Eye drop showdown: which artificial tear works best for dry eyes?
NCT ID NCT07451184
First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 2 times
Summary
This study compares two lubricating eye drops—Systane PRO PF and Thealoz Duo—to see which one better relieves dry eye symptoms. About 100 adults with dry eye will use each drop for 4 weeks, one twice a day and the other four times a day. The goal is to find out if they work equally well or if one provides superior comfort.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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36 people
The number who actually took part.
- Started
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Feb 2026
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Are at least 18 years of age and have full legal capacity to volunteer; 2. Have understood and signed an institutional review board (IRB)/ independent ethics committee (IEC) approved informed consent form; 3. Are willing and able to attend all study visits as required per protocol; 4. Are willing to discontinue use of all habitual artificial tear supplements and use only the study drops as directed for the entire study duration; 5. Have dry eye symptomatology as per Tear Film \& Ocular Surface Society Dry Eye WorkShop (TFOS DEWS) II definition: * Have an Ocular Surface Disease Index (OSDI) score ≥13; 6. Have an absence of active\* anterior segment disease; 7. Have not worn contact lenses for the previous 14 days before screening, and are willing to not wear contact lenses for the duration of the study; 8. Are correctable to a visual acuity of +0.20 LogMAR or better (in at least one eye) with refraction results. Exclusion Criteria: 1. Have taken part in an interventional clinical study within the previous 14 days before screening; 2. Are participating in any concurrent ocular or interventional clinical trial; 3. Have any active\* ocular inflammation, infection, or are using ocular topical treatment (other than dry eye drops); 4. Started any systemic medication known to cause dry eye (e.g., anti-histamine, antidepressants, benzodiazepines, etc.) within 30 days before screening. Stable dosing for \>30 days before screening is allowed, but changes (including commencing new) of dosing of such medication within the study period would lead to early exit from the study; 5. Had any ocular injury or surgery within the 1 year prior to screening, nor have ocular surgery planned/ anticipated; 6. Have biomicroscopy signs of grade 3 or more (Efron scale); 7. Have known sensitivity to the diagnostic pharmaceuticals or to any ingredients in the study products; 8. Are pregnant, lactating or planning a pregnancy at the time of enrolment; 9. Are a member of the Centre for Ocular Research \& Education directly involved in this study (on the delegation log); 10. Are an employee of Alcon.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre for Ocular Research & Education (CORE)
Waterloo, Ontario, N2L 3G1, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new eyedrop heal the cornea in dry eye disease?
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- Can a new eye drop fully clear dry eye redness?
- Could a common dry eye drop shield the Cornea's inner layer?