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Can a liver cancer drug stop eye cancer spread?

NCT ID NCT02517736

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested the drug sorafenib (Nexavar) in 32 adults with uveal melanoma that had spread to other parts of the body. The goal was to see if the drug could stop tumors from growing for at least 24 weeks. Sorafenib is already used for other cancers, and researchers wanted to know if it could help people with this rare eye cancer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sorafenib (Nexavar)
What this could lead to
If it works, this could provide a treatment option to slow tumor growth in patients with metastatic uveal melanoma.
What could go wrong
This is a small, early-phase trial with only 32 participants, so results may not apply broadly. Sorafenib can cause side effects like fatigue, diarrhea, and skin reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2012

Finished

Jan 2015

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female over 18 years old suffering from uveal melanoma with metastasis * At least one measurable metastases by more than 10 mm acoording to Response Evaluation Criteria in Solid Tumors (RECIST) * At least 28 days from the previous treatment (systemic or major surgery) * Performance Index (WHO ≤ 2 or ≥ 70% Karnofsky) * Weight loss compared to pre morbid weight \<20% in the last 12 months * White blood cells at least 3000 / mm 3, polynuclear neutrophils less than 1500 / mm3, platelets at least 100,000 / mm3, hemoglobin at least 9.0 g / dl * Total Bilirubin ≤1.5 x upper limit of normal (ULN) (or less than or equal to 2.5 in liver metastasis), ASAT and ALAT ≤ 2.5 x ULN (or ≤ 5 in liver metastasis) Serum Creatinine (calculated using the cockcroft-Gault method) ≤ 1.5 x ULN, Amylase and lipase \<1.5 x ULN * prothrombin rate and international normalized ratio (INR) or activated partial thromboplastin time (aPTT) ≤ 1.5 x ULN. Possibility of using low molecular weight heparin in place of anti vitamin K treatment * higher life expectancy than or equal to 3 months * Negative pregnancy test for women of childbearing age and using a method of contraception during treatment * No one benefiting from a Social Security scheme * Informed consent and signed by the patient or his legal representative Exclusion Criteria: * • Patient who received more than 2 lines of treatment (chemotherapy or immunotherapy), whatever the indication * Major surgery (excluding the possible diagnostic biopsy) or radiation therapy in the 4 weeks preceding the inclusion * single liver metastasis treatable by surgery * active peptic ulcer, uncontrolled * Other progressive malignancy or during treatment (except basal cell carcinoma) * Cardiac arrhythmias requiring anti-arrhythmic (excluding beta-blockers or digoxin for chronic atrial fibrillation), active or ischemic coronary disease (myocardial infarction within the last 6 months), or heart failure\> New York Heart Association (NYHA) class II * Bacterial or fungal infection active (grade\> 2 Common Toxicity Criteria for Adverse Effects (CTCAE) v4.03) * known HIV infection or chronic hepatitis B or C * cerebral or meningeal tumor metastasis (symptomatic or asymptomatic) * epileptic disease requiring anti-epileptic taken * Previous history of organ transplantation or peripheral stem cells * Patient kidney dialysis * Concomitant treatment with cytochrome P450 3A4 (CYP3A4) inducers such as rifampin, St. John's wort, phenytoin, carbamazepine, phenobarbital and dexamethasone * Prior therapy with bevacizumab or other targeted therapy * Known or suspected allergy to sorafenib * Any unstable chronic illness can jeopardize patient safety or its compliance * Women pregnant or lactating * coagulopathy * Uncontrolled hypertension * Inability to swallow * Failure to submit to medical monitoring of the trial due to geographical, social or psychic * Persons deprived of liberty or under supervision * Patient refusing ambulatory care * Patient simultaneously participating in another clinical trial

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Service d'ophtalmologie, CHU de Caen

    Caen, 14000, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.