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Music may boost brain activity in coma patients, study finds

NCT ID NCT02742506

Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how music and familiar sounds affect brain activity in people with consciousness disorders after a coma, as well as in healthy volunteers. Researchers measured brain responses (P300 waves) to hearing a person's own name or other sounds. The goal was to understand if music can improve alertness and cognitive function in these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help develop music-based tools to assess or improve consciousness in brain-damaged patients.
What could go wrong
This is a small, completed observational study, not a treatment trial. Results may not lead to direct clinical changes or benefit patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

86 people

The number who actually took part.

Started

Jun 2013

Finished

Oct 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Brain-damaged patients : Inclusion Criteria: * Disorders of consciousness (Traumatic brain injury, stroke or anoxic encephalopathy) * Coma diagnosis (Plum and Posner, 1966), vegetative state (Task Force, 1994) or minimally conscious state (Giacino, Ashwal et al. 2002) * Lack of autonomic crisis since one week minimum * Medical condition considered stable * Patients who do not present hearing loss. Peaks I and II of Brainstem Auditory Evoked Potentials (BAEP) will be normal. Exclusion Criteria: * Hearing Problem * Uncontrolled Epilepsy * Autonomic crises * Medical unstable state * Pregnant or likely to be (interrogation data) or breastfeeding woman Healthy participants : Inclusion Criteria: * Subjects with normal hearing * Absence of neurological disorder * Subjects able to understand the experimental instructions Exclusion Criteria: * Hearing problems and / or hearing loss higher than 30 decibels Hearing Level (dB HL) at a frequency band from 250 to 8000 Hz * Neurological disorders * Pregnant or likely to be (interrogation data) or breastfeeding woman

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Conditions

The condition(s) this trial relates to.

Coma Consciousness Disorders ocular motor apraxia, Cogan type Persistent Vegetative State

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMA

Contacts and locations

Locations

  • Hospices Civils de Lyon - Hôpital Neurologique Pierre Wertheimer - Service de Médecine Physique et Réadaptation

    Lyon, 69500, France

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