine medical data to see how well the drug resolved fluid in the eye and improved vi…

This study tests whether a special camera called the OcuMet Beacon can detect stressed cells in the retina of people with geographic atrophy, an advanced form of age-related macular degeneration. Researchers want to see if the patterns of stress match areas of damage seen on stan…

This study is a systematic review that gathers and analyzes existing research on digital eye strain among people who learn or work online. It aims to find out how common the condition is, what factors increase the risk, and what strategies can help prevent or manage it. The revie…

This study compared two different eye imaging machines (Clarus and Optos) to see how well they measure geographic atrophy, a form of vision loss from age-related macular degeneration. Researchers enrolled 62 patients and took images with each device, then compared the measurement…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study looks at what people with age-related macular degeneration (AMD) know about their disease and what they need to manage it better. Researchers will survey and interview 118 patients to understand their knowledge, daily challenges, and support needs. The goal is to use t…

Cataracts cloud the eye's lens and can lead to blindness if untreated. This study compared two common surgical techniques—Divide-and-Conquer and Subluxation—to see which causes less damage to the cornea's inner cell layer. 294 adults having cataract surgery took part, and researc…

This study watched 50 doctors from different specialties as they treated a mannequin pretending to be in a coma. The goal was to see how well their actions matched current medical guidelines. The results could help improve training and recommendations for real-life coma care.

This study used MRI to measure blood flow in the eye's main artery in 20 adults with untreated glaucoma and compared it to healthy people. The goal was to understand how blood flow problems might contribute to glaucoma damage. Participants had one MRI scan, and no treatment was g…

This study used high-powered 3-Tesla MRI to compare the visual pathways in the brains of 114 people with glaucoma and healthy volunteers. Researchers looked at the structure and volume of brain areas involved in vision to see if glaucoma causes damage beyond the eye. The goal was…

This study followed 248 children with nearsightedness who wore soft bifocal contact lenses for two years and then switched to regular lenses for a third year. Researchers measured eye growth, light exposure, and pupil responses to understand why some children's nearsightedness ge…

This study looked at 20 adults who wear an artificial eye to see if it causes more dry eye symptoms and damage to the tiny oil glands in the eyelids. Researchers compared the artificial eye side with the healthy eye side using special imaging and questionnaires. The goal was to u…

This study involved 10 adults with severe dry eye disease who did not respond to standard treatments. Researchers measured levels of growth factors and vitamins in autologous serum eye drops before and after filtration, to see if filtering reduces their concentration. The goal is…

This study tested a new questionnaire to better understand eye rubbing habits in people with or suspected keratoconus, a condition where the cornea thins and bulges. Researchers enrolled 292 participants to see if the questionnaire is reliable and useful. The goal is to improve h…

This completed study looked at how 26 premature infants and babies with Pierre Robin sequence suck. The goal was to better understand their feeding challenges so doctors and families can offer better support. Researchers used a special device to measure sucking patterns, aiming t…

This study looked at whether monitoring moderate diabetic retinopathy (an eye condition caused by diabetes) through tele-expertise (remote specialist review) works as well as the usual in-person eye doctor visits. Researchers followed 97 patients with diabetes and moderate retino…

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This study followed 326 people newly diagnosed with glaucoma or high eye pressure to see how many got worse over 2 to 4 years of standard monitoring in hospital eye clinics. Researchers measured the rate of disease progression and looked for factors that might predict worsening. …

This study followed 516 older adults in France for 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers used eye exams and imaging to track the disease and look for risk factors like genetics and lifestyle. The goal is …

This study looked at how the position of a patient's arms during spinal anesthesia affects pressure inside the eye. Sixty adults having hernia repair were randomly placed with arms at their sides or hands on their chest. Eye pressure was measured before and after anesthesia to se…

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This study compared two devices that measure the eye before cataract surgery to help pick the right lens implant. 144 Thai adults had both measurements taken on the same day. The goal was to see which device more accurately predicted the patient's vision one month after surgery.

This study examined how vision loss progresses in people with geographic atrophy, an advanced form of dry age-related macular degeneration. Researchers analyzed past medical records and eye images from 60 patients to see which retinal changes are linked to faster vision decline. …

This study looked at a rare disease called IgG4-related disease, which causes swelling and scarring in organs. Researchers compared immune cells in the blood of 75 people: those with the disease, those with Sjogren syndrome, and healthy volunteers. The goal was to better understa…

This study looked at whether a food safety training program helps food service employees improve their knowledge, attitudes, and practices around safe food handling. About 200 adult workers took part, and the training covered personal hygiene and safe food preparation. The goal w…

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study looked at 100 adults with atopic dermatitis (eczema) who were prescribed tralokinumab. Researchers tracked how many developed eye problems like conjunctivitis within 4 months of starting the drug. The goal was to better understand these side effects in real-world use, …

This pilot study tested whether giving a sedative pill (alprazolam) before cataract surgery works as well as IV sedation (midazolam) in adults 65 and older. Twenty participants were randomly assigned to one of the two approaches, and researchers measured how well their thinking a…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…

This study looked at the costs of cataract surgery done in a doctor's office versus an ambulatory surgery center. Researchers analyzed data from 76 patients who had routine cataract surgery. The goal was to see which setting is more cost-effective.

This study looked back at 170 adults with a serious eye infection called endophthalmitis to see if early surgery (within 48 hours) helps vision more than starting with medicine alone. Researchers compared how well people could see one month after treatment. The goal is to find ou…

This study looked at how often people with primary Sjögren's syndrome have digestive issues. Researchers asked 151 patients about 10 different digestive symptoms using a simple questionnaire. The goal was to understand which symptoms are most common and how they relate to how lon…

This early-phase study at Stanford looked at how a nutritional supplement called alpha-ketoglutarate is absorbed into the eyes when taken orally. Seventeen adults with age-related eye diseases participated. The main goal was to measure changes in the supplement's level in eye flu…

This study looked at 78 people in Pakistan who had surgery for a detached retina. Doctors compared two types of fillers used inside the eye after surgery—gas or silicone oil—to see if one caused more shifting of the retina afterward. The goal was to learn how the choice of filler…

This study looked at the DNA changes (mutations) in eye cancers called ocular melanoma. Researchers analyzed tumor samples from 58 patients to understand how these cancers develop and spread. The goal was to identify key mutations that could lead to better treatments in the futur…

This completed study looked at 31 people with dry eye to see if measuring corneal sensitivity (how well the eye feels touch) can detect early-stage neurotrophic keratopathy, a condition where the cornea loses sensation. Researchers aimed to find out which dry eye patients might l…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study looked at proteins in the eye fluid of 100 people with wet age-related macular degeneration (AMD). The goal was to measure certain growth factors that might explain why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers collected a …

This study looked at data from 1100 people who had SMILE laser eye surgery to fix nearsightedness. Researchers used a computer model to predict how well patients would see one year after surgery. The goal was to see if the model could give more accurate results than the usual pla…

This study compared gum health and levels of inflammatory substances in the mouth and blood of 25 people with non-infectious uveitis (an eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and cytokines like TNF-α and IL-10. The goal was…

This study followed 609 nearsighted adults who had lens surgery to see if a natural eye change called posterior vitreous detachment (PVD) affects their risk of retinal detachment. Participants were grouped by whether they had PVD before surgery or not, and were monitored for up t…

This study looked at 154 people with keratoconus, a condition that thins and bulges the cornea, to understand why it is often worse in one eye than the other. Researchers compared those with uneven severity to those with similar severity in both eyes, focusing on eye rubbing habi…

This pilot study tested whether a patient navigator—a person who helps coordinate medical care—could increase eye exam rates in 35 adults with diabetes who were at high risk for blindness. Participants met with a navigator quarterly to overcome barriers to care. The study measure…

This study tested a digital color scale to objectively measure scarring of the eye's surface in people with recurrent pterygium, a growth that can come back after surgery. Researchers took photos of 25 patients' eyes and used software to analyze the scar tissue. The goal was to s…

This study looked at 44 people with a rare inherited eye condition called Leber Hereditary Optic Neuropathy (LHON) that causes vision loss. Researchers reviewed medical records and asked participants about their vision, health, and quality of life. The goal was to better understa…

This study looked for two rare genetic diseases, Gaucher disease and acid sphingomyelinase deficiency (ASMD), in 122 adults with an unexplained enlarged spleen or who had their spleen removed for unknown reasons. Researchers used a simple blood spot test to check enzyme activity …

This study analyzed tear and eye fluid samples from 100 cataract surgery patients to find biomarkers that could predict dry eye disease after surgery. Researchers used advanced chemical analysis to look for clues in the eye's surface cells and inner fluid. The goal is to better u…

This study looked at 91 people with a type of bleeding in the eye caused by age-related macular degeneration (AMD). It compared two treatments: surgery followed by anti-VEGF injections, or a gas injection followed by anti-VEGF injections. The goal was to see which approach helps …

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at 202 people who had surgery for retinal detachment, a condition where the light-sensitive layer at the back of the eye pulls away. Researchers used high-resolution eye scans and vision tests to see how the eye heals over a year. The goal was to better understa…

This study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature newborns born before 29 weeks. The goal was to see if lower …

This study looked at how the COVID-19 lockdown changed the health habits and medical care of 1,343 people with chronic conditions like heart disease, multiple sclerosis, and hemophilia. Researchers used phone surveys to track medication use, lifestyle changes, and access to healt…

This completed French study followed 748 adults undergoing retina/vitreous surgery to see if taking blood thinners (anticoagulants or antiplatelets) raises the risk of bleeding complications. Researchers compared patients who continued or stopped their medication with those not o…

This study measured muscle activity in surgeons performing hysterectomies with robotic assistance versus conventional laparoscopy. The goal was to see which method causes less physical strain, potentially reducing work-related injuries. Four trained surgeons participated, and the…

This study looked at 30 patients with a type of age-related macular degeneration (AMD) to see how treatment affects the barrier between blood and eye fluid. Researchers measured protein levels in the eye fluid before and during anti-angiogenic therapy. The goal was to better unde…

This completed study looked at fluid samples from the eyes of 137 people undergoing surgery for retinal detachment or other eye conditions. Researchers measured fats and proteins in these fluids to understand inflammation and cell death that can harm vision after surgery. The goa…

This study collected information from nearly 1,000 people in France with inherited retinal diseases (IRDs) to better understand the genetics behind these conditions. Researchers looked at genetic test results and disease types to help build a national registry. The goal is to imp…

This study examined whether certain genes are linked to a severe form of diabetic eye disease called proliferative diabetic retinopathy (PDR). Researchers analyzed DNA from 302 people with type 2 diabetes, some with PDR and some without. The goal was to find genetic markers that …

This study followed 76 women with congenital toxoplasmosis (a parasitic infection present from birth) to see if pregnancy increases the risk of eye inflammation (retinochoroiditis). Researchers checked eye exams done during pregnancy and after childbirth, comparing them to non-pr…

This study observed 5000 cataract surgery patients to see if using a special handpiece (Active Sentry) makes the procedure safer. The handpiece helps control pressure inside the eye during surgery, which may reduce the amount of energy needed and lower the risk of complications. …

This study tested whether artificial intelligence (AI) can help doctors better predict how diabetic retinopathy (an eye disease from diabetes) will progress. Over 3,000 adults with diabetes were followed for about 2 years. The goal was to create a smarter system that uses eye ima…

This completed study gathered detailed measurements of the eye's surface and visual imperfections from 52 adults with keratoconus, a condition that thins and bulges the cornea. Researchers used a special scanner to map the cornea and sclera. The goal is to use this real-world dat…

This study looked at whether a central monitoring station outside the operating room could safely replace having an anesthesia nurse in each room during eye surgeries like cataract removal. Researchers compared the rate of complications (like high blood pressure or low oxygen) be…

This study looked at eye damage in 34 people who were hospitalized for severe COVID-19. Researchers used many eye exams and scans to find problems like inflammation, dry eye, and blood vessel damage. The goal was to better understand what eye issues can happen after a serious COV…

This study looked at two ways of monitoring wet age-related macular degeneration (AMD) using eye scans: standard OCT B-scans and a newer technique called OCT angiography. The goal was to see if the newer scan could better detect when the disease is active, helping doctors decide …

This study looked at 120 children with glaucoma or suspected glaucoma who needed eye exams under anesthesia. The goal was to see if a standard anesthesia plan could produce consistent and reliable eye pressure measurements. Researchers measured how deep the anesthesia was and com…

This study looked at two methods for fixing a tissue graft after removing a pterygium, a growth on the eye's surface. In 30 patients with pterygium in both eyes, one eye received stitches and the other did not. Researchers used special imaging to compare healing, comfort, and gra…

This study reviewed medical records of 274 adults who had emergency surgery for a torn aorta (aortic dissection). Researchers looked at how often patients had brain complications like stroke or coma after surgery and whether those complications led to longer stays in the intensiv…

This study followed 150 children aged 2 to 12 who have a port wine stain on a leg. Researchers tracked how the stain changes as the child grows, and whether it leads to problems like blood vessel issues or bone growth differences. The goal was to learn more about the condition an…

This study looked at 400 people aged 60-90 who had cataract surgery. They received either a white or yellow artificial lens. Researchers wanted to see if the color of the lens affected sleep time, sleep quality, and mood two months after surgery. The idea is that blue light filte…

This study looked at how safe and effective the drug Soliris is for Korean patients with a rare disease called NMOSD. It involved 11 people who were already taking the drug as part of their normal medical care. The goal was to track side effects and see if the drug helped prevent…

This study tested a new questionnaire designed to measure how well babies (0-36 months old) with eye diseases can see, even before they can talk. The goal was to help doctors decide the best time for surgery. The study included 150 children with different eye conditions and check…

This study looked at 46 people who had a first episode of optic neuritis (inflammation of the optic nerve). Researchers used special MRI scans to measure the length of the damaged nerve area and then checked how much vision-related nerve loss occurred one year later. The goal was…

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This study looked at 202 adults with type 2 diabetes and early-stage diabetic eye disease (non-proliferative diabetic retinopathy). Researchers used non-invasive eye scans to find markers that could predict if the disease would get worse or lead to sight-threatening problems. The…

This study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…

This completed study looked at 100 people with low-to-moderate nearsightedness who chose either SMILE or LASEK laser eye surgery. Researchers measured contrast sensitivity and eye-brain signals to see how visual quality changed after surgery. The goal was to understand how age af…

This study looked at 10 people with rare genetic conditions that cause very low cholesterol and trouble absorbing vitamins. Researchers measured a protective pigment in the eye called macular pigment, which may be low in these patients and could explain why some still develop vis…

This study followed 250 children under 4 years old with congenital glaucoma in France. Researchers wanted to see if finding the disease earlier leads to better eyesight at age 4. They measured vision and eye pressure to understand how timing of diagnosis affects long-term outcome…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This study looked at 27 adults with Sjögren's syndrome to find out how common jaw joint problems (TMD) are and if they relate to disease activity. Researchers measured jaw function, mouth opening, head posture, and oral health. The goal was to better understand the link between S…

This study looked at why people with Lowe syndrome, a rare genetic disorder, may have unusual bleeding. Researchers took blood samples from 30 patients to test how well their platelets work. The goal was to confirm and understand any platelet problems that could cause bleeding ev…

This study looked at 175 premature babies to see if high iron levels in their blood during the first month of life are linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured iron-related markers and tracked which babies developed ROP. The …

This study looked at brain activity in 43 people in a coma after severe brain injury. Researchers used MRI scans to see how different brain regions communicate, aiming to understand what happens in the brain during coma and as people wake up. No treatment was given; the goal was …

This study looked at new ways to measure and train eye movements in 21 people with macular degeneration, a condition that causes central vision loss. The goal was to see if training could help them use their remaining side vision more effectively. The research focused on understa…

This study looked at 470 people with age-related macular degeneration (AMD) to see if special eye scans (SDOCT) can predict vision loss and disease worsening. Participants were already in the AREDS 2 trial and had moderate to high risk of progression. Researchers tracked changes …

This study followed about 100 babies who were treated for retinopathy of prematurity (ROP) with either Eylea injections or laser therapy in an earlier trial. Researchers checked their vision and eye health years later to see how well the treatments held up. The goal is to underst…

This study looked at the brain's lymphatic system in 40 women with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss. Researchers used a special MRI technique to compare lymphatic vessels in patients and healthy controls. The goal wa…

This study looked at how stable a Clareon artificial lens stays in the eye after cataract surgery. It included 34 people with either very short or very long eyes. The researchers measured changes in eye structure and vision results, but no new treatment was tested.

This study looked at whether telling healthy adults their genetic risk for age-related macular degeneration (AMD) encourages them to eat more carotenoid-rich foods, which are good for eye health. Eighty Caucasian participants aged 18 to 64 without AMD were given genetic risk info…

This study looked at why some people lose cells on the inner surface of their cornea after having a special lens implant for severe nearsightedness. Researchers compared fluid and tear samples from 126 patients having lens removal or routine cataract surgery. The goal was to see …

This study looked at specific cells in the blood of 40 women with either Sjögren's syndrome or systemic sclerosis. The goal was to see if counting these cells could help understand the diseases better. No treatment was given; it was purely an observational study to explore potent…

This study followed 31 children with GM1 or GM2 gangliosidosis (including Tay-Sachs and Sandhoff disease) to carefully measure how their neurological symptoms, like walking and speech, change over time. The goal was to create a clear picture of disease progression to help design …

This completed study looked at 556 people to understand how night vision problems are connected to early age-related macular degeneration (AMD). Participants took vision tests and had detailed eye imaging. The goal was to find reliable markers that could help design future treatm…

This study examined 60 children under 18 with an unexplained enlarged spleen to see how often rare diseases like Gaucher disease were the cause. Researchers ruled out common reasons first, then tested for specific enzyme deficiencies. The goal was to better understand what hidden…

This study looked at two important eye measurements—angle kappa and angle alpha—in 70 healthy adults. Researchers used eye exams and imaging to see how these angles relate to each other. The goal is to help eye doctors better plan surgeries like cataract or laser correction.

This study looked at whether measuring tumor DNA in the blood can help doctors know if surgery to remove liver metastases from uveal melanoma was successful. Researchers took blood samples from 60 patients before and after surgery and during follow-up. The goal was to see if chan…

This study tested whether personalized risk profiling (including genetic testing) and coaching can motivate people with age-related macular degeneration (AMD) to change their lifestyle. 150 participants received standard lifestyle advice plus supplements, and some also got person…

This study looked at whether multiple sclerosis (MS) and its treatments affect a woman's egg supply. Researchers measured a hormone called AMH in blood samples from over 800 women with MS or a related condition. The goal was to see if disease activity or medications impact ovaria…

This completed study tested NCX 470 eye drops in 18 healthy adults to see how they change fluid dynamics inside the eye. Participants received either the active drop or a placebo for 8 days. The goal was to measure fluid production, drainage, and pressure. Results will help resea…

This study looked at 905 people with uveitis, an eye inflammation, to see if a standardized step-by-step diagnostic plan works as well as letting doctors choose any tests they want. The goal was to find the cause of the uveitis more efficiently and at a lower cost. Researchers co…

This study tested a new, non-invasive eye scan called OCT angiography to see if it can better detect changes in abnormal blood vessels in people with wet age-related macular degeneration (AMD) who are being treated with Eylea. Researchers followed 49 patients to compare the new s…

This study looked at how music and familiar sounds affect brain activity in people with consciousness disorders after a coma, as well as in healthy volunteers. Researchers measured brain responses (P300 waves) to hearing a person's own name or other sounds. The goal was to unders…