Could your gut bacteria be linked to eye disease?
NCT ID NCT01859299
First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 11 times
Summary
This study looked at the natural bacteria in the gut of 131 adults with and without uveitis, an inflammatory eye disease. Researchers collected stool and blood samples and performed eye exams to see if differences in gut bacteria are linked to eye inflammation. No treatment was given; the goal was simply to gather information.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could point toward new ways to treat or prevent uveitis by targeting gut bacteria.
- What could go wrong
- This is an observational study, not a treatment trial. It only looks for links between gut bacteria and eye inflammation, so it may not lead to any direct medical advances.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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131 people
The number who actually took part.
- Started
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Aug 2013
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
200 participants: 150 with uveitis; 50 healthy controls
- Ages
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18 to 120 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: Inclusion Criteria for Uveitis Participants 1. Participant must be 18 years of age or older. 2. Participant must have a diagnosis of: Uveitis (or ocular inflammatory disorder) 3. Participant must be able to undergo slit lamp biomicroscopy. 4. Participant must understand and sign the protocol s informed consent document. Inclusion Criteria for Healthy Volunteers 1. Participant must be 18 years of age or older. 2. Participant must be able to undergo slit lamp biomicroscopy. 3. Healthy controls will be age-and sex-matched individuals with no personal history of uveitis or other rheumatologic/autoimmune diseases (such as arthritis, inflammatory bowel disease, type 1 diabetes mellitus, psoriasis, Sjorgren s syndrome or multiple sclerosis) and no current use of corticosteroids, disease modifying antirheumatic drugs (DMARDs) including those with antibiotic properties (e.g., gold salts, sulfasalazine, hydroxychloroquine, minocycline) or any immunomodulatory drugs. 4. Participant must understand and sign the protocol s informed consent document. EXCLUSION CRITERIA: Exclusion Criteria for Uveitis Participants 1. Participants who are unable to provide informed consent. 2. Recent (\<3 months prior) use of any antibiotic therapy 3. Current consumption of probiotics 4. Current extreme diet (parenteral nutrition, macrobiotic diet, etc.) 5. Known gastrointestinal (GI) tract neoplasm 6. Recent GI tract infection (gastroenteritis, colitis, diverticulitis, appendicitis) within the last month 7. Chronic unexplained diarrhea 8. Participant has or had a significant active infection (an infection requiring treatment as determined by the investigator) that required systemic antibiotic treatment within the past three months 9. Participant has any GI tract surgery leaving permanent residua (e.g., gastrectomy; bariatric surgery; colectomy) 10. Participant has inflammatory bowel disease (IBD) 11. Participant is pregnant or lactating. Exclusion Criteria for Healthy Volunteers 1. Recent (\<3 months prior) use of any antibiotic therapy 2. Current consumption of probiotics 3. Current extreme diet (parenteral nutrition, macrobiotic diet, etc.) 4. Known gastrointestinal (GI) tract neoplasm 5. Recent GI tract infection (gastroenteritis, colitis, diverticulitis, appendicitis) within the last month 6. Chronic unexplained diarrhea 7. Participant has or had a significant active infection (an infection requiring treatment as determined by the investigator) that required systemic antibiotic treatment within the past three months 8. Participant has any GI tract surgery leaving permanent residua (e.g., gastrectomy; bariatric surgery; colectomy) 9. Participant has inflammatory bowel disease (IBD) 10. Participant is pregnant or lactating.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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